Details for: NRXN1

Gene ID: 9378

Symbol: NRXN1

Ensembl ID: ENSG00000179915

Description: neurexin 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 14.45
    Marker Score: 48,442
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 11.02
    Marker Score: 57,831
  • Cell Name: granule cell (CL0000120)
    Fold Change: 10.82
    Marker Score: 81,562
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 10.38
    Marker Score: 55,765
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 9.33
    Marker Score: 21,441
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 8.11
    Marker Score: 273,929
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 7.41
    Marker Score: 9,227
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 6.53
    Marker Score: 4,297
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 5.7
    Marker Score: 2,740
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 5.46
    Marker Score: 2,825
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 5.4
    Marker Score: 2,421
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.67
    Marker Score: 3,519
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 4.66
    Marker Score: 2,707
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 4.57
    Marker Score: 5,694
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.31
    Marker Score: 19,937
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.22
    Marker Score: 5,933
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 4.08
    Marker Score: 2,285
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 3.73
    Marker Score: 1,131
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 3.71
    Marker Score: 1,225
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.24
    Marker Score: 69,215
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.17
    Marker Score: 9,037
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3.13
    Marker Score: 5,259
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.03
    Marker Score: 1,167
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.95
    Marker Score: 7,053
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.92
    Marker Score: 58,095
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22,104
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.87
    Marker Score: 42,845
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104,431
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.74
    Marker Score: 2,375
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.6
    Marker Score: 3,215
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.59
    Marker Score: 10,745
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.59
    Marker Score: 1,084
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.55
    Marker Score: 2,933
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.4
    Marker Score: 88,553
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.37
    Marker Score: 9,153
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.27
    Marker Score: 1,354
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,678
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.11
    Marker Score: 21,751
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 128,013
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.07
    Marker Score: 2,495
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.05
    Marker Score: 8,367
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2
    Marker Score: 1,890
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.95
    Marker Score: 1,020
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.94
    Marker Score: 529
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,339
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,167
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.78
    Marker Score: 3,623
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.73
    Marker Score: 599
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.67
    Marker Score: 1,003
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,556
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.64
    Marker Score: 552
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.63
    Marker Score: 1,795
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.62
    Marker Score: 586
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,164
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.55
    Marker Score: 6,482
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3,460
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,427
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.45
    Marker Score: 1,552
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.44
    Marker Score: 1,356
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.38
    Marker Score: 1,267
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.35
    Marker Score: 2,752
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.34
    Marker Score: 843
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.31
    Marker Score: 410
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 20,009
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.23
    Marker Score: 608
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.15
    Marker Score: 729
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,794
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.13
    Marker Score: 1,268
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.09
    Marker Score: 438
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 1.08
    Marker Score: 315
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.06
    Marker Score: 502
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 430
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1,213
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,785
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,010
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.96
    Marker Score: 306
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.94
    Marker Score: 244
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,314
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.92
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.9
    Marker Score: 254
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.9
    Marker Score: 433
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.87
    Marker Score: 386
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.87
    Marker Score: 661
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.84
    Marker Score: 239
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.81
    Marker Score: 2,999
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.79
    Marker Score: 3,314
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Isoforms**: Neurexin 1 exists in two main isoforms: Neurexin 1A (NRXN1A) and Neurexin 1B (NRXN1B), which differ in their N-terminal domains. 2. **Cellular localization**: Neurexin 1 is primarily expressed in the nervous system, with high levels found in neurons, glial cells, and certain types of non-neuronal cells. 3. **Synaptic function**: Neurexin 1 plays a critical role in the formation and maintenance of synapses, regulating synaptic structure and function. 4. **Neurotransmitter regulation**: Neurexin 1 interacts with various neurotransmitters, including acetylcholine, glutamate, and GABA, to regulate synaptic transmission. **Pathways and Functions** 1. **Axon guidance**: Neurexin 1 is involved in axon guidance, regulating the formation of neural connections during development. 2. **Synaptic plasticity**: Neurexin 1 regulates synaptic plasticity, the ability of synapses to adapt and change in response to experience. 3. **Neurotransmitter release**: Neurexin 1 interacts with neurotransmitters to regulate their release and uptake at synapses. 4. **Neurodevelopmental disorders**: Neurexin 1 has been implicated in various neurodevelopmental disorders, including ASD, schizophrenia, and synaptic dysfunction. **Clinical Significance** 1. **Autism spectrum disorder (ASD)**: Neurexin 1 has been identified as a genetic risk factor for ASD, with studies suggesting a link between NRXN1 variants and the development of ASD. 2. **Schizophrenia**: Neurexin 1 has also been implicated in schizophrenia, with research suggesting a link between NRXN1 variants and the development of the disorder. 3. **Synaptic dysfunction**: Neurexin 1 plays a critical role in maintaining synaptic function, and alterations in NRXN1 expression have been linked to synaptic dysfunction in various neurological disorders. 4. **Therapeutic potential**: Neurexin 1 has been identified as a potential therapeutic target for the treatment of neurodevelopmental disorders and synaptic dysfunction. In conclusion, Neurexin 1 is a critical gene involved in the development and function of the nervous system. Its role in regulating synaptic structure and function makes it a potential therapeutic target for the treatment of neurodevelopmental disorders and synaptic dysfunction. Further research is needed to fully elucidate the mechanisms by which Neurexin 1 regulates synaptic function and to explore its therapeutic potential.

