Details for: IKBKG

Gene ID: 8517

Symbol: IKBKG

Ensembl ID: ENSG00000269335

Description: inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.8548
    Cell Significance Index: -14.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.1225
    Cell Significance Index: -16.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 31.6689
    Cell Significance Index: -16.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.0721
    Cell Significance Index: -14.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5280
    Cell Significance Index: -12.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.4674
    Cell Significance Index: -10.6500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.2145
    Cell Significance Index: 52.9700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.9687
    Cell Significance Index: 41.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9739
    Cell Significance Index: -4.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8641
    Cell Significance Index: 780.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8468
    Cell Significance Index: 44.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7868
    Cell Significance Index: 10.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.7233
    Cell Significance Index: 26.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5847
    Cell Significance Index: 95.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5761
    Cell Significance Index: 62.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4721
    Cell Significance Index: 28.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4423
    Cell Significance Index: 3.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4057
    Cell Significance Index: 8.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3891
    Cell Significance Index: 6.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3576
    Cell Significance Index: 41.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3129
    Cell Significance Index: 36.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3095
    Cell Significance Index: 21.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3046
    Cell Significance Index: 5.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2893
    Cell Significance Index: 57.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2851
    Cell Significance Index: 18.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2629
    Cell Significance Index: 26.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2141
    Cell Significance Index: 26.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1943
    Cell Significance Index: 5.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1907
    Cell Significance Index: 84.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1794
    Cell Significance Index: 8.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1528
    Cell Significance Index: 20.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1517
    Cell Significance Index: 1.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1475
    Cell Significance Index: 14.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1442
    Cell Significance Index: 25.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1423
    Cell Significance Index: 28.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1385
    Cell Significance Index: 3.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1234
    Cell Significance Index: 6.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1221
    Cell Significance Index: 6.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1202
    Cell Significance Index: 3.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1117
    Cell Significance Index: 3.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0929
    Cell Significance Index: 4.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0926
    Cell Significance Index: 17.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0840
    Cell Significance Index: 5.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0826
    Cell Significance Index: 2.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0734
    Cell Significance Index: 3.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0643
    Cell Significance Index: 2.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0603
    Cell Significance Index: 3.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0579
    Cell Significance Index: 7.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0551
    Cell Significance Index: 30.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0445
    Cell Significance Index: 30.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0296
    Cell Significance Index: 10.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0218
    Cell Significance Index: 2.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0126
    Cell Significance Index: 0.1900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0084
    Cell Significance Index: 0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0080
    Cell Significance Index: 12.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0066
    Cell Significance Index: 0.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0026
    Cell Significance Index: 0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0021
    Cell Significance Index: 2.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0015
    Cell Significance Index: 1.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0054
    Cell Significance Index: -0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0139
    Cell Significance Index: -0.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0147
    Cell Significance Index: -0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0165
    Cell Significance Index: -2.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0166
    Cell Significance Index: -12.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0171
    Cell Significance Index: -12.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0217
    Cell Significance Index: -0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0220
    Cell Significance Index: -10.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0237
    Cell Significance Index: -13.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0241
    Cell Significance Index: -15.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0263
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0319
    Cell Significance Index: -5.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0397
    Cell Significance Index: -3.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0460
    Cell Significance Index: -0.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0482
    Cell Significance Index: -3.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0507
    Cell Significance Index: -14.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0572
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0677
    Cell Significance Index: -14.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0726
    Cell Significance Index: -2.0800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0768
    Cell Significance Index: -0.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0810
    Cell Significance Index: -1.6800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0939
    Cell Significance Index: -1.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1173
    Cell Significance Index: -7.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1258
    Cell Significance Index: -13.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1446
    Cell Significance Index: -9.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1611
    Cell Significance Index: -4.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1657
    Cell Significance Index: -2.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1764
    Cell Significance Index: -4.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1875
    Cell Significance Index: -3.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1894
    Cell Significance Index: -15.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1930
    Cell Significance Index: -10.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2320
    Cell Significance Index: -10.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2332
    Cell Significance Index: -3.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2561
    Cell Significance Index: -15.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2702
    Cell Significance Index: -10.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2976
    Cell Significance Index: -7.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3029
    Cell Significance Index: -5.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3146
    Cell Significance Index: -11.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IBKKG is a critical component of the IKK complex, which is responsible for phosphorylating and activating NF-κB. The gene is primarily expressed in cells involved in immune responses, such as myeloid dendritic cells, monocytes, and T cells. IKBKG is characterized by its ability to regulate the activation of NF-κB through the FADD/ RIP-1 pathway, which is mediated by caspase-8 and -10. The gene is also involved in the regulation of other signaling pathways, including those involved in apoptosis, inflammatory responses, and antiviral mechanisms. **Pathways and Functions** IBKKG is involved in various signaling pathways, including: 1. **NF-κB activation**: IKBKG is essential for the activation of NF-κB, a transcription factor involved in immune responses, inflammation, and cell survival. 2. **Apoptotic process**: IKBKG regulates the activation of caspase-8 and -10, which are involved in the apoptosis pathway. 3. **Antiviral mechanisms**: IKBKG is involved in the regulation of interferon-alpha/beta production, which is essential for antiviral responses. 4. **Inflammatory responses**: IKBKG regulates the activation of NF-κB, which is involved in the production of pro-inflammatory cytokines. 5. **Immune response**: IKBKG is essential for the activation of immune cells, including T cells and dendritic cells. **Clinical Significance** Mutations in the IKBKG gene have been associated with several immune-related disorders, including: 1. **Anhidrotic Ectodermal Dysplasia with Immunodeficiency (EDA-ID)**: A rare genetic disorder characterized by immunodeficiency, ectodermal dysplasia, and anhidrosis. 2. **Scid**: A severe combined immunodeficiency disease characterized by impaired T cell and B cell function. 3. **Immunodeficiency**: IKBKG mutations can lead to impaired immune function, making individuals susceptible to infections. In conclusion, the IKBKG gene plays a critical role in regulating the immune system and inflammation. Mutations in this gene can lead to immune-related disorders, highlighting the importance of this gene in maintaining immune function and overall health.

