Gene DGKG - ENSG00000058866 | NCBI Gene ID: 1608

Details for: DGKG

Gene ID: 1608

Symbol: DGKG

Ensembl ID: ENSG00000058866

Description: diacylglycerol kinase gamma

Associated with

Effects of pip2 hydrolysis
(R-HSA-114508)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Atp-dependent diacylglycerol kinase activity
(GO:0004143)
Atp binding
(GO:0005524)
Calcium ion binding
(GO:0005509)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Diacylglycerol metabolic process
(GO:0046339)
Glycerolipid metabolic process
(GO:0046486)
Intracellular signal transduction
(GO:0035556)
Lipid binding
(GO:0008289)
Lipid phosphorylation
(GO:0046834)
Membrane
(GO:0016020)
Negative regulation of protein kinase c signaling
(GO:0090038)
Neuron development
(GO:0048666)
Phosphatidic acid biosynthetic process
(GO:0006654)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Regulation of dendrite development
(GO:0050773)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.03
Marker Score: 5425
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.91
Marker Score: 8587.5
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.8
Marker Score: 4596
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.65
Marker Score: 15273.5
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.45
Marker Score: 77135
Cell Name: cardiac neuron (CL0010022)
Fold Change: 3.24
Marker Score: 4032
Cell Name: mature astrocyte (CL0002627)
Fold Change: 3.19
Marker Score: 2096
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.05
Marker Score: 65045
Cell Name: contractile cell (CL0000183)
Fold Change: 2.91
Marker Score: 1576
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.89
Marker Score: 913
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.87
Marker Score: 8190
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.77
Marker Score: 1618
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.54
Marker Score: 9048
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.48
Marker Score: 3070
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.34
Marker Score: 2504
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.26
Marker Score: 659
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.19
Marker Score: 5474
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.16
Marker Score: 3627
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.04
Marker Score: 1941
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.98
Marker Score: 75332
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.92
Marker Score: 18206
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.9
Marker Score: 16095
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.88
Marker Score: 16132
Cell Name: astrocyte (CL0000127)
Fold Change: 1.82
Marker Score: 1574.5
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.71
Marker Score: 3478
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1164
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.6
Marker Score: 2462
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.57
Marker Score: 31214
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.52
Marker Score: 1518.5
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.51
Marker Score: 486
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168336
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.46
Marker Score: 53731
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.44
Marker Score: 13569
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.4
Marker Score: 3307
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.33
Marker Score: 20845
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 850
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.24
Marker Score: 388
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.23
Marker Score: 41525
Cell Name: fast muscle cell (CL0000190)
Fold Change: 1.22
Marker Score: 369
Cell Name: melanocyte (CL0000148)
Fold Change: 1.17
Marker Score: 473
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 483
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.12
Marker Score: 734
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.11
Marker Score: 68183
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.1
Marker Score: 5095
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 499
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.06
Marker Score: 1487.5
Cell Name: megakaryocyte (CL0000556)
Fold Change: 1.04
Marker Score: 593
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.04
Marker Score: 18414
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.01
Marker Score: 4199
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71803
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48028
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.99
Marker Score: 473
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.94
Marker Score: 244
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.93
Marker Score: 558
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.93
Marker Score: 7104
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 371
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.91
Marker Score: 2622
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5154
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.9
Marker Score: 246
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.87
Marker Score: 295
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.86
Marker Score: 660
Cell Name: neuron (CL0000540)
Fold Change: 0.86
Marker Score: 3498
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.85
Marker Score: 356
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.84
Marker Score: 12611
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.83
Marker Score: 301
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.82
Marker Score: 3182
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.8
Marker Score: 2825
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.79
Marker Score: 548
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.78
Marker Score: 4677
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.77
Marker Score: 447
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.77
Marker Score: 882
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.76
Marker Score: 308
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 687
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.75
Marker Score: 3151
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.73
Marker Score: 254
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 459
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.69
Marker Score: 7129
Cell Name: T cell (CL0000084)
Fold Change: 0.67
Marker Score: 1156
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.66
Marker Score: 169
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.66
Marker Score: 1545
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.65
Marker Score: 207
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.65
Marker Score: 2166
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.64
Marker Score: 572
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.63
Marker Score: 433
Cell Name: pericyte (CL0000669)
Fold Change: 0.62
Marker Score: 362
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.61
Marker Score: 297
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.61
Marker Score: 270
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.6
Marker Score: 1439
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.54
Marker Score: 355

Hover over a box to see details here...

