Details for: INPP4B

Gene ID: 8821

Symbol: INPP4B

Ensembl ID: ENSG00000109452

Description: inositol polyphosphate-4-phosphatase type II B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 278.1185
    Cell Significance Index: -43.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.9954
    Cell Significance Index: -41.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 91.5922
    Cell Significance Index: -37.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.1189
    Cell Significance Index: -43.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.8808
    Cell Significance Index: -54.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.4412
    Cell Significance Index: -25.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 5.8602
    Cell Significance Index: 449.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.6471
    Cell Significance Index: 379.7100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.0892
    Cell Significance Index: 31.3200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 4.9081
    Cell Significance Index: 63.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.8124
    Cell Significance Index: 123.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.6608
    Cell Significance Index: 1671.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.6310
    Cell Significance Index: 160.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.3593
    Cell Significance Index: 127.2100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 3.1369
    Cell Significance Index: 43.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.6431
    Cell Significance Index: 64.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.5558
    Cell Significance Index: 1767.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.4878
    Cell Significance Index: 66.6600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.3280
    Cell Significance Index: 31.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.2871
    Cell Significance Index: 57.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2641
    Cell Significance Index: 454.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.0896
    Cell Significance Index: 59.6300
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 1.9692
    Cell Significance Index: 15.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.8410
    Cell Significance Index: 3466.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.7685
    Cell Significance Index: 26.6500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.3942
    Cell Significance Index: 21.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.3303
    Cell Significance Index: 844.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0276
    Cell Significance Index: 101.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9443
    Cell Significance Index: 852.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.9288
    Cell Significance Index: 96.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9181
    Cell Significance Index: 47.6900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7720
    Cell Significance Index: 9.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.7397
    Cell Significance Index: 10.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6627
    Cell Significance Index: 40.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5368
    Cell Significance Index: 40.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4988
    Cell Significance Index: 54.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3831
    Cell Significance Index: 23.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3637
    Cell Significance Index: 59.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2327
    Cell Significance Index: 5.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2030
    Cell Significance Index: 92.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1999
    Cell Significance Index: 36.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1882
    Cell Significance Index: 23.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1726
    Cell Significance Index: 11.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1402
    Cell Significance Index: 215.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1158
    Cell Significance Index: 3.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1013
    Cell Significance Index: 3.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0684
    Cell Significance Index: 93.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0649
    Cell Significance Index: 35.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0645
    Cell Significance Index: 118.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0274
    Cell Significance Index: 0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0137
    Cell Significance Index: -10.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0186
    Cell Significance Index: -11.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0187
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0293
    Cell Significance Index: -21.7100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0329
    Cell Significance Index: -0.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0341
    Cell Significance Index: -4.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0363
    Cell Significance Index: -0.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0548
    Cell Significance Index: -0.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0634
    Cell Significance Index: -47.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0729
    Cell Significance Index: -32.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0756
    Cell Significance Index: -12.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1099
    Cell Significance Index: -4.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1277
    Cell Significance Index: -3.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1292
    Cell Significance Index: -37.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1404
    Cell Significance Index: -29.5700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1507
    Cell Significance Index: -0.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1526
    Cell Significance Index: -30.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2317
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2391
    Cell Significance Index: -27.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2409
    Cell Significance Index: -28.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2444
    Cell Significance Index: -24.9700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2630
    Cell Significance Index: -3.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2786
    Cell Significance Index: -3.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2848
    Cell Significance Index: -6.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3082
    Cell Significance Index: -39.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3238
    Cell Significance Index: -2.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3384
    Cell Significance Index: -18.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3532
    Cell Significance Index: -41.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4043
    Cell Significance Index: -46.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4253
    Cell Significance Index: -54.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4488
    Cell Significance Index: -9.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4506
    Cell Significance Index: -35.6900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5287
    Cell Significance Index: -5.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5364
    Cell Significance Index: -14.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5378
    Cell Significance Index: -28.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5451
    Cell Significance Index: -17.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5540
    Cell Significance Index: -11.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5620
    Cell Significance Index: -26.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5667
    Cell Significance Index: -12.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6059
    Cell Significance Index: -11.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6233
    Cell Significance Index: -19.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6335
    Cell Significance Index: -20.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6378
    Cell Significance Index: -17.0300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.6631
    Cell Significance Index: -7.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6767
    Cell Significance Index: -31.5500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6813
    Cell Significance Index: -13.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6813
    Cell Significance Index: -11.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6815
    Cell Significance Index: -43.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7216
    Cell Significance Index: -37.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The INPP4B gene is a member of the inositol polyphosphate-4-phosphatase family, which is responsible for the dephosphorylation of inositol phosphates. The INPP4B protein is a bifunctional enzyme that exhibits 4-phosphatase activity on IP3 and IP2, as well as 3,4-bisphosphatase activity on IP2. This unique activity profile allows INPP4B to fine-tune the levels of inositol phosphates in response to cellular signals. The INPP4B protein is also known to interact with various proteins, including signaling molecules and structural proteins, to regulate its activity and localization. **Pathways and Functions:** The INPP4B gene is involved in several critical signaling pathways, including: 1. **Phospholipid metabolism:** INPP4B regulates the levels of inositol phosphates, which are essential for phospholipid metabolism and cellular signaling. 2. **Signal transduction:** INPP4B modulates the activity of signaling molecules, such as IP3 and IP2, which are involved in various cellular processes, including cell proliferation, differentiation, and survival. 3. **Metabolism:** INPP4B is involved in the regulation of metabolic pathways, including glycolysis, lipolysis, and lipid synthesis. 4. **Cell cycle regulation:** INPP4B has been shown to regulate the cell cycle by modulating the activity of cyclin-dependent kinases and the p53 tumor suppressor protein. **Clinical Significance:** Dysregulation of INPP4B has been implicated in various diseases, including: 1. **Cancer:** INPP4B is often downregulated in cancer cells, leading to increased cell proliferation and survival. 2. **Metabolic disorders:** INPP4B dysfunction has been linked to metabolic disorders, such as insulin resistance and type 2 diabetes. 3. **Cardiovascular diseases:** INPP4B is involved in the regulation of cardiac function and has been implicated in cardiovascular diseases, such as heart failure and arrhythmias. 4. **Neurological disorders:** INPP4B has been shown to play a role in the regulation of neuronal signaling and has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the INPP4B gene is a critical regulator of inositol phosphate metabolism and plays a key role in various cellular signaling pathways. Dysregulation of INPP4B has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3826388075