Genular Protein ID: 674836825

Symbol: NEMO_HUMAN

Name: FIP-3

UniProtKB Accession Codes:

Q9Y6K9 Q7LBY6 Q7Z7F1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CPTAC 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EMBL 13 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 30 RefSeq 6 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9927690

Title: Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.

PubMed ID: 9927690

DOI: 10.1073/pnas.96.3.1042

PubMed ID: 10087442

Title: Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28.

PubMed ID: 10087442

DOI: 10.1007/bf02256442

PubMed ID: 9751060

Title: IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.

PubMed ID: 9751060

DOI: 10.1038/26261

PubMed ID: 10839543

Title: Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti.

PubMed ID: 10839543

DOI: 10.1038/35013114

PubMed ID: 10944468

Title: cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs.

PubMed ID: 10944468

DOI: 10.1006/bbrc.2000.3282

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9891086

Title: IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex.

PubMed ID: 9891086

DOI: 10.1128/mcb.19.2.1526

PubMed ID: 10364167

Title: Role of adapter function in oncoprotein-mediated activation of NF-kappaB: human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma.

PubMed ID: 10364167

DOI: 10.1074/jbc.274.25.17402

PubMed ID: 11064457

Title: Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein.

PubMed ID: 11064457

DOI: 10.1038/sj.onc.1203894

PubMed ID: 11389905

Title: Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions.

PubMed ID: 11389905

DOI: 10.1016/s0014-5793(01)02504-2

PubMed ID: 11418127

Title: CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation.

PubMed ID: 11418127

DOI: 10.1016/s0014-5793(01)02535-2

PubMed ID: 11080499

Title: Role of ikkgamma/nemo in assembly of the IkappaB kinase complex.

PubMed ID: 11080499

DOI: 10.1074/jbc.m008353200

PubMed ID: 12133833

Title: Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.

