Details for: RIMS2

Gene ID: 9699

Symbol: RIMS2

Ensembl ID: ENSG00000176406

Description: regulating synaptic membrane exocytosis 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 7.09
    Marker Score: 125,879
  • Cell Name: granule cell (CL0000120)
    Fold Change: 6.17
    Marker Score: 46,508
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 6.03
    Marker Score: 13,858
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.82
    Marker Score: 31,273
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 5.67
    Marker Score: 7,974
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.62
    Marker Score: 29,508
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 5.58
    Marker Score: 4,200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.54
    Marker Score: 187,147
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 5.45
    Marker Score: 18,286
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 4.8
    Marker Score: 1,585
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 4.57
    Marker Score: 2,363
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.46
    Marker Score: 20,628
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.26
    Marker Score: 1,909
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.68
    Marker Score: 1,921
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 3.6
    Marker Score: 4,487
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.43
    Marker Score: 9,779
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.29
    Marker Score: 1,045
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3
    Marker Score: 1,741
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.92
    Marker Score: 58,142
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22,093
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.83
    Marker Score: 42,385
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.83
    Marker Score: 1,359
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.79
    Marker Score: 848
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.73
    Marker Score: 103,764
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.7
    Marker Score: 804
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.66
    Marker Score: 4,475
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.66
    Marker Score: 1,021
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.6
    Marker Score: 1,091
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.6
    Marker Score: 10,796
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.54
    Marker Score: 7,236
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.45
    Marker Score: 90,459
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.37
    Marker Score: 9,167
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.22
    Marker Score: 1,243
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.08
    Marker Score: 21,482
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127,568
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.05
    Marker Score: 2,534
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.03
    Marker Score: 8,263
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.94
    Marker Score: 529
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,357
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,183
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 1.88
    Marker Score: 633
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.79
    Marker Score: 3,637
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,562
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.65
    Marker Score: 1,899
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.63
    Marker Score: 973
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,166
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.49
    Marker Score: 6,216
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,008
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.46
    Marker Score: 879
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.37
    Marker Score: 29,251
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17,738
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.03
    Marker Score: 2,415
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,038
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.98
    Marker Score: 393
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 652
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,227
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.89
    Marker Score: 330
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.86
    Marker Score: 3,592
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.82
    Marker Score: 393
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.81
    Marker Score: 163
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.8
    Marker Score: 252
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.78
    Marker Score: 1,587
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 584
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.76
    Marker Score: 3,182
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 687
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.74
    Marker Score: 364
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.69
    Marker Score: 454
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.68
    Marker Score: 1,000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 441
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.65
    Marker Score: 779
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.63
    Marker Score: 184
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.61
    Marker Score: 270
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6
    Marker Score: 1,055
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 385
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.6
    Marker Score: 169
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.58
    Marker Score: 166
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.58
    Marker Score: 1,702
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.58
    Marker Score: 210
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.57
    Marker Score: 537
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.57
    Marker Score: 687
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.56
    Marker Score: 612
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.55
    Marker Score: 125
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.55
    Marker Score: 593
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.55
    Marker Score: 1,312
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.54
    Marker Score: 180

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RIMS2 is a protein that plays a pivotal role in regulating synaptic membrane exocytosis. It is a member of the RIM protein family, which has been implicated in the regulation of synaptic vesicle fusion and release. The RIMS2 protein is characterized by its ability to bind to and regulate the activity of small GTPases, such as RAB3 and RAB27A, which are essential for the regulation of synaptic vesicle exocytosis. RIMS2 also interacts with other proteins, including synaptotagmin and syntaxin, to regulate the fusion of synaptic vesicles with the presynaptic membrane. **Pathways and Functions:** RIMS2 is involved in several key pathways that regulate synaptic transmission, including: 1. **Calcium-ion regulated exocytosis**: RIMS2 plays a crucial role in regulating the release of neurotransmitters in response to calcium ion influx. 2. **Adenylate cyclase-modulating G protein-coupled receptor signaling pathway**: RIMS2 interacts with G protein-coupled receptors to regulate adenylate cyclase activity, which is essential for the regulation of synaptic transmission. 3. **Intracellular protein transport**: RIMS2 is involved in the regulation of intracellular protein transport, including the transport of synaptic vesicles and neurotransmitters. 4. **Regulation of synaptic plasticity**: RIMS2 plays a crucial role in regulating synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). **Clinical Significance:** Dysregulation of RIMS2 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: RIMS2 has been implicated in the regulation of synaptic transmission in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Neuropsychiatric disorders**: RIMS2 has been implicated in the regulation of synaptic transmission in neuropsychiatric disorders, such as schizophrenia and bipolar disorder. 3. **Neurodevelopmental disorders**: RIMS2 has been implicated in the regulation of synaptic transmission in neurodevelopmental disorders, such as autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). In conclusion, RIMS2 is a critical regulator of synaptic membrane exocytosis, and its dysregulation has been implicated in various neurological disorders. Further research is needed to fully understand the mechanisms by which RIMS2 regulates synaptic transmission and to develop novel therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 4065423595

