Details for: OFD1

Gene ID: 8481

Symbol: OFD1

Ensembl ID: ENSG00000046651

Description: OFD1 centriole and centriolar satellite protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 289.7550
    Cell Significance Index: -45.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 157.6229
    Cell Significance Index: -39.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.6232
    Cell Significance Index: -49.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.5305
    Cell Significance Index: -42.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.4428
    Cell Significance Index: -48.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 73.8724
    Cell Significance Index: -49.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.2632
    Cell Significance Index: -42.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.5821
    Cell Significance Index: -47.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.8589
    Cell Significance Index: -39.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.3034
    Cell Significance Index: -48.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.2395
    Cell Significance Index: -22.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.0847
    Cell Significance Index: 199.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.4102
    Cell Significance Index: 16.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3596
    Cell Significance Index: 63.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2363
    Cell Significance Index: 64.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2208
    Cell Significance Index: 33.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2166
    Cell Significance Index: 241.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2053
    Cell Significance Index: 54.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0622
    Cell Significance Index: 213.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0222
    Cell Significance Index: 132.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9812
    Cell Significance Index: 27.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9621
    Cell Significance Index: 27.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8293
    Cell Significance Index: 748.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7956
    Cell Significance Index: 93.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7490
    Cell Significance Index: 42.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7062
    Cell Significance Index: 90.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6890
    Cell Significance Index: 68.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6036
    Cell Significance Index: 108.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5951
    Cell Significance Index: 213.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5749
    Cell Significance Index: 26.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5290
    Cell Significance Index: 65.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5020
    Cell Significance Index: 68.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4867
    Cell Significance Index: 265.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4433
    Cell Significance Index: 34.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4168
    Cell Significance Index: 9.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4098
    Cell Significance Index: 283.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3891
    Cell Significance Index: 10.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3523
    Cell Significance Index: 26.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3331
    Cell Significance Index: 147.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3077
    Cell Significance Index: 18.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2904
    Cell Significance Index: 7.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2757
    Cell Significance Index: 19.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2558
    Cell Significance Index: 16.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2479
    Cell Significance Index: 47.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1481
    Cell Significance Index: 6.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0958
    Cell Significance Index: 180.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0943
    Cell Significance Index: 59.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0924
    Cell Significance Index: 15.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0632
    Cell Significance Index: 2.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0455
    Cell Significance Index: 70.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0342
    Cell Significance Index: 63.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0275
    Cell Significance Index: 1.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0191
    Cell Significance Index: 25.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0137
    Cell Significance Index: 0.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0104
    Cell Significance Index: -7.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0195
    Cell Significance Index: -8.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0235
    Cell Significance Index: -17.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0321
    Cell Significance Index: -20.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0618
    Cell Significance Index: -34.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0804
    Cell Significance Index: -8.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0865
    Cell Significance Index: -4.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0866
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1078
    Cell Significance Index: -12.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1259
    Cell Significance Index: -26.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1430
    Cell Significance Index: -41.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1504
    Cell Significance Index: -17.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1573
    Cell Significance Index: -22.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2026
    Cell Significance Index: -13.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2367
    Cell Significance Index: -5.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2562
    Cell Significance Index: -29.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2646
    Cell Significance Index: -13.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2912
    Cell Significance Index: -10.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3149
    Cell Significance Index: -2.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3965
    Cell Significance Index: -5.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4027
    Cell Significance Index: -10.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4086
    Cell Significance Index: -4.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4123
    Cell Significance Index: -42.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4643
    Cell Significance Index: -10.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4881
    Cell Significance Index: -11.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5042
    Cell Significance Index: -8.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5204
    Cell Significance Index: -13.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5342
    Cell Significance Index: -42.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5425
    Cell Significance Index: -15.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6016
    Cell Significance Index: -15.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6475
    Cell Significance Index: -19.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6921
    Cell Significance Index: -17.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7245
    Cell Significance Index: -44.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8073
    Cell Significance Index: -17.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8711
    Cell Significance Index: -27.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8808
    Cell Significance Index: -23.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8957
    Cell Significance Index: -14.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9627
    Cell Significance Index: -31.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9671
    Cell Significance Index: -30.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9980
    Cell Significance Index: -20.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0512
    Cell Significance Index: -22.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0551
    Cell Significance Index: -15.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0556
    Cell Significance Index: -36.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0736
    Cell Significance Index: -39.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1024
    Cell Significance Index: -31.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The OFD1 gene encodes a protein that localizes to centriolar satellites, which are microtubule-based structures that surround the centrioles. Centriolar satellites are thought to play a role in the regulation of centriole biogenesis, maintenance, and separation. The OFD1 protein has been shown to interact with other proteins, including alpha-tubulin, gamma-tubulin, and aurora kinase A (Aurka), which are essential for centriole biogenesis and cell cycle progression. **Pathways and Functions:** The OFD1 gene is involved in several key cellular pathways, including: 1. **Centriole biogenesis and maintenance:** OFD1 is required for the formation and maintenance of centrioles and centrosomes. Centrioles are essential for the formation of cilia, flagella, and the spindle fibers that separate chromosomes during mitosis. 2. **Cell cycle regulation:** OFD1 interacts with Aurora kinase A (Aurka) and other proteins to regulate the cell cycle, particularly during the G2/M transition. 3. **Ciliary basal body formation:** OFD1 plays a critical role in the formation of ciliary basal bodies, which are essential for the assembly and maintenance of cilia. 4. **Left-right asymmetry:** OFD1 has been implicated in the establishment of left-right asymmetry in the embryo, which is critical for the development of the cardiovascular system and other organs. **Clinical Significance:** Mutations in the OFD1 gene have been associated with Oral-Facial-Digital Syndrome 1, a rare genetic disorder characterized by abnormalities in the development of the oral, facial, and digital tissues. Other conditions, such as cerebral folate malabsorption and primary ciliary dyskinesia, have also been linked to OFD1 mutations. The OFD1 gene is also of interest in the study of cancer, as mutations in the gene have been associated with an increased risk of certain types of cancer, including breast and prostate cancer. In conclusion, the OFD1 gene is a critical component of centriolar satellites and plays a vital role in the formation and function of centrioles and centrosomes. Mutations in the OFD1 gene have significant implications for human health, particularly in the development of genetic disorders and an increased risk of certain types of cancer. Further research is needed to fully elucidate the functions of the OFD1 gene and its role in human disease.

