Details for: LTB4R

Gene ID: 1241

Symbol: LTB4R

Ensembl ID: ENSG00000213903

Description: leukotriene B4 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 37.2239
    Cell Significance Index: -5.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.0675
    Cell Significance Index: -5.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 13.1419
    Cell Significance Index: -6.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.0772
    Cell Significance Index: -6.2600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 4.0675
    Cell Significance Index: 9.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.0784
    Cell Significance Index: 42.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.7438
    Cell Significance Index: 76.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9449
    Cell Significance Index: -5.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6523
    Cell Significance Index: -6.5200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.6340
    Cell Significance Index: 24.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4758
    Cell Significance Index: -3.2300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.1044
    Cell Significance Index: 9.4900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.8682
    Cell Significance Index: 7.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8666
    Cell Significance Index: 23.2200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.8009
    Cell Significance Index: 11.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7911
    Cell Significance Index: 150.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6568
    Cell Significance Index: 12.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5862
    Cell Significance Index: 57.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5639
    Cell Significance Index: 15.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4537
    Cell Significance Index: 409.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3943
    Cell Significance Index: 174.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3347
    Cell Significance Index: 8.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3042
    Cell Significance Index: 19.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3039
    Cell Significance Index: 49.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2834
    Cell Significance Index: 8.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2763
    Cell Significance Index: 30.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2292
    Cell Significance Index: 16.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2092
    Cell Significance Index: 12.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1780
    Cell Significance Index: 4.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1514
    Cell Significance Index: 10.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1362
    Cell Significance Index: 2.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0971
    Cell Significance Index: 19.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0937
    Cell Significance Index: 2.0300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0809
    Cell Significance Index: 0.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0752
    Cell Significance Index: 1.0700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0650
    Cell Significance Index: 0.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0626
    Cell Significance Index: 2.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0531
    Cell Significance Index: 2.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0449
    Cell Significance Index: 0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0346
    Cell Significance Index: 6.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0266
    Cell Significance Index: 1.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0263
    Cell Significance Index: 1.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0263
    Cell Significance Index: 3.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0237
    Cell Significance Index: 0.5200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0237
    Cell Significance Index: 0.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0230
    Cell Significance Index: 0.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0228
    Cell Significance Index: 1.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0210
    Cell Significance Index: 2.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0139
    Cell Significance Index: 0.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0133
    Cell Significance Index: 2.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0087
    Cell Significance Index: 1.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0083
    Cell Significance Index: 4.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0074
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0022
    Cell Significance Index: 4.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0004
    Cell Significance Index: 0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0008
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0050
    Cell Significance Index: -1.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0050
    Cell Significance Index: -6.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0054
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0056
    Cell Significance Index: -0.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0065
    Cell Significance Index: -0.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0073
    Cell Significance Index: -0.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0125
    Cell Significance Index: -5.6700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0184
    Cell Significance Index: -0.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0186
    Cell Significance Index: -2.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0272
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0325
    Cell Significance Index: -6.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0332
    Cell Significance Index: -3.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0432
    Cell Significance Index: -3.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0507
    Cell Significance Index: -3.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0520
    Cell Significance Index: -2.3000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0563
    Cell Significance Index: -0.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0573
    Cell Significance Index: -5.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0617
    Cell Significance Index: -3.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0631
    Cell Significance Index: -2.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0732
    Cell Significance Index: -4.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0806
    Cell Significance Index: -2.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0865
    Cell Significance Index: -2.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0936
    Cell Significance Index: -3.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1084
    Cell Significance Index: -5.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1094
    Cell Significance Index: -3.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1097
    Cell Significance Index: -3.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1110
    Cell Significance Index: -1.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1141
    Cell Significance Index: -2.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1155
    Cell Significance Index: -3.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1156
    Cell Significance Index: -1.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1191
    Cell Significance Index: -1.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1204
    Cell Significance Index: -4.4200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1302
    Cell Significance Index: -1.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1352
    Cell Significance Index: -3.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1380
    Cell Significance Index: -2.7000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1387
    Cell Significance Index: -3.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1400
    Cell Significance Index: -1.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor structure:** LTB4R is a member of the class A/1 rhodopsin-like receptor family and belongs to the G protein-coupled receptor (GPCR) superfamily. 2. **Ligand binding:** LTB4R binds to its ligand, leukotriene B4 (LTB4), with high affinity, triggering receptor activation. 3. **Signaling pathways:** The activation of LTB4R triggers a signaling cascade that involves the activation of Gq proteins, leading to the production of pro-inflammatory mediators, such as inositol trisphosphate (IP3) and diacylglycerol (DAG). 4. **Cellular localization:** LTB4R is expressed in various cell types, including basal epithelial cells of the tracheobronchial tree, CD14-positive monocytes, stratified epithelial cells, and neurons. **Pathways and Functions:** 1. **Inflammatory response:** LTB4R plays a key role in mediating the inflammatory response by recruiting immune cells to sites of inflammation and promoting the production of pro-inflammatory mediators. 2. **Immune response:** LTB4R is involved in regulating immune responses, including the activation of T cells and the production of cytokines. 3. **Muscle contraction:** LTB4R has been shown to regulate muscle contraction by activating Gq proteins and leading to the production of inositol trisphosphate (IP3). 4. **Neurological functions:** LTB4R is expressed in neurons and is involved in regulating neuroinflammation and neurodegenerative diseases. **Clinical Significance:** Dysregulation of LTB4R has been implicated in various diseases, including: 1. **Asthma:** LTB4R is involved in the pathogenesis of asthma, and its dysregulation contributes to airway inflammation and hyperresponsiveness. 2. **Inflammatory bowel disease (IBD):** LTB4R is expressed in the gut and is involved in regulating inflammation and immune responses in IBD. 3. **Neurological disorders:** LTB4R has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer:** LTB4R is overexpressed in certain types of cancer, including breast cancer and colorectal cancer, and is involved in regulating tumor growth and metastasis. In conclusion, the Leukotriene B4 Receptor is a key player in mediating the effects of leukotriene B4, a potent pro-inflammatory mediator. Its dysregulation contributes to various diseases, including asthma, inflammatory bowel disease, neurological disorders, and cancer. Further research is needed to fully understand the role of LTB4R in these diseases and to develop novel therapeutic strategies targeting this receptor.