Symbol: RIMS2_HUMAN

Name: Regulating synaptic membrane exocytosis protein 2

UniProtKB Accession Codes:

Q9UQ26 B3KX91 F8WD47 O43413 Q86XL9 Q8IWV9 Q8IWW1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 3 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 4 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12620390

Title: Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins.

PubMed ID: 12620390

DOI: 10.1016/s0888-7543(02)00024-1

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23999003

Title: SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.

PubMed ID: 23999003

DOI: 10.1016/j.jdermsci.2013.07.010

PubMed ID: 32470375

Title: Loss of Function of RIMS2 Causes a Syndromic Congenital Cone-Rod Synaptic Disease with Neurodevelopmental and Pancreatic Involvement.

PubMed ID: 32470375

DOI: 10.1016/j.ajhg.2020.04.018

Sequence Information:

  • Length: 1411
  • Mass: 160403
  • Checksum: 9D4E83F4CBE4A864
  • Sequence:
    • MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 
QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 
PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 
WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 
TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 
PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 
QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 
RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 
RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 
ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE 
MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS KDGDRLIGRI 
LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL 
EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ 
KMDRPSISVT SPMSPGMLRD VPQFLSGQLS IKLWFDKVGH QLIVTILGAK DLPSREDGRP 
RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP KWNQTFIYSP VHRREFRERM LEITLWDQAR 
VREEESEFLG EILIELETAL LDDEPHWYKL QTHDVSSLPL PHPSPYMPRR QLHGESPTRR 
LQRSKRISDS EVSDYDCDDG IGVVSDYRHD GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV 
DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT MTGHYNTISR MDRHRVMDDH YSPDRDRDCE 
AADRQPYHRS RSTEQRPLLE RTTTRSRSTE RPDTNLMRSM PSLMTGRSAP PSPALSRSHP 
RTGSVQTSPS STPVAGRRGR QLPQLPPKGT LDRKAGGKKL RSTVQRSTET GLAVEMRNWM 
TRQASRESTD GSMNSYSSEG NLIFPGVRLA SDSQFSDFLD GLGPAQLVGR QTLATPAMGD 
IQVGMMDKKG QLEVEIIRAR GLVVKPGSKT LPAPYVKVYL LDNGVCIAKK KTKVARKTLE 
PLYQQLLSFE ESPQGKVLQI IVWGDYGRMD HKSFMGVAQI LLDELELSNM VIGWFKLFPP 
SSLVDPTLAP LTRRASQSSL ESSTGPSYSR S

Genular Protein ID: 1514271625

Symbol: A0A994J503_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J503

Database IDs:

