Details for: INPP4B
Gene ID: 8821
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: INPP4B
Ensembl ID: ENSG00000109452
Description: inositol polyphosphate-4-phosphatase type II B
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 69.94rCSI 83.54%PRS 51.62
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CSI 66.24rCSI 82.41%PRS 49.86
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CSI 52.28rCSI 84.08%PRS 53.66
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CSI 48.8rCSI 70.02%PRS 60.08
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CSI 44.62rCSI 78.8%PRS 50.87
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CSI 44.39rCSI 74.51%PRS 51.76
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CSI 38.29rCSI 67.13%PRS 63.07
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CSI 34.84rCSI 69.95%PRS 59.83
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CSI 34.58rCSI 44.58%PRS 53.16
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CSI 32.28rCSI 77.2%PRS 57.29
-
CSI 30.36rCSI 73.79%PRS 50.17
-
CSI 27.84rCSI 60.4%PRS 58.26
-
CSI 26.28rCSI 82.19%PRS 56.04
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CSI 25.35rCSI 67.5%PRS 58.9
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CSI 25.16rCSI 69.34%PRS 65.52
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CSI 24.64rCSI 72.73%PRS 69.69
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CSI 24.26rCSI 17.04%PRS 86.59
-
CSI 22.17rCSI 72.86%PRS 57.07
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CSI 20.66rCSI 20.29%PRS 85.2
-
CSI 20.36rCSI 47%PRS 58.69
-
CSI 20.01rCSI 31.83%PRS 63.26
-
CSI 19.93rCSI 71.73%PRS 49.95
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CSI 19.82rCSI 74.91%PRS 52.34
-
CSI 19.68rCSI 48.71%PRS 69.39
-
CSI 19.08rCSI 61.89%PRS 69.83
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CSI 17.98rCSI 12.51%PRS 85.14
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CSI 17.2rCSI 13.9%PRS 80.91
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CSI 16.86rCSI 48.82%PRS 71.16
-
CSI 16.01rCSI 54.23%PRS 65.15
-
CSI 15.54rCSI 14.37%PRS 87.6
-
CSI 15.39rCSI 57.64%PRS 62.55
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CSI 15.21rCSI 52.08%PRS 58.28
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CSI 15.04rCSI 23.88%PRS 80.67
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CSI 14.27rCSI 31.52%PRS 56.44
-
CSI 13.45rCSI 12.71%PRS 69.87
-
CSI 13.33rCSI 27.39%PRS 59.26
-
CSI 13.3rCSI 42.81%PRS 68.29
-
CSI 13.21rCSI 13.78%PRS 70.59
-
CSI 12.89rCSI 48.65%PRS 54.43
-
CSI 12.66rCSI 33.73%PRS 52.89
-
CSI 12.48rCSI 14.9%PRS 87.77
-
CSI 12.24rCSI 21.99%PRS 63.63
-
CSI 11.93rCSI 16.52%PRS 69.93
-
CSI 11.93rCSI 37.27%PRS 53.58
-
CSI 11.77rCSI 26.87%PRS 61.95
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CSI 11.73rCSI 13.75%PRS 85.62
-
CSI 11.34rCSI 24.96%PRS 74.82
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CSI 11.15rCSI 8.81%PRS 57.81
-
CSI 11.14rCSI 8.25%PRS 63.43
-
