Details for: TNFRSF11A

Gene ID: 8792

Symbol: TNFRSF11A

Ensembl ID: ENSG00000141655

Description: TNF receptor superfamily member 11a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 56.3502
    Cell Significance Index: -8.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.4578
    Cell Significance Index: -8.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.6920
    Cell Significance Index: -8.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.4203
    Cell Significance Index: 51.2500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.9052
    Cell Significance Index: 22.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 2.0470
    Cell Significance Index: 21.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9856
    Cell Significance Index: 57.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.8070
    Cell Significance Index: 27.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6234
    Cell Significance Index: 35.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6129
    Cell Significance Index: -3.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4177
    Cell Significance Index: 154.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3147
    Cell Significance Index: 59.5900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.9417
    Cell Significance Index: 9.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8125
    Cell Significance Index: 132.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7400
    Cell Significance Index: 15.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6858
    Cell Significance Index: 67.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6377
    Cell Significance Index: 8.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6201
    Cell Significance Index: 28.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5486
    Cell Significance Index: 11.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3838
    Cell Significance Index: 13.4900
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.2658
    Cell Significance Index: 2.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2592
    Cell Significance Index: 6.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2330
    Cell Significance Index: 210.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2130
    Cell Significance Index: 11.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1868
    Cell Significance Index: 35.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1737
    Cell Significance Index: 8.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1364
    Cell Significance Index: 27.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1168
    Cell Significance Index: 3.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1061
    Cell Significance Index: 73.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1023
    Cell Significance Index: 18.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0452
    Cell Significance Index: 24.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0281
    Cell Significance Index: 17.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0224
    Cell Significance Index: 2.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0223
    Cell Significance Index: 2.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0200
    Cell Significance Index: 2.5900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0110
    Cell Significance Index: 0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0077
    Cell Significance Index: 2.7500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0037
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0033
    Cell Significance Index: 0.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0032
    Cell Significance Index: 1.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0029
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0024
    Cell Significance Index: -1.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0046
    Cell Significance Index: -2.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -12.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0071
    Cell Significance Index: -10.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0086
    Cell Significance Index: -11.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0113
    Cell Significance Index: -8.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0121
    Cell Significance Index: -8.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0162
    Cell Significance Index: -2.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0167
    Cell Significance Index: -0.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0208
    Cell Significance Index: -2.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0210
    Cell Significance Index: -9.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0243
    Cell Significance Index: -7.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0266
    Cell Significance Index: -5.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0279
    Cell Significance Index: -0.7600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0289
    Cell Significance Index: -0.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0442
    Cell Significance Index: -4.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0497
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0522
    Cell Significance Index: -5.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0534
    Cell Significance Index: -4.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0547
    Cell Significance Index: -7.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0618
    Cell Significance Index: -8.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0735
    Cell Significance Index: -5.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0826
    Cell Significance Index: -8.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0848
    Cell Significance Index: -5.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0869
    Cell Significance Index: -3.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0935
    Cell Significance Index: -11.0300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0973
    Cell Significance Index: -2.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1105
    Cell Significance Index: -7.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1207
    Cell Significance Index: -9.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1215
    Cell Significance Index: -3.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1220
    Cell Significance Index: -8.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1262
    Cell Significance Index: -4.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1376
    Cell Significance Index: -4.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1376
    Cell Significance Index: -1.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1404
    Cell Significance Index: -6.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1461
    Cell Significance Index: -3.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1524
    Cell Significance Index: -7.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1695
    Cell Significance Index: -8.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1736
    Cell Significance Index: -10.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1741
    Cell Significance Index: -9.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1841
    Cell Significance Index: -4.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1907
    Cell Significance Index: -10.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1997
    Cell Significance Index: -6.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2300
    Cell Significance Index: -7.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2305
    Cell Significance Index: -8.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2348
    Cell Significance Index: -3.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2513
    Cell Significance Index: -7.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2526
    Cell Significance Index: -7.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2587
    Cell Significance Index: -8.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2618
    Cell Significance Index: -6.7300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2676
    Cell Significance Index: -3.7000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2708
    Cell Significance Index: -1.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2788
    Cell Significance Index: -7.4700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2851
    Cell Significance Index: -3.8000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2880
    Cell Significance Index: -1.7400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3006
    Cell Significance Index: -4.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Receptor function**: TNFRSF11A is a type II transmembrane receptor that binds to TNF, a trimeric cytokine that mediates various cellular responses. 2. **Wide tissue expression**: TNFRSF11A is expressed in multiple cell types, including T-helper 17 cells, osteoclasts, cardiac endothelial cells, and epithelial cells. 3. **Signaling pathways**: The TNFRSF11A receptor is involved in various signaling pathways, including the NF-κB pathway, which regulates inflammation, immune responses, and cell survival. 4. **Biological functions**: TNFRSF11A regulates inflammation, immune responses, bone metabolism, and cell proliferation. **Pathways and Functions** 1. **Adaptive immune response**: TNFRSF11A regulates the adaptive immune response by modulating the activity of T-helper 17 cells and other immune cells. 2. **Cell-cell signaling**: The TNFRSF11A receptor is involved in cell-cell signaling, regulating interactions between immune cells and other cell types. 3. **Cellular response to zinc ion starvation**: TNFRSF11A regulates the cellular response to zinc ion starvation, which is essential for maintaining cellular homeostasis. 4. **Cytokine signaling in immune system**: The TNFRSF11A receptor is involved in cytokine signaling in the immune system, regulating the activity of immune cells. 5. **Osteoclast differentiation and bone resorption**: TNFRSF11A regulates osteoclast differentiation and bone resorption, which is essential for maintaining bone homeostasis. **Clinical Significance** 1. **Autoimmune disorders**: Dysregulation of TNFRSF11A has been implicated in various autoimmune disorders, including rheumatoid arthritis and systemic lupus erythematosus. 2. **Cancer**: TNFRSF11A is overexpressed in certain types of cancer, including breast cancer and colon cancer, and is associated with poor prognosis. 3. **Bone diseases**: TNFRSF11A regulates bone metabolism, and dysregulation of this receptor is implicated in bone diseases, including osteoporosis and Paget's disease. 4. **Inflammatory diseases**: TNFRSF11A is involved in the regulation of inflammation, and dysregulation of this receptor is implicated in various inflammatory diseases, including cardiovascular disease and atherosclerosis. In conclusion, TNFRSF11A is a critical regulator of inflammation, immune responses, and bone metabolism. Dysregulation of this receptor is implicated in various diseases, including autoimmune disorders, cancer, and bone diseases. Further research is needed to fully understand the role of TNFRSF11A in human disease and to develop therapeutic strategies to target this receptor.

