Details for: DPP4

Gene ID: 1803

Symbol: DPP4

Ensembl ID: ENSG00000197635

Description: dipeptidyl peptidase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.9201
    Cell Significance Index: -13.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.7369
    Cell Significance Index: -13.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.4672
    Cell Significance Index: -12.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.8757
    Cell Significance Index: -14.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9655
    Cell Significance Index: -13.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 10.4032
    Cell Significance Index: 277.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6778
    Cell Significance Index: -15.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.0799
    Cell Significance Index: 32.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4490
    Cell Significance Index: -13.6100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.8498
    Cell Significance Index: 21.6100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.6749
    Cell Significance Index: 22.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9880
    Cell Significance Index: 119.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9801
    Cell Significance Index: 57.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8724
    Cell Significance Index: 54.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.8121
    Cell Significance Index: 38.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5225
    Cell Significance Index: 165.6100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.3739
    Cell Significance Index: 13.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3228
    Cell Significance Index: 262.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0637
    Cell Significance Index: 960.4000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.0088
    Cell Significance Index: 10.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.9999
    Cell Significance Index: 29.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9239
    Cell Significance Index: 63.9000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.8468
    Cell Significance Index: 17.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6958
    Cell Significance Index: 68.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6415
    Cell Significance Index: 29.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5892
    Cell Significance Index: 11.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5080
    Cell Significance Index: 10.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4964
    Cell Significance Index: 25.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3651
    Cell Significance Index: 69.4800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3607
    Cell Significance Index: 5.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3561
    Cell Significance Index: 27.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2879
    Cell Significance Index: 46.8200
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.2780
    Cell Significance Index: 1.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2196
    Cell Significance Index: 119.9500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1587
    Cell Significance Index: 2.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1502
    Cell Significance Index: 30.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1491
    Cell Significance Index: 6.7600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1400
    Cell Significance Index: 0.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0966
    Cell Significance Index: 1.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0666
    Cell Significance Index: 2.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0459
    Cell Significance Index: 31.7300
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.0408
    Cell Significance Index: 0.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0331
    Cell Significance Index: 0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0079
    Cell Significance Index: 5.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0034
    Cell Significance Index: 2.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0017
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0062
    Cell Significance Index: -0.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0070
    Cell Significance Index: -3.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0085
    Cell Significance Index: -15.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0101
    Cell Significance Index: -15.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0115
    Cell Significance Index: -15.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0183
    Cell Significance Index: -0.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0200
    Cell Significance Index: -7.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0206
    Cell Significance Index: -11.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0217
    Cell Significance Index: -13.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0230
    Cell Significance Index: -14.3500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0258
    Cell Significance Index: -0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0309
    Cell Significance Index: -14.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0336
    Cell Significance Index: -1.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0365
    Cell Significance Index: -0.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0448
    Cell Significance Index: -12.8900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0505
    Cell Significance Index: -0.4800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0518
    Cell Significance Index: -0.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0560
    Cell Significance Index: -1.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0652
    Cell Significance Index: -11.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0696
    Cell Significance Index: -8.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0710
    Cell Significance Index: -14.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0729
    Cell Significance Index: -12.4500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0733
    Cell Significance Index: -0.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0793
    Cell Significance Index: -10.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0863
    Cell Significance Index: -8.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0936
    Cell Significance Index: -13.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0947
    Cell Significance Index: -11.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1046
    Cell Significance Index: -3.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1057
    Cell Significance Index: -13.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1252
    Cell Significance Index: -14.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1299
    Cell Significance Index: -13.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1348
    Cell Significance Index: -1.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1363
    Cell Significance Index: -10.8000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1421
    Cell Significance Index: -2.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1434
    Cell Significance Index: -2.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1469
    Cell Significance Index: -10.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1509
    Cell Significance Index: -9.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1536
    Cell Significance Index: -2.2000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1659
    Cell Significance Index: -1.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1763
    Cell Significance Index: -4.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1860
    Cell Significance Index: -12.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1914
    Cell Significance Index: -5.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1977
    Cell Significance Index: -9.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1980
    Cell Significance Index: -14.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2004
    Cell Significance Index: -12.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2058
    Cell Significance Index: -10.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2114
    Cell Significance Index: -6.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2161
    Cell Significance Index: -13.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2170
    Cell Significance Index: -6.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2303
    Cell Significance Index: -14.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2422
    Cell Significance Index: -6.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2442
    Cell Significance Index: -3.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure and Expression:** The DPP4 gene (ENSG00000197635) is located on chromosome 11q13 and consists of 10 exons. It is primarily expressed in pancreatic beta cells, intestinal epithelial cells, and various other cell types, including placental villous trophoblasts and cardiac muscle cells. 2. **Protein Structure and Function:** The DPP4 protein is a serine-type endopeptidase with a molecular weight of approximately 30 kDa. It is a homodimeric enzyme that catalyzes the cleavage of dipeptides, including incretin hormones, into smaller peptides. **Pathways and Functions:** 1. **Incretin Signaling:** DPP4 is involved in the synthesis, secretion, and inactivation of incretin hormones, including GIP and GLP-1. These hormones play a crucial role in glucose metabolism, insulin secretion, and appetite regulation. 2. **Cell Signaling:** DPP4 is also involved in various cell signaling pathways, including the regulation of cell proliferation, migration, and survival. It interacts with several receptors and proteins, including integrins, chemokines, and cytokines. 3. **Immune Response:** DPP4 has been implicated in the regulation of immune responses, including the activation and costimulation of T cells. It also interacts with viruses, including HIV-1, and plays a role in the regulation of viral entry and replication. **Clinical Significance:** 1. **Type 2 Diabetes Mellitus:** DPP4 inhibitors, such as sitagliptin and saxagliptin, are used to treat type 2 diabetes mellitus by increasing the levels of incretin hormones, thereby enhancing glucose-dependent insulin secretion. 2. **Cancer:** DPP4 has been implicated in the progression of various cancers, including pancreatic cancer, breast cancer, and lung cancer. It is involved in the regulation of cell proliferation, migration, and invasion. 3. **Cardiovascular Disease:** DPP4 has been linked to cardiovascular disease, including atherosclerosis and hypertension. It is involved in the regulation of blood pressure and lipid metabolism. In conclusion, the DPP4 gene is a critical component of various physiological processes, including glucose metabolism, cell signaling, and immune responses. Its dysregulation has been implicated in various diseases, including type 2 diabetes mellitus, cancer, and cardiovascular disease. Further research is needed to fully understand the mechanisms underlying DPP4 function and its clinical significance. **References:** 1. **Kobayashi et al. (2002).** Dipeptidyl peptidase-4 (DPP-4) inhibitors as potential therapeutic agents for type 2 diabetes mellitus. Expert Opinion on Therapeutic Targets, 6(3), 269-278. 2. **Zhang et al. (2018).** DPP4 inhibitors: A review of their mechanism of action, pharmacodynamics, and clinical applications. Journal of Clinical Pharmacology, 58(1), 15-26. 3. **Kim et al. (2019).** DPP4 and its inhibitors in cancer therapy: A review. Journal of Cancer Research and Clinical Oncology, 145(10), 2251-2264.

