Details for: CSNK1A1L

Gene ID: 122011

Symbol: CSNK1A1L

Ensembl ID: ENSG00000180138

Description: casein kinase 1 alpha 1 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 6.2361
    Cell Significance Index: -0.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 3.8440
    Cell Significance Index: -0.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4932
    Cell Significance Index: 36.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 0.7948
    Cell Significance Index: -0.9800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0862
    Cell Significance Index: 2.1500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0679
    Cell Significance Index: 0.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0623
    Cell Significance Index: 1.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0617
    Cell Significance Index: 0.6400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0610
    Cell Significance Index: 0.6900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0345
    Cell Significance Index: 0.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0174
    Cell Significance Index: 0.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0155
    Cell Significance Index: 1.8100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0142
    Cell Significance Index: 0.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0073
    Cell Significance Index: 0.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0069
    Cell Significance Index: 0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0007
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -3.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0042
    Cell Significance Index: -0.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0042
    Cell Significance Index: -1.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0049
    Cell Significance Index: -0.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0055
    Cell Significance Index: -1.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0064
    Cell Significance Index: -1.1500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0076
    Cell Significance Index: -0.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0094
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0106
    Cell Significance Index: -1.3000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0130
    Cell Significance Index: -2.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0154
    Cell Significance Index: -2.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0154
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0170
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0189
    Cell Significance Index: -2.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0199
    Cell Significance Index: -0.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0206
    Cell Significance Index: -0.3300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0210
    Cell Significance Index: -0.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0253
    Cell Significance Index: -0.7500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0256
    Cell Significance Index: -0.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0278
    Cell Significance Index: -1.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0281
    Cell Significance Index: -1.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0290
    Cell Significance Index: -0.7900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0295
    Cell Significance Index: -0.2900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0306
    Cell Significance Index: -1.5400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0314
    Cell Significance Index: -0.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0314
    Cell Significance Index: -0.4500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0320
    Cell Significance Index: -0.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0332
    Cell Significance Index: -2.0400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0344
    Cell Significance Index: -0.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0368
    Cell Significance Index: -0.6200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0373
    Cell Significance Index: -0.7300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0381
    Cell Significance Index: -0.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0394
    Cell Significance Index: -1.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0399
    Cell Significance Index: -2.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0415
    Cell Significance Index: -2.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0417
    Cell Significance Index: -0.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0437
    Cell Significance Index: -1.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0470
    Cell Significance Index: -2.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0476
    Cell Significance Index: -1.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0487
    Cell Significance Index: -1.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0513
    Cell Significance Index: -1.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0518
    Cell Significance Index: -2.3500
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0524
    Cell Significance Index: -0.5600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0534
    Cell Significance Index: -0.6500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0554
    Cell Significance Index: -0.7100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0556
    Cell Significance Index: -0.9500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0567
    Cell Significance Index: -0.3500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0568
    Cell Significance Index: -0.7200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0571
    Cell Significance Index: -0.8000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0586
    Cell Significance Index: -1.0100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0597
    Cell Significance Index: -0.8700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0605
    Cell Significance Index: -2.4800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0619
    Cell Significance Index: -0.6400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0631
    Cell Significance Index: -0.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0652
    Cell Significance Index: -0.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0653
    Cell Significance Index: -1.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0656
    Cell Significance Index: -1.6800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0663
    Cell Significance Index: -0.9100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0664
    Cell Significance Index: -0.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0674
    Cell Significance Index: -3.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0676
    Cell Significance Index: -2.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0678
    Cell Significance Index: -1.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0686
    Cell Significance Index: -2.5200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0686
    Cell Significance Index: -0.7100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0696
    Cell Significance Index: -0.8200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0705
    Cell Significance Index: -0.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0709
    Cell Significance Index: -1.3100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0728
    Cell Significance Index: -0.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0730
    Cell Significance Index: -1.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0731
    Cell Significance Index: -1.5800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0732
    Cell Significance Index: -1.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0771
    Cell Significance Index: -1.6100
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0781
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Isoform**: CSNK1A1L is an isoform of the casein kinase 1 alpha 1 gene, which is a member of the protein kinase family. 2. **Cellular Expression**: CSNK1A1L is expressed in a wide range of cell types, including cardiac endothelial cells, goblet cells, intestinal crypt stem cells, and cerebral cortex GABAergic interneurons. 3. **Phosphorylation Activity**: CSNK1A1L exhibits protein serine/threonine kinase activity, enabling it to phosphorylate and regulate various cellular substrates. 4. **Wnt Signaling Modulation**: CSNK1A1L is involved in the negative regulation of the canonical Wnt signaling pathway, which plays a crucial role in cell proliferation, differentiation, and survival. **Pathways and Functions:** 1. **Wnt Signaling Pathway**: CSNK1A1L regulates the Wnt signaling pathway by phosphorylating and inhibiting key components, such as β-catenin and TCF/LEF transcription factors. 2. **Cellular Signaling**: CSNK1A1L modulates various cellular signaling processes, including peptidyl-serine phosphorylation, ATP binding, and signal transduction. 3. **Cellular Differentiation**: CSNK1A1L may influence cellular differentiation by regulating the Wnt signaling pathway and other downstream effectors. 4. **Apoptosis**: CSNK1A1L may also modulate apoptosis by regulating the Wnt signaling pathway and other pro-survival or pro-apoptotic pathways. **Clinical Significance:** The dysregulation of CSNK1A1L has been implicated in various diseases, including cancer, where it may contribute to tumorigenesis and tumor progression. Additionally, CSNK1A1L may play a role in neurodegenerative diseases, such as Alzheimer's disease, where it may contribute to neuronal dysfunction and death. Further research is needed to fully elucidate the clinical significance of CSNK1A1L and its potential therapeutic applications. In conclusion, CSNK1A1L is a novel regulator of cellular signaling and Wnt pathway, which plays a crucial role in maintaining cellular homeostasis and regulating various physiological processes. Further studies are necessary to fully understand the molecular mechanisms underlying the functions of CSNK1A1L and its potential therapeutic applications in various diseases.

Genular Protein ID: 2634193672

Symbol: KC1AL_HUMAN

Name: Casein kinase I isoform alpha-like

UniProtKB Accession Codes:

Q8N752 Q5T2N2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 3 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 337
  • Mass: 39086
  • Checksum: 6110F854D739B142
  • Sequence:
    • MTNNSGSKAE LVVGGKYKLV RKIGSGSFGD VYLGITTTNG EDVAVKLESQ KVKHPQLLYE 
SKLYTILQGG VGIPHMHWYG QEKDNNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM 
ISRIEYVHTK NFLHRDIKPD NFLMGTGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKH 
LIGTVRYASI NAHLGIEQSR RDDMESLGYV FMYFNRTSLP WQGLRAMTKK QKYEKISEKK 
MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE VPDYMYLRQL FRILFRTLNH QYDYTFDWTM 
LKQKAAQQAA SSSGQGQQAQ TQTGKQTEKN KNNVKDN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.