Details for: DTX1

Gene ID: 1840

Symbol: DTX1

Ensembl ID: ENSG00000135144

Description: deltex E3 ubiquitin ligase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1989
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.68
    Marker Score: 2023
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1165
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.39
    Marker Score: 29660
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.36
    Marker Score: 669
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.24
    Marker Score: 394
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.13
    Marker Score: 3346
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.09
    Marker Score: 4421
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 498
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.04
    Marker Score: 2825.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2072
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.01
    Marker Score: 1922
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.01
    Marker Score: 3888
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.99
    Marker Score: 9292
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.96
    Marker Score: 9869
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.95
    Marker Score: 463
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.95
    Marker Score: 36075
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.92
    Marker Score: 13787
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.91
    Marker Score: 3791
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.88
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.87
    Marker Score: 6668
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.86
    Marker Score: 1323
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.84
    Marker Score: 7211
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.84
    Marker Score: 51589
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.83
    Marker Score: 504
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.83
    Marker Score: 7863
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.8
    Marker Score: 29646
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.76
    Marker Score: 193
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.72
    Marker Score: 14230
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.71
    Marker Score: 23948
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.71
    Marker Score: 835
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.65
    Marker Score: 704.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.61
    Marker Score: 6835
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.6
    Marker Score: 2