Details for: SOCS2

Gene ID: 8835

Symbol: SOCS2

Ensembl ID: ENSG00000120833

Description: suppressor of cytokine signaling 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 96.8850
    Cell Significance Index: -15.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 38.0621
    Cell Significance Index: -17.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.7983
    Cell Significance Index: -9.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 16.3686
    Cell Significance Index: 262.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.1935
    Cell Significance Index: -17.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6633
    Cell Significance Index: -17.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.5237
    Cell Significance Index: 420.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.1838
    Cell Significance Index: 91.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5007
    Cell Significance Index: -17.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3857
    Cell Significance Index: -7.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.0480
    Cell Significance Index: 52.3200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.0090
    Cell Significance Index: 20.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8022
    Cell Significance Index: 49.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7802
    Cell Significance Index: 132.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3741
    Cell Significance Index: 15.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3266
    Cell Significance Index: 91.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3217
    Cell Significance Index: 68.6600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.0742
    Cell Significance Index: 7.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9966
    Cell Significance Index: 29.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7542
    Cell Significance Index: 21.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7141
    Cell Significance Index: 42.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6962
    Cell Significance Index: 628.6400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.6815
    Cell Significance Index: 2.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5973
    Cell Significance Index: 5.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5951
    Cell Significance Index: 10.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5812
    Cell Significance Index: 63.2200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4533
    Cell Significance Index: 2.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4315
    Cell Significance Index: 70.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3247
    Cell Significance Index: 8.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3012
    Cell Significance Index: 8.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2110
    Cell Significance Index: 42.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2052
    Cell Significance Index: 20.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2005
    Cell Significance Index: 9.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1698
    Cell Significance Index: 5.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1680
    Cell Significance Index: 23.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1670
    Cell Significance Index: 20.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1402
    Cell Significance Index: 2.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1366
    Cell Significance Index: 2.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1270
    Cell Significance Index: 24.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1251
    Cell Significance Index: 3.6100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0751
    Cell Significance Index: 1.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0705
    Cell Significance Index: 9.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0679
    Cell Significance Index: 0.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0667
    Cell Significance Index: 12.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0549
    Cell Significance Index: 7.0900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0527
    Cell Significance Index: 0.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0305
    Cell Significance Index: 10.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0302
    Cell Significance Index: 0.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0175
    Cell Significance Index: 3.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0175
    Cell Significance Index: 2.9900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0130
    Cell Significance Index: 0.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0105
    Cell Significance Index: 7.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0077
    Cell Significance Index: 14.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0074
    Cell Significance Index: 0.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0069
    Cell Significance Index: 0.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0012
    Cell Significance Index: 0.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0058
    Cell Significance Index: -3.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0065
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0097
    Cell Significance Index: -17.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0114
    Cell Significance Index: -17.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0134
    Cell Significance Index: -18.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0135
    Cell Significance Index: -5.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0163
    Cell Significance Index: -9.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0220
    Cell Significance Index: -13.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0233
    Cell Significance Index: -3.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0291
    Cell Significance Index: -0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0352
    Cell Significance Index: -15.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0386
    Cell Significance Index: -2.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0441
    Cell Significance Index: -9.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0503
    Cell Significance Index: -14.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0758
    Cell Significance Index: -7.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0852
    Cell Significance Index: -9.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0874
    Cell Significance Index: -2.8000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0918
    Cell Significance Index: -1.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0961
    Cell Significance Index: -6.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1054
    Cell Significance Index: -12.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1056
    Cell Significance Index: -2.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1102
    Cell Significance Index: -5.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1261
    Cell Significance Index: -7.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1293
    Cell Significance Index: -3.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1358
    Cell Significance Index: -15.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1413
    Cell Significance Index: -3.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1437
    Cell Significance Index: -8.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1562
    Cell Significance Index: -18.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1573
    Cell Significance Index: -16.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1842
    Cell Significance Index: -14.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1890
    Cell Significance Index: -8.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2042
    Cell Significance Index: -13.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2570
    Cell Significance Index: -14.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2616
    Cell Significance Index: -7.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2828
    Cell Significance Index: -5.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2992
    Cell Significance Index: -18.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3097
    Cell Significance Index: -13.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3115
    Cell Significance Index: -10.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3156
    Cell Significance Index: -6.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3168
    Cell Significance Index: -10.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3412
    Cell Significance Index: -10.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3459
    Cell Significance Index: -8.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure:** The SOCS2 gene is located on chromosome 5q31.3 and consists of 11 exons, encoding a 372-amino acid protein. 2. **Expression Pattern:** SOCS2 is highly expressed in early pro-B cells, late pro-B cells, neural progenitor cells, decidual cells, pulmonary artery endothelial cells, and CD34-positive hematopoietic stem cells. 3. **Protein Structure:** SOCS2 contains a conserved N-terminal domain, which interacts with JAKs and STAT proteins, and a C-terminal domain, which mediates protein-protein interactions and ubiquitination. **Pathways and Functions:** 1. **JAK/STAT Signaling Pathway:** SOCS2 negatively regulates cytokine signaling by binding to JAKs and STAT proteins, preventing the activation of downstream signaling pathways. 2. **Growth Hormone Receptor Signaling:** SOCS2 inhibits growth hormone receptor signaling, thereby regulating cell growth and metabolism. 3. **Interleukin-7 Signaling:** SOCS2 negatively regulates interleukin-7 signaling, which is critical for the development and survival of lymphoid cells. 4. **Apoptosis Regulation:** SOCS2 inhibits apoptosis by interacting with pro-apoptotic proteins and promoting their degradation. 5. **Cell Growth Regulation:** SOCS2 regulates cell growth by modulating the activity of growth hormone receptors and insulin-like growth factor receptors. **Clinical Significance:** 1. **Immune Disorders:** SOCS2 dysregulation has been implicated in various immune disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus, as well as immunodeficiency disorders, such as chronic lymphocytic leukemia. 2. **Cancer:** SOCS2 expression is often downregulated in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a tumor suppressor. 3. **Metabolic Disorders:** SOCS2 regulates glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as diabetes and obesity. 4. **Neurological Disorders:** SOCS2 has been implicated in the regulation of neuronal development and survival, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SOCS2 is a critical regulator of immune response, cell growth, and metabolism, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the mechanisms of SOCS2 action and its potential therapeutic applications.