PubMed ID: 12133833

DOI: 10.1074/jbc.m205069200

PubMed ID: 11971985

Title: Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.

PubMed ID: 11971985

DOI: 10.1128/mcb.22.10.3549-3561.2002

PubMed ID: 14651848

Title: Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress.

PubMed ID: 14651848

DOI: 10.1016/s0092-8674(03)00895-x

PubMed ID: 12657630

Title: In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase.

PubMed ID: 12657630

DOI: 10.1074/jbc.m301705200

PubMed ID: 12612076

Title: Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.

PubMed ID: 12612076

DOI: 10.1128/mcb.23.6.2029-2041.2003

PubMed ID: 12917691

Title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.

PubMed ID: 12917691

DOI: 10.1038/nature01802

PubMed ID: 15620648

Title: The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.

PubMed ID: 15620648

DOI: 10.1016/j.cub.2004.12.032

PubMed ID: 14754897

Title: ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.

PubMed ID: 14754897

DOI: 10.1074/jbc.m309491200

PubMed ID: 15456791

Title: PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.

PubMed ID: 15456791

DOI: 10.1074/jbc.m406741200

PubMed ID: 15125833

Title: The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.

PubMed ID: 15125833

DOI: 10.1016/s1097-2765(04)00236-9

PubMed ID: 14695475

Title: Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.

PubMed ID: 14695475

DOI: 10.1038/nature02273

PubMed ID: 16360037

Title: PIDD mediates NF-kappaB activation in response to DNA damage.

PubMed ID: 16360037

DOI: 10.1016/j.cell.2005.09.036

PubMed ID: 16547522

Title: Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation.

PubMed ID: 16547522

DOI: 10.1038/ncb1384

PubMed ID: 16497931

Title: Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.

PubMed ID: 16497931

DOI: 10.1126/science.1121513

PubMed ID: 17135271

Title: Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

PubMed ID: 17135271

DOI: 10.1074/jbc.m609503200

PubMed ID: 17562858

Title: Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

PubMed ID: 17562858

DOI: 10.1128/mcb.00270-07

PubMed ID: 18164680

Title: Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347.

PubMed ID: 18164680

DOI: 10.1016/j.bbrc.2007.12.123

PubMed ID: 18079694

Title: A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.

PubMed ID: 18079694

DOI: 10.1038/sj.emboj.7601962

PubMed ID: 17977820

Title: Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.

PubMed ID: 17977820

DOI: 10.1074/jbc.m708856200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18287044

Title: NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.

PubMed ID: 18287044

DOI: 10.1073/pnas.0712313105

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19033441

Title: The zinc finger of NEMO is a functional ubiquitin-binding domain.

PubMed ID: 19033441

DOI: 10.1074/jbc.m806655200

PubMed ID: 19854139

Title: Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.

PubMed ID: 19854139

DOI: 10.1016/j.molcel.2009.09.037

PubMed ID: 19136968

Title: Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

PubMed ID: 19136968

DOI: 10.1038/ncb1821

PubMed ID: 19854204

Title: DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding.

PubMed ID: 19854204

DOI: 10.1016/j.jmb.2009.10.018

PubMed ID: 20010814

Title: A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response.

PubMed ID: 20010814

DOI: 10.1038/ncb2006

PubMed ID: 20724660

Title: Polyubiquitin conjugation to NEMO by tripartite motif protein 23 (TRIM23) is critical in antiviral defense.

PubMed ID: 20724660

DOI: 10.1073/pnas.1004621107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21518757

Title: TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.

PubMed ID: 21518757

DOI: 10.1074/jbc.m110.215426

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21474709

Title: TRIM40 promotes neddylation of IKKgamma and is downregulated in gastrointestinal cancers.

PubMed ID: 21474709

DOI: 10.1093/carcin/bgr068

PubMed ID: 21606507

Title: Polyubiquitin binding to ABIN1 is required to prevent autoimmunity.

PubMed ID: 21606507

DOI: 10.1084/jem.20102177

PubMed ID: 22099304

Title: Direct, noncatalytic mechanism of IKK inhibition by A20.

