Details for: DRP2

Gene ID: 1821

Symbol: DRP2

Ensembl ID: ENSG00000102385

Description: dystrophin related protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 58.6325
    Cell Significance Index: -9.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.1925
    Cell Significance Index: -9.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2011
    Cell Significance Index: 134.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1436
    Cell Significance Index: 68.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4776
    Cell Significance Index: 296.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9919
    Cell Significance Index: 37.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9900
    Cell Significance Index: 43.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7530
    Cell Significance Index: 18.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7526
    Cell Significance Index: 34.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7312
    Cell Significance Index: 16.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6236
    Cell Significance Index: 118.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6114
    Cell Significance Index: 41.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4864
    Cell Significance Index: 13.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4577
    Cell Significance Index: 164.1700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.4176
    Cell Significance Index: 5.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3981
    Cell Significance Index: 39.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3807
    Cell Significance Index: 9.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3471
    Cell Significance Index: 313.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2909
    Cell Significance Index: 17.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2171
    Cell Significance Index: 35.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2086
    Cell Significance Index: 144.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2003
    Cell Significance Index: 21.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1709
    Cell Significance Index: 3.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1066
    Cell Significance Index: 6.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0666
    Cell Significance Index: 4.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0059
    Cell Significance Index: 0.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0049
    Cell Significance Index: 2.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0033
    Cell Significance Index: 0.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0017
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0045
    Cell Significance Index: -6.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0057
    Cell Significance Index: -7.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0132
    Cell Significance Index: -8.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0164
    Cell Significance Index: -8.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0171
    Cell Significance Index: -0.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0178
    Cell Significance Index: -10.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0224
    Cell Significance Index: -6.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0321
    Cell Significance Index: -4.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0334
    Cell Significance Index: -0.8400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0335
    Cell Significance Index: -0.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0367
    Cell Significance Index: -7.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0370
    Cell Significance Index: -1.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0432
    Cell Significance Index: -7.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0433
    Cell Significance Index: -0.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0435
    Cell Significance Index: -6.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0480
    Cell Significance Index: -10.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0497
    Cell Significance Index: -6.8300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0504
    Cell Significance Index: -0.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0530
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0558
    Cell Significance Index: -9.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0581
    Cell Significance Index: -1.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0638
    Cell Significance Index: -7.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0658
    Cell Significance Index: -7.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0672
    Cell Significance Index: -7.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0822
    Cell Significance Index: -8.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0854
    Cell Significance Index: -4.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0869
    Cell Significance Index: -9.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0877
    Cell Significance Index: -8.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0927
    Cell Significance Index: -1.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1067
    Cell Significance Index: -2.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1071
    Cell Significance Index: -8.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1121
    Cell Significance Index: -3.6700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1154
    Cell Significance Index: -1.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1208
    Cell Significance Index: -6.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1332
    Cell Significance Index: -6.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1367
    Cell Significance Index: -2.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1387
    Cell Significance Index: -2.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1387
    Cell Significance Index: -8.7400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1411
    Cell Significance Index: -3.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1414
    Cell Significance Index: -9.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1444
    Cell Significance Index: -3.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1477
    Cell Significance Index: -1.4000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1483
    Cell Significance Index: -1.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1542
    Cell Significance Index: -8.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1553
    Cell Significance Index: -5.4400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1612
    Cell Significance Index: -2.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1720
    Cell Significance Index: -8.9400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1773
    Cell Significance Index: -3.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1900
    Cell Significance Index: -8.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1953
    Cell Significance Index: -5.0200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1973
    Cell Significance Index: -2.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2193
    Cell Significance Index: -8.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2298
    Cell Significance Index: -2.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2378
    Cell Significance Index: -7.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2439
    Cell Significance Index: -3.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2492
    Cell Significance Index: -4.1700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2517
    Cell Significance Index: -3.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2580
    Cell Significance Index: -5.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2587
    Cell Significance Index: -8.9900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2627
    Cell Significance Index: -1.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2693
    Cell Significance Index: -7.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2786
    Cell Significance Index: -7.9900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2923
    Cell Significance Index: -7.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2962
    Cell Significance Index: -5.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3011
    Cell Significance Index: -8.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3074
    Cell Significance Index: -6.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3092
    Cell Significance Index: -9.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DRP2 is a transmembrane protein that belongs to the dystrophin-related protein family, which also includes dystrophin and dystroglycan. Its expression is widespread in the CNS, with significant levels found in neurons, glial cells, and immune cells. DRP2 is characterized by its ability to interact with various proteins, including dystroglycan, synaptophysin, and synaptic proteins, to regulate synaptic function and plasticity. **Pathways and Functions:** DRP2 is involved in several key pathways, including: 1. **Glutamatergic Synapse Organization**: DRP2 regulates the organization and function of glutamatergic synapses, which are critical for learning and memory. 2. **Synaptic Signaling**: DRP2 modulates synaptic signaling pathways, including the regulation of neurotransmitter release and uptake. 3. **Central Nervous System Development**: DRP2 plays a role in the development and maturation of neurons and glial cells in the CNS. 4. **Zinc Ion Binding**: DRP2 has been shown to bind to zinc ions, which is essential for its function in regulating synaptic function and plasticity. **Clinical Significance:** DRP2 has been implicated in various neurological disorders, including: 1. **Autism Spectrum Disorder (ASD)**: Studies have shown that DRP2 expression is altered in individuals with ASD, suggesting a potential role in the pathogenesis of the disorder. 2. **Schizophrenia**: DRP2 has been linked to schizophrenia, with altered expression levels and functional changes observed in individuals with the disorder. 3. **Neurodevelopmental Disorders**: DRP2 has been implicated in various neurodevelopmental disorders, including cerebral palsy and intellectual disability. In conclusion, DRP2 is a critical protein that plays a significant role in regulating synaptic function, plasticity, and neural development. Further research is needed to fully elucidate the mechanisms by which DRP2 contributes to neurological disorders, and to explore potential therapeutic strategies for targeting this protein in the treatment of these conditions. **Recommendations:** 1. **Further Research**: Conduct in-depth studies to investigate the role of DRP2 in neurological disorders, including ASD, schizophrenia, and neurodevelopmental disorders. 2. **Imaging Techniques**: Utilize advanced imaging techniques, such as electron microscopy and super-resolution microscopy, to visualize DRP2 in situ and investigate its dynamics in neural tissue. 3. **Therapeutic Strategies**: Explore potential therapeutic strategies for targeting DRP2 in the treatment of neurological disorders, including small molecule inhibitors and gene therapy approaches. By elucidating the mechanisms by which DRP2 contributes to neurological disorders, we may uncover new therapeutic targets for the treatment of these conditions and improve our understanding of the complex mechanisms underlying brain function and development.