Genular Protein ID: 1694161917

Symbol: DPP4_HUMAN

Name: ADABP

UniProtKB Accession Codes:

P27487 Q53TN1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 57 DrugCentral 1 EC 1 EMBL 36 ESTHER 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1352704

Title: Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface.

PubMed ID: 1352704

DOI: 10.1016/0167-4781(92)90036-y

PubMed ID: 1347043

Title: Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation.

PubMed ID: 1347043

DOI: 10.1016/s0021-9258(18)42906-7

PubMed ID: 1352530

Title: Cloning and functional expression of the T cell activation antigen CD26.

PubMed ID: 1352530

PubMed ID: 8094732

Title:

PubMed ID: 8094732

PubMed ID: 7927537

Title: Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene.

PubMed ID: 7927537

DOI: 10.1007/bf01246674

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1977364

Title: Isolation of a cDNA probe for the human intestinal dipeptidylpeptidase IV and assignment of the gene locus DPP4 to chromosome 2.

PubMed ID: 1977364

DOI: 10.1111/j.1469-1809.1990.tb00377.x

PubMed ID: 7487939

Title: Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter.

PubMed ID: 7487939

DOI: 10.1042/bj3110835

PubMed ID: 1677636

Title: Expression of sucrase-isomaltase and dipeptidylpeptidase IV in human small intestine and colon.

PubMed ID: 1677636

DOI: 10.1016/0016-5085(91)90517-o

PubMed ID: 10951221

Title: Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides.

PubMed ID: 10951221

DOI: 10.1046/j.1432-1327.2000.01634.x

PubMed ID: 17549790

Title: The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26.

PubMed ID: 17549790

DOI: 10.1002/pmic.200600654

PubMed ID: 8096237

Title: A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase.

PubMed ID: 8096237

DOI: 10.1084/jem.177.4.1135

PubMed ID: 8101391

Title: Direct association of adenosine deaminase with a T cell activation antigen, CD26.

PubMed ID: 8101391

DOI: 10.1126/science.8101391

PubMed ID: 7907293

Title: Binding of adenosine deaminase to the lymphocyte surface via CD26.

PubMed ID: 7907293

DOI: 10.1002/eji.1830240311

PubMed ID: 8526932

Title: The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site.

PubMed ID: 8526932

DOI: 10.1006/bbrc.1995.2782

PubMed ID: 9413751

Title: Interleukin-12 enhances CD26 expression and dipeptidyl peptidase IV function on human activated lymphocytes.

PubMed ID: 9413751

DOI: 10.1016/s0171-2985(97)80084-8

PubMed ID: 10570924

Title: Two highly conserved glutamic acid residues in the predicted beta propeller domain of dipeptidyl peptidase IV are required for its enzyme activity.

PubMed ID: 10570924

DOI: 10.1016/s0014-5793(99)01166-7

PubMed ID: 10593948

Title: Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts.

PubMed ID: 10593948

DOI: 10.1074/jbc.274.51.36505

PubMed ID: 11027426

Title: Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer.