**Key characteristics:** * DGKG is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the DGK family of serine/threonine kinases. * DGKG is a key regulator of calcium signaling, as it is a key enzyme in the regulation of calcium-dependent processes such as cell cycle progression, proliferation, and apoptosis. * DGKG is also involved in the regulation of platelet activation and aggregation. * It is a key regulator of blood clotting, as it is involved in the regulation of hemostasis. **Pathways and functions:** * DGKG is involved in the regulation of cell cycle progression, proliferation, and apoptosis. * It is a key regulator of the cell cycle, as it is involved in the regulation of cell cycle checkpoints, such as the G1/S transition. * DGKG is also involved in the regulation of apoptosis, as it is a key regulator of the decision of cells to undergo apoptosis or survive. * It is also involved in the regulation of inflammation, as it is a key regulator of the production of inflammatory cytokines. * DGKG is involved in the regulation of platelet activation and aggregation. * It is a key regulator of blood clotting, as it is involved in the regulation of hemostasis. **Clinical significance:** * Mutations in DGKG have been linked to a number of human diseases, including cardiovascular disease, stroke, and cancer. * DGKG inhibitors are being investigated as a potential treatment for these diseases. * By understanding the role of DGKG in human disease, it may be possible to develop new therapies for these conditions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Diacylglycerol kinase gamma

Genular Protein ID: 53157362

Symbol: DGKG_HUMAN

Name: Diacylglycerol kinase gamma

UniProtKB Accession Codes:

P49619 B2RAH4 Q2M1H4 Q5FWG1

Database IDs:

Citations:

PubMed ID: 8034597

Title: Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells.

PubMed ID: 8034597

DOI: 10.1016/s0021-9258(17)32336-0

PubMed ID: 10071200

Title: Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1).

PubMed ID: 10071200

DOI: 10.1007/s004390050917

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 791
Mass: 89124
Checksum: A1382CF1B2CD7362
Sequence:

MGEERWVSLT PEEFDQLQKY SEYSSKKIKD ALTEFNEGGS LKQYDPHEPI SYDVFKLFMR 
AYLEVDLPQP LSTHLFLAFS QKPRHETSDH PTEGASNSEA NSADTNIQNA DNATKADEAC 
APDTESNMAE KQAPAEDQVA ATPLEPPVPR SSSSESPVVY LKDVVCYLSL LETGRPQDKL 
EFMFRLYDSD ENGLLDQAEM DCIVNQMLHI AQYLEWDPTE LRPILKEMLQ GMDYDRDGFV 
SLQEWVHGGM TTIPLLVLLG MDDSGSKGDG RHAWTMKHFK KPTYCNFCHI MLMGVRKQGL 
CCTYCKYTVH ERCVSRNIPG CVKTYSKAKR SGEVMQHAWV EGNSSVKCDR CHKSIKCYQS 
VTARHCVWCR MTFHRKCELS TLCDGGELRD HILLPTSICP ITRDRPGEKS DGCVSAKGEL 
VMQYKIIPTP GTHPLLVLVN PKSGGRQGER ILRKFHYLLN PKQVFNLDNG GPTPGLNFFR 
DTPDFRVLAC GGDGTVGWIL DCIDKANFAK HPPVAVLPLG TGNDLARCLR WGGGYEGGSL 
TKILKDIEQS PLVMLDRWHL EVIPREEVEN GDQVPYSIMN NYFSIGVDAS IAHRFHVMRE 
KHPEKFNSRM KNKLWYFEFG TSETFAATCK KLHDHIELEC DGVGVDLSNI FLEGIAILNI 
PSMYGGTNLW GENKKNRAVI RESRKGVTDP KELKFCVQDL SDQLLEVVGL EGAMEMGQIY 
TGLKSAGRRL AQCASVTIRT NKLLPMQVDG EPWMQPCCTI KITHKNQAPM MMGPPQKSSF 
FSLRRKSRSK D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DGKG

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells. PubMed ID: 8034597

Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1). PubMed ID: 10071200

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334