Genular Protein ID: 637519626

Symbol: DRP2_HUMAN

Name: Dystrophin-related protein 2

UniProtKB Accession Codes:

Q13474 A6ZKI5 A8K1B0 B1B1F3 B4DIZ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8640231

Title: Characterization of DRP2, a novel human dystrophin homologue.

PubMed ID: 8640231

DOI: 10.1038/ng0696-223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 957
  • Mass: 107962
  • Checksum: 95B26DCFF45DDE12
  • Sequence:
    • MQPMVMQGCP YTLPRCHDWQ AADQFHHSSS LRSTCPHPQV RAAVTSPAPP QDGAGVPCLS 
LKLLNGSVGA SGPLEPPAMN LCWNEIKKKS HNLRARLEAF SDHSGKLQLP LQEIIDWLSQ 
KDEELSAQLP LQGDVALVQQ EKETHAAFME EVKSRGPYIY SVLESAQAFL SQHPFEELEE 
PHSESKDTSP KQRIQNLSRF VWKQATVASE LWEKLTARCV DQHRHIERTL EQLLEIQGAM 
EELSTTLSQA EGVRATWEPI GDLFIDSLPE HIQAIKLFKE EFSPMKDGVK LVNDLAHQLA 
ISDVHLSMEN SQALEQINVR WKQLQASVSE RLKQLQDAHR DFGPGSQHFL SSSVQVPWER 
AISPNKVPYY INHQAQTTCW DHPKMTELYQ TLADLNNIKF SAYRTAMKLR RVQKALRLDL 
VTLTTALEIF NEHDLQASEH VMDVVEVIHC LTALYERLEE ERGILVNVPL CVDMSLNWLL 
NVFDSGRSGK MRALSFKTGI ACLCGTEVKE KLQYLFSQVA NSGSQCDQRH LGVLLHEAIQ 
VPRQLGEVAA FGGSNVEPSV RSCFRFSTGK PVIEASQFLE WVNLEPQSMV WLAVLHRVTI 
AEQVKHQTKC SICRQCPIKG FRYRSLKQFN VDICQTCFLT GRASKGNKLH YPIMEYYTPT 
TSSENMRDFA TTLKNKFRSK HYFSKHPQRG YLPVQSVLEA DYSETPASSP MWPHADTHSR 
IEHFASRLAE MESQNCSFFN DSLSPDDSID EDQYLLRHSS PITDREPAFG QQAPCSVATE 
SKGELQKILA HLEDENRILQ GELRRLKWQH EEAAEAPSLA DGSTEAATDH RNEELLAEAR 
ILRQHKSRLE TRMQILEDHN KQLESQLQRL RELLLQPPTE SDGSGSAGSS LASSPQQSEG 
SHPREKGQTT PDTEAADDVG SKSQDVSLCL EDIMEKLRHA FPSVRSSDVT ANTLLAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.