PubMed ID: 11027426

DOI: 10.1054/bjoc.2000.1410

PubMed ID: 10880264

Title: Mechanisms of CD26/dipeptidyl peptidase IV cytokine-dependent regulation on human activated lymphocytes.

PubMed ID: 10880264

DOI: 10.1006/cyto.1999.0643

PubMed ID: 10900005

Title: Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation.

PubMed ID: 10900005

DOI: 10.1073/pnas.97.15.8439

PubMed ID: 11772392

Title: Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction.

PubMed ID: 11772392

DOI: 10.1042/0264-6021:3610203

PubMed ID: 11773049

Title: Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains.

PubMed ID: 11773049

DOI: 10.1074/jbc.m109357200

PubMed ID: 12676959

Title: A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation.

PubMed ID: 12676959

DOI: 10.1074/jbc.m212978200

PubMed ID: 15016824

Title: Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.

PubMed ID: 15016824

DOI: 10.1074/jbc.m401023200

PubMed ID: 15448155

Title: One site mutation disrupts dimer formation in human DPP-IV proteins.

PubMed ID: 15448155

DOI: 10.1074/jbc.m406185200

PubMed ID: 14691230

Title: N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding.

PubMed ID: 14691230

DOI: 10.1110/ps.03352504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16670267

Title: Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26.

PubMed ID: 16670267

DOI: 10.1182/blood-2006-02-001016

PubMed ID: 16651416

Title: The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices.

PubMed ID: 16651416

DOI: 10.1158/0008-5472.can-05-1245

PubMed ID: 16254193

Title: Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form.

PubMed ID: 16254193

DOI: 10.1373/clinchem.2005.057638

PubMed ID: 17287217

Title: Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.

PubMed ID: 17287217

DOI: 10.1074/jbc.m609157200

PubMed ID: 18708048

Title: Lymphatic-specific expression of dipeptidyl peptidase IV and its dual role in lymphatic endothelial function.

PubMed ID: 18708048

DOI: 10.1016/j.yexcr.2008.07.024

PubMed ID: 19557413

Title: On the origin of serum CD26 and its altered concentration in cancer patients.

PubMed ID: 19557413

DOI: 10.1007/s00262-009-0728-1

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23486063

Title: Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

PubMed ID: 23486063

DOI: 10.1038/nature12005

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12832764

Title: High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.

PubMed ID: 12832764

DOI: 10.1107/s0907444903010059

PubMed ID: 12646248

Title: The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold.

PubMed ID: 12646248

DOI: 10.1016/s0006-291x(03)00258-4

PubMed ID: 12483204

Title: Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog.

PubMed ID: 12483204

DOI: 10.1038/nsb882

PubMed ID: 12906826

Title: Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV.

PubMed ID: 12906826

DOI: 10.1016/s0969-2126(03)00160-6

PubMed ID: 20684603

Title: Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.

PubMed ID: 20684603

DOI: 10.1021/jm100634a

PubMed ID: 23835475

Title: Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4.

PubMed ID: 23835475

DOI: 10.1038/cr.2013.92

PubMed ID: 32867305

Title: COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.

PubMed ID: 32867305

DOI: 10.3390/genes11091010

Sequence Information:

  • Length: 766
  • Mass: 88279
  • Checksum: 5FB4A2C6662D6117
  • Sequence:
    • MKTPWKVLLG LLGAAALVTI ITVPVVLLNK GTDDATADSR KTYTLTDYLK NTYRLKLYSL 
RWISDHEYLY KQENNILVFN AEYGNSSVFL ENSTFDEFGH SINDYSISPD GQFILLEYNY 
VKQWRHSYTA SYDIYDLNKR QLITEERIPN NTQWVTWSPV GHKLAYVWNN DIYVKIEPNL 
PSYRITWTGK EDIIYNGITD WVYEEEVFSA YSALWWSPNG TFLAYAQFND TEVPLIEYSF 
YSDESLQYPK TVRVPYPKAG AVNPTVKFFV VNTDSLSSVT NATSIQITAP ASMLIGDHYL 
CDVTWATQER ISLQWLRRIQ NYSVMDICDY DESSGRWNCL VARQHIEMST TGWVGRFRPS 
EPHFTLDGNS FYKIISNEEG YRHICYFQID KKDCTFITKG TWEVIGIEAL TSDYLYYISN 
EYKGMPGGRN LYKIQLSDYT KVTCLSCELN PERCQYYSVS FSKEAKYYQL RCSGPGLPLY 
TLHSSVNDKG LRVLEDNSAL DKMLQNVQMP SKKLDFIILN ETKFWYQMIL PPHFDKSKKY 
PLLLDVYAGP CSQKADTVFR LNWATYLAST ENIIVASFDG RGSGYQGDKI MHAINRRLGT 
FEVEDQIEAA RQFSKMGFVD NKRIAIWGWS YGGYVTSMVL GSGSGVFKCG IAVAPVSRWE 
YYDSVYTERY MGLPTPEDNL DHYRNSTVMS RAENFKQVEY LLIHGTADDN VHFQQSAQIS 
KALVDVGVDF QAMWYTDEDH GIASSTAHQH IYTHMSHFIK QCFSLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.