Genular Protein ID: 2769073551

Symbol: LT4R1_HUMAN

Name: Leukotriene B4 receptor 1

UniProtKB Accession Codes:

Q15722 Q13305 Q53XV5 Q92641 Q9BSU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 6 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8702478

Title: Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells.

PubMed ID: 8702478

DOI: 10.1074/jbc.271.31.18363

PubMed ID: 8558062

Title: New members of the chemokine receptor gene family.

PubMed ID: 8558062

DOI: 10.1002/jlb.59.1.18

PubMed ID: 9177352

Title: A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.

PubMed ID: 9177352

DOI: 10.1038/42506

PubMed ID: 8921391

Title: Cloning of cDNA encoding a putative chemoattractant receptor.

PubMed ID: 8921391

DOI: 10.1006/geno.1996.0541

PubMed ID: 10934229

Title: Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene.

PubMed ID: 10934229

DOI: 10.1084/jem.192.3.413

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12077128

Title: Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.

PubMed ID: 12077128

DOI: 10.1074/jbc.m202723200

Sequence Information:

  • Length: 352
  • Mass: 37557
  • Checksum: 5A7BFC0A659AC81C
  • Sequence:
    • MNTTSSAAPP SLGVEFISLL AIILLSVALA VGLPGNSFVV WSILKRMQKR SVTALMVLNL 
ALADLAVLLT APFFLHFLAQ GTWSFGLAGC RLCHYVCGVS MYASVLLITA MSLDRSLAVA 
RPFVSQKLRT KAMARRVLAG IWVLSFLLAT PVLAYRTVVP WKTNMSLCFP RYPSEGHRAF 
HLIFEAVTGF LLPFLAVVAS YSDIGRRLQA RRFRRSRRTG RLVVLIILTF AAFWLPYHVV 
NLAEAGRALA GQAAGLGLVG KRLSLARNVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF 
VAKLLEGTGS EASSTRRGGS LGQTARSGPA ALEPGPSESL TASSPLKLNE LN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.