Details for: B4GALT2

Gene ID: 8704

Symbol: B4GALT2

Ensembl ID: ENSG00000117411

Description: beta-1,4-galactosyltransferase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 100.1638
    Cell Significance Index: -15.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.2133
    Cell Significance Index: -15.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.6609
    Cell Significance Index: -13.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.2656
    Cell Significance Index: -13.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.9040
    Cell Significance Index: -15.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0927
    Cell Significance Index: -16.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9425
    Cell Significance Index: -6.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9731
    Cell Significance Index: 26.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8332
    Cell Significance Index: 213.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1072
    Cell Significance Index: 999.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0322
    Cell Significance Index: 61.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0153
    Cell Significance Index: 110.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9051
    Cell Significance Index: 147.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7436
    Cell Significance Index: 38.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6818
    Cell Significance Index: 9.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5055
    Cell Significance Index: 34.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4860
    Cell Significance Index: 22.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4342
    Cell Significance Index: 19.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4044
    Cell Significance Index: 8.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3945
    Cell Significance Index: 11.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3818
    Cell Significance Index: 75.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3520
    Cell Significance Index: 66.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3206
    Cell Significance Index: 44.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3127
    Cell Significance Index: 138.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3068
    Cell Significance Index: 61.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2730
    Cell Significance Index: 19.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2626
    Cell Significance Index: 5.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2559
    Cell Significance Index: 31.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2413
    Cell Significance Index: 131.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2287
    Cell Significance Index: 6.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2238
    Cell Significance Index: 22.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1946
    Cell Significance Index: 35.0900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1753
    Cell Significance Index: 2.4600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1609
    Cell Significance Index: 2.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1539
    Cell Significance Index: 9.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1343
    Cell Significance Index: 2.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1258
    Cell Significance Index: 45.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1076
    Cell Significance Index: 2.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0915
    Cell Significance Index: 15.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0891
    Cell Significance Index: 3.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0810
    Cell Significance Index: 1.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0747
    Cell Significance Index: 4.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0635
    Cell Significance Index: 43.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0188
    Cell Significance Index: 0.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0180
    Cell Significance Index: 2.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0149
    Cell Significance Index: 28.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0140
    Cell Significance Index: 0.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0125
    Cell Significance Index: 1.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0109
    Cell Significance Index: 0.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0108
    Cell Significance Index: -14.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0125
    Cell Significance Index: -7.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0184
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0191
    Cell Significance Index: -14.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0274
    Cell Significance Index: -15.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0310
    Cell Significance Index: -14.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0311
    Cell Significance Index: -19.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0320
    Cell Significance Index: -0.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0383
    Cell Significance Index: -1.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0418
    Cell Significance Index: -12.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0431
    Cell Significance Index: -3.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0657
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0706
    Cell Significance Index: -8.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0801
    Cell Significance Index: -8.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0865
    Cell Significance Index: -2.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0880
    Cell Significance Index: -12.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0884
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0942
    Cell Significance Index: -19.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1067
    Cell Significance Index: -2.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1267
    Cell Significance Index: -7.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1340
    Cell Significance Index: -15.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1354
    Cell Significance Index: -8.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1453
    Cell Significance Index: -11.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1491
    Cell Significance Index: -3.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1505
    Cell Significance Index: -15.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1521
    Cell Significance Index: -1.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1604
    Cell Significance Index: -12.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1789
    Cell Significance Index: -11.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1824
    Cell Significance Index: -4.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2022
    Cell Significance Index: -5.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2048
    Cell Significance Index: -10.7600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2477
    Cell Significance Index: -1.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2658
    Cell Significance Index: -3.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2761
    Cell Significance Index: -7.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2837
    Cell Significance Index: -12.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2930
    Cell Significance Index: -10.1800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2988
    Cell Significance Index: -2.5400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3133
    Cell Significance Index: -4.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3181
    Cell Significance Index: -7.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3338
    Cell Significance Index: -5.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3363
    Cell Significance Index: -7.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3401
    Cell Significance Index: -12.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3462
    Cell Significance Index: -8.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3620
    Cell Significance Index: -12.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3674
    Cell Significance Index: -12.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3680
    Cell Significance Index: -11.7200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3736
    Cell Significance Index: -3.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** B4GALT2 is a member of the beta-1,4-galactosyltransferase family, which are enzymes responsible for the transfer of galactose units from UDP-galactose to growing carbohydrate chains. The gene is characterized by its ability to catalyze the transfer of galactose units to N-acetyllactosamine and keratan sulfate, resulting in the formation of complex glycoconjugates. The enzyme is also involved in the biosynthesis of glycosaminoglycans, such as keratan sulfate, which are essential components of the extracellular matrix. **Pathways and Functions** B4GALT2 is involved in various cellular processes, including: 1. **Glycosylation**: The gene plays a crucial role in the formation of glycoproteins and glycolipids, which are essential components of cell surfaces. 2. **Cell surface development**: B4GALT2 is involved in the development and maintenance of cell surfaces, particularly in the brain and intestinal epithelium. 3. **Immune cell function**: The gene is significantly expressed in immune cells, suggesting its involvement in immune cell function and development. 4. **Developmental processes**: B4GALT2 is involved in the development of the cerebellum and the formation of Purkinje cells. 5. **Metabolic processes**: The gene is involved in the metabolism of carbohydrates and proteins, particularly in the formation of glycosaminoglycans. **Clinical Significance** Dysregulation of B4GALT2 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in the B4GALT2 gene have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: The gene is overexpressed in certain types of cancer, suggesting its potential role in tumorigenesis. 3. **Immune system disorders**: Dysregulation of B4GALT2 has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 4. **Developmental disorders**: The gene is involved in the development of the brain and intestinal epithelium, and dysregulation of B4GALT2 has been implicated in developmental disorders, such as autism spectrum disorder. In conclusion, B4GALT2 is a critical gene involved in the biosynthesis of glycoproteins and glycolipids, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of B4GALT2 in human disease and to develop therapeutic strategies to target this gene in the treatment of diseases.