Genular Protein ID: 4151448918

Symbol: NRX1B_HUMAN

Name: Neurexin I-beta

UniProtKB Accession Codes:

P58400 E7ETA5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 74 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 HGNC 2 HPA 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 2 Pharos 1 Proteomes 1 ProteomicsDB 2 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 2 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9921901

Title: CCG repeats in cDNAs from human brain.

PubMed ID: 9921901

DOI: 10.1007/s004390050889

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 18423203

Title: CASK functions as a Mg2+-independent neurexin kinase.

PubMed ID: 18423203

DOI: 10.1016/j.cell.2008.02.036

PubMed ID: 20090838

Title: beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC.

PubMed ID: 20090838

DOI: 10.1371/journal.ppat.1000726

PubMed ID: 27418511

Title: Structural basis for integration of GluD receptors within synaptic organizer complexes.

PubMed ID: 27418511

DOI: 10.1126/science.aae0104

PubMed ID: 18084303

Title: Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions.

PubMed ID: 18084303

DOI: 10.1038/nsmb1350

Sequence Information:

  • Length: 472
  • Mass: 50424
  • Checksum: C86516C0EB7A2D01
  • Sequence:
    • MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG ASSLGAHHIH 
HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI TYKWPPNDRP STRADRLAIG 
FSTVQKEAVL VRVDSSSGLG DYLELHIHQG KIGVKFNVGT DDIAIEESNA IINDGKYHVV 
RFTRSGGNAT LQVDSWPVIE RYPAGNNDNE RLAIARQRIP YRLGRVVDEW LLDKGRQLTI 
FNSQATIIIG GKEQGQPFQG QLSGLYYNGL KVLNMAAEND ANIAIVGNVR LVGEVPSSMT 
TESTATAMQS EMSTSIMETT TTLATSTARR GKPPTKEPIS QTTDDILVAS AECPSDDEDI 
DPCEPSSGGL ANPTRAGGRE PYPGSAEVIR ESSSTTGMVV GIVAAAALCI LILLYAMYKY 
RNRDEGSYHV DESRNYISNS AQSNGAVVKE KQPSSAKSSN KNKKNKDKEY YV

Genular Protein ID: 3239538310

Symbol: NRX1A_HUMAN

Name: Neurexin-1

UniProtKB Accession Codes:

Q9ULB1 A7KRL9 O60323 Q53TJ9 Q53TQ1 Q5HYI0 Q9C079 Q9C080 Q9C081 Q9H3M2 Q9UDM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CORUM 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 11 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 18179900

Title: Disruption of neurexin 1 associated with autism spectrum disorder.

PubMed ID: 18179900

DOI: 10.1016/j.ajhg.2007.09.011

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 11944992

Title: Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

PubMed ID: 11944992

DOI: 10.1006/geno.2002.6734

PubMed ID: 19896112

Title: CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila.

PubMed ID: 19896112

DOI: 10.1016/j.ajhg.2009.10.004

PubMed ID: 21424692

Title: Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.

PubMed ID: 21424692

DOI: 10.1007/s00439-011-0975-z

PubMed ID: 25352602

Title: Calsyntenin-3 molecular architecture and interaction with neurexin 1alpha.

PubMed ID: 25352602

DOI: 10.1074/jbc.m114.606806

PubMed ID: 22892527

Title: Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders.

