Details for: SPINK13

Gene ID: 153218

Symbol: SPINK13

Ensembl ID: ENSG00000214510

Description: serine peptidase inhibitor Kazal type 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.2709
    Cell Significance Index: 87.6500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.4773
    Cell Significance Index: 2.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2096
    Cell Significance Index: 6.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2014
    Cell Significance Index: 4.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1884
    Cell Significance Index: 11.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0368
    Cell Significance Index: 0.6300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0367
    Cell Significance Index: 0.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0256
    Cell Significance Index: 1.9600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0245
    Cell Significance Index: 0.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0192
    Cell Significance Index: 2.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0187
    Cell Significance Index: 3.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0113
    Cell Significance Index: 4.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0112
    Cell Significance Index: 0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0091
    Cell Significance Index: 16.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0091
    Cell Significance Index: 12.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0085
    Cell Significance Index: 13.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0037
    Cell Significance Index: 0.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0024
    Cell Significance Index: 1.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0014
    Cell Significance Index: 0.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0017
    Cell Significance Index: -0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0024
    Cell Significance Index: -1.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0036
    Cell Significance Index: -1.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0040
    Cell Significance Index: -1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0041
    Cell Significance Index: -0.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0059
    Cell Significance Index: -0.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0061
    Cell Significance Index: -1.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0065
    Cell Significance Index: -0.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0065
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0080
    Cell Significance Index: -1.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0086
    Cell Significance Index: -0.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0087
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0098
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0105
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0130
    Cell Significance Index: -1.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0145
    Cell Significance Index: -0.5500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0147
    Cell Significance Index: -0.3000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0156
    Cell Significance Index: -0.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0158
    Cell Significance Index: -0.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0167
    Cell Significance Index: -1.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0205
    Cell Significance Index: -1.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0278
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0278
    Cell Significance Index: -0.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0279
    Cell Significance Index: -0.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0285
    Cell Significance Index: -1.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0290
    Cell Significance Index: -0.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0292
    Cell Significance Index: -0.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0305
    Cell Significance Index: -1.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0309
    Cell Significance Index: -1.4500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0313
    Cell Significance Index: -0.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0345
    Cell Significance Index: -1.1000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0356
    Cell Significance Index: -0.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0365
    Cell Significance Index: -1.2800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0370
    Cell Significance Index: -0.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0408
    Cell Significance Index: -0.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0435
    Cell Significance Index: -1.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0455
    Cell Significance Index: -1.2700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0465
    Cell Significance Index: -0.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0471
    Cell Significance Index: -1.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0475
    Cell Significance Index: -0.9400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0497
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0498
    Cell Significance Index: -0.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0505
    Cell Significance Index: -1.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0507
    Cell Significance Index: -0.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0508
    Cell Significance Index: -1.4500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0523
    Cell Significance Index: -0.3800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0529
    Cell Significance Index: -0.8900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0529
    Cell Significance Index: -1.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0533
    Cell Significance Index: -1.3300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0538
    Cell Significance Index: -0.5100
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0541
    Cell Significance Index: -0.5600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0556
    Cell Significance Index: -0.6900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0570
    Cell Significance Index: -0.8000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0581
    Cell Significance Index: -1.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0586
    Cell Significance Index: -2.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0586
    Cell Significance Index: -1.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0600
    Cell Significance Index: -1.7200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0601
    Cell Significance Index: -0.7300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0603
    Cell Significance Index: -0.8900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0613
    Cell Significance Index: -1.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0625
    Cell Significance Index: -1.6700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0642
    Cell Significance Index: -0.8100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0658
    Cell Significance Index: -0.8200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0659
    Cell Significance Index: -1.6800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0669
    Cell Significance Index: -0.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0685
    Cell Significance Index: -1.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0686
    Cell Significance Index: -2.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0691
    Cell Significance Index: -1.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0705
    Cell Significance Index: -0.8400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0714
    Cell Significance Index: -1.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0714
    Cell Significance Index: -1.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0734
    Cell Significance Index: -1.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0757
    Cell Significance Index: -1.5100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0764
    Cell Significance Index: -1.0300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0789
    Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine Peptidase Inhibitor Kazal Type 13:** SPINK13 belongs to the Kazal-type SPI family, which is characterized by its ability to inhibit serine-type endopeptidases. 2. **Negative Regulation of Acrosome Reaction:** SPINK13 has been shown to regulate the acrosome reaction, a critical process in fertilization, by inhibiting the activity of serine-type endopeptidases. 3. **Protein Binding:** SPINK13 has the ability to bind to various proteins, including serine-type endopeptidases, thereby modulating their activity. 4. **Significantly Expressed Cells:** SPINK13 is expressed in a wide range of cell types, including progenitor cells, Mueller cells, retinal cone cells, and blood vessel endothelial cells. **Pathways and Functions:** 1. **Extracellular Region:** SPINK13 is involved in regulating the extracellular environment by inhibiting serine-type endopeptidases, thereby modulating the activity of various signaling molecules. 2. **Negative Regulation of Acrosome Reaction:** SPINK13 regulates the acrosome reaction by inhibiting the activity of serine-type endopeptidases, which is essential for fertilization. 3. **Protein Binding:** SPINK13 binds to various proteins, including serine-type endopeptidases, modulating their activity and regulating cellular processes. 4. **Serine-Type Endopeptidase Inhibition:** SPINK13 inhibits the activity of serine-type endopeptidases, which are involved in various cellular processes, including proteolysis and signaling. **Clinical Significance:** 1. **Retinal Diseases:** Dysregulation of SPINK13 has been implicated in the pathogenesis of retinal disorders, including retinitis pigmentosa and macular degeneration. 2. **Fertilization:** SPINK13 regulates the acrosome reaction, which is essential for fertilization. Dysregulation of SPINK13 may lead to infertility. 3. **Cancer:** SPINK13 has been shown to have anti-tumor properties, and its dysregulation has been implicated in the development of various cancers. 4. **Neurological Disorders:** SPINK13 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, SPINK13 is a multifunctional gene that plays a crucial role in regulating various physiological processes, including the negative regulation of the acrosome reaction, protein binding, and serine-type endopeptidase inhibition. Its dysregulation has been implicated in the pathogenesis of various diseases, including retinal disorders, cancer, and neurological disorders. Further research is needed to fully elucidate the functions and significance of SPINK13.

Genular Protein ID: 93938400

Symbol: ISK13_HUMAN

Name: Serine protease inhibitor Kazal-type 13

UniProtKB Accession Codes:

Q1W4C9 A1A4Y2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 94
  • Mass: 11051
  • Checksum: 120BA36AD5A8B79F
  • Sequence:
    • MAAFPHKIIF FLVCSTLTHV AFSGIFNKRD FTRWPKPRCK MYIPLDPDYN ADCPNVTAPV 
CASNGHTFQN ECFFCVEQRE FHYRIKFEKY GKCD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.