CSI 11.05rCSI 8.85%PRS 87.6
-
CSI 10.93rCSI 36.62%PRS 55
-
CSI 10.72rCSI 8.16%PRS 83.36
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CSI 10.7rCSI 62.99%PRS 52.87
-
CSI 10.56rCSI 17.11%PRS 66.17
-
CSI 10.52rCSI 26.62%PRS 77.39
-
CSI 10.46rCSI 12.67%PRS 54.16
-
CSI 10.31rCSI 19.32%PRS 58.3
-
CSI 10.29rCSI 20.88%PRS 48.82
-
CSI 10.17rCSI 7.3%PRS 84.07
-
CSI 10.04rCSI 29.79%PRS 80.28
-
CSI 9.45rCSI 12.14%PRS 61.89
-
CSI 9.1rCSI 37.09%PRS 81.66
-
CSI 9.08rCSI 6.12%PRS 83.75
-
CSI 9.03rCSI 12.35%PRS 76.15
-
CSI 8.98rCSI 6.75%PRS 76.49
-
CSI 8.81rCSI 18.29%PRS 67.68
-
CSI 8.61rCSI 13.74%PRS 62.28
-
CSI 8.51rCSI 62.52%PRS 57.23
-
CSI 8.46rCSI 20.17%PRS 71.07
-
CSI 8.12rCSI 21.16%PRS 71.11
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CSI 8.11rCSI 19.81%PRS 63.63
-
CSI 8.04rCSI 8.8%PRS 73.77
-
CSI 8.04rCSI 45.42%PRS 55.89
-
CSI 7.99rCSI 49.92%PRS 61.98
-
CSI 7.83rCSI 7.07%PRS 67.95
-
CSI 7.74rCSI 13.39%PRS 61.03
-
CSI 7.73rCSI 9.72%PRS 90.86
-
CSI 7.7rCSI 8.06%PRS 67.55
-
CSI 7.67rCSI 17.2%PRS 52.39
-
CSI 7.65rCSI 18.25%PRS 70.75
-
CSI 7.46rCSI 30.08%PRS 70
-
CSI 6.95rCSI 33.31%PRS 70.61
-
CSI 6.93rCSI 33.16%PRS 68.5
-
CSI 6.77rCSI 6.53%PRS 62.29
-
CSI 6.69rCSI 9.11%PRS 90.93
-
CSI 6.68rCSI 76.56%PRS 60.71
-
CSI 6.59rCSI 35.05%PRS 62.07
-
CSI 6.48rCSI 6.03%PRS 71.36
-
CSI 6.3rCSI 8.62%PRS 62.83
-
CSI 6.29rCSI 9.61%PRS 71.32
-
CSI 6.29rCSI 4.37%PRS 82.04
-
CSI 6.18rCSI 10.13%PRS 59.62
-
CSI 6.15rCSI 5.6%PRS 84.02
-
CSI 5.98rCSI 7.95%PRS 76.94
-
CSI 5.98rCSI 9.11%PRS 66.86
-
CSI 5.91rCSI 24.1%PRS 63.43
-
CSI 5.79rCSI 4.34%PRS 84.59
-
CSI 5.73rCSI 9.8%PRS 85.94
-
CSI 5.73rCSI 5.03%PRS 75.99
-
CSI 5.71rCSI 10.37%PRS 83.87
-
CSI 0.4rCSI 1.8%PRS 80.8%
-
CSI 0.5rCSI 2.8%PRS 89.0%
-
CSI 0.6rCSI 6.4%PRS 90.0%
-
CSI 1.1rCSI 8.2%PRS 62.9%
-
CSI 1.1rCSI 3.6%PRS 69.8%
-
CSI 1.1rCSI 2.1%PRS 74.0%
-
CSI 1.2rCSI 9.3%PRS 65.9%
-
CSI 1.2rCSI 6.9%PRS 77.7%
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CSI 1.2rCSI 13.0%PRS 67.9%
-
CSI 1.2rCSI 7.2%PRS 63.8%
-
CSI 1.3rCSI 9.4%PRS 62.5%
-
CSI 1.4rCSI 8.1%PRS 81.0%
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CSI 1.5rCSI 2.7%PRS 80.6%
-
CSI 1.5rCSI 4.1%PRS 66.4%
-
CSI 1.5rCSI 2.4%PRS 72.7%
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CSI 1.5rCSI 3.9%PRS 65.5%
-
CSI 1.5rCSI 15.1%PRS 91.1%
-
CSI 1.6rCSI 2.0%PRS 67.6%
-
CSI 1.7rCSI 12.7%PRS 75.0%
-
CSI 1.7rCSI 1.5%PRS 58.6%
-
CSI 1.9rCSI 4.1%PRS 77.4%
-
CSI 1.9rCSI 4.9%PRS 73.0%
-
CSI 1.9rCSI 2.0%PRS 74.1%
-
CSI 1.9rCSI 2.7%PRS 73.1%
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CSI 2.0rCSI 3.0%PRS 75.0%
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CSI 2.0rCSI 11.0%PRS 92.3%
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CSI 2.2rCSI 4.8%PRS 81.3%
-
CSI 2.3rCSI 2.9%PRS 74.8%
-
CSI 2.4rCSI 4.7%PRS 85.3%
-
CSI 2.4rCSI 12.7%PRS 63.5%
-
CSI 2.5rCSI 6.4%PRS 91.0%
-
CSI 2.5rCSI 2.5%PRS 73.2%
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CSI 2.5rCSI 21.8%PRS 66.5%