PubMed ID: 22892527

DOI: 10.1038/ejhg.2012.175

Sequence Information:

  • Length: 1477
  • Mass: 161883
  • Checksum: FF845FB428B1A683
  • Sequence:
    • MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 
RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 
RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 
KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 
AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 
IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 
KFNDNAWHDV KVTRNLRQHS GIGHAMVTIS VDGILTTTGY TQEDYTMLGS DDFFYVGGSP 
STADLPGSPV SNNFMGCLKE VVYKNNDVRL ELSRLAKQGD PKMKIHGVVA FKCENVATLD 
PITFETPESF ISLPKWNAKK TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF 
FAIEMLDGHL YLLLDMGSGT IKIKALLKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA 
PGESEILDLD DELYLGGLPE NKAGLVFPTE VWTALLNYGY VGCIRDLFID GQSKDIRQMA 
EVQSTAGVKP SCSKETAKPC LSNPCKNNGM CRDGWNRYVC DCSGTGYLGR SCEREATVLS 
YDGSMFMKIQ LPVVMHTEAE DVSLRFRSQR AYGILMATTS RDSADTLRLE LDAGRVKLTV 
NLDCIRINCN SSKGPETLFA GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT 
RLEFHNIETG IITERRYLSS VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR 
NIIADPVTFK TKSSYVALAT LQAYTSMHLF FQFKTTSLDG LILYNSGDGN DFIVVELVKG 
YLHYVFDLGN GANLIKGSSN KPLNDNQWHN VMISRDTSNL HTVKIDTKIT TQITAGARNL 
DLKSDLYIGG VAKETYKSLP KLVHAKEGFQ GCLASVDLNG RLPDLISDAL FCNGQIERGC 
EGPSTTCQED SCSNQGVCLQ QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP 
PNDRPSTRAD RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI 
EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG RQLTIFNSQA TIIIGGKEQG 
QPFQGQLSGL YYNGLKVLNM AAENDANIAI VGNVRLVGEV PSSMTTESTA TAMQSEMSTS 
IMETTTTLAT STARRGKPPT KEPISQTTDD ILVASAECPS DDEDIDPCEP SSGGLANPTR 
AGGREPYPGS AEVIRESSST TGMVVGIVAA AALCILILLY AMYKYRNRDE GSYHVDESRN 
YISNSAQSNG AVVKEKQPSS AKSSNKNKKN KDKEYYV

Genular Protein ID: 251393241

Symbol: H0Y568_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y568

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 139
  • Mass: 15303
  • Checksum: 0808FABABE954D6D
  • Sequence:
    • MDMRWHCENL QTTDDILVAS AECPSDDEDI DPCEPSSANP TRAGGREPYP GSAEVIRESS 
STTGMVVGIV AAAALCILIL LYAMYKYRNR DEGSYHVDES RNYISNSAQS NGAVVKEKQP 
SSAKSSNKNK KNKDKEYYV

Genular Protein ID: 1918607816

Symbol: E7EQN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EQN4

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 278
  • Mass: 30371
  • Checksum: FDDF6EC31CAB06BD
  • Sequence:
    • MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 
RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 
RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 
KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 
AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKD

Genular Protein ID: 3781549319

Symbol: A0A1D5RMU6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1D5RMU6

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 3 SMART 3 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 1499
  • Mass: 164655
  • Checksum: F8481191C84C9CD7
  • Sequence:
    • MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 
RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 
RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 
KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 
AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 
IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 
KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS 
PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ GDPKMKIHGV VAFKCENVAT LDPITFETPE 
SFISLPKWNA KKTGSISFDF RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG 
HLYLLLDMGS GTIKIKALLK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD 
LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEVQSTAGV 
KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK 
IQLPVVMHTE AEDVSLRFRS QRAYGILMAT TSRDSADTLR LELDAGRVKL TVNLDCIRIN 
CNSSKGPETL FAGYNLNDNE WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE 
TGIITERRYL SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT 
FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL 
GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI 
GGVAKETYKS LPKLVHAKEG FQGCLASVDL NGRLPDLISD ALFCNGQIER GCEGPSTTCQ 
EDSCSNQGVC LQQWDGFSCD CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR 
ADRLAIGFST VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN 
DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD 
KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG 
EVPSSMTTES TATAMQSEMS TSIMETTTTL ATSTARRGKP PTKEPISQTT DDILVASAEC 
PSDDEDIDPC EPSSGGLANP TRAGGREPYP GSAEVIRESS STTGMVVGIV AAAALCILIL 
LYAMYKYRNR DEGSYHVDES RNYISNSAQS NGAVVKEKQP SSAKSSNKNK KNKDKEYYV