CDD 3 EMBL 8 EPD 1 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 1081
  • Mass: 123201
  • Checksum: 8BE3566D54572DB9
  • Sequence:
    • MQFETLRQVC NSVLSHFHGV FSSPPNILQN ELFGQTLNNA RKRSPSVSRD QNRRYDQREE 
REEYSQYATS DTAMPRSPSD YADRRSQHEP QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE 
DVESRDEYER QRREEEYQSR YRSDPNLARY PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS 
LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS 
PPTPRRSPLP IDRPDLRRTD SLRKQHHLDP SSAVRKTKRE KMETMLRNDS LSSDQSESVR 
PPPPKPHKSK KGGKMRQISL SSSEEELAST PEYTSCDDVE IESESVSEKG DMDYNWLDHT 
SWHSSEASPM SLHPVTWQPS KDGDRLIGRI LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE 
SGRLCAFITK VKKGSLADTV GHLRPGDEVL EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL 
VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ KMDRPSISVT SPMSPGMLRD VPQFLSGQLS 
IKLWFDKVGH QLIVTILGAK DLPSREDGRP RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP 
KWNQTFIYSP VHRREFRERM LEITLWDQAR VREEESEFLG EILIELETAL LDDEPHWYKL 
QTHDVSSLPL PHPSPYMPRR QLHGESPTRR LQRSKRISDS EVSDYDCDDG IGVVSDYRHD 
GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT 
MTGHYNTISR MDRHRVMDDH YSPDRDRSHP RTGSVQTSPS STPVAGRRGR QLPQLPPKGT 
LDRKAGGKKL RSTVQRSTET GLAVEMRNWM TRQASRESTD GSMNSYSSEG NLIFPGVRLA 
SDSQFSDFLD GLGPAQLVGR QTLATPAMGD IQVGMMDKKG QLEVEIIRAR GLVVKPGSKT 
LPAPYVKVYL LDNGVCIAKK KTKVARKTLE PLYQQLLSFE ESPQGKVLQI IVWGDYGRMD 
HKSFMGVAQI LLDELELSNM VIGWFKLFPP SSLVDPTLAP LTRRASQSSL ESSTGPSYSR 
S

Genular Protein ID: 3812064721

Symbol: A0A994J7W6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J7W6

Database IDs:

CDD 3 EMBL 8 EPD 1 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 1103
  • Mass: 125844
  • Checksum: A4C8393C814C6930
  • Sequence:
    • MQFETLRQVC NSVLSHFHGV FSSPPNILQN ELFGQTLNNA RKRSPSVSRD QNRRYDQREE 
REEYSQYATS DTAMPRSPSD YADRRSQHEP QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE 
DVESRDEYER QRREEEYQSR YRSDPNLARY PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS 
LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS 
PPTPRRSPLP IDRPDLRRTD SLRKQHHLDP SSAVRKTKRE KMETMLRNDS LSSDQSESVR 
PPPPKPHKSK KGGKMRQISL SSSEEELAST PEYTSCDDVE IESESVSEKG DMDYNWLDHT 
SWHSSEASPM SLHPVTWQPS KDGDRLIGRI LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE 
SGRLCAFITK VKKGSLADTV GHLRPGDEVL EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL 
VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ KMDRPSISVT SPMSPGMLRD VPQFLSGQLS 
IKLWFDKVGH QLIVTILGAK DLPSREDGRP RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP 
KWNQTFIYSP VHRREFRERM LEITLWDQAR VREEESEFLG EILIELETAL LDDEPHWYKL 
QTHDVSSLPL PHPSPYMPRR QLHGESPTRR LQRSKRISDS EVSDYDCDDG IGVVSDYRHD 
GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT 
MTGHYNTISR MDRHRVMDDH YSPDRDSHFL TLPRSRYSQT IDHHHRDGRS HPRTGSVQTS 
PSSTPVAGRR GRQLPQLPPK GTLDRKAGGK KLRSTVQRST ETGLAVEMRN WMTRQASRES 
TDGSMNSYSS EGNLIFPGVR LASDSQFSDF LDGLGPAQLV GRQTLATPAM GDIQVGMMDK 
KGQLEVEIIR ARGLVVKPGS KTLPAPYVKV YLLDNGVCIA KKKTKVARKT LEPLYQQLLS 
FEESPQGKVL QIIVWGDYGR MDHKSFMGVA QILLDELELS NMVIGWFKLF PPSSLVDPTL 
APLTRRASQS SLESSTGPSY SRS

Genular Protein ID: 1708216291

Symbol: A0A994J5M6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J5M6

Database IDs:

ARBA 4 CDD 3 EMBL 8 EPD 1 Ensembl 2 GO 6 Gene3D 3 GeneTree 1 HGNC 1 InterPro 10 NCBI Taxonomy 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 3

