Details for: DPP4

Gene ID: 1803

Symbol: DPP4

Ensembl ID: ENSG00000197635

Description: dipeptidyl peptidase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 4.98
    Marker Score: 15967
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.62
    Marker Score: 10735
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.11
    Marker Score: 4809
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.76
    Marker Score: 4316
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.75
    Marker Score: 6868
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.7
    Marker Score: 22613.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.65
    Marker Score: 2536
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.64
    Marker Score: 717
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.6
    Marker Score: 13707
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.45
    Marker Score: 842
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.42
    Marker Score: 1164.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.38
    Marker Score: 8801
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.29
    Marker Score: 859
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.26
    Marker Score: 1279
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.26
    Marker Score: 4472
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.26
    Marker Score: 6044
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.21
    Marker Score: 488
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2168.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.14
    Marker Score: 2678
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16960
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.03
    Marker Score: 5419
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71785
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48009
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.99
    Marker Score: 881
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.97
    Marker Score: 335
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1522
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5241
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.88
    Marker Score: 206
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.87
    Marker Score: 13983
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.86
    Marker Score: 423
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.81
    Marker Score: 380
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.81
    Marker Score: 235
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.79
    Marker Score: 394
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.77
    Marker Score: 233
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.76
    Marker Score: 3180
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.76
    Marker Score: 287
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.76
    Marker Score: 1810
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.75
    Marker Score: 4894
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 296
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.73
    Marker Score: 428
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2970
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.7
    Marker Score: 743
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.7
    Marker Score: 170
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.7
    Marker Score: 358
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 630
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.68
    Marker Score: 209.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.65
    Marker Score: 210
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.64
    Marker Score: 331
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.64
    Marker Score: 256
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.63
    Marker Score: 630
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.63
    Marker Score: 438
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.63
    Marker Score: 33191
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.62
    Marker Score: 256
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 369
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.61
    Marker Score: 1195
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.6
    Marker Score: 5936
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.58
    Marker Score: 301
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.58
    Marker Score: 623.5
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.58
    Marker Score: 157
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.57
    Marker Score: 157
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.56
    Marker Score: 2382
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.56
    Marker Score: 1743
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.55
    Marker Score: 340
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.55
    Marker Score: 137
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.55
    Marker Score: 848.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.55
    Marker Score: 873
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.53
    Marker Score: 847
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.52
    Marker Score: 323
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.51
    Marker Score: 539
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.51
    Marker Score: 331
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.5
    Marker Score: 11214.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.5
    Marker Score: 1341
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.5
    Marker Score: 1123
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5
    Marker Score: 3202
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.5
    Marker Score: 188
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.48
    Marker Score: 105
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.48
    Marker Score: 174
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.48
    Marker Score: 107
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.47
    Marker Score: 225
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.47
    Marker Score: 298
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.46
    Marker Score: 429
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.46
    Marker Score: 182
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.45
    Marker Score: 27980.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.45
    Marker Score: 351
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.44
    Marker Score: 322
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.44
    Marker Score: 141
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.43
    Marker Score: 866

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Other Information

**Key characteristics:** * DPP4 is a serine-type endopeptidase that is expressed in high levels in the central nervous system (CNS). * It is a key enzyme in the regulation of neurotransmitter release and synaptic plasticity. * DPP4 is also involved in inflammation and immune responses. **Pathways and functions:** * DPP4 is involved in the regulation of neurotransmitter release from presynaptic neurons. * It is a key enzyme in the regulation of synaptic plasticity, which is the ability of the brain to modify its structure and function in response to experience. * DPP4 is also involved in the regulation of inflammation and immune responses. * It is a key enzyme in the production of growth factors and cytokines, which are proteins that regulate cell growth, differentiation, and inflammation. **Clinical significance:** * Mutations in the DPP4 gene have been linked to several neurological disorders, including autism, schizophrenia, and depression. * DPP4 inhibitors are being investigated as potential treatments for these disorders. **Additional information:** * The gene encoding DPP4 is located on chromosome 15q21.1. * It is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. * DPP4 is a relatively new protein, with the first human gene encoding the protein being identified in 1993.

