Details for: DCT

Gene ID: 1638

Symbol: DCT

Ensembl ID: ENSG00000080166

Description: dopachrome tautomerase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.36
    Marker Score: 14060
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.27
    Marker Score: 2461
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.75
    Marker Score: 936
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.7
    Marker Score: 536
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.66
    Marker Score: 3146
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.16
    Marker Score: 2367
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.15
    Marker Score: 464
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.03
    Marker Score: 6837
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.02
    Marker Score: 297
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15668
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2498
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.98
    Marker Score: 969
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.97
    Marker Score: 584
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.95
    Marker Score: 369
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.72
    Marker Score: 232
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.72
    Marker Score: 1480
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.7
    Marker Score: 335
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.63
    Marker Score: 1726
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.6
    Marker Score: 208
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 471
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.48
    Marker Score: 746
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.44
    Marker Score: 1775
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.43
    Marker Score: 189
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.42
    Marker Score: 389
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.41
    Marker Score: 163
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 217
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.36
    Marker Score: 3397
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.35
    Marker Score: 155
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.34
    Marker Score: 20957
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.33
    Marker Score: 2821
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.32
    Marker Score: 333
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.3
    Marker Score: 257
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.28
    Marker Score: 2650
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.28
    Marker Score: 2827
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.25
    Marker Score: 382
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.24
    Marker Score: 5181
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.23
    Marker Score: 85
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.21
    Marker Score: 7931
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.21
    Marker Score: 471.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.21
    Marker Score: 70
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.2
    Marker Score: 49
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.19
    Marker Score: 3726
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.17
    Marker Score: 2485
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.16
    Marker Score: 1700
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 382
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.16
    Marker Score: 198
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.14
    Marker Score: 412
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.14
    Marker Score: 548
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 158
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.12
    Marker Score: 59
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.11
    Marker Score: 4281
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 123
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.11
    Marker Score: 376
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1
    Marker Score: 145
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.1
    Marker Score: 432
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1
    Marker Score: 588
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.1
    Marker Score: 733
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.09
    Marker Score: 165
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.09
    Marker Score: 1184
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.09
    Marker Score: 98
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.09
    Marker Score: 369
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.08
    Marker Score: 135
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.08
    Marker Score: 131
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.07
    Marker Score: 97
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 131
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.07
    Marker Score: 70

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The DCT gene is located on chromosome 17q21.1. - It is a large gene, encoding a protein that is over 1,000 amino acids long. - The DCT protein is a transmembrane protein that is expressed in a variety of cell types. - It is responsible for the conversion of dopachrome, a pigment that is produced by the enzyme tyrosinase, into dopachrome tautomerase. - Dopachrome tautomerase is an enzyme that is involved in the biosynthesis of melanin, a pigment that gives skin its color. **Pathways and functions:** - The DCT gene is involved in the development and maintenance of the skin, eyes, and hair. - It is expressed in cells that are responsible for producing or regulating melanin. - Melanin is a pigment that is responsible for the color of hair, eyes, and skin. - The DCT gene is also involved in the regulation of neuroblast proliferation. - It is expressed in cells that are responsible for the development of the central nervous system. **Clinical significance:** - Mutations in the DCT gene have been linked to a number of human diseases, including albinism, which is a condition in which the skin, eyes, and hair are unable to produce melanin. - The DCT gene is also involved in the regulation of the immune system, and mutations in the gene have been linked to a number of autoimmune diseases. - Targeting the DCT gene has been investigated as a therapeutic strategy for a variety of diseases, including cancer and albinism.

Genular Protein ID: 2953912995

Symbol: TYRP2_HUMAN

Name: L-dopachrome Delta-isomerase

UniProtKB Accession Codes:

P40126 Q09GT4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8148378

Title: Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2.

PubMed ID: 8148378

DOI: 10.1016/0167-4781(94)90292-5

PubMed ID: 8206391

Title: Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA.

PubMed ID: 8206391

DOI: 10.1016/0378-1119(94)90114-7

PubMed ID: 8306979

Title: Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells.

PubMed ID: 8306979

DOI: 10.1111/j.1432-1033.1994.tb19922.x

PubMed ID: 11777994

Title: Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy.

PubMed ID: 11777994

DOI: 10.4049/jimmunol.168.2.951

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8530077

Title: Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family.

PubMed ID: 8530077

DOI: 10.1006/geno.1995.1211

PubMed ID: 7929451

Title: Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression.

PubMed ID: 7929451

DOI: 10.1016/s0021-9258(18)47128-1

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 28842328

Title: Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3.

PubMed ID: 28842328

DOI: 10.1016/j.jid.2017.07.833

PubMed ID: 33100333

Title: Dopachrome tautomerase variants in patients with oculocutaneous albinism.

PubMed ID: 33100333

DOI: 10.1038/s41436-020-00997-8

Sequence Information:

  • Length: 519
  • Mass: 59145
  • Checksum: AFDDF21768002A89
  • Sequence:
    • MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN VCGSQQGRGQ 
CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN FAGYNCGDCK FGWTGPNCER 
KKPPVIRQNI HSLSPQEREQ FLGALDLAKK RVHPDYVITT QHWLGLLGPN GTQPQFANCS 
VYDFFVWLHY YSVRDTLLGP GRPYRAIDFS HQGPAFVTWH RYHLLCLERD LQRLIGNESF 
ALPYWNFATG RNECDVCTDQ LFGAARPDDP TLISRNSRFS SWETVCDSLD DYNHLVTLCN 
GTYEGLLRRN QMGRNSMKLP TLKDIRDCLS LQKFDNPPFF QNSTFSFRNA LEGFDKADGT 
LDSQVMSLHN LVHSFLNGTN ALPHSAANDP IFVVLHSFTD AIFDEWMKRF NPPADAWPQE 
LAPIGHNRMY NMVPFFPPVT NEELFLTSDQ LGYSYAIDLP VSVEETPGWP TTLLVVMGTL 
VALVGLFVLL AFLQYRRLRK GYTPLMETHL SSKRYTEEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.