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 1402
  • Mass: 159389
  • Checksum: 77C31AD97F3F824C
  • Sequence:
    • MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKE EEKEQSVLKK 
LHQQFEMYKE QVKKMGEESQ QQQEQKGDAP TCGICHKTKF ADGCGHNCSY CQTKFCARCG 
GRVSLRSNKV MWVCNLCRKQ QEILTKSGAW FYNSGSNTPQ QPDQKVLRGL RNEEAPQEKK 
PKLHEQTQFQ GPSGDLSVPA VEKSRSHGLT RQHSIKNGSG VKHHIASDIA SDRKRSPSVS 
RDQNRRYDQR EEREEYSQYA TSDTAMPRSP SDYADRRSQH EPQFYEDSDH LSYRDSNRRS 
HRHSKEYIVD DEDVESRDEY ERQRREEEYQ SRYRSDPNLA RYPVKPQPYE EQMRIHAEVS 
RARHERRHSD VSLANADLED SRISMLRMDR PSRQRSISER RAAMENQRSY SMERTREAQG 
PSSYAQRTTN HSPPTPRRSP LPIDRPDLRR TDSLRKQHHL DPSSAVRKTK REKMETMLRN 
DSLSSDQSES VRPPPPKPHK SKKGGKMRQI SLSSSEEELA STPEYTSCDD VEIESESVSE 
KGDSQKGKRK TSEQAVLSDS NTRSERQKEM MYFGGHSLEE DLEWSEPQIK DSGVDTCSST 
TLNEEHSHSD KHPVTWQPSK DGDRLIGRIL LNKRLKDGSV PRDSGAMLGL KVVGGKMTES 
GRLCAFITKV KKGSLADTVG HLRPGDEVLE WNGRLLQGAT FEEVYNIILE SKPEPQVELV 
VSRPIGDIPR IPDSTHAQLE SSSSSFESQK MDRPSISVTS PMSPGMLRDV PQFLSGQLSI 
KLWFDKVGHQ LIVTILGAKD LPSREDGRPR NPYVKIYFLP DRSDKNKRRT KTVKKTLEPK 
WNQTFIYSPV HRREFRERML EITLWDQARV REEESEFLGE ILIELETALL DDEPHWYKLQ 
THDVSSLPLP HPSPYMPRRQ LHGESPTRRL QRSKRISDSE VSDYDCDDGI GVVSDYRHDG 
RDLQSSTLSV PEQVMSSNHC SPSGSPHRVD VIGRTRSWSP SVPPPQSRNV EQGLRGTRTM 
TGHYNTISRM DRHRVMDDHY SPDRDSHFLT LPRSRYSQTI DHHHRDGRDC EAADRQPYHR 
SRSTEQRPLL ERTTTRSRST ERPDTNLMRS MPSLMTGRSA PPSPALSRSH PRTGSVQTSP 
SSTPVAGRRG RQLPQLPPKG TLDRKAGGKK LRSTVQRSTE TGLAVEMRNW MTRQASREST 
DGSMNSYSSE GNLIFPGVRL ASDSQFSDFL DGLGPAQLVG RQTLATPAMG DIQVGMMDKK 
GQLEVEIIRA RGLVVKPGSK TLPAPYVKVY LLDNGVCIAK KKTKVARKTL EPLYQQLLSF 
EESPQGKVLQ IIVWGDYGRM DHKSFMGVAQ ILLDELELSN MVIGWFKLFP PSSLVDPTLA 
PLTRRASQSS LESSTGPSYS RS

Genular Protein ID: 3456988759

Symbol: A0A8Q3SIU4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SIU4

Database IDs:

ARBA 4 CDD 3 EMBL 8 EPD 1 Ensembl 2 GO 6 Gene3D 3 GeneTree 1 HGNC 1 InterPro 10 MANE-Select 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 3

