Details for: PRSS12

Gene ID: 8492

Symbol: PRSS12

Ensembl ID: ENSG00000164099

Description: serine protease 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.2827
    Cell Significance Index: -8.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.6411
    Cell Significance Index: -8.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.9611
    Cell Significance Index: 44.3700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.9240
    Cell Significance Index: 18.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7673
    Cell Significance Index: 40.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7148
    Cell Significance Index: 77.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4407
    Cell Significance Index: 74.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3446
    Cell Significance Index: 255.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2573
    Cell Significance Index: 27.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8026
    Cell Significance Index: 21.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7377
    Cell Significance Index: 72.9800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.6437
    Cell Significance Index: 6.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5397
    Cell Significance Index: 15.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5248
    Cell Significance Index: 7.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4622
    Cell Significance Index: 27.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4456
    Cell Significance Index: 48.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4025
    Cell Significance Index: 65.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4004
    Cell Significance Index: 46.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3521
    Cell Significance Index: 10.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2790
    Cell Significance Index: 19.3000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.2729
    Cell Significance Index: 2.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2562
    Cell Significance Index: 7.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1204
    Cell Significance Index: 3.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1081
    Cell Significance Index: 74.8000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1015
    Cell Significance Index: 1.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0921
    Cell Significance Index: 5.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0827
    Cell Significance Index: 14.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0817
    Cell Significance Index: 10.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0760
    Cell Significance Index: 15.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0703
    Cell Significance Index: 2.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0601
    Cell Significance Index: 8.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0527
    Cell Significance Index: 23.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0466
    Cell Significance Index: 0.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0348
    Cell Significance Index: 6.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0297
    Cell Significance Index: 16.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.8500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0041
    Cell Significance Index: -1.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0063
    Cell Significance Index: -9.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0073
    Cell Significance Index: -9.9400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0099
    Cell Significance Index: -0.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0103
    Cell Significance Index: -7.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0117
    Cell Significance Index: -7.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0138
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0155
    Cell Significance Index: -9.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0173
    Cell Significance Index: -7.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0174
    Cell Significance Index: -0.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0204
    Cell Significance Index: -0.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0270
    Cell Significance Index: -1.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0272
    Cell Significance Index: -7.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0326
    Cell Significance Index: -6.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0371
    Cell Significance Index: -7.8100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0452
    Cell Significance Index: -0.4200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0471
    Cell Significance Index: -0.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0499
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0604
    Cell Significance Index: -6.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0614
    Cell Significance Index: -7.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0699
    Cell Significance Index: -1.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0758
    Cell Significance Index: -8.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0778
    Cell Significance Index: -2.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0815
    Cell Significance Index: -2.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0815
    Cell Significance Index: -2.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0832
    Cell Significance Index: -8.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0836
    Cell Significance Index: -8.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0939
    Cell Significance Index: -5.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0940
    Cell Significance Index: -1.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0967
    Cell Significance Index: -2.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1008
    Cell Significance Index: -2.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1011
    Cell Significance Index: -6.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1088
    Cell Significance Index: -8.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1089
    Cell Significance Index: -7.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1090
    Cell Significance Index: -6.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1187
    Cell Significance Index: -9.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1196
    Cell Significance Index: -5.6200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1221
    Cell Significance Index: -1.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1231
    Cell Significance Index: -5.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1242
    Cell Significance Index: -9.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1376
    Cell Significance Index: -1.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1390
    Cell Significance Index: -1.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1409
    Cell Significance Index: -7.3400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1421
    Cell Significance Index: -1.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1625
    Cell Significance Index: -8.5300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1677
    Cell Significance Index: -2.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1748
    Cell Significance Index: -7.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1790
    Cell Significance Index: -4.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2068
    Cell Significance Index: -7.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2069
    Cell Significance Index: -2.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2179
    Cell Significance Index: -6.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2200
    Cell Significance Index: -8.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2300
    Cell Significance Index: -4.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2334
    Cell Significance Index: -4.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2361
    Cell Significance Index: -6.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2362
    Cell Significance Index: -8.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2395
    Cell Significance Index: -6.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2452
    Cell Significance Index: -8.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2458
    Cell Significance Index: -4.8600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2461
    Cell Significance Index: -6.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2511
    Cell Significance Index: -8.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine protease activity:** PRSS12 possesses a catalytic serine residue, which is essential for its proteolytic activity, enabling it to cleave peptides and proteins. 2. **Tissue-specific expression:** PRSS12 is highly expressed in various tissues, including the lung, brain, and placenta, suggesting its importance in specific cellular contexts. 3. **Neurotransmitter regulation:** PRSS12 has been shown to interact with neurotransmitters, such as GABA, and influence synaptic transmission in the brain. 4. **Cellular localization:** PRSS12 is localized to different cellular compartments, including the plasma membrane, cytoplasmic vesicles, and synaptic clefts. **Pathways and Functions:** 1. **Immune response:** PRSS12 has been implicated in the regulation of immune responses, particularly in the context of neuroinflammation and neurodegenerative diseases. It may modulate the activity of immune cells, such as T cells and macrophages. 2. **Neurotransmitter regulation:** PRSS12 interacts with neurotransmitters, including GABA, and influences synaptic transmission in the brain. This suggests a role in regulating neuronal excitability and synaptic plasticity. 3. **Cellular differentiation:** PRSS12 may play a role in the differentiation of various cell types, including immune cells and neural cells. 4. **Tissue development:** PRSS12 has been shown to be involved in tissue development, particularly in the lung and placenta, where it may regulate cellular growth and differentiation. **Clinical Significance:** 1. **Neurodegenerative diseases:** PRSS12 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neuroinflammation and neuronal damage. 2. **Respiratory disorders:** PRSS12 may play a role in respiratory disorders, such as chronic obstructive pulmonary disease (COPD) and asthma, where it may influence airway inflammation and remodeling. 3. **Pregnancy complications:** PRSS12 has been shown to be involved in placental development and function, suggesting its potential role in pregnancy complications, such as preterm labor and preeclampsia. 4. **Cancer:** PRSS12 has been implicated in cancer, particularly in the context of tumor progression and metastasis, where it may regulate cellular migration and invasion. In conclusion, PRSS12 is a serine protease with diverse roles in immune and non-immune cells, including neurotransmitter regulation, cellular differentiation, and tissue development. Its clinical significance extends to various diseases, including neurodegenerative disorders, respiratory disorders, and pregnancy complications. Further research is needed to fully understand the functions of PRSS12 and its potential therapeutic applications.