Genular Protein ID: 2500693433

Symbol: TNR11_HUMAN

Name: Tumor necrosis factor receptor superfamily member 11A

UniProtKB Accession Codes:

Q9Y6Q6 I4EC36 I4EC38 I4EC39 I7JE63 N0GVH0 Q59EP9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367155

Title: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

PubMed ID: 9367155

DOI: 10.1038/36593

PubMed ID: 23664977

Title: Alternative splicing generates a truncated isoform of human TNFRSF11A (RANK) with an altered capacity to activate NF-kappaB.

PubMed ID: 23664977

DOI: 10.1016/j.gene.2013.04.075

PubMed ID: 9878548

Title: RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis.

PubMed ID: 9878548

DOI: 10.1006/bbrc.1998.9788

PubMed ID: 9774460

Title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

PubMed ID: 9774460

DOI: 10.1074/jbc.273.43.28355

PubMed ID: 15750601

Title: The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis.

PubMed ID: 15750601

DOI: 10.1038/nm1203

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23478294

Title: Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.

PubMed ID: 23478294

DOI: 10.1038/cr.2013.33

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10615125

Title: Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis.

PubMed ID: 10615125

DOI: 10.1038/71667

PubMed ID: 18606301

Title: Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations.

PubMed ID: 18606301

DOI: 10.1016/j.ajhg.2008.06.015

Sequence Information:

  • Length: 616
  • Mass: 66034
  • Checksum: E3DE9A7A08196F81
  • Sequence:
    • MAPRARRRRP LFALLLLCAL LARLQVALQI APPCTSEKHY EHLGRCCNKC EPGKYMSSKC 
TTTSDSVCLP CGPDEYLDSW NEEDKCLLHK VCDTGKALVA VVAGNSTTPR RCACTAGYHW 
SQDCECCRRN TECAPGLGAQ HPLQLNKDTV CKPCLAGYFS DAFSSTDKCR PWTNCTFLGK 
RVEHHGTEKS DAVCSSSLPA RKPPNEPHVY LPGLIILLLF ASVALVAAII FGVCYRKKGK 
ALTANLWHWI NEACGRLSGD KESSGDSCVS THTANFGQQG ACEGVLLLTL EEKTFPEDMC 
YPDQGGVCQG TCVGGGPYAQ GEDARMLSLV SKTEIEEDSF RQMPTEDEYM DRPSQPTDQL 
LFLTEPGSKS TPPFSEPLEV GENDSLSQCF TGTQSTVGSE SCNCTEPLCR TDWTPMSSEN 
YLQKEVDSGH CPHWAASPSP NWADVCTGCR NPPGEDCEPL VGSPKRGPLP QCAYGMGLPP 
EEEASRTEAR DQPEDGADGR LPSSARAGAG SGSSPGGQSP ASGNVTGNSN STFISSGQVM 
NFKGDIIVVY VSQTSQEGAA AAAEPMGRPV QEETLARRDS FAGNGPRFPD PCGGPEGLRE 
PEKASRPVQE QGGAKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.