Details for: DTX1

Gene ID: 1840

Symbol: DTX1

Ensembl ID: ENSG00000135144

Description: deltex E3 ubiquitin ligase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.5974
    Cell Significance Index: -10.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.1852
    Cell Significance Index: -10.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6216
    Cell Significance Index: -10.6300
  • Cell Name: centroblast (CL0009112)
    Fold Change: 6.0178
    Cell Significance Index: 14.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.8053
    Cell Significance Index: 120.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2765
    Cell Significance Index: 27.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2063
    Cell Significance Index: 229.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0887
    Cell Significance Index: 107.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9130
    Cell Significance Index: 107.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8434
    Cell Significance Index: 761.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5710
    Cell Significance Index: 12.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5665
    Cell Significance Index: 113.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4959
    Cell Significance Index: 177.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4576
    Cell Significance Index: 11.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3910
    Cell Significance Index: 63.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3602
    Cell Significance Index: 39.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3553
    Cell Significance Index: 8.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3315
    Cell Significance Index: 7.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3125
    Cell Significance Index: 19.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2796
    Cell Significance Index: 193.3800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2770
    Cell Significance Index: 3.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2568
    Cell Significance Index: 4.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2009
    Cell Significance Index: 5.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1911
    Cell Significance Index: 3.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1833
    Cell Significance Index: 8.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1784
    Cell Significance Index: 12.3400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1738
    Cell Significance Index: 2.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1466
    Cell Significance Index: 2.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1350
    Cell Significance Index: 7.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1128
    Cell Significance Index: 4.2700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0931
    Cell Significance Index: 1.6100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0827
    Cell Significance Index: 0.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0800
    Cell Significance Index: 1.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0419
    Cell Significance Index: 2.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0314
    Cell Significance Index: 2.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0175
    Cell Significance Index: 0.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0079
    Cell Significance Index: 1.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0018
    Cell Significance Index: 0.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0015
    Cell Significance Index: -1.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0080
    Cell Significance Index: -10.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0141
    Cell Significance Index: -8.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0146
    Cell Significance Index: -0.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0167
    Cell Significance Index: -12.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0174
    Cell Significance Index: -9.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0193
    Cell Significance Index: -10.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0212
    Cell Significance Index: -9.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0214
    Cell Significance Index: -13.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0286
    Cell Significance Index: -8.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0323
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0336
    Cell Significance Index: -3.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0408
    Cell Significance Index: -0.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0417
    Cell Significance Index: -0.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0464
    Cell Significance Index: -0.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0468
    Cell Significance Index: -6.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0474
    Cell Significance Index: -8.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0479
    Cell Significance Index: -8.6400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0484
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0559
    Cell Significance Index: -11.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0610
    Cell Significance Index: -8.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0702
    Cell Significance Index: -1.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0702
    Cell Significance Index: -4.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0750
    Cell Significance Index: -9.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0757
    Cell Significance Index: -9.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0851
    Cell Significance Index: -5.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0856
    Cell Significance Index: -9.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0970
    Cell Significance Index: -9.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1012
    Cell Significance Index: -2.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1034
    Cell Significance Index: -2.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1038
    Cell Significance Index: -10.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1047
    Cell Significance Index: -2.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1069
    Cell Significance Index: -8.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1124
    Cell Significance Index: -3.6000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1142
    Cell Significance Index: -1.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1159
    Cell Significance Index: -3.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1184
    Cell Significance Index: -2.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1244
    Cell Significance Index: -9.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1255
    Cell Significance Index: -4.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1302
    Cell Significance Index: -6.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1310
    Cell Significance Index: -2.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1326
    Cell Significance Index: -9.8900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1630
    Cell Significance Index: -2.3500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1648
    Cell Significance Index: -2.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1652
    Cell Significance Index: -4.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1744
    Cell Significance Index: -1.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1755
    Cell Significance Index: -8.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1861
    Cell Significance Index: -6.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1868
    Cell Significance Index: -5.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1927
    Cell Significance Index: -2.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1971
    Cell Significance Index: -12.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2065
    Cell Significance Index: -4.3100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2076
    Cell Significance Index: -2.4200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2110
    Cell Significance Index: -2.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2122
    Cell Significance Index: -5.1400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2124
    Cell Significance Index: -2.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DTEX1 is a protein that exhibits the following characteristics: 1. **E3 ubiquitin ligase activity**: DTEX1 possesses the ability to recognize and bind to specific ubiquitination targets, leading to their degradation through the ubiquitin-proteasome pathway. 2. **Regulation of cell differentiation**: DTEX1 is involved in the regulation of cell differentiation in various cell types, including neurons, T cells, and epithelial cells. 3. **Involvement in Notch signaling pathway**: DTEX1 interacts with the Notch signaling pathway, which is a key regulator of cell fate decisions during development and tissue homeostasis. 4. **Ubiquitin protein ligase activity**: DTEX1 exhibits ubiquitin protein ligase activity, which is essential for the regulation of protein degradation and cellular processes. **Pathways and Functions** DTEX1 is involved in several cellular pathways, including: 1. **Notch signaling pathway**: DTEX1 interacts with Notch receptors and downstream effectors, regulating the activation of transcription factors that control cell fate decisions. 2. **Cellular response to leukemia inhibitory factor (LIF)**: DTEX1 is involved in the regulation of cellular responses to LIF, a cytokine that plays a crucial role in immune system development and function. 3. **Regulation of neuron differentiation**: DTEX1 regulates the differentiation of neurons, including the regulation of Notch signaling pathway components. 4. **T cell differentiation**: DTEX1 is involved in the regulation of T cell differentiation, including the regulation of Notch signaling pathway components. **Clinical Significance** The dysregulation of DTEX1 has been implicated in various diseases, including: 1. **Neurological disorders**: The dysregulation of DTEX1 has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Immune system disorders**: DTEX1 has been implicated in immune system disorders, including autoimmune diseases and cancer. 3. **Cancer**: DTEX1 has been found to be overexpressed in certain types of cancer, including colon cancer and leukemia. In conclusion, DTEX1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell differentiation, proliferation, and signaling pathways. The dysregulation of DTEX1 has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the role of DTEX1 in human biology and disease.

