Details for: TNK1

Gene ID: 8711

Symbol: TNK1

Ensembl ID: ENSG00000174292

Description: tyrosine kinase non receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.4448
    Cell Significance Index: -4.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.5049
    Cell Significance Index: -4.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.2420
    Cell Significance Index: -4.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.7147
    Cell Significance Index: -4.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9241
    Cell Significance Index: 20.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7778
    Cell Significance Index: 702.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7434
    Cell Significance Index: 38.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7050
    Cell Significance Index: 42.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6897
    Cell Significance Index: 9.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6572
    Cell Significance Index: 71.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5857
    Cell Significance Index: 26.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5361
    Cell Significance Index: 15.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5300
    Cell Significance Index: 86.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4992
    Cell Significance Index: 7.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4682
    Cell Significance Index: 7.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3847
    Cell Significance Index: 44.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3553
    Cell Significance Index: 24.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2677
    Cell Significance Index: 16.8800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2162
    Cell Significance Index: 3.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1759
    Cell Significance Index: 17.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1462
    Cell Significance Index: 17.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1420
    Cell Significance Index: 62.7700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1375
    Cell Significance Index: 0.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1133
    Cell Significance Index: 20.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1116
    Cell Significance Index: 3.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0911
    Cell Significance Index: 1.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0874
    Cell Significance Index: 16.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0814
    Cell Significance Index: 0.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0775
    Cell Significance Index: 5.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0751
    Cell Significance Index: 3.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0727
    Cell Significance Index: 1.9800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0723
    Cell Significance Index: 0.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0709
    Cell Significance Index: 2.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0676
    Cell Significance Index: 1.6900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.0633
    Cell Significance Index: 0.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0610
    Cell Significance Index: 12.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0553
    Cell Significance Index: 1.7700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0552
    Cell Significance Index: 0.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0549
    Cell Significance Index: 2.5600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0506
    Cell Significance Index: 0.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0459
    Cell Significance Index: 25.0400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0443
    Cell Significance Index: 0.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0322
    Cell Significance Index: 1.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0319
    Cell Significance Index: 6.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0278
    Cell Significance Index: 2.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0259
    Cell Significance Index: 1.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0251
    Cell Significance Index: 4.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0214
    Cell Significance Index: 2.4600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0132
    Cell Significance Index: 0.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0103
    Cell Significance Index: 0.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0037
    Cell Significance Index: 5.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0033
    Cell Significance Index: 1.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0024
    Cell Significance Index: 4.4800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0009
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0035
    Cell Significance Index: -2.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0035
    Cell Significance Index: -2.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0040
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0074
    Cell Significance Index: -3.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0080
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0087
    Cell Significance Index: -5.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0116
    Cell Significance Index: -1.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0121
    Cell Significance Index: -3.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0123
    Cell Significance Index: -0.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0132
    Cell Significance Index: -1.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0137
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0231
    Cell Significance Index: -4.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0255
    Cell Significance Index: -2.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0309
    Cell Significance Index: -0.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0314
    Cell Significance Index: -1.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0315
    Cell Significance Index: -0.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0354
    Cell Significance Index: -2.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0411
    Cell Significance Index: -0.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0429
    Cell Significance Index: -4.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0486
    Cell Significance Index: -3.8500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0492
    Cell Significance Index: -0.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0528
    Cell Significance Index: -2.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0552
    Cell Significance Index: -0.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0584
    Cell Significance Index: -0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0643
    Cell Significance Index: -3.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0704
    Cell Significance Index: -4.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0746
    Cell Significance Index: -2.0000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0753
    Cell Significance Index: -0.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0776
    Cell Significance Index: -4.0400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0889
    Cell Significance Index: -0.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0889
    Cell Significance Index: -1.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0917
    Cell Significance Index: -3.1900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0921
    Cell Significance Index: -1.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0921
    Cell Significance Index: -1.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0965
    Cell Significance Index: -2.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0989
    Cell Significance Index: -3.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1020
    Cell Significance Index: -3.3400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1031
    Cell Significance Index: -0.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1039
    Cell Significance Index: -3.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1097
    Cell Significance Index: -1.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNK1 is a non-receptor tyrosine kinase, meaning it lacks a transmembrane domain and is not embedded in the cell membrane. This characteristic distinguishes it from receptor tyrosine kinases, which are membrane-bound enzymes that respond to external ligands. TNK1 is also a non-receptor tyrosine-protein kinase, indicating that it phosphorylates tyrosine residues on target proteins. The gene's product, TNK1_HUMAN, is a non-receptor tyrosine-protein kinase that exhibits non-specific kinase activity, meaning it phosphorylates a wide range of substrates without specific binding to ligands. **Pathways and Functions:** TNK1 is involved in various cellular processes, including: 1. **Cell signaling:** TNK1 phosphorylates and activates downstream signaling molecules, such as STAT proteins, which regulate gene expression and cellular responses to stimuli. 2. **Protein autophosphorylation:** TNK1 autophosphorylates itself, which is a crucial step in its activation and regulation. 3. **Protein binding:** TNK1 interacts with various proteins, including substrates, adapters, and regulatory molecules, to modulate its activity and substrate specificity. 4. **Protein phosphorylation:** TNK1 phosphorylates tyrosine residues on target proteins, which can alter their activity, localization, or stability. **Clinical Significance:** The dysregulation of TNK1 has been implicated in various diseases, including: 1. **Cancer:** Overexpression or mutation of TNK1 has been observed in several types of cancer, including leukemia, lymphoma, and breast cancer. TNK1 may contribute to tumorigenesis by promoting cell proliferation, survival, and metastasis. 2. **Neurological disorders:** TNK1 has been implicated in the pathogenesis of neurological disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder. Abnormal TNK1 expression and activity may contribute to the development of these conditions. 3. **Gastrointestinal disorders:** TNK1 has been linked to gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Abnormal TNK1 expression and activity may contribute to the development of these conditions. In conclusion, TNK1 is a non-receptor tyrosine kinase gene that plays a crucial role in various cellular processes, including cell signaling, protein autophosphorylation, and protein phosphorylation. The dysregulation of TNK1 has been implicated in several diseases, highlighting its potential as a therapeutic target for the treatment of various conditions. Further research is necessary to fully elucidate the mechanisms of TNK1 and its clinical significance.