Genular Protein ID: 257659886

Symbol: OFD1_HUMAN

Name: Oral-facial-digital syndrome 1 protein

UniProtKB Accession Codes:

O75665 B9ZVU5 O75666 Q4VAK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 20 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9722947

Title: Characterization of Cxorf5 (71-7A), a novel human cDNA mapping to Xp22 and encoding a protein containing coiled-coil alpha-helical domains.

PubMed ID: 9722947

DOI: 10.1006/geno.1998.5348

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33934390

Title: The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.

PubMed ID: 33934390

DOI: 10.15252/embj.2020106503

PubMed ID: 12595504

Title: OFD1, the gene mutated in oral-facial-digital syndrome type 1, is expressed in the metanephros and in human embryonic renal mesenchymal cells.

PubMed ID: 12595504

DOI: 10.1097/01.asn.0000054497.48394.d2

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16783569

Title: A novel X-linked recessive mental retardation syndrome comprising macrocephaly and ciliary dysfunction is allelic to oral-facial-digital type I syndrome.

PubMed ID: 16783569

DOI: 10.1007/s00439-006-0210-5

PubMed ID: 17761535

Title: Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex.

PubMed ID: 17761535

DOI: 10.1091/mbc.e07-03-0198

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19800048

Title: OFD1 is mutated in X-linked Joubert syndrome and interacts with LCA5-encoded lebercilin.

PubMed ID: 19800048

DOI: 10.1016/j.ajhg.2009.09.002

PubMed ID: 20230748

Title: Ofd1, a human disease gene, regulates the length and distal structure of centrioles.

PubMed ID: 20230748

DOI: 10.1016/j.devcel.2009.12.022

PubMed ID: 20835237

Title: Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy.

PubMed ID: 20835237

DOI: 10.1038/ng.662

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22619378

Title: Deep intronic mutation in OFD1, identified by targeted genomic next-generation sequencing, causes a severe form of X-linked retinitis pigmentosa (RP23).