Genular Protein ID: 1776775192

Symbol: SOCS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

O14508 A8K3D1 O14542 O95102 Q9UKS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 7 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9266833

Title: Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.

PubMed ID: 9266833

DOI: 10.1006/bbrc.1997.7080

PubMed ID: 9344848

Title: Cloning and characterization of novel CIS family genes.

PubMed ID: 9344848

DOI: 10.1006/bbrc.1997.7484

PubMed ID: 9727029

Title: Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.

PubMed ID: 9727029

DOI: 10.1074/jbc.273.37.24095

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10512686

Title: Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.

PubMed ID: 10512686

DOI: 10.1006/geno.1999.5937

PubMed ID: 11781573

Title: Design and application of a cytokine-receptor-based interaction trap.

PubMed ID: 11781573

DOI: 10.1038/ncb1201-1114

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21980433

Title: The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.

PubMed ID: 21980433

DOI: 10.1371/journal.pone.0025358

PubMed ID: 23401859

Title: DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.

PubMed ID: 23401859

DOI: 10.1128/mcb.01342-12

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25505247

Title: Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).

PubMed ID: 25505247

DOI: 10.1074/jbc.m114.616664

PubMed ID: 31578312

Title: KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.

PubMed ID: 31578312

DOI: 10.1172/jci.insight.129110

PubMed ID: 16675548

Title: Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.

PubMed ID: 16675548

DOI: 10.1073/pnas.0601638103

PubMed ID: 23897481

Title: Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes.

PubMed ID: 23897481

DOI: 10.1107/s0907444913011220

PubMed ID: 31182716

Title: Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase.

PubMed ID: 31182716

DOI: 10.1038/s41467-019-10190-4

PubMed ID: 34857742

Title: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.

PubMed ID: 34857742

DOI: 10.1038/s41467-021-26983-5

PubMed ID: 37816714

Title: Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.

PubMed ID: 37816714

DOI: 10.1038/s41467-023-41894-3

Sequence Information:

  • Length: 198
  • Mass: 22172
  • Checksum: DAFC4AD97F8182BF
  • Sequence:
    • MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW GSMTVNEAKE 
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 
SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL YLTKPLYTSA PSLQHLCRLT INKCTGAIWG 
LPLPTRLKDY LEEYKFQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.