Genular Protein ID: 4103281831

Symbol: TNK1_HUMAN

Name: Non-receptor tyrosine-protein kinase TNK1

UniProtKB Accession Codes:

Q13470 O95364 Q8IYI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 3 Ensembl 5 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8632913

Title: Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells.

PubMed ID: 8632913

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10873601

Title: Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1.

PubMed ID: 10873601

DOI: 10.1006/bbrc.2000.2887

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18974114

Title: Tnk1/Kos1 knockout mice develop spontaneous tumors.

PubMed ID: 18974114

DOI: 10.1158/0008-5472.can-08-1467

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 666
  • Mass: 72468
  • Checksum: AA7FBEF6CC778181
  • Sequence:
    • MLPEAGSLWL LKLLRDIQLA QFYWPILEEL NVTRPEHFDF VKPEDLDGIG MGRPAQRRLS 
EALKRLRSGP KSKNWVYKIL GGFAPEHKEP TLPSDSPRHL PEPEGGLKCL IPEGAVCRGE 
LLGSGCFGVV HRGLWTLPSG KSVPVAVKSL RVGPEGPMGT ELGDFLREVS VMMNLEHPHV 
LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPPLLVA LLCLFLRQLA GAMAYLGARG 
LVHRDLATRN LLLASPRTIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRHGAF 
SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEDRA RLPRPPLCSR ALYSLALRCW 
APHPADRPSF SHLEGLLQEA GPSEACCVRD VTEPGALRME TGDPITVIEG SSSFHSPDST 
IWKGQNGRTF KVGSFPASAV TLADAGGLPA TRPVHRGTPA RGDQHPGSID GDRKKANLWD 
APPARGQRRN MPLERMKGIS RSLESVLSLG PRPTGGGSSP PEIRQARAVP QGPPGLPPRP 
PLSSSSPQPS QPSRERLPWP KRKPPHNHPM GMPGARKAAA LSGGLLSDPE LQRKIMEVEL 
SVHGVTHQEC QTALGATGGD VVSAIRNLKV DQLFHLSSRS RADCWRILEH YQWDLSAASR 
YVLARP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.