Genular Protein ID: 1694161917

Symbol: DPP4_HUMAN

Name: ADABP

UniProtKB Accession Codes:

P27487 Q53TN1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 57 DrugCentral 1 EC 1 EMBL 36 ESTHER 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1352704

Title: Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface.

PubMed ID: 1352704

DOI: 10.1016/0167-4781(92)90036-y

PubMed ID: 1347043

Title: Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation.

PubMed ID: 1347043

DOI: 10.1016/s0021-9258(18)42906-7

PubMed ID: 1352530

Title: Cloning and functional expression of the T cell activation antigen CD26.

PubMed ID: 1352530

PubMed ID: 8094732

Title:

PubMed ID: 8094732

PubMed ID: 7927537

Title: Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene.

PubMed ID: 7927537

DOI: 10.1007/bf01246674

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1977364

Title: Isolation of a cDNA probe for the human intestinal dipeptidylpeptidase IV and assignment of the gene locus DPP4 to chromosome 2.

PubMed ID: 1977364

DOI: 10.1111/j.1469-1809.1990.tb00377.x

PubMed ID: 7487939

Title: Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter.

PubMed ID: 7487939

DOI: 10.1042/bj3110835

PubMed ID: 1677636

Title: Expression of sucrase-isomaltase and dipeptidylpeptidase IV in human small intestine and colon.

PubMed ID: 1677636

DOI: 10.1016/0016-5085(91)90517-o

PubMed ID: 10951221

Title: Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides.

PubMed ID: 10951221

DOI: 10.1046/j.1432-1327.2000.01634.x

PubMed ID: 17549790

Title: The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26.

PubMed ID: 17549790

DOI: 10.1002/pmic.200600654

PubMed ID: 8096237

Title: A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase.

PubMed ID: 8096237

DOI: 10.1084/jem.177.4.1135

PubMed ID: 8101391

Title: Direct association of adenosine deaminase with a T cell activation antigen, CD26.

PubMed ID: 8101391

DOI: 10.1126/science.8101391

PubMed ID: 7907293

Title: Binding of adenosine deaminase to the lymphocyte surface via CD26.

PubMed ID: 7907293

DOI: 10.1002/eji.1830240311

PubMed ID: 8526932

Title: The cysteine-rich region of dipeptidyl peptidase IV (CD 26) is the collagen-binding site.

PubMed ID: 8526932

DOI: 10.1006/bbrc.1995.2782

PubMed ID: 9413751

Title: Interleukin-12 enhances CD26 expression and dipeptidyl peptidase IV function on human activated lymphocytes.

PubMed ID: 9413751

DOI: 10.1016/s0171-2985(97)80084-8

PubMed ID: 10570924

Title: Two highly conserved glutamic acid residues in the predicted beta propeller domain of dipeptidyl peptidase IV are required for its enzyme activity.

PubMed ID: 10570924

DOI: 10.1016/s0014-5793(99)01166-7

PubMed ID: 10593948

Title: Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts.

PubMed ID: 10593948

DOI: 10.1074/jbc.274.51.36505

PubMed ID: 11027426

Title: Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer.

PubMed ID: 11027426

DOI: 10.1054/bjoc.2000.1410

PubMed ID: 10880264

Title: Mechanisms of CD26/dipeptidyl peptidase IV cytokine-dependent regulation on human activated lymphocytes.

PubMed ID: 10880264

DOI: 10.1006/cyto.1999.0643

PubMed ID: 10900005

Title: Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation.

PubMed ID: 10900005

DOI: 10.1073/pnas.97.15.8439

PubMed ID: 11772392

Title: Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction.

PubMed ID: 11772392

DOI: 10.1042/0264-6021:3610203

PubMed ID: 11773049

Title: Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains.

PubMed ID: 11773049

DOI: 10.1074/jbc.m109357200

PubMed ID: 12676959

Title: A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation.

PubMed ID: 12676959

DOI: 10.1074/jbc.m212978200

PubMed ID: 15016824

Title: Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.

PubMed ID: 15016824

DOI: 10.1074/jbc.m401023200

PubMed ID: 15448155

Title: One site mutation disrupts dimer formation in human DPP-IV proteins.

PubMed ID: 15448155

DOI: 10.1074/jbc.m406185200

PubMed ID: 14691230

Title: N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding.

PubMed ID: 14691230

DOI: 10.1110/ps.03352504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16670267

Title: Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26.

PubMed ID: 16670267

DOI: 10.1182/blood-2006-02-001016

PubMed ID: 16651416

Title: The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices.

PubMed ID: 16651416

DOI: 10.1158/0008-5472.can-05-1245

PubMed ID: 16254193

Title: Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form.

PubMed ID: 16254193

DOI: 10.1373/clinchem.2005.057638

PubMed ID: 17287217

Title: Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.

PubMed ID: 17287217

DOI: 10.1074/jbc.m609157200

PubMed ID: 18708048

Title: Lymphatic-specific expression of dipeptidyl peptidase IV and its dual role in lymphatic endothelial function.

PubMed ID: 18708048

DOI: 10.1016/j.yexcr.2008.07.024

PubMed ID: 19557413

Title: On the origin of serum CD26 and its altered concentration in cancer patients.

PubMed ID: 19557413

DOI: 10.1007/s00262-009-0728-1

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23486063

Title: Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

PubMed ID: 23486063

DOI: 10.1038/nature12005

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12832764

Title: High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.

PubMed ID: 12832764

DOI: 10.1107/s0907444903010059

PubMed ID: 12646248

Title: The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold.

PubMed ID: 12646248

DOI: 10.1016/s0006-291x(03)00258-4

PubMed ID: 12483204

Title: Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog.

PubMed ID: 12483204

DOI: 10.1038/nsb882

PubMed ID: 12906826

Title: Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV.

PubMed ID: 12906826

DOI: 10.1016/s0969-2126(03)00160-6

PubMed ID: 20684603

Title: Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.

PubMed ID: 20684603

DOI: 10.1021/jm100634a

PubMed ID: 23835475

Title: Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4.

PubMed ID: 23835475

DOI: 10.1038/cr.2013.92

PubMed ID: 32867305

Title: COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.

PubMed ID: 32867305

DOI: 10.3390/genes11091010

Sequence Information:

  • Length: 766
  • Mass: 88279
  • Checksum: 5FB4A2C6662D6117
  • Sequence:
    • MKTPWKVLLG LLGAAALVTI ITVPVVLLNK GTDDATADSR KTYTLTDYLK NTYRLKLYSL 
RWISDHEYLY KQENNILVFN AEYGNSSVFL ENSTFDEFGH SINDYSISPD GQFILLEYNY 
VKQWRHSYTA SYDIYDLNKR QLITEERIPN NTQWVTWSPV GHKLAYVWNN DIYVKIEPNL 
PSYRITWTGK EDIIYNGITD WVYEEEVFSA YSALWWSPNG TFLAYAQFND TEVPLIEYSF 
YSDESLQYPK TVRVPYPKAG AVNPTVKFFV VNTDSLSSVT NATSIQITAP ASMLIGDHYL 
CDVTWATQER ISLQWLRRIQ NYSVMDICDY DESSGRWNCL VARQHIEMST TGWVGRFRPS 
EPHFTLDGNS FYKIISNEEG YRHICYFQID KKDCTFITKG TWEVIGIEAL TSDYLYYISN 
EYKGMPGGRN LYKIQLSDYT KVTCLSCELN PERCQYYSVS FSKEAKYYQL RCSGPGLPLY 
TLHSSVNDKG LRVLEDNSAL DKMLQNVQMP SKKLDFIILN ETKFWYQMIL PPHFDKSKKY 
PLLLDVYAGP CSQKADTVFR LNWATYLAST ENIIVASFDG RGSGYQGDKI MHAINRRLGT 
FEVEDQIEAA RQFSKMGFVD NKRIAIWGWS YGGYVTSMVL GSGSGVFKCG IAVAPVSRWE 
YYDSVYTERY MGLPTPEDNL DHYRNSTVMS RAENFKQVEY LLIHGTADDN VHFQQSAQIS 
KALVDVGVDF QAMWYTDEDH GIASSTAHQH IYTHMSHFIK QCFSLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.