Details for: EPYC

Gene ID: 1833

Symbol: EPYC

Ensembl ID: ENSG00000083782

Description: epiphycan

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3179
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1520
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2221
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.68
    Marker Score: 2178
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.21
    Marker Score: 766
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.16
    Marker Score: 522.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 803
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2469
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.94
    Marker Score: 265
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.92
    Marker Score: 492
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 496
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.78
    Marker Score: 455
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 506
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1413
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 509
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.6
    Marker Score: 1234
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.59
    Marker Score: 358
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 349
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1124
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.55
    Marker Score: 522
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.5
    Marker Score: 529.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 480
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.44
    Marker Score: 6929
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 230
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.37
    Marker Score: 150
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.35
    Marker Score: 555
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 347
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.27
    Marker Score: 329.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 127
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.25
    Marker Score: 464
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 110
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.19
    Marker Score: 509
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.17
    Marker Score: 312
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.16
    Marker Score: 102
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 124
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 312
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.12
    Marker Score: 217
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.11
    Marker Score: 195
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 88
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 111
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.09
    Marker Score: 377
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.09
    Marker Score: 73
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 144
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.07
    Marker Score: 91
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 96
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: endosteal cell (CL0002157)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 66
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 278
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.04
    Marker Score: 171
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 39
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.03
    Marker Score: 45

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Other Information

**Key characteristics:** * EPYC is a glycoprotein with a molecular weight of approximately 150 kDa. * It is expressed in a variety of cell types, including blood vessel endothelial cells, conventional dendritic cells, plasma cells, monocytes, granulocyte monocyte progenitor cells, chondrocytes, goblet cells, early T lineage precursor cells, and cerebral cortex GABAergic interneurons. * It is known to be a transmembrane protein, with a extracellular domain that is responsible for binding to the ECM protein fibronectin and a cytoplasmic domain that is involved in signaling. **Pathways and functions:** * EPYC is a key component of the ECM of the eye, where it is involved in the formation and maintenance of the structural integrity and transparency of the eye. * It is also involved in the regulation of cell migration, adhesion, and signaling in the eye. * Studies have shown that EPYC mutations can lead to a number of eye diseases, including cataracts, glaucoma, and macular degeneration. **Clinical significance:** * EPYC is a promising target for the treatment of eye diseases. * By blocking EPYC, it is possible to prevent the development of these diseases. * EPYC inhibitors are currently being tested in clinical trials for the treatment of age-related macular degeneration, glaucoma, and cataracts.

Genular Protein ID: 1257423664

Symbol: EPYC_HUMAN

Name: Epiphycan

UniProtKB Accession Codes:

Q99645 A8K3M7 Q8NEJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8975717

Title: Characterization of human DSPG3, a small dermatan sulfate proteoglycan.

PubMed ID: 8975717

DOI: 10.1006/geno.1996.0643

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 322
  • Mass: 36637
  • Checksum: E11061A38AA7240E
  • Sequence:
    • MKTLAGLVLG LVIFDAAVTA PTLESINYDS ETYDATLEDL DNLYNYENIP VDKVEIEIAT 
VMPSGNRELL TPPPQPEKAQ EEEEEEESTP RLIDGSSPQE PEFTGVLGPH TNEDFPTCLL 
CTCISTTVYC DDHELDAIPP LPKNTAYFYS RFNRIKKINK NDFASLSDLK RIDLTSNLIS 
EIDEDAFRKL PQLRELVLRD NKIRQLPELP TTLTFIDISN NRLGRKGIKQ EAFKDMYDLH 
HLYLTDNNLD HIPLPLPENL RALHLQNNNI LEMHEDTFCN VKNLTYIRKA LEDIRLDGNP 
INLSKTPQAY MCLPRLPVGS LV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.