PubMed ID: 22099304

DOI: 10.1016/j.molcel.2011.09.015

PubMed ID: 21455173

Title: Linear ubiquitination prevents inflammation and regulates immune signalling.

PubMed ID: 21455173

DOI: 10.1038/nature09816

PubMed ID: 21455180

Title: SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex.

PubMed ID: 21455180

DOI: 10.1038/nature09815

PubMed ID: 21455181

Title: SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis.

PubMed ID: 21455181

DOI: 10.1038/nature09814

PubMed ID: 22672233

Title: NLRP10 enhances Shigella-induced pro-inflammatory responses.

PubMed ID: 22672233

DOI: 10.1111/j.1462-5822.2012.01822.x

PubMed ID: 23453969

Title: IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

PubMed ID: 23453969

DOI: 10.1016/j.celrep.2013.01.031

PubMed ID: 24012789

Title: Identifying post-translational modifications of NEMO by tandem mass spectrometry after high affinity purification.

PubMed ID: 24012789

DOI: 10.1016/j.pep.2013.08.020

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24586164

Title: Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.

PubMed ID: 24586164

DOI: 10.1371/journal.ppat.1003960

PubMed ID: 26334375

Title: IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).

PubMed ID: 26334375

DOI: 10.1016/j.cellsig.2015.08.018

PubMed ID: 25861989

Title: TRAF family member-associated NF-kappaB activator (TANK) inhibits genotoxic nuclear factor kappaB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase.

PubMed ID: 25861989

DOI: 10.1074/jbc.m115.643767

PubMed ID: 26296658

Title: Dimer of arfaptin 2 regulates NF-kappaB signaling by interacting with IKKbeta/NEMO and inhibiting IKKbeta kinase activity.

PubMed ID: 26296658

DOI: 10.1016/j.cellsig.2015.08.012

PubMed ID: 27777308

Title: Molecular determinants of scaffold-induced linear ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T cell receptor and oncogenic caspase recruitment domain-containing protein 11 (CARD11) signaling.

PubMed ID: 27777308

DOI: 10.1074/jbc.m116.754028

PubMed ID: 28490597

Title: Molluscum contagiosum virus protein MC005 inhibits NF-kappaB activation by targeting NEMO-regulated IkappaB kinase activation.

PubMed ID: 28490597

DOI: 10.1128/jvi.00545-17

PubMed ID: 32935379

Title: Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.

PubMed ID: 32935379

DOI: 10.15252/embj.2020105139

PubMed ID: 33567255

Title: SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO.

PubMed ID: 33567255

DOI: 10.1016/j.celrep.2021.108761

PubMed ID: 18313693

Title: Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation.

PubMed ID: 18313693

DOI: 10.1016/j.jmb.2008.01.048

PubMed ID: 18462684

Title: Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.

PubMed ID: 18462684

DOI: 10.1016/j.str.2008.02.012

PubMed ID: 19185524

Title: Structural basis for recognition of diubiquitins by NEMO.

PubMed ID: 19185524

DOI: 10.1016/j.molcel.2009.01.012

PubMed ID: 11047757

Title: A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO).

PubMed ID: 11047757

DOI: 10.1086/316914

PubMed ID: 11590134

Title: A recurrent deletion in the ubiquitously expressed NEMO (IKK-gamma) gene accounts for the vast majority of incontinentia pigmenti mutations.

PubMed ID: 11590134

DOI: 10.1093/hmg/10.19.2171

PubMed ID: 11242109

Title: X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappa B signaling.

PubMed ID: 11242109

DOI: 10.1038/85837

PubMed ID: 11224521

Title: Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia.

PubMed ID: 11224521

DOI: 10.1038/85277

PubMed ID: 12045264

Title: Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations.

PubMed ID: 12045264

DOI: 10.1172/jci14858

PubMed ID: 15229184

Title: Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation.

PubMed ID: 15229184

DOI: 10.1093/hmg/ddh192

PubMed ID: 15100680

Title: The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation.

PubMed ID: 15100680

DOI: 10.1016/j.jaci.2004.01.762

PubMed ID: 15356572

Title: Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia.