Genular Protein ID: 2077857894

Symbol: NETR_HUMAN

Name: Neurotrypsin

UniProtKB Accession Codes:

P56730 Q9UP16

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9540828

Title: Cloning and sequencing of the cDNA encoding human neurotrypsin.

PubMed ID: 9540828

DOI: 10.1016/s0167-4781(97)00205-4

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 10103056

Title: Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis.

PubMed ID: 10103056

DOI: 10.1046/j.1432-1327.1999.00266.x

PubMed ID: 12459588

Title: Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation.

PubMed ID: 12459588

DOI: 10.1126/science.1076521

Sequence Information:

  • Length: 875
  • Mass: 97067
  • Checksum: EB357047C39371BC
  • Sequence:
    • MTLARFVLAL MLGALPEVVG FDSVLNDSLH HSHRHSPPAG PHYPYYLPTQ QRPPRTRPPP 
PLPRFPRPPR ALPAQRPHAL QAGHTPRPHP WGCPAGEPWV SVTDFGAPCL RWAEVPPFLE 
RSPPASWAQL RGQRHNFCRS PDGAGRPWCF YGDARGKVDW GYCDCRHGSV RLRGGKNEFE 
GTVEVYASGV WGTVCSSHWD DSDASVICHQ LQLGGKGIAK QTPFSGLGLI PIYWSNVRCR 
GDEENILLCE KDIWQGGVCP QKMAAAVTCS FSHGPTFPII RLAGGSSVHE GRVELYHAGQ 
WGTVCDDQWD DADAEVICRQ LGLSGIAKAW HQAYFGEGSG PVMLDEVRCT GNELSIEQCP 
KSSWGEHNCG HKEDAGVSCT PLTDGVIRLA GGKGSHEGRL EVYYRGQWGT VCDDGWTELN 
TYVVCRQLGF KYGKQASANH FEESTGPIWL DDVSCSGKET RFLQCSRRQW GRHDCSHRED 
VSIACYPGGE GHRLSLGFPV RLMDGENKKE GRVEVFINGQ WGTICDDGWT DKDAAVICRQ 
LGYKGPARAR TMAYFGEGKG PIHVDNVKCT GNERSLADCI KQDIGRHNCR HSEDAGVICD 
YFGKKASGNS NKESLSSVCG LRLLHRRQKR IIGGKNSLRG GWPWQVSLRL KSSHGDGRLL 
CGATLLSSCW VLTAAHCFKR YGNSTRSYAV RVGDYHTLVP EEFEEEIGVQ QIVIHREYRP 
DRSDYDIALV RLQGPEEQCA RFSSHVLPAC LPLWRERPQK TASNCYITGW GDTGRAYSRT 
LQQAAIPLLP KRFCEERYKG RFTGRMLCAG NLHEHKRVDS CQGDSGGPLM CERPGESWVV 
YGVTSWGYGC GVKDSPGVYT KVSAFVPWIK SVTKL

Genular Protein ID: 1852013819

Symbol: Q96I80_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96I80

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 505
  • Mass: 55659
  • Checksum: 7FF863A6246226BD
  • Sequence:
    • MTLARFVLAL MLGALPEVVG FDSVLNDSLH HSHRHSPPAG PHYPYYLPTQ QRPPTTRPPP 
PLPRFPRPPR ALPAQRPHAL QAGHTPRPHP WGCPAGEPWV SVTDFGAPCL RWAEVPPFLE 
RSPPASWAQL RGQRHNFCRS PDGAGRPWCF YGDARGKVDW GYCDCRHGSV RLRGGKNEFE 
GTVEVYASGV WGTVCSSHWD DSDASVICHQ LQLGGKGIAK QTPFSGLGLI PIYWSNVRCR 
GDEENILLCE KDIWQGGVCP QKMAAAVTCS FSHGPTFPII RLAGGSSVHE GRVELYHAGQ 
WGTVCDDQWD DADAEVICRQ LGLSGIAKAW HQAYFGEGSG PVMLDEVRCT GNELSIEQCP 
KSSWGEHNCG HKEDAGVSCT PLTDGVIRLA GGKGSHEGRL EVYYRGQWGT VCDDGWTELN 
TYVVCRQLGF KYGKQASANH FEESTGPIWL DDVSCSGKET RFLQCSRRQW GRHDCSHRED 
VSIACYPGGE GHRLSLGFPV RLMDG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.