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 1607
  • Mass: 181913
  • Checksum: 3C2ACC1CF8422BB5
  • Sequence:
    • MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKE EEKEQSVLKV 
KEEHKPQLTQ WFPFSGITEL VNNVLQPQQK QQNEKEPQTK LHQQFEMYKE QVKKMGEESQ 
QQQEQKGDAP TCGICHKTKF ADGCGHNCSY CQTKFCARCG GRVSLRSNKE DKVVMWVCNL 
CRKQQEILTK SGAWFYNSGS NTPQQPDQKV LRGLRNEEAP QEKKPKLHEQ TQFQGPSGDL 
SVPAVEKSRS HGLTRQHSIK NGSGVKHHIA SDIASDRKRS PSVSRDQNRR YDQREEREEY 
SQYATSDTAM PRSPSDYADR RSQHEPQFYE DSDHLSYRDS NRRSHRHSKE YIVDDEDVES 
RDEYERQRRE EEYQSRYRSD PNLARYPVKP QPYEEQMRIH AEVSRARHER RHSDVSLANA 
DLEDSRISML RMDRPSRQRS ISERRAAMEN QRSYSMERTR EAQGPSSYAQ RTTNHSPPTP 
RRSPLPIDRP DLRRTDSLRK QHHLDPSSAV RKTKREKMET MLRNDSLSSD QSESVRPPPP 
KPHKSKKGGK MRQISLSSSE EELASTPEYT SCDDVEIESE SVSEKGDSQK GKRKTSEQAV 
LSDSNTRSER QKEMMYFGGH SLEEDLEWSE PQIKDSGVDT CSSTTLNEEH SHSDKHPVTW 
QPSKDGDRLI GRILLNKRLK DGSVPRDSGA MLGLKVVGGK MTESGRLCAF ITKVKKGSLA 
DTVGHLRPGD EVLEWNGRLL QGATFEEVYN IILESKPEPQ VELVVSRPIG DIPRIPDSTH 
AQLESSSSSF ESQKMDRPSI SVTSPMSPGM LRDVPQFLSG QLSIKLWFDK VGHQLIVTIL 
GAKDLPSRED GRPRNPYVKI YFLPDRSDKN KRRTKTVKKT LEPKWNQTFI YSPVHRREFR 
ERMLEITLWD QARVREEESE FLGEILIELE TALLDDEPHW YKLQTHDVSS LPLPHPSPYM 
PRRQLHGESP TRRLQRSKRI SDSEVSDYDC DDGIGVVSDY RHDGRDLQSS TLSVPEQVMS 
SNHCSPSGSP HRVDVIGRTR SWSPSVPPPQ SRNVEQGLRG TRTMTGHYNT ISRMDRHRVM 
DDHYSPDRDR DCEAADRQPY HRSRSTEQRP LLERTTTRSR STERPDTNLM RSMPSLMTGR 
SAPPSPALSR SHPRTGSVQT SPSSTPVAGR RGRQLPQLPP KGTLDRKELD STRRRYAGTM 
DIEERNRQMK INKYKQVAGS DPRLEQDYHS KYRSGWDPHR GADNVSTKSS DSDVSDISAV 
SRTSSASRFS STSYMSVQSE RPGGNKKISV FTSKMQSRQM GISGKNMTKS TSISGDMCSL 
EKNDGSQSDT AVGTLGTSGK KRRSSLGAKM VAIVGLSRKS RSASQLSQTE AGGKKLRSTV 
QRSTETGLAV EMRNWMTRQA SRESTDGSMN SYSSEGNLIF PGVRLASDSQ FSDFLDGLGP 
AQLVGRQTLA TPAMGDIQVG MMDKKGQLEV EIIRARGLVV KPGSKTLPAP YVKVYLLDNG 
VCIAKKKTKV ARKTLEPLYQ QLLSFEESPQ GKVLQIIVWG DYGRMDHKSF MGVAQILLDE 
LELSNMVIGW FKLFPPSSLV DPTLAPLTRR ASQSSLESST GPSYSRS

Genular Protein ID: 2449500785

Symbol: A0A8Q3SJ53_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SJ53

Database IDs:

