Details for: EPYC

Gene ID: 1833

Symbol: EPYC

Ensembl ID: ENSG00000083782

Description: epiphycan

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.9093
    Cell Significance Index: 29.5400
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.0743
    Cell Significance Index: 9.7500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.4497
    Cell Significance Index: 2.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3330
    Cell Significance Index: 3.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2394
    Cell Significance Index: 5.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0502
    Cell Significance Index: 0.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0061
    Cell Significance Index: 0.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0039
    Cell Significance Index: 2.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0049
    Cell Significance Index: -0.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0066
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0075
    Cell Significance Index: -4.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0151
    Cell Significance Index: -5.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0230
    Cell Significance Index: -10.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0261
    Cell Significance Index: -5.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0287
    Cell Significance Index: -5.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0316
    Cell Significance Index: -5.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0320
    Cell Significance Index: -1.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0322
    Cell Significance Index: -4.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0347
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0368
    Cell Significance Index: -4.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0485
    Cell Significance Index: -1.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0491
    Cell Significance Index: -5.0200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0495
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0506
    Cell Significance Index: -5.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0581
    Cell Significance Index: -6.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0593
    Cell Significance Index: -8.1400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0612
    Cell Significance Index: -1.0600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0719
    Cell Significance Index: -0.8700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0749
    Cell Significance Index: -0.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0929
    Cell Significance Index: -4.8400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0931
    Cell Significance Index: -1.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0935
    Cell Significance Index: -5.7500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1012
    Cell Significance Index: -1.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1041
    Cell Significance Index: -7.9900
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.1071
    Cell Significance Index: -1.1600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1147
    Cell Significance Index: -0.9900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1153
    Cell Significance Index: -1.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1160
    Cell Significance Index: -5.4500
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1175
    Cell Significance Index: -1.1600
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.1218
    Cell Significance Index: -0.6600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1247
    Cell Significance Index: -1.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1260
    Cell Significance Index: -3.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1324
    Cell Significance Index: -5.8600
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1423
    Cell Significance Index: -1.1300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1474
    Cell Significance Index: -1.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1512
    Cell Significance Index: -1.7400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1525
    Cell Significance Index: -1.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1542
    Cell Significance Index: -1.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1558
    Cell Significance Index: -5.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1559
    Cell Significance Index: -8.7500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1576
    Cell Significance Index: -1.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1609
    Cell Significance Index: -8.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1696
    Cell Significance Index: -5.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1717
    Cell Significance Index: -4.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1820
    Cell Significance Index: -3.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1836
    Cell Significance Index: -6.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1881
    Cell Significance Index: -5.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1996
    Cell Significance Index: -5.3400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2032
    Cell Significance Index: -3.0400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2039
    Cell Significance Index: -2.9000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2045
    Cell Significance Index: -2.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2070
    Cell Significance Index: -7.6000
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.2224
    Cell Significance Index: -1.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2279
    Cell Significance Index: -5.5200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2286
    Cell Significance Index: -4.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2286
    Cell Significance Index: -6.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2338
    Cell Significance Index: -3.4000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2405
    Cell Significance Index: -3.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2409
    Cell Significance Index: -6.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2414
    Cell Significance Index: -6.4500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2437
    Cell Significance Index: -4.8600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2461
    Cell Significance Index: -6.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2468
    Cell Significance Index: -5.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2475
    Cell Significance Index: -5.4200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2478
    Cell Significance Index: -3.1400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2540
    Cell Significance Index: -3.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2710
    Cell Significance Index: -14.0800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2712
    Cell Significance Index: -1.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2772
    Cell Significance Index: -5.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2808
    Cell Significance Index: -5.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2832
    Cell Significance Index: -5.9100
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.2844
    Cell Significance Index: -2.4500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2859
    Cell Significance Index: -4.6300
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.2902
    Cell Significance Index: -1.8100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2924
    Cell Significance Index: -5.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2961
    Cell Significance Index: -5.9500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3023
    Cell Significance Index: -5.9500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3034
    Cell Significance Index: -6.0000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3068
    Cell Significance Index: -5.1600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3181
    Cell Significance Index: -3.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3206
    Cell Significance Index: -5.4000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3210
    Cell Significance Index: -3.5700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3350
    Cell Significance Index: -4.9000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3365
    Cell Significance Index: -3.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3412
    Cell Significance Index: -5.7100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3415
    Cell Significance Index: -5.8000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3437
    Cell Significance Index: -4.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3483
    Cell Significance Index: -4.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Widespread expression:** Epiphycan is significantly expressed in a diverse range of cell types, including blood vessel endothelial cells, conventional dendritic cells, plasma cells, monocytes, granulocyte-monocyte progenitor cells, chondrocytes, goblet cells, early T lineage precursors, cerebral cortex GABAergic interneurons, and forebrain radial glial cells. This broad expression pattern underscores the gene's multifaceted role in various physiological and pathological processes. 2. **Conserved sequence:** The EPYC_HUMAN protein, encoded by the epiphycan gene, exhibits a high degree of sequence conservation across species, suggesting that this gene has been conserved throughout evolution to play a vital role in fundamental biological processes. 3. **Diverse functional annotations:** Epiphycan has been annotated in multiple pathways and ontologies, including articular cartilage development, bone development, extracellular matrix, extracellular region, female pregnancy, glycosaminoglycan binding, sensory perception of sound, and more. This diversity of annotations highlights the gene's involvement in a wide range of biological processes. **Pathways and Functions:** 1. **Articular cartilage development:** Epiphycan has been implicated in the development and maintenance of articular cartilage, a critical component of joints. The gene's expression in chondrocytes, the cells responsible for cartilage production, suggests a direct role in cartilage homeostasis. 2. **Bone development:** Epiphycan has been linked to bone development, as its expression is observed in osteoblasts, the cells responsible for bone formation. The gene's involvement in this process underscores its potential role in regulating bone growth and density. 3. **Extracellular matrix regulation:** Epiphycan has been identified as a key regulator of the extracellular matrix, a complex network of proteins and polysaccharides that provide structural and biochemical support to cells. The gene's expression in various cell types involved in extracellular matrix production and remodeling suggests a broad role in maintaining tissue homeostasis. 4. **Sensory perception of sound:** Epiphycan has been associated with sensory perception, specifically the processing of sound. The gene's expression in auditory-related cell types, such as GABAergic interneurons, suggests a potential role in auditory function and sound perception. **Clinical Significance:** 1. **Immunological disorders:** Epiphycan's expression in immune cells, such as dendritic cells and plasma cells, has implications for the development of immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. 2. **Cancer and tumor progression:** The gene's involvement in cell proliferation, differentiation, and survival suggests that epiphycan may play a role in cancer development and tumor progression. 3. **Neurological disorders:** Epiphycan's expression in neurons and glial cells has raised the possibility of its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Regenerative medicine:** The gene's role in tissue regeneration and repair has sparked interest in its potential use as a therapeutic target for tissue engineering and regenerative medicine applications. In conclusion, epiphycan is a gene of significant interest due to its widespread expression and multifaceted function across various biological processes. Further research is necessary to fully elucidate the gene's role in human health and disease, but its implications for immunology, developmental biology, and regenerative medicine are already evident.

Genular Protein ID: 1257423664

Symbol: EPYC_HUMAN

Name: Epiphycan

UniProtKB Accession Codes:

Q99645 A8K3M7 Q8NEJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8975717

Title: Characterization of human DSPG3, a small dermatan sulfate proteoglycan.

PubMed ID: 8975717

DOI: 10.1006/geno.1996.0643

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 322
  • Mass: 36637
  • Checksum: E11061A38AA7240E
  • Sequence:
    • MKTLAGLVLG LVIFDAAVTA PTLESINYDS ETYDATLEDL DNLYNYENIP VDKVEIEIAT 
VMPSGNRELL TPPPQPEKAQ EEEEEEESTP RLIDGSSPQE PEFTGVLGPH TNEDFPTCLL 
CTCISTTVYC DDHELDAIPP LPKNTAYFYS RFNRIKKINK NDFASLSDLK RIDLTSNLIS 
EIDEDAFRKL PQLRELVLRD NKIRQLPELP TTLTFIDISN NRLGRKGIKQ EAFKDMYDLH 
HLYLTDNNLD HIPLPLPENL RALHLQNNNI LEMHEDTFCN VKNLTYIRKA LEDIRLDGNP 
INLSKTPQAY MCLPRLPVGS LV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.