Details for: TRIM24

Gene ID: 8805

Symbol: TRIM24

Ensembl ID: ENSG00000122779

Description: tripartite motif containing 24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 237.1657
    Cell Significance Index: -36.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.5052
    Cell Significance Index: -34.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.8125
    Cell Significance Index: -37.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.4017
    Cell Significance Index: -33.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.8052
    Cell Significance Index: -33.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.5340
    Cell Significance Index: -38.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.0024
    Cell Significance Index: -39.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9757
    Cell Significance Index: -30.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0182
    Cell Significance Index: -15.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.6689
    Cell Significance Index: 728.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.5472
    Cell Significance Index: 199.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.9561
    Cell Significance Index: 79.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7872
    Cell Significance Index: 176.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6078
    Cell Significance Index: 40.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5923
    Cell Significance Index: 97.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5475
    Cell Significance Index: 41.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5451
    Cell Significance Index: 554.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.5063
    Cell Significance Index: 36.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3574
    Cell Significance Index: 272.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2573
    Cell Significance Index: 1135.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1505
    Cell Significance Index: 125.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8308
    Cell Significance Index: 149.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8214
    Cell Significance Index: 568.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7846
    Cell Significance Index: 22.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7115
    Cell Significance Index: 54.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6458
    Cell Significance Index: 33.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6167
    Cell Significance Index: 13.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6036
    Cell Significance Index: 31.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6003
    Cell Significance Index: 73.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5966
    Cell Significance Index: 8.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5030
    Cell Significance Index: 22.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4880
    Cell Significance Index: 18.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4829
    Cell Significance Index: 78.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4804
    Cell Significance Index: 12.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3616
    Cell Significance Index: 197.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2766
    Cell Significance Index: 4.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2762
    Cell Significance Index: 18.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2731
    Cell Significance Index: 37.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2610
    Cell Significance Index: 12.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2426
    Cell Significance Index: 6.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2424
    Cell Significance Index: 107.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2347
    Cell Significance Index: 14.7900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1646
    Cell Significance Index: 1.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1537
    Cell Significance Index: 1.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1399
    Cell Significance Index: 3.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1204
    Cell Significance Index: 4.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0673
    Cell Significance Index: 11.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0463
    Cell Significance Index: 2.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0429
    Cell Significance Index: 80.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0377
    Cell Significance Index: 0.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0327
    Cell Significance Index: 20.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0322
    Cell Significance Index: 49.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0303
    Cell Significance Index: 0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0174
    Cell Significance Index: 32.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0113
    Cell Significance Index: 15.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0078
    Cell Significance Index: 0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0211
    Cell Significance Index: -15.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0221
    Cell Significance Index: -13.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0224
    Cell Significance Index: -16.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0391
    Cell Significance Index: -29.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0447
    Cell Significance Index: -6.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0543
    Cell Significance Index: -30.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0883
    Cell Significance Index: -2.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0946
    Cell Significance Index: -12.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1181
    Cell Significance Index: -33.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1286
    Cell Significance Index: -27.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1312
    Cell Significance Index: -9.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1558
    Cell Significance Index: -2.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1761
    Cell Significance Index: -22.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1938
    Cell Significance Index: -19.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1996
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2133
    Cell Significance Index: -24.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2189
    Cell Significance Index: -25.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2330
    Cell Significance Index: -26.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2384
    Cell Significance Index: -27.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2855
    Cell Significance Index: -13.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3150
    Cell Significance Index: -10.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3264
    Cell Significance Index: -33.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4099
    Cell Significance Index: -30.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4178
    Cell Significance Index: -33.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4406
    Cell Significance Index: -27.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4423
    Cell Significance Index: -11.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4504
    Cell Significance Index: -23.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4681
    Cell Significance Index: -9.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4740
    Cell Significance Index: -5.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4809
    Cell Significance Index: -13.0900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4983
    Cell Significance Index: -6.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5249
    Cell Significance Index: -8.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5907
    Cell Significance Index: -19.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6048
    Cell Significance Index: -21.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6207
    Cell Significance Index: -3.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6287
    Cell Significance Index: -9.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6377
    Cell Significance Index: -20.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6774
    Cell Significance Index: -13.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7933
    Cell Significance Index: -10.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7975
    Cell Significance Index: -15.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8010
    Cell Significance Index: -17.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8388
    Cell Significance Index: -16.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8407
    Cell Significance Index: -29.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRIM24 exhibits several distinct characteristics that make it an essential protein in the cell. These include: 1. **TRIM domain**: The TRIM domain is a conserved region of the protein that mediates protein-protein interactions, protein degradation, and transcriptional regulation. 2. **Histone modification**: TRIM24 has been shown to interact with histones, modifying their acetylation and methylation states, which is essential for regulating gene expression. 3. **Transcriptional regulation**: TRIM24 acts as a transcriptional regulator, interacting with transcription factors, RNA polymerase II, and other components of the transcriptional machinery to modulate gene expression. 4. **Protein stability**: TRIM24 regulates protein stability by interacting with ubiquitin ligases and E3 ubiquitin ligases, which are responsible for protein degradation. 5. **Signal transduction**: TRIM24 is involved in signal transduction pathways, including those mediated by growth factor receptors, estrogen receptors, and p53. **Pathways and Functions** TRIM24 is involved in various cellular processes, including: 1. **Calcium ion homeostasis**: TRIM24 regulates calcium ion homeostasis by interacting with calcium-binding proteins and modulating their activity. 2. **Estrogen response**: TRIM24 interacts with estrogen receptors, modulating their activity and regulating gene expression in response to estrogen stimuli. 3. **Cellular proliferation**: TRIM24 regulates cellular proliferation by interacting with transcription factors and signaling pathways, including those mediated by FGFR1. 4. **Apoptosis**: TRIM24 regulates apoptosis by interacting with p53 and other components of the apoptotic machinery. 5. **Vitamin D receptor signaling**: TRIM24 interacts with vitamin D receptors, modulating their activity and regulating gene expression in response to vitamin D stimuli. **Clinical Significance** Dysregulation of TRIM24 has been implicated in various diseases, including: 1. **Cancer**: TRIM24 is often overexpressed in cancer cells, where it promotes tumorigenesis and metastasis. 2. **Neurological disorders**: TRIM24 is involved in the regulation of neuronal function and is implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders**: TRIM24 plays a role in regulating immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis. 4. **Endocrine disorders**: TRIM24 is involved in the regulation of endocrine functions, including those mediated by estrogen and thyroid hormones. In conclusion, TRIM24 is a multifunctional protein that plays a crucial role in various cellular processes, including transcriptional regulation, signal transduction, and protein stability. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TRIM24 function and its role in human disease.