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CSI 2.5rCSI 1.9%PRS 83.8%
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CSI 2.6rCSI 2.0%PRS 89.5%
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CSI 2.7rCSI 6.1%PRS 65.7%
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CSI 2.8rCSI 2.2%PRS 73.8%
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CSI 2.8rCSI 8.1%PRS 80.0%
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CSI 2.8rCSI 11.1%PRS 69.8%
-
CSI 2.9rCSI 8.0%PRS 80.2%
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CSI 3.0rCSI 8.1%PRS 77.0%
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CSI 3.0rCSI 31.1%PRS 64.7%
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CSI 3.0rCSI 6.2%PRS 70.0%
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CSI 3.1rCSI 8.1%PRS 66.7%
-
CSI 3.2rCSI 77.2%PRS 51.4%
-
CSI 3.2rCSI 77.4%PRS 50.8%
-
CSI 3.2rCSI 11.7%PRS 87.7%
-
CSI 3.3rCSI 3.4%PRS 76.0%
-
CSI 3.3rCSI 4.7%PRS 66.8%
-
CSI 3.3rCSI 4.1%PRS 72.4%
-
CSI 3.4rCSI 68.9%PRS 62.3%
-
CSI 3.4rCSI 8.8%PRS 68.8%
-
CSI 3.4rCSI 15.4%PRS 54.3%
-
CSI 3.6rCSI 60.9%PRS 86.3%
-
CSI 3.7rCSI 5.3%PRS 85.4%
-
CSI 3.7rCSI 7.3%PRS 67.1%
-
CSI 3.7rCSI 2.5%PRS 73.4%
-
CSI 3.8rCSI 77.4%PRS 60.8%
-
CSI 3.9rCSI 6.8%PRS 77.7%
-
CSI 3.9rCSI 11.4%PRS 59.7%
-
CSI 4.0rCSI 32.1%PRS 64.1%
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CSI 4.1rCSI 18.2%PRS 70.9%
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CSI 4.2rCSI 3.3%PRS 86.7%
-
CSI 4.3rCSI 12.2%PRS 88.7%
-
CSI 4.3rCSI 6.3%PRS 75.5%
-
CSI 4.3rCSI 19.1%PRS 59.7%
-
CSI 4.4rCSI 11.1%PRS 60.2%
-
CSI 4.4rCSI 10.6%PRS 86.2%
-
CSI 4.4rCSI 31.5%PRS 70.0%
-
CSI 4.5rCSI 30.0%PRS 66.7%
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CSI 4.7rCSI 31.8%PRS 64.9%
-
CSI 4.7rCSI 10.8%PRS 71.3%
-
CSI 4.8rCSI 12.7%PRS 79.0%
-
CSI 4.8rCSI 11.6%PRS 76.3%
-
CSI 4.9rCSI 4.8%PRS 87.5%
-
CSI 5.0rCSI 7.3%PRS 63.6%
-
CSI 5.0rCSI 18.9%PRS 61.1%
-
CSI 5.0rCSI 3.0%PRS 86.8%
-
CSI 5.1rCSI 72.3%PRS 61.6%
-
CSI 5.2rCSI 8.3%PRS 74.8%
-
CSI 5.2rCSI 9.5%PRS 62.0%
-
CSI 5.3rCSI 6.1%PRS 61.6%
-
CSI 5.5rCSI 47.2%PRS 57.6%
-
CSI 5.5rCSI 13.0%PRS 72.8%
-
CSI 5.6rCSI 15.0%PRS 61.5%
-
CSI 5.6rCSI 28.0%PRS 66.4%
-
CSI 5.6rCSI 35.3%PRS 52.5%
-
CSI 5.7rCSI 10.4%PRS 83.9%
-
CSI 5.7rCSI 5.0%PRS 76.0%
-
CSI 5.7rCSI 9.8%PRS 85.9%
-
CSI 5.8rCSI 4.3%PRS 84.6%
-
CSI 5.9rCSI 24.1%PRS 63.4%
-
CSI 6.0rCSI 9.1%PRS 66.9%
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CSI 6.0rCSI 8.0%PRS 76.9%
-
CSI 6.2rCSI 5.6%PRS 84.0%
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CSI 6.2rCSI 10.1%PRS 59.6%
-
CSI 6.3rCSI 4.4%PRS 82.0%
-
CSI 6.3rCSI 9.6%PRS 71.3%
-
CSI 6.3rCSI 8.6%PRS 62.8%
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CSI 6.5rCSI 6.0%PRS 71.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3826388075
Symbol: INP4B_HUMAN
Name: Inositol polyphosphate 4-phosphatase type II
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9295334
Title: The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.