Genular Protein ID: 1210404130

Symbol: DTX1_HUMAN

Name: E3 ubiquitin-protein ligase DTX1

UniProtKB Accession Codes:

Q86Y01 O60630 Q9BS04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 21 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9590294

Title: Human deltex is a conserved regulator of Notch signalling.

PubMed ID: 9590294

DOI: 10.1038/ng0598-74

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11869684

Title: Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

PubMed ID: 11869684

DOI: 10.1016/s1074-7613(02)00271-6

PubMed ID: 11564735

Title: Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.

PubMed ID: 11564735

DOI: 10.1074/jbc.m105245200

PubMed ID: 12753744

Title: Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.

PubMed ID: 12753744

DOI: 10.1016/s1074-7613(03)00111-0

PubMed ID: 12670957

Title: The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.

PubMed ID: 12670957

DOI: 10.1074/jbc.m301157200

PubMed ID: 17028573

Title: Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains.

PubMed ID: 17028573

DOI: 10.1038/sj.embor.7400822

PubMed ID: 21124883

Title: The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation.

PubMed ID: 21124883

DOI: 10.1371/journal.pbio.1000545

Sequence Information:

  • Length: 620
  • Mass: 67368
  • Checksum: 3BF3ECE46E25CCD4
  • Sequence:
    • MSRPGHGGLM PVNGLGFPPQ NVARVVVWEW LNEHSRWRPY TATVCHHIEN VLKEDARGSV 
VLGQVDAQLV PYIIDLQSMH QFRQDTGTMR PVRRNFYDPS SAPGKGIVWE WENDGGAWTA 
YDMDICITIQ NAYEKQHPWL DLSSLGFCYL IYFNSMSQMN RQTRRRRRLR RRLDLAYPLT 
VGSIPKSQSW PVGASSGQPC SCQQCLLVNS TRAASNAILA SQRRKAPPAP PLPPPPPPGG 
PPGALAVRPS ATFTGAALWA APAAGPAEPA PPPGAPPRSP GAPGGARTPG QNNLNRPGPQ 
RTTSVSARAS IPPGVPALPV KNLNGTGPVH PALAGMTGIL LCAAGLPVCL TRAPKPILHP 
PPVSKSDVKP VPGVPGVCRK TKKKHLKKSK NPEDVVRRYM QKVKNPPDED CTICMERLVT 
ASGYEGVLRH KGVRPELVGR LGRCGHMYHL LCLVAMYSNG NKDGSLQCPT CKAIYGEKTG 
TQPPGKMEFH LIPHSLPGFP DTQTIRIVYD IPTGIQGPEH PNPGKKFTAR GFPRHCYLPN 
NEKGRKVLRL LITAWERRLI FTIGTSNTTG ESDTVVWNEI HHKTEFGSNL TGHGYPDASY 
LDNVLAELTA QGVSEAAAKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.