Symbol: INP4B_HUMAN

Name: Inositol polyphosphate 4-phosphatase type II

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9295334

Title: The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.

PubMed ID: 9295334

DOI: 10.1074/jbc.272.38.23859

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19647222

Title: Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.

PubMed ID: 19647222

DOI: 10.1016/j.ccr.2009.06.006

PubMed ID: 24070612

Title: Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.

PubMed ID: 24070612

DOI: 10.1016/j.bbrc.2013.09.077

PubMed ID: 24591580

Title: Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.

PubMed ID: 24591580

DOI: 10.1073/pnas.1311029111

Sequence Information:

  • Length: 924
  • Mass: 104738
  • Checksum: 57DE9D98E0168D41
  • Sequence:
  • MEIKEEGASE EGQHFLPTAQ ANDPGDCQFT SIQKTPNEPQ LEFILACKDL VAPVRDRKLN 
    TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS EYPIYEETKI KLTVYDVKDK 
    SHDTVRTSVL PEHKDPPPEV GRSFLGYASF KVGELLKSKE QLLVLSLRTS DGGKVVGTIE 
    VSVVKMGEIE DGEADHITTD VQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR 
    FPTSDNKWMR IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV 
    LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ VHSPHLKDAL 
    YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI YYSPENTAKA KEVLSNINQL 
    QPLIATHADL LLNSASQHSP DSLKNSLKML SEKTELFVHA FKDQLVRSAL LALYTARPGG 
    ILKKPPSPKS STEESSPQDQ PPVMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD 
    KLIERDGGSE GSGGNNDGEK EPSLTDAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ 
    SLTFVLLQEL AYSLPQCLML TLRRDIVFSQ ALAGLVCGFI IKLQTSLYDP GFLQQLHTVG 
    LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK SNDVLPVITG RREHYVVEVK 
    LPARMFESLP LQIKEGQLLH VYPVLFNVGI NEQQTLAERF GDVSLQESIN QENFELLQEY 
    YKIFMEKMPP DYISHFQEQN DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT 
    CCKSAKDRTS MSVTLEQCSI LRDEHQLHKD FFIRALDCMR REGCRIENVL KNIKCRKYAF 
    NMLQLMAFPK YYRPPEGTYG KADT

Genular Protein ID: 3726916394

Symbol: E7EQN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 938
  • Mass: 105960
  • Checksum: 2AF57FA2B7718330
  • Sequence:
  • MEIKEEGASE EGQHFLPTAQ ANDPGDCQFT SIQKTPNEPQ LEFILACKDL VAPVRDRKLN 
    TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS EYPIYEETKI KLTVYDVKDK 
    SHDTVRTSVL PEHKDPPPEV GRSFLGYASF KVGELLKSKE QLLVLSLRTS DGGKVVGTIE 
    VSVVKMGEIE DGEADHITTD VQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR 
    FPTSDNKWMR IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV 
    LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ VHSPHLKDAL 
    YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI YYSPENTAKA KEVLSNINQL 
    QPLIATHADL LLNSASQHSP DSLKNSLKML SEKTELFVHA FKDQLVRSAL LALYTARPGG 
    ILKKPPSPKS STEESSPQDQ PPVMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD 
    KLIERDGGSE GSGGNNDGEK EPSLTDAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ 
    SLTFVLLQEL AYSLPQCLML TLRRDIVFSQ ALAGLVCGFI IKLQTSLYDP GFLQQLHTVG 
    LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK SNDVLPVITG RREHYVVEVK 
    LPARMFESLP LQIKEGQLLH VYPVLFNVGI NEQQTLAERF GDVSLQESIN QENFELLQEY 
    YKIFMEKMPP DYISHFQEQN DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT 
    CCKSAKDRTS MSVTLEQCSI LRDEHQLHKD FFIRALDCMR SRQTQGALNE SDDPETGCLT 
    DNKPTSRHFY PVALLLVSSH LLVVWLILSL ALLLAKYQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.