PubMed ID: 22619378

DOI: 10.1093/hmg/dds194

PubMed ID: 24121310

Title: A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis.

PubMed ID: 24121310

DOI: 10.1038/emboj.2013.223

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24089205

Title: Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.

PubMed ID: 24089205

DOI: 10.1038/nature12606

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24997988

Title: The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation.

PubMed ID: 24997988

DOI: 10.1038/ng.3031

PubMed ID: 26643951

Title: OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome.

PubMed ID: 26643951

DOI: 10.1093/hmg/ddv488

PubMed ID: 11179005

Title: Identification of the gene for oral-facial-digital type I syndrome.

PubMed ID: 11179005

DOI: 10.1086/318802

PubMed ID: 11950863

Title: Four novel mutations in the OFD1 (Cxorf5) gene in Finnish patients with oral-facial-digital syndrome 1.

PubMed ID: 11950863

DOI: 10.1136/jmg.39.4.292

PubMed ID: 16397067

Title: Clinical, molecular, and genotype-phenotype correlation studies from 25 cases of oral-facial-digital syndrome type 1: a French and Belgian collaborative study.

PubMed ID: 16397067

DOI: 10.1136/jmg.2004.027672

PubMed ID: 23033313

Title: Novel mutations including deletions of the entire OFD1 gene in 30 families with type 1 orofaciodigital syndrome: A study of the extensive clinical variability.

PubMed ID: 23033313

DOI: 10.1002/humu.22224

PubMed ID: 26477546

Title: Joubert Syndrome in French Canadians and Identification of Mutations in CEP104.

PubMed ID: 26477546

DOI: 10.1016/j.ajhg.2015.09.009

Sequence Information:

  • Length: 1012
  • Mass: 116671
  • Checksum: C2BF4376F89E6738
  • Sequence:
    • MMAQSNMFTV ADVLSQDELR KKLYQTFKDR GILDTLKTQL RNQLIHELMH PVLSGELQPR 
SISVEGSSLL IGASNSLVAD HLQRCGYEYS LSVFFPESGL AKEKVFTMQD LLQLIKINPT 
SSLYKSLVSG SDKENQKGFL MHFLKELAEY HQAKESCNME TQTSSTFNRD SLAEKLQLID 
DQFADAYPQR IKFESLEIKL NEYKREIEEQ LRAEMCQKLK FFKDTEIAKI KMEAKKKYEK 
ELTMFQNDFE KACQAKSEAL VLREKSTLER IHKHQEIETK EIYAQRQLLL KDMDLLRGRE 
AELKQRVEAF ELNQKLQEEK HKSITEALRR QEQNIKSFEE TYDRKLKNEL LKYQLELKDD 
YIIRTNRLIE DERKNKEKAV HLQEELIAIN SKKEELNQSV NRVKELELEL ESVKAQSLAI 
TKQNHMLNEK VKEMSDYSLL KEEKLELLAQ NKLLKQQLEE SRNENLRLLN RLAQPAPELA 
VFQKELRKAE KAIVVEHEEF ESCRQALHKQ LQDEIEHSAQ LKAQILGYKA SVKSLTTQVA 
DLKLQLKQTQ TALENEVYCN PKQSVIDRSV NGLINGNVVP CNGEISGDFL NNPFKQENVL 
ARMVASRITN YPTAWVEGSS PDSDLEFVAN TKARVKELQQ EAERLEKAFR SYHRRVIKNS 
AKSPLAAKSP PSLHLLEAFK NITSSSPERH IFGEDRVVSE QPQVGTLEER NDVVEALTGS 
AASRLRGGTS SRRLSSTPLP KAKRSLESEM YLEGLGRSHI ASPSPCPDRM PLPSPTESRH 
SLSIPPVSSP PEQKVGLYRR QTELQDKSEF SDVDKLAFKD NEEFESSFES AGNMPRQLEM 
GGLSPAGDMS HVDAAAAAVP LSYQHPSVDQ KQIEEQKEEE KIREQQVKER RQREERRQSN 
LQEVLERERR ELEKLYQERK MIEESLKIKI KKELEMENEL EMSNQEIKDK SAHSENPLEK 
YMKIIQQEQD QESADKSSKK MVQEGSLVDT LQSSDKVESL TGFSHEELDD SW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.