Details for: RGS11

Gene ID: 8786

Symbol: RGS11

Ensembl ID: ENSG00000076344

Description: regulator of G protein signaling 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.4823
    Cell Significance Index: -14.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.3417
    Cell Significance Index: -14.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.9355
    Cell Significance Index: 58.9700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.2860
    Cell Significance Index: 17.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.1137
    Cell Significance Index: 133.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1409
    Cell Significance Index: 69.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8447
    Cell Significance Index: 169.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7872
    Cell Significance Index: 13.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7542
    Cell Significance Index: 8.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7320
    Cell Significance Index: 17.7300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4929
    Cell Significance Index: 7.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4844
    Cell Significance Index: 173.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2836
    Cell Significance Index: 6.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2334
    Cell Significance Index: 23.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2326
    Cell Significance Index: 12.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2117
    Cell Significance Index: 191.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2103
    Cell Significance Index: 145.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2055
    Cell Significance Index: 5.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1766
    Cell Significance Index: 13.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1614
    Cell Significance Index: 4.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1523
    Cell Significance Index: 3.3000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1151
    Cell Significance Index: 0.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1133
    Cell Significance Index: 18.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1118
    Cell Significance Index: 21.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0965
    Cell Significance Index: 12.3700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0840
    Cell Significance Index: 0.7400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0767
    Cell Significance Index: 0.9300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0576
    Cell Significance Index: 0.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0525
    Cell Significance Index: 2.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0492
    Cell Significance Index: 3.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0471
    Cell Significance Index: 5.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0459
    Cell Significance Index: 2.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0429
    Cell Significance Index: 0.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0242
    Cell Significance Index: 45.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0187
    Cell Significance Index: 11.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0065
    Cell Significance Index: 9.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0061
    Cell Significance Index: 8.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0020
    Cell Significance Index: 0.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0011
    Cell Significance Index: 0.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -7.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0095
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0136
    Cell Significance Index: -0.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0152
    Cell Significance Index: -2.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0188
    Cell Significance Index: -13.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0192
    Cell Significance Index: -10.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0199
    Cell Significance Index: -15.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0203
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0247
    Cell Significance Index: -15.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0293
    Cell Significance Index: -1.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0336
    Cell Significance Index: -4.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0408
    Cell Significance Index: -11.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0626
    Cell Significance Index: -11.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0636
    Cell Significance Index: -13.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0680
    Cell Significance Index: -7.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0734
    Cell Significance Index: -14.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0905
    Cell Significance Index: -2.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0919
    Cell Significance Index: -1.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0945
    Cell Significance Index: -3.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0949
    Cell Significance Index: -11.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0973
    Cell Significance Index: -12.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1001
    Cell Significance Index: -1.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1009
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1096
    Cell Significance Index: -12.5600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1116
    Cell Significance Index: -1.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1213
    Cell Significance Index: -2.6200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1228
    Cell Significance Index: -1.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1271
    Cell Significance Index: -12.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1340
    Cell Significance Index: -2.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1345
    Cell Significance Index: -14.0000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1447
    Cell Significance Index: -0.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1605
    Cell Significance Index: -3.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1630
    Cell Significance Index: -2.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1729
    Cell Significance Index: -8.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1770
    Cell Significance Index: -13.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1942
    Cell Significance Index: -10.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1949
    Cell Significance Index: -6.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1978
    Cell Significance Index: -3.4200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2192
    Cell Significance Index: -2.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2301
    Cell Significance Index: -8.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2325
    Cell Significance Index: -15.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2379
    Cell Significance Index: -11.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2430
    Cell Significance Index: -12.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2436
    Cell Significance Index: -13.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2530
    Cell Significance Index: -6.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2669
    Cell Significance Index: -8.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2737
    Cell Significance Index: -5.8300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2753
    Cell Significance Index: -3.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2765
    Cell Significance Index: -12.0200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2779
    Cell Significance Index: -5.8000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2842
    Cell Significance Index: -3.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2900
    Cell Significance Index: -5.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3024
    Cell Significance Index: -8.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3280
    Cell Significance Index: -12.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3314
    Cell Significance Index: -9.5000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3339
    Cell Significance Index: -2.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS11 is a member of the regulator of G-protein signaling (RGS) family, which comprises a group of proteins that negatively regulate G-protein signaling pathways. RGS11 exhibits GTPase activating protein (GAP) activity, which degrades G-protein α-subunits, thereby inhibiting G-protein signaling. The gene is specifically expressed in neurons and is involved in the regulation of various signaling pathways, including GPCR signaling, Gα(i) signaling, and intracellular signal transduction. **Pathways and Functions:** RGS11 is involved in the regulation of G-protein coupled receptor signaling pathways, where it counteracts the activity of G-proteins. This gene is specifically involved in: 1. **Cooperation of pdcl (phlp1) and tric/cct in G-protein beta folding:** RGS11 interacts with pdcl (phlp1) and tric/cct proteins to regulate the folding of G-protein β-subunits. 2. **G-protein β-subunit binding:** RGS11 binds to G-protein β-subunits, regulating their activity and the downstream signaling events. 3. **Gα(i) signaling events:** RGS11 modulates Gα(i) signaling events, which are involved in various physiological processes, including neuronal signaling and metabolism. 4. **GPCR downstream signaling:** RGS11 regulates the downstream signaling events of GPCRs, which are involved in various physiological processes, including neurotransmission and cell growth. **Clinical Significance:** Dysregulation of RGS11 has been implicated in several neurological disorders, including: 1. **Retinitis pigmentosa:** RGS11 mutations have been associated with retinitis pigmentosa, a genetic disorder affecting the retina. 2. **Neurodegenerative diseases:** RGS11 dysregulation has been implicated in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Migraine:** RGS11 has been implicated in migraine pathophysiology, with dysregulation of RGS11 contributing to the development of migraine headaches. 4. **Neuropsychiatric disorders:** RGS11 has been implicated in neuropsychiatric disorders, including schizophrenia and bipolar disorder. In conclusion, RGS11 is a crucial gene that regulates G-protein signaling pathways, and its dysregulation has been implicated in various neurological disorders. Further research is needed to elucidate the molecular mechanisms underlying RGS11 dysregulation and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 4193939754

Symbol: RGS11_HUMAN

Name: Regulator of G-protein signaling 11

UniProtKB Accession Codes:

O94810 O75883 Q4TT71 Q4TT72

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 11 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 4 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9789084

Title: A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.

PubMed ID: 9789084

DOI: 10.1073/pnas.95.22.13307

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10339615

Title: Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.

PubMed ID: 10339615

DOI: 10.1073/pnas.96.11.6489

Sequence Information:

  • Length: 467
  • Mass: 52946
  • Checksum: 46BEE11D77C2C5F7
  • Sequence:
    • MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW 
LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE 
LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL 
VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT 
RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW 
GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA 
PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE 
AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA

Genular Protein ID: 3896178551

Symbol: B7Z285_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z285

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 261
  • Mass: 29492
  • Checksum: D6426EAC619B9FAF
  • Sequence:
    • MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW 
LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE 
LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL 
VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMV EASRTRGTRP EGASEPRSSK 
TLCSNQSHPD PTSGKMHLEP H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.