CDD 3 EMBL 8 EPD 1 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 1324
  • Mass: 149890
  • Checksum: D59850D39BD3DA71
  • Sequence:
    • MQFETLRQVC NSVLSHFHGV FSSPPNILQN ELFGQTLNNA RKRSPSVSRD QNRRYDQREE 
REEYSQYATS DTAMPRSPSD YADRRSQHEP QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE 
DVESRDEYER QRREEEYQSR YRSDPNLARY PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS 
LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS 
PPTPRRSPLP IDRPDLRRTD SLRKQHHLDP SSAVRKTKRE KMETMLRNDS LSSDQSESVR 
PPPPKPHKSK KGGKMRQISL SSSEEELAST PEYTSCDDVE IESESVSEKG DMDYNWLDHT 
SWHSSEASPM SLHPVTWQPS KDGDRLIGRI LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE 
SGRLCAFITK VKKGSLADTV GHLRPGDEVL EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL 
VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ KMDRPSISVT SPMSPGMLRD VPQFLSGQLS 
IKLWFDKVGH QLIVTILGAK DLPSREDGRP RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP 
KWNQTFIYSP VHRREFRERM LEITLWDQAR VREEESEFLG EILIELETAL LDDEPHWYKL 
QTHDVSSLPL PHPSPYMPRR QLHGESPTRR LQRSKRISDS EVSDYDCDDG IGVVSDYRHD 
GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT 
MTGHYNTISR MDRHRVMDDH YSPDRDRDCE AADRQPYHRS RSTEQRPLLE RTTTRSRSTE 
RPDTNLMRSM PSLMTGRSAP PSPALSRSHP RTGSVQTSPS STPVAGRRGR QLPQLPPKGT 
LDRNNGVKEI EPYEGTMDIE ERNRQMKINK YKQVAGSDPR LEQDYHSKYR SGWDPHRGAD 
NVSTKSSDSD VSDISAVSRT SSASRFSSTS YMSVQSERPG GNKKISVFTS KMQSRQMGIS 
GKNMTKSTSI SGDMCSLEKN DGSQSDTAVG TLGTSGKKRR SSLGAKMVAI VGLSRKSRSA 
SQLSQTEAGG KKLRSTVQRS TETGLAVEMR NWMTRQASRE STDGSMNSYS SEGNLIFPGV 
RLASDSQFSD FLDGLGPAQL VGRQTLATPA MGDIQVGMMD KKGQLEVEII RARGLVVKPG 
SKTLPAPYVK VYLLDNGVCI AKKKTKVARK TLEPLYQQLL SFEESPQGKV LQIIVWGDYG 
RMDHKSFMGV AQILLDELEL SNMVIGWFKL FPPSSLVDPT LAPLTRRASQ SSLESSTGPS 
YSRS

Genular Protein ID: 3719072220

Symbol: F8W6W8_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W6W8

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 3 ChiTaRS 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 1356
  • Mass: 153781
  • Checksum: 1560DF19A3372895
  • Sequence:
    • MQFETLRQVC NSVLSHFHGV FSSPPNILQN ELFGQTLNNA RKRSPSVSRD QNRRYDQREE 
REEYSQYATS DTAMPRSPSD YADRRSQHEP QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE 
DVESRDEYER QRREEEYQSR YRSDPNLARY PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS 
LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS 
PPTPRRSPLP IDRPDLRRTD SLRKQHHLDP SSAVRKTKRE KMETMLRNDS LSSDQSESVR 
PPPPKPHKSK KGGKMRQISL SSSEEELAST PEYTSCDDVE IESESVSEKG DMDYNWLDHT 
SWHSSEASPM SLHPVTWQPS KDGDRLIGRI LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE 
SGRLCAFITK VKKGSLADTV GHLRPGDEVL EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL 
VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ KMDRPSISVT SPMSPGMLRD VPQFLSGQLS 
IKLWFDKVGH QLIVTILGAK DLPSREDGRP RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP 
KWNQTFIYSP VHRREFRERM LEITLWDQAR VREEESEFLG EILIELETAL LDDEPHWYKL 
QTHDVSSLPL PHPSPYMPRR QLHGESPTRR LQRSKRISDS EVSDYDCDDG IGVVSDYRHD 
GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT 
MTGHYNTISR MDRHRVMDDH YSPDRDSHFL TLPRSRYSQT IDHHHRDGRD CEAADRQPYH 
RSRSTEQRPL LERTTTRSRS TERPDTNLMR SMPSLMTGRS APPSPALSRS HPRTGSVQTS 
PSSTPVAGRR GRQLPQLPPK GTLDRNNGVK EIEPYEELDS TRRRYAGTMD IEERNRQMKI 
NKYKQVAGSD PRLEQDYHSK YRSGWDPHRG ADNVSTKSSD SDVSDISAVS RTSSASRFSS 
TSYMSVQSER PGGNKKISVF TSKMQSRQMG ISGKNMTKST SISGDMCSLE KNDGSQSDTA 
VGTLGTSGKK RRSSLGAKMV AIVGLSRKSR SASQLSQTEA GGKKLRSTVQ RSTETGLAVE 
MRNWMTRQAS RESTDGSMNS YSSEGNLIFP GVRLASDSQF SDFLDGLGPA QLVGRQTLAT 
PAMGDIQVGM MDKKGQLEVE IIRARGLVVK PGSKTLPAPY VKVYLLDNGV CIAKKKTKVA 
RKTLEPLYQQ LLSFEESPQG KVLQIIVWGD YGRMDHKSFM GVAQILLDEL ELSNMVIGWF 
KLFPPSSLVD PTLAPLTRRA SQSSLESSTG PSYSRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.