Details for: LTB4R

Gene ID: 1241

Symbol: LTB4R

Ensembl ID: ENSG00000213903

Description: leukotriene B4 receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.71
    Marker Score: 1938
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.4
    Marker Score: 3485
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.08
    Marker Score: 8427
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.01
    Marker Score: 3751
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71794
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48019
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.97
    Marker Score: 8382
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.96
    Marker Score: 53588
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.94
    Marker Score: 295
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5137
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5271
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8
    Marker Score: 838
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1238
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 676
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 281
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2830.5
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.67
    Marker Score: 293
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.65
    Marker Score: 210
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 422
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.62
    Marker Score: 4595
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1374
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 325
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.47
    Marker Score: 388.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.45
    Marker Score: 500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.43
    Marker Score: 686
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.42
    Marker Score: 258
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.41
    Marker Score: 527
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.39
    Marker Score: 230
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.39
    Marker Score: 3937
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.39
    Marker Score: 94
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.38
    Marker Score: 431
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.37
    Marker Score: 237
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.37
    Marker Score: 1545
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.36
    Marker Score: 156
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.35
    Marker Score: 195
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.35
    Marker Score: 151
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.35
    Marker Score: 225
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.34
    Marker Score: 134
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.34
    Marker Score: 117
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.33
    Marker Score: 123
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.33
    Marker Score: 329
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.33
    Marker Score: 111
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.33
    Marker Score: 638
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.32
    Marker Score: 1304
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.32
    Marker Score: 156
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.31
    Marker Score: 408
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.31
    Marker Score: 107
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.31
    Marker Score: 116
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.3
    Marker Score: 302
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.3
    Marker Score: 145
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.29
    Marker Score: 213
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 90
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.28
    Marker Score: 210
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.28
    Marker Score: 186
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.28
    Marker Score: 67
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.28
    Marker Score: 54
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.27
    Marker Score: 707
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.27
    Marker Score: 64
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.26
    Marker Score: 170
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.26
    Marker Score: 3467
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.26
    Marker Score: 887
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.26
    Marker Score: 6556
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.25
    Marker Score: 416.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.25
    Marker Score: 223
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.25
    Marker Score: 105
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.25
    Marker Score: 167
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.25
    Marker Score: 123
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.25
    Marker Score: 223
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.25
    Marker Score: 54
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.25
    Marker Score: 155
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.25
    Marker Score: 1490.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.24
    Marker Score: 2096
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.24
    Marker Score: 161
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.23
    Marker Score: 2726
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.23
    Marker Score: 56
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.23
    Marker Score: 114
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.23
    Marker Score: 108
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.23
    Marker Score: 568.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.23
    Marker Score: 57
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.23
    Marker Score: 213
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.23
    Marker Score: 57
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.22
    Marker Score: 49

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Other Information

**Key characteristics:** * LTB4R1 is a member of the G alpha (q) family of GPCRs. * It is expressed in high levels in epithelial cells, which are found in various tissues throughout the body. * LTB4R1 is also expressed in immune cells, including monocytes, macrophages, and dendritic cells. * It is a ligand-gated ion channel, meaning that it opens when a ligand binds to it. **Pathways and functions:** * LTB4R1 is a key regulator of inflammation. * It is expressed in high levels in epithelial cells in tissues that are exposed to inflammatory stimuli. * When LTB4R1 is stimulated by its ligand, it opens and allows calcium ions to flow into the cell. * This calcium influx causes a variety of inflammatory responses, including the production of cytokines and chemokines, the recruitment of immune cells, and the dilation of blood vessels. **Clinical significance:** * Mutations in the LTB4R1 gene have been linked to a number of inflammatory diseases, including asthma, arthritis, and inflammatory bowel disease. * LTB4R1 is a potential target for new therapies for these diseases. **Additional information:** * The LTB4R gene is located on chromosome 19q21.1. * It is a large gene, with a length of approximately 30,000 base pairs. * It contains 21 exons and 19 intronic regions. * LTB4R1 is a highly conserved protein, with similar sequences found in mammals, birds, and fish.

Genular Protein ID: 2769073551

Symbol: LT4R1_HUMAN

Name: Leukotriene B4 receptor 1

UniProtKB Accession Codes:

Q15722 Q13305 Q53XV5 Q92641 Q9BSU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 9 EMDB 1 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8702478

Title: Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells.

PubMed ID: 8702478

DOI: 10.1074/jbc.271.31.18363

PubMed ID: 8558062

Title: New members of the chemokine receptor gene family.

PubMed ID: 8558062

DOI: 10.1002/jlb.59.1.18

PubMed ID: 9177352

Title: A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.

PubMed ID: 9177352

DOI: 10.1038/42506

PubMed ID: 8921391

Title: Cloning of cDNA encoding a putative chemoattractant receptor.

PubMed ID: 8921391

DOI: 10.1006/geno.1996.0541

PubMed ID: 10934229

Title: Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene.

PubMed ID: 10934229

DOI: 10.1084/jem.192.3.413

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12077128

Title: Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.

PubMed ID: 12077128

DOI: 10.1074/jbc.m202723200

Sequence Information:

  • Length: 352
  • Mass: 37557
  • Checksum: 5A7BFC0A659AC81C
  • Sequence:
    • MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR SVTALMVLNL 
ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS MYASVLLITA MSLDRSLAVA 
RPFVSQKLRT KAMARRVLAG IWVLSFLLAT PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF 
HLIFEAVTGF LLPFLAVVAS YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV 
NLAEAGRALA GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF 
VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE LN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.