Details for: THOC5

Gene ID: 8563

Symbol: THOC5

Ensembl ID: ENSG00000100296

Description: THO complex subunit 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.5788
    Cell Significance Index: -17.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.2454
    Cell Significance Index: -17.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.1931
    Cell Significance Index: -16.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 37.1123
    Cell Significance Index: -19.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.5668
    Cell Significance Index: -19.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.7744
    Cell Significance Index: -16.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.7832
    Cell Significance Index: -19.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7977
    Cell Significance Index: -18.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0354
    Cell Significance Index: -19.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2040
    Cell Significance Index: -12.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0065
    Cell Significance Index: -6.5800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2171
    Cell Significance Index: 35.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8649
    Cell Significance Index: 184.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0291
    Cell Significance Index: 111.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0061
    Cell Significance Index: 163.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7957
    Cell Significance Index: 47.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7353
    Cell Significance Index: 145.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7138
    Cell Significance Index: 44.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5541
    Cell Significance Index: 111.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4456
    Cell Significance Index: 51.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4020
    Cell Significance Index: 27.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3317
    Cell Significance Index: 229.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3104
    Cell Significance Index: 111.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2146
    Cell Significance Index: 11.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2082
    Cell Significance Index: 28.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2065
    Cell Significance Index: 5.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2020
    Cell Significance Index: 13.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1666
    Cell Significance Index: 3.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1417
    Cell Significance Index: 77.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1400
    Cell Significance Index: 7.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1343
    Cell Significance Index: 24.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1324
    Cell Significance Index: 3.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1260
    Cell Significance Index: 14.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1145
    Cell Significance Index: 5.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1023
    Cell Significance Index: 4.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1018
    Cell Significance Index: 6.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0966
    Cell Significance Index: 7.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0853
    Cell Significance Index: 37.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0844
    Cell Significance Index: 2.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0589
    Cell Significance Index: 2.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0574
    Cell Significance Index: 7.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0531
    Cell Significance Index: 6.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0457
    Cell Significance Index: 8.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0365
    Cell Significance Index: 4.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0119
    Cell Significance Index: 0.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0085
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0057
    Cell Significance Index: 10.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0036
    Cell Significance Index: 5.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0032
    Cell Significance Index: 5.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0015
    Cell Significance Index: 2.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0126
    Cell Significance Index: -0.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0128
    Cell Significance Index: -8.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0167
    Cell Significance Index: -12.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0175
    Cell Significance Index: -12.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0191
    Cell Significance Index: -8.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0231
    Cell Significance Index: -17.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0301
    Cell Significance Index: -5.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0325
    Cell Significance Index: -18.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0351
    Cell Significance Index: -21.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0397
    Cell Significance Index: -0.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0429
    Cell Significance Index: -4.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0504
    Cell Significance Index: -7.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0557
    Cell Significance Index: -0.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0596
    Cell Significance Index: -17.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0632
    Cell Significance Index: -4.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0694
    Cell Significance Index: -4.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0904
    Cell Significance Index: -4.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0920
    Cell Significance Index: -6.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0932
    Cell Significance Index: -1.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0997
    Cell Significance Index: -1.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1014
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1037
    Cell Significance Index: -21.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1069
    Cell Significance Index: -3.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1166
    Cell Significance Index: -3.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1171
    Cell Significance Index: -2.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1181
    Cell Significance Index: -3.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1253
    Cell Significance Index: -3.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1258
    Cell Significance Index: -1.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1340
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1364
    Cell Significance Index: -15.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1423
    Cell Significance Index: -4.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1525
    Cell Significance Index: -5.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1561
    Cell Significance Index: -4.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1782
    Cell Significance Index: -18.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1836
    Cell Significance Index: -5.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1860
    Cell Significance Index: -4.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2126
    Cell Significance Index: -16.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2298
    Cell Significance Index: -5.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2336
    Cell Significance Index: -2.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2351
    Cell Significance Index: -6.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2594
    Cell Significance Index: -13.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2796
    Cell Significance Index: -5.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2846
    Cell Significance Index: -6.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3194
    Cell Significance Index: -19.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3323
    Cell Significance Index: -3.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3466
    Cell Significance Index: -8.9100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3572
    Cell Significance Index: -2.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3732
    Cell Significance Index: -5.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The THOC5 gene exhibits several key characteristics that highlight its significance in gene expression and immune system function: 1. **Expression in multiple cell types**: THOC5 is expressed in a wide range of cell types, including hematopoietic cells, neurons, and epithelial cells, underscoring its importance in various tissues and cell types. 2. **Role in transcription export**: THOC5 is a component of the THO complex, which is responsible for the export of mature mRNA from the nucleus to the cytoplasm. 3. **Regulation of gene expression**: THOC5 is involved in the regulation of gene expression, particularly in the context of immune system development and function. 4. **Signaling pathways**: THOC5 is implicated in several signaling pathways, including cytokine signaling in the immune system and signaling by CSF1 (m-CSF) in myeloid cells. **Pathways and Functions** The THOC5 gene is involved in several key pathways and functions, including: 1. **Chromosome and telomeric region regulation**: THOC5 is involved in the regulation of chromosome structure and telomeric regions, which are critical for maintaining genomic stability. 2. **Cytokine signaling in the immune system**: THOC5 is implicated in cytokine signaling pathways, which are essential for the development and function of the immune system. 3. **Monocyte differentiation**: THOC5 is involved in the differentiation of monocytes, which are a type of white blood cell that plays a critical role in the immune system. 4. **RNA processing and export**: THOC5 is a component of the THO complex, which is responsible for the export of mature mRNA from the nucleus to the cytoplasm. 5. **Primitive hemopoiesis**: THOC5 is involved in the regulation of primitive hemopoiesis, which is the process by which blood cells are generated from stem cells. **Clinical Significance** The THOC5 gene has significant clinical implications, particularly in the context of immune system disorders. Mutations in the THOC5 gene have been associated with several immunodeficiency disorders, including: 1. **Immunodeficiency**: THOC5 mutations can lead to impaired immune function, making individuals more susceptible to infections. 2. **Autoimmune disorders**: THOC5 mutations have been linked to autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Cancer**: THOC5 mutations have been implicated in the development of certain types of cancer, including leukemia and lymphoma. In conclusion, the THOC5 gene plays a critical role in the regulation of gene expression, particularly in the context of immune system development and function. Its significance in multiple cell types and tissues highlights its importance in various biological processes, and its implications in immunodeficiency disorders and cancer underscore the need for further research into the function and regulation of this gene.

