Details for: DGKG

Gene ID: 1608

Symbol: DGKG

Ensembl ID: ENSG00000058866

Description: diacylglycerol kinase gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 219.3574
    Cell Significance Index: -34.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.9389
    Cell Significance Index: -34.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.1202
    Cell Significance Index: -35.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.6814
    Cell Significance Index: -34.1300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6442
    Cell Significance Index: -16.7300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 6.2059
    Cell Significance Index: 86.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 4.7027
    Cell Significance Index: 80.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.6255
    Cell Significance Index: 311.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.1124
    Cell Significance Index: 315.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.2831
    Cell Significance Index: 93.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.6441
    Cell Significance Index: 1200.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.8568
    Cell Significance Index: 193.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7560
    Cell Significance Index: 38.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.5130
    Cell Significance Index: 2848.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.3027
    Cell Significance Index: 2402.4500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.2924
    Cell Significance Index: 17.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.1988
    Cell Significance Index: 1845.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.1679
    Cell Significance Index: 1588.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1239
    Cell Significance Index: 30.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1073
    Cell Significance Index: 222.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9194
    Cell Significance Index: 41.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8628
    Cell Significance Index: 596.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7231
    Cell Significance Index: 137.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6714
    Cell Significance Index: 133.2400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.6626
    Cell Significance Index: 7.3100
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.6407
    Cell Significance Index: 7.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5553
    Cell Significance Index: 199.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.5280
    Cell Significance Index: 9.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5089
    Cell Significance Index: 323.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4034
    Cell Significance Index: 364.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3383
    Cell Significance Index: 33.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2199
    Cell Significance Index: 1.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1515
    Cell Significance Index: 6.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1473
    Cell Significance Index: 4.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1400
    Cell Significance Index: 22.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0667
    Cell Significance Index: 9.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0360
    Cell Significance Index: 0.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0157
    Cell Significance Index: -0.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0361
    Cell Significance Index: -3.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0446
    Cell Significance Index: -32.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0447
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0453
    Cell Significance Index: -33.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0516
    Cell Significance Index: -39.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0565
    Cell Significance Index: -30.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0599
    Cell Significance Index: -2.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0619
    Cell Significance Index: -1.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0666
    Cell Significance Index: -37.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0667
    Cell Significance Index: -12.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0700
    Cell Significance Index: -43.7400
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.0808
    Cell Significance Index: -0.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0883
    Cell Significance Index: -39.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0977
    Cell Significance Index: -28.1100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1577
    Cell Significance Index: -1.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1872
    Cell Significance Index: -23.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1918
    Cell Significance Index: -11.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2023
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2028
    Cell Significance Index: -42.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2075
    Cell Significance Index: -5.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2078
    Cell Significance Index: -35.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2325
    Cell Significance Index: -27.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2337
    Cell Significance Index: -16.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2411
    Cell Significance Index: -33.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2608
    Cell Significance Index: -3.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2688
    Cell Significance Index: -8.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2765
    Cell Significance Index: -35.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2832
    Cell Significance Index: -33.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2969
    Cell Significance Index: -6.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2989
    Cell Significance Index: -6.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3021
    Cell Significance Index: -9.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3050
    Cell Significance Index: -31.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3177
    Cell Significance Index: -4.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3297
    Cell Significance Index: -6.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3311
    Cell Significance Index: -19.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3400
    Cell Significance Index: -43.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3464
    Cell Significance Index: -6.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3468
    Cell Significance Index: -39.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4116
    Cell Significance Index: -32.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4214
    Cell Significance Index: -21.8900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4254
    Cell Significance Index: -5.4600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4516
    Cell Significance Index: -4.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4814
    Cell Significance Index: -35.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4905
    Cell Significance Index: -30.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4916
    Cell Significance Index: -11.7900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4966
    Cell Significance Index: -10.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5098
    Cell Significance Index: -28.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5184
    Cell Significance Index: -18.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5342
    Cell Significance Index: -34.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5410
    Cell Significance Index: -28.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5487
    Cell Significance Index: -28.8100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.5846
    Cell Significance Index: -7.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6005
    Cell Significance Index: -14.9800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6806
    Cell Significance Index: -7.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7026
    Cell Significance Index: -15.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.7027
    Cell Significance Index: -10.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7144
    Cell Significance Index: -33.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7456
    Cell Significance Index: -23.8800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7692
    Cell Significance Index: -9.9800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7944
    Cell Significance Index: -25.1300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.8156
    Cell Significance Index: -9.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DGKG is a member of the diacylglycerol kinase family, which catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). This reaction is essential for regulating cellular signaling pathways, particularly those involving protein kinase C (PKC). DGKG has been shown to interact with various receptors, including G protein-coupled receptors (GPCRs), and plays a role in modulating the activity of PKC. **Pathways and Functions:** DGKG is involved in multiple signaling pathways, including: 1. **G alpha (q) signaling events:** DGKG interacts with GPCRs, modulating the activity of G alpha (q) subunits, which are essential for various cellular responses, including platelet activation and aggregation. 2. **Intracellular signal transduction:** DGKG regulates the activity of PKC, which is involved in numerous cellular processes, including cell proliferation, differentiation, and survival. 3. **Lipid metabolism:** DGKG is essential for the conversion of DAG to PA, which is a key regulator of lipid metabolism and cell signaling. 4. **Neuron development and regulation:** DGKG plays a role in regulating dendrite development and neuron function, highlighting its importance in the nervous system. **Clinical Significance:** DGKG has been implicated in various diseases, including: 1. **Cardiovascular diseases:** DGKG has been shown to play a role in platelet activation and aggregation, which are key events in the development of cardiovascular diseases. 2. **Neurological disorders:** DGKG has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where dysregulation of lipid metabolism and signaling pathways contributes to disease progression. 3. **Cancer:** DGKG has been shown to regulate cell proliferation, differentiation, and survival, making it a potential target for cancer therapy. **Significantly Expressed Cells:** DGKG is expressed in various cell types, including: 1. **Anterior lens cell** 2. **Ciliary muscle cell** 3. **Lens epithelial cell** 4. **Pigmented epithelial cell** 5. **Regular ventricular cardiac myocyte** 6. **Cardiac neuron** 7. **Mature astrocyte** 8. **Astrocyte of the cerebral cortex** 9. **Contractile cell** 10. **Smooth muscle cell of sphincter of pupil** In conclusion, DGKG is a multifunctional enzyme that plays a crucial role in regulating various cellular processes, including signal transduction, lipid metabolism, and cell development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in immunological processes.