PubMed ID: 15356572

DOI: 10.1016/j.jaci.2004.06.052

PubMed ID: 25152375

Title: TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-kappaB activation.

PubMed ID: 25152375

DOI: 10.1016/j.cellsig.2014.08.008

PubMed ID: 24920812

Title: Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon.

PubMed ID: 24920812

DOI: 10.1128/jvi.00869-14

PubMed ID: 27695001

Title: Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract.

PubMed ID: 27695001

DOI: 10.1038/ni.3580

PubMed ID: 31874111

Title: Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.

PubMed ID: 31874111

DOI: 10.1172/jci129301

PubMed ID: 35289316

Title: Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype.

PubMed ID: 35289316

DOI: 10.1172/jci128808

PubMed ID: 16818673

Title: X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production.

PubMed ID: 16818673

DOI: 10.1084/jem.20060085

PubMed ID: 17728323

Title: Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti.

PubMed ID: 17728323

DOI: 10.1093/hmg/ddm237

PubMed ID: 20434027

Title: NEMO gene mutations in Chinese patients with incontinentia pigmenti.

PubMed ID: 20434027

DOI: 10.1016/s0929-6646(10)60042-3

PubMed ID: 24339369

Title: Insight into IKBKG/NEMO locus: report of new mutations and complex genomic rearrangements leading to incontinentia pigmenti disease.

PubMed ID: 24339369

DOI: 10.1002/humu.22483

PubMed ID: 16950813

Title: IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease.

PubMed ID: 16950813

DOI: 10.1136/jmg.2006.044446

Sequence Information:

  • Length: 419
  • Mass: 48198
  • Checksum: 322D1037881447FF
  • Sequence:
    • MNRHLWKSQL CEMVQPSGGP AADQDVLGEE SPLGKPAMLH LPSEQGAPET LQRCLEENQE 
LRDAIRQSNQ ILRERCEELL HFQASQREEK EFLMCKFQEA RKLVERLGLE KLDLKRQKEQ 
ALREVEHLKR CQQQMAEDKA SVKAQVTSLL GELQESQSRL EAATKECQAL EGRARAASEQ 
ARQLESEREA LQQQHSVQVD QLRMQGQSVE AALRMERQAA SEEKRKLAQL QVAYHQLFQE 
YDNHIKSSVV GSERKRGMQL EDLKQQLQQA EEALVAKQEV IDKLKEEAEQ HKIVMETVPV 
LKAQADIYKA DFQAERQARE KLAEKKELLQ EQLEQLQREY SKLKASCQES ARIEDMRKRH 
VEVSQAPLPP APAYLSSPLA LPSQRRSPPE EPPDFCCPKC QYQAPDMDTL QIHVMECIE

Genular Protein ID: 672843924

Symbol: A0A087X1B1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X1B1

Database IDs:

ARBA 19 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 418
  • Mass: 48070
  • Checksum: 72E7BCE3035BE60A
  • Sequence:
    • MNRHLWKSQL CEMVQPSGGP AADQDVLGEE SPLGKPAMLH LPSEQGAPET LQRCLEENQE 
LRDAIRQSNQ ILRERCEELL HFQASQREEK EFLMCKFQEA RKLVERLGLE KLDLKRQKEQ 
ALREVEHLKR CQQMAEDKAS VKAQVTSLLG ELQESQSRLE AATKECQALE GRARAASEQA 
RQLESEREAL QQQHSVQVDQ LRMQGQSVEA ALRMERQAAS EEKRKLAQLQ VAYHQLFQEY 
DNHIKSSVVG SERKRGMQLE DLKQQLQQAE EALVAKQEVI DKLKEEAEQH KIVMETVPVL 
KAQADIYKAD FQAERQAREK LAEKKELLQE QLEQLQREYS KLKASCQESA RIEDMRKRHV 
EVSQAPLPPA PAYLSSPLAL PSQRRSPPEE PPDFCCPKCQ YQAPDMDTLQ IHVMECIE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.