Genular Protein ID: 3559282464

Symbol: THOC5_HUMAN

Name: Functional spliceosome-associated protein 79

UniProtKB Accession Codes:

Q13769 O60839 Q9UPZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 3 Ensembl 4 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8242058

Title: Cloning of a novel, anonymous gene from a megabase-range YAC and cosmid contig in the neurofibromatosis type 2/meningioma region on human chromosome 22q12.

PubMed ID: 8242058

DOI: 10.1093/hmg/2.9.1361

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15833825

Title: Linking transcriptional elongation and messenger RNA export to metastatic breast cancers.

PubMed ID: 15833825

DOI: 10.1158/0008-5472.can-04-3624

PubMed ID: 15998806

Title: Recruitment of the human TREX complex to mRNA during splicing.

PubMed ID: 15998806

DOI: 10.1101/gad.1302205

PubMed ID: 17190602

Title: Human mRNA export machinery recruited to the 5' end of mRNA.

PubMed ID: 17190602

DOI: 10.1016/j.cell.2006.10.044

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18373705

Title: THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover.

PubMed ID: 18373705

DOI: 10.1111/j.1365-2141.2008.07090.x

PubMed ID: 18974867

Title: Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication.

PubMed ID: 18974867

DOI: 10.1371/journal.ppat.1000194

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19165146

Title: Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.

PubMed ID: 19165146

DOI: 10.1038/emboj.2009.5

PubMed ID: 19059247

Title: Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).

PubMed ID: 19059247

DOI: 10.1016/j.febslet.2008.11.024

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22144908

Title: Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.

PubMed ID: 22144908

DOI: 10.1371/journal.pgen.1002386

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22893130

Title: TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.

PubMed ID: 22893130

DOI: 10.1038/ncomms2005

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23299939

Title: Chtop is a component of the dynamic TREX mRNA export complex.

PubMed ID: 23299939

DOI: 10.1038/emboj.2012.342

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23032722

Title: A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.

PubMed ID: 23032722

DOI: 10.1038/leu.2012.283

PubMed ID: 23685434

Title: Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I.

PubMed ID: 23685434

DOI: 10.1093/nar/gkt414

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25662211

Title: Luzp4 defines a new mRNA export pathway in cancer cells.

PubMed ID: 25662211

DOI: 10.1093/nar/gkv070

PubMed ID: 26382858

Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.

PubMed ID: 26382858

DOI: 10.1038/ncomms9192

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 33191911

Title: Structure of the human core transcription-export complex reveals a hub for multivalent interactions.

PubMed ID: 33191911

DOI: 10.7554/elife.61503

PubMed ID: 37020021

Title: mRNA recognition and packaging by the human transcription-export complex.

PubMed ID: 37020021

DOI: 10.1038/s41586-023-05904-0

Sequence Information:

  • Length: 683
  • Mass: 78508
  • Checksum: 59550FA548835016
  • Sequence:
    • MSSESSKKRK PKVIRSDGAP AEGKRNRSDT EQEGKYYSEE AEVDLRDPGR DYELYKYTCQ 
ELQRLMAEIQ DLKSRGGKDV AIEIEERRIQ SCVHFMTLKK LNRLAHIRLK KGRDQTHEAK 
QKVDAYHLQL QNLLYEVMHL QKEITKCLEF KSKHEEIDLV SLEEFYKEAP PDISKAEVTM 
GDPHQQTLAR LDWELEQRKR LAEKYRECLS NKEKILKEIE VKKEYLSSLQ PRLNSIMQAS 
LPVQEYLFMP FDQAHKQYET ARHLPPPLYV LFVQATAYGQ ACDKTLSVAI EGSVDEAKAL 
FKPPEDSQDD ESDSDAEEEQ TTKRRRPTLG VQLDDKRKEM LKRHPLSVML DLKCKDDSVL 
HLTFYYLMNL NIMTVKAKVT TAMELITPIS AGDLLSPDSV LSCLYPGDHG KKTPNPANQY 
QFDKVGILTL SDYVLELGHP YLWVQKLGGL HFPKEQPQQT VIADHSLSAS HMETTMKLLK 
TRVQSRLALH KQFASLEHGI VPVTSDCQYL FPAKVVSRLV KWVTVAHEDY MELHFTKDIV 
DAGLAGDTNL YYMALIERGT AKLQAAVVLN PGYSSIPPVF QLCLNWKGEK TNSNDDNIRA 
MEGEVNVCYK ELCGPWPSHQ LLTNQLQRLC VLLDVYLETE SHDDSVEGPK EFPQEKMCLR 
LFRGPSRMKP FKYNHPQGFF SHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.