Genular Protein ID: 53157362

Symbol: DGKG_HUMAN

Name: Diacylglycerol kinase gamma

UniProtKB Accession Codes:

P49619 B2RAH4 Q2M1H4 Q5FWG1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 33 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 30 Ensembl 3 ExpressionAtlas 1 GO 18 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 Rhea 10 SABIO-RK 1 SIGNOR 1 SMART 4 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8034597

Title: Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells.

PubMed ID: 8034597

DOI: 10.1016/s0021-9258(17)32336-0

PubMed ID: 10071200

Title: Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1).

PubMed ID: 10071200

DOI: 10.1007/s004390050917

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 791
  • Mass: 89124
  • Checksum: A1382CF1B2CD7362
  • Sequence:
    • MGEERWVSLT PEEFDQLQKY SEYSSKKIKD ALTEFNEGGS LKQYDPHEPI SYDVFKLFMR 
AYLEVDLPQP LSTHLFLAFS QKPRHETSDH PTEGASNSEA NSADTNIQNA DNATKADEAC 
APDTESNMAE KQAPAEDQVA ATPLEPPVPR SSSSESPVVY LKDVVCYLSL LETGRPQDKL 
EFMFRLYDSD ENGLLDQAEM DCIVNQMLHI AQYLEWDPTE LRPILKEMLQ GMDYDRDGFV 
SLQEWVHGGM TTIPLLVLLG MDDSGSKGDG RHAWTMKHFK KPTYCNFCHI MLMGVRKQGL 
CCTYCKYTVH ERCVSRNIPG CVKTYSKAKR SGEVMQHAWV EGNSSVKCDR CHKSIKCYQS 
VTARHCVWCR MTFHRKCELS TLCDGGELRD HILLPTSICP ITRDRPGEKS DGCVSAKGEL 
VMQYKIIPTP GTHPLLVLVN PKSGGRQGER ILRKFHYLLN PKQVFNLDNG GPTPGLNFFR 
DTPDFRVLAC GGDGTVGWIL DCIDKANFAK HPPVAVLPLG TGNDLARCLR WGGGYEGGSL 
TKILKDIEQS PLVMLDRWHL EVIPREEVEN GDQVPYSIMN NYFSIGVDAS IAHRFHVMRE 
KHPEKFNSRM KNKLWYFEFG TSETFAATCK KLHDHIELEC DGVGVDLSNI FLEGIAILNI 
PSMYGGTNLW GENKKNRAVI RESRKGVTDP KELKFCVQDL SDQLLEVVGL EGAMEMGQIY 
TGLKSAGRRL AQCASVTIRT NKLLPMQVDG EPWMQPCCTI KITHKNQAPM MMGPPQKSSF 
FSLRRKSRSK D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.