Genular Protein ID: 1021770414

Symbol: B4GT2_HUMAN

Name: Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase

UniProtKB Accession Codes:

O60909 B3KTP0 B4DE14 D3DPY6 D3DPY7 O60511 Q4V9L9 Q5T4X5 Q5T4Y5 Q9BUP6 Q9NSY7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CDD 1 CTD 1 ChEBI 25 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 4 EMBL 13 Ensembl 4 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 5 Rhea 6 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9405390

Title: A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.

PubMed ID: 9405390

DOI: 10.1074/jbc.272.51.31979

PubMed ID: 9597550

Title: The expanding beta 4-galactosyltransferase gene family: messages from the databanks.

PubMed ID: 9597550

DOI: 10.1093/glycob/8.5.517

PubMed ID: 11588157

Title: Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.

PubMed ID: 11588157

DOI: 10.1093/glycob/11.10.813

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10580128

Title: Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

PubMed ID: 10580128

DOI: 10.1016/s0304-4165(99)00168-3

Sequence Information:

  • Length: 372
  • Mass: 41972
  • Checksum: A6F7800251AA1E4F
  • Sequence:
    • MSRLLGGTLE RVCKAVLLLC LLHFLVAVIL YFDVYAQHLA FFSRFSARGP AHALHPAASS 
SSSSSNCSRP NATASSSGLP EVPSALPGPT APTLPPCPDS PPGLVGRLLI EFTSPMPLER 
VQRENPGVLM GGRYTPPDCT PAQTVAVIIP FRHREHHLRY WLHYLHPILR RQRLRYGVYV 
INQHGEDTFN RAKLLNVGFL EALKEDAAYD CFIFSDVDLV PMDDRNLYRC GDQPRHFAIA 
MDKFGFRLPY AGYFGGVSGL SKAQFLRING FPNEYWGWGG EDDDIFNRIS LTGMKISRPD 
IRIGRYRMIK HDRDKHNEPN PQRFTKIQNT KLTMKRDGIG SVRYQVLEVS RQPLFTNITV 
DIGRPPSWPP RG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.