PubMed ID: 9295334
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19647222
Title: Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
PubMed ID: 19647222
PubMed ID: 24070612
Title: Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.
PubMed ID: 24070612
PubMed ID: 24591580
Title: Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.
PubMed ID: 24591580
Sequence Information:
- Length: 924
- Mass: 104738
- Checksum: 57DE9D98E0168D41
- Sequence:
MEIKEEGASE EGQHFLPTAQ ANDPGDCQFT SIQKTPNEPQ LEFILACKDL VAPVRDRKLN TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS EYPIYEETKI KLTVYDVKDK SHDTVRTSVL PEHKDPPPEV GRSFLGYASF KVGELLKSKE QLLVLSLRTS DGGKVVGTIE VSVVKMGEIE DGEADHITTD VQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR FPTSDNKWMR IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ VHSPHLKDAL YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI YYSPENTAKA KEVLSNINQL QPLIATHADL LLNSASQHSP DSLKNSLKML SEKTELFVHA FKDQLVRSAL LALYTARPGG ILKKPPSPKS STEESSPQDQ PPVMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD KLIERDGGSE GSGGNNDGEK EPSLTDAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ SLTFVLLQEL AYSLPQCLML TLRRDIVFSQ ALAGLVCGFI IKLQTSLYDP GFLQQLHTVG LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK SNDVLPVITG RREHYVVEVK LPARMFESLP LQIKEGQLLH VYPVLFNVGI NEQQTLAERF GDVSLQESIN QENFELLQEY YKIFMEKMPP DYISHFQEQN DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT CCKSAKDRTS MSVTLEQCSI LRDEHQLHKD FFIRALDCMR REGCRIENVL KNIKCRKYAF NMLQLMAFPK YYRPPEGTYG KADT
Genular Protein ID: 3726916394
Symbol: E7EQN9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
Sequence Information:
- Length: 938
- Mass: 105960
- Checksum: 2AF57FA2B7718330
- Sequence:
MEIKEEGASE EGQHFLPTAQ ANDPGDCQFT SIQKTPNEPQ LEFILACKDL VAPVRDRKLN TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS EYPIYEETKI KLTVYDVKDK SHDTVRTSVL PEHKDPPPEV GRSFLGYASF KVGELLKSKE QLLVLSLRTS DGGKVVGTIE VSVVKMGEIE DGEADHITTD VQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR FPTSDNKWMR IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ VHSPHLKDAL YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI YYSPENTAKA KEVLSNINQL QPLIATHADL LLNSASQHSP DSLKNSLKML SEKTELFVHA FKDQLVRSAL LALYTARPGG ILKKPPSPKS STEESSPQDQ PPVMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD KLIERDGGSE GSGGNNDGEK EPSLTDAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ SLTFVLLQEL AYSLPQCLML TLRRDIVFSQ ALAGLVCGFI IKLQTSLYDP GFLQQLHTVG LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK SNDVLPVITG RREHYVVEVK LPARMFESLP LQIKEGQLLH VYPVLFNVGI NEQQTLAERF GDVSLQESIN QENFELLQEY YKIFMEKMPP DYISHFQEQN DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT CCKSAKDRTS MSVTLEQCSI LRDEHQLHKD FFIRALDCMR SRQTQGALNE SDDPETGCLT DNKPTSRHFY PVALLLVSSH LLVVWLILSL ALLLAKYQ