Genular Protein ID: 3916682501

Symbol: TIF1A_HUMAN

Name: Transcription intermediary factor 1-alpha

UniProtKB Accession Codes:

O15164 A4D1R7 A4D1R8 O95854

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 5 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 19 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9115274

Title: Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.

PubMed ID: 9115274

DOI: 10.1074/jbc.272.18.12062

PubMed ID: 10022127

Title: TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.

PubMed ID: 10022127

DOI: 10.1038/sj.onc.1202655

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10935545

Title: Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor.

PubMed ID: 10935545

DOI: 10.1210/mend.14.8.0502

PubMed ID: 10439047

Title: The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.

PubMed ID: 10439047

DOI: 10.1038/sj.onc.1202824

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16322096

Title: Transcriptional intermediary factor 1alpha mediates physical interaction and functional synergy between the coactivator-associated arginine methyltransferase 1 and glucocorticoid receptor-interacting protein 1 nuclear receptor coactivators.

PubMed ID: 16322096

DOI: 10.1210/me.2005-0393

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19909775

Title: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.

PubMed ID: 19909775

DOI: 10.1016/j.bbamcr.2009.11.001

PubMed ID: 19556538

Title: Trim24 targets endogenous p53 for degradation.

PubMed ID: 19556538

DOI: 10.1073/pnas.0813177106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22629402

Title: TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members.

PubMed ID: 22629402

DOI: 10.1371/journal.pone.0037470

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24820418

Title: TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage.

PubMed ID: 24820418

DOI: 10.1128/mcb.01705-12

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32324863

Title: TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.

PubMed ID: 32324863

DOI: 10.1084/jem.20192083

PubMed ID: 33724611

Title: E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase-1/IL-1beta-mediated pyroptosis in endometriosis.

PubMed ID: 33724611

DOI: 10.1002/cbin.11592

PubMed ID: 21164480

Title: TRIM24 links a non-canonical histone signature to breast cancer.

PubMed ID: 21164480

DOI: 10.1038/nature09542

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1050
  • Mass: 116831
  • Checksum: D341E8022AACC67E
  • Sequence:
    • MEVAVEKAVA AAAAASAAAS GGPSAAPSGE NEAESRQGPD SERGGEAARL NLLDTCAVCH 
QNIQSRAPKL LPCLHSFCQR CLPAPQRYLM LPAPMLGSAE TPPPVPAPGS PVSGSSPFAT 
QVGVIRCPVC SQECAERHII DNFFVKDTTE VPSSTVEKSN QVCTSCEDNA EANGFCVECV 
EWLCKTCIRA HQRVKFTKDH TVRQKEEVSP EAVGVTSQRP VFCPFHKKEQ LKLYCETCDK 
LTCRDCQLLE HKEHRYQFIE EAFQNQKVII DTLITKLMEK TKYIKFTGNQ IQNRIIEVNQ 
NQKQVEQDIK VAIFTLMVEI NKKGKALLHQ LESLAKDHRM KLMQQQQEVA GLSKQLEHVM 
HFSKWAVSSG SSTALLYSKR LITYRLRHLL RARCDASPVT NNTIQFHCDP SFWAQNIINL 
GSLVIEDKES QPQMPKQNPV VEQNSQPPSG LSSNQLSKFP TQISLAQLRL QHMQQQVMAQ 
RQQVQRRPAP VGLPNPRMQG PIQQPSISHQ QPPPRLINFQ NHSPKPNGPV LPPHPQQLRY 
PPNQNIPRQA IKPNPLQMAF LAQQAIKQWQ ISSGQGTPST TNSTSSTPSS PTITSAAGYD 
GKAFGSPMID LSSPVGGSYN LPSLPDIDCS STIMLDNIVR KDTNIDHGQP RPPSNRTVQS 
PNSSVPSPGL AGPVTMTSVH PPIRSPSASS VGSRGSSGSS SKPAGADSTH KVPVVMLEPI 
RIKQENSGPP ENYDFPVVIV KQESDEESRP QNANYPRSIL TSLLLNSSQS STSEETVLRS 
DAPDSTGDQP GLHQDNSSNG KSEWLDPSQK SPLHVGETRK EDDPNEDWCA VCQNGGELLC 
CEKCPKVFHL SCHVPTLTNF PSGEWICTFC RDLSKPEVEY DCDAPSHNSE KKKTEGLVKL 
TPIDKRKCER LLLFLYCHEM SLAFQDPVPL TVPDYYKIIK NPMDLSTIKK RLQEDYSMYS 
KPEDFVADFR LIFQNCAEFN EPDSEVANAG IKLENYFEEL LKNLYPEKRF PKPEFRNESE 
DNKFSDDSDD DFVQPRKKRL KSIEERQLLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.