Genular Protein ID: 2927392295

Symbol: H7BYC7_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7BYC7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 142
  • Mass: 15530
  • Checksum: 70FAE8135BEB82BE
  • Sequence:
    • MDMRWHCENL QTTDDILVAS AECPSDDEDI DPCEPSSGGL ANPTRAGGRE PYPGSAEVIR 
ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYHV DESRNYISNS AQSNGAVVKE 
KQPSSAKSSN KNKKNKDKEY YV

Genular Protein ID: 2068425397

Symbol: A0A0D9SEM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0D9SEM5

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 469
  • Mass: 50196
  • Checksum: 9BB86B15015C9DD1
  • Sequence:
    • MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG ASSLGAHHIH 
HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI TYKWPPNDRP STRADRLAIG 
FSTVQKEAVL VRVDSSSGLG DYLELHIHQG KIGVKFNVGT DDIAIEESNA IINDGKYHVV 
RFTRSGGNAT LQVDSWPVIE RYPAGNNDNE RLAIARQRIP YRLGRVVDEW LLDKGRQLTI 
FNSQATIIIG GKEQGQPFQG QLSGLYYNGL KVLNMAAEND ANIAIVGNVR LVGEVPSSMT 
TESTATAMQS EMSTSIMETT TTLATSTARR GKPPTKEPIS QTTDDILVAS AECPSDDEDI 
DPCEPSSANP TRAGGREPYP GSAEVIRESS STTGMVVGIV AAAALCILIL LYAMYKYRNR 
DEGSYHVDES RNYISNSAQS NGAVVKEKQP SSAKSSNKNK KNKDKEYYV

Genular Protein ID: 3647841494

Symbol: E7ERL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ERL8

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 35 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MANE-Select 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMART 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 1507
  • Mass: 165446
  • Checksum: D1716CC37589747E
  • Sequence:
    • MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 
RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 
RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 
KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 
AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 
IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 
KFNDNAWHDV KVTRNLRQHS GIGHAMVTIS VDGILTTTGY TQEDYTMLGS DDFFYVGGSP 
STADLPGSPV SNNFMGCLKE VVYKNNDVRL ELSRLAKQGD PKMKIHGVVA FKCENVATLD 
PITFETPESF ISLPKWNAKK TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF 
FAIEMLDGHL YLLLDMGSGT IKIKALLKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA 
PGESEILDLD DELYLGGLPE NKAGLVFPTE VWTALLNYGY VGCIRDLFID GQSKDIRQMA 
EVQSTAGVKP SCSKETAKPC LSNPCKNNGM CRDGWNRYVC DCSGTGYLGR SCEREATVLS 
YDGSMFMKIQ LPVVMHTEAE DVSLRFRSQR AYGILMATTS RDSADTLRLE LDAGRVKLTV 
NLDCIRINCN SSKGPETLFA GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT 
RLEFHNIETG IITERRYLSS VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR 
NIIADPVTFK TKSSYVALAT LQAYTSMHLF FQFKTTSLDG LILYNSGDGN DFIVVELVKG 
YLHYVFDLGN GANLIKGSSN KPLNDNQWHN VMISRDTSNL HTVKIDTKIT TQITAGARNL 
DLKSDLYIGG VAKETYKSLP KLVHAKEGFQ GCLASVDLNG RLPDLISDAL FCNGQIERGC 
EGPSTTCQED SCSNQGVCLQ QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP 
PNDRPSTRAD RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI 
EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG NNDNERLAIA RQRIPYRLGR 
VVDEWLLDKG RQLTIFNSQA TIIIGGKEQG QPFQGQLSGL YYNGLKVLNM AAENDANIAI 
VGNVRLVGEV PSSMTTESTA TAMQSEMSTS IMETTTTLAT STARRGKPPT KEPISQTTDD 
ILVASAECPS DDEDIDPCEP SSGGLANPTR AGGREPYPGS AEVIRESSST TGMVVGIVAA 
AALCILILLY AMYKYRNRDE GSYHVDESRN YISNSAQSNG AVVKEKQPSS AKSSNKNKKN 
KDKEYYV

Genular Protein ID: 1092661161

Symbol: A0A0D9SEQ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0D9SEQ7

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 277
  • Mass: 30241
  • Checksum: AD1598E42DBA2AB9
  • Sequence:
    • MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 
RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 
RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 
KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 
AVCDCSRTGF RGKDCSQDNN VEGLAHLMMG DQGKSKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.