Details for: DRP2

Gene ID: 1821

Symbol: DRP2

Ensembl ID: ENSG00000102385

Description: dystrophin related protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.62
    Marker Score: 1618.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.51
    Marker Score: 55704
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.47
    Marker Score: 15183
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.4
    Marker Score: 13267
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.35
    Marker Score: 82884
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1977
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.23
    Marker Score: 10589
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.12
    Marker Score: 4628
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.09
    Marker Score: 10252
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.97
    Marker Score: 444
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.96
    Marker Score: 3723
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5288
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.85
    Marker Score: 16809
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.79
    Marker Score: 11842
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.78
    Marker Score: 1534
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.74
    Marker Score: 5640
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.7
    Marker Score: 403
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.69
    Marker Score: 26322
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 492
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.59
    Marker Score: 3919
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.56
    Marker Score: 2294
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.55
    Marker Score: 1035
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.53
    Marker Score: 563
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.48
    Marker Score: 987
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.45
    Marker Score: 981
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 824
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.36
    Marker Score: 187.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.31
    Marker Score: 120
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4870
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.31
    Marker Score: 380
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 172
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.28
    Marker Score: 160
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.22
    Marker Score: 94
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.22
    Marker Score: 263
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 60.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 92
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.19
    Marker Score: 6301
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.18
    Marker Score: 750
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.18
    Marker Score: 122.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.17
    Marker Score: 302
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.16
    Marker Score: 2115
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.13
    Marker Score: 509
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.13
    Marker Score: 147
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.13
    Marker Score: 585
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.12
    Marker Score: 36.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.12
    Marker Score: 1261
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.12
    Marker Score: 276
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.12
    Marker Score: 90
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.12
    Marker Score: 2471
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.11
    Marker Score: 226
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.11
    Marker Score: 252
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.1
    Marker Score: 103
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1
    Marker Score: 98
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 228
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1
    Marker Score: 133
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.1
    Marker Score: 33

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Other Information

**Key characteristics:** - DRP2 is a transmembrane protein that is composed of 140 amino acids. - It is expressed in neurons and glial cells in the CNS. - It is a cytoskeletal protein that is involved in the formation and maintenance of the postsynaptic density. - It is a key component of the Egr2 and sox10-mediated initiation of schwann cell myelination. **Pathways and functions:** - DRP2 is involved in the development and maintenance of the brain and spinal cord. - It is a key component of the postsynaptic density, which is the structure that connects neurons together. - It is involved in the formation and maintenance of synapses, which are the points at which neurons communicate with each other. - DRP2 is also involved in the regulation of neuronal survival and differentiation. **Clinical significance:** - Mutations in DRP2 have been linked to a number of neurological disorders, including cerebral palsy and autism. - DRP2 is a potential therapeutic target for these disorders. **Additional information:** - DRP2 is a member of the dystrophin family of transmembrane proteins. - It is expressed in all neurons and glial cells in the CNS. - It is a highly conserved protein, with a similar sequence in mice and humans.

Genular Protein ID: 637519626

Symbol: DRP2_HUMAN

Name: Dystrophin-related protein 2

UniProtKB Accession Codes:

Q13474 A6ZKI5 A8K1B0 B1B1F3 B4DIZ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8640231

Title: Characterization of DRP2, a novel human dystrophin homologue.

PubMed ID: 8640231

DOI: 10.1038/ng0696-223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 957
  • Mass: 107962
  • Checksum: 95B26DCFF45DDE12
  • Sequence:
    • MQPMVMQGCP YTLPRCHDWQ AADQFHHSSS LRSTCPHPQV RAAVTSPAPP QDGAGVPCLS 
LKLLNGSVGA SGPLEPPAMN LCWNEIKKKS HNLRARLEAF SDHSGKLQLP LQEIIDWLSQ 
KDEELSAQLP LQGDVALVQQ EKETHAAFME EVKSRGPYIY SVLESAQAFL SQHPFEELEE 
PHSESKDTSP KQRIQNLSRF VWKQATVASE LWEKLTARCV DQHRHIERTL EQLLEIQGAM 
EELSTTLSQA EGVRATWEPI GDLFIDSLPE HIQAIKLFKE EFSPMKDGVK LVNDLAHQLA 
ISDVHLSMEN SQALEQINVR WKQLQASVSE RLKQLQDAHR DFGPGSQHFL SSSVQVPWER 
AISPNKVPYY INHQAQTTCW DHPKMTELYQ TLADLNNIKF SAYRTAMKLR RVQKALRLDL 
VTLTTALEIF NEHDLQASEH VMDVVEVIHC LTALYERLEE ERGILVNVPL CVDMSLNWLL 
NVFDSGRSGK MRALSFKTGI ACLCGTEVKE KLQYLFSQVA NSGSQCDQRH LGVLLHEAIQ 
VPRQLGEVAA FGGSNVEPSV RSCFRFSTGK PVIEASQFLE WVNLEPQSMV WLAVLHRVTI 
AEQVKHQTKC SICRQCPIKG FRYRSLKQFN VDICQTCFLT GRASKGNKLH YPIMEYYTPT 
TSSENMRDFA TTLKNKFRSK HYFSKHPQRG YLPVQSVLEA DYSETPASSP MWPHADTHSR 
IEHFASRLAE MESQNCSFFN DSLSPDDSID EDQYLLRHSS PITDREPAFG QQAPCSVATE 
SKGELQKILA HLEDENRILQ GELRRLKWQH EEAAEAPSLA DGSTEAATDH RNEELLAEAR 
ILRQHKSRLE TRMQILEDHN KQLESQLQRL RELLLQPPTE SDGSGSAGSS LASSPQQSEG 
SHPREKGQTT PDTEAADDVG SKSQDVSLCL EDIMEKLRHA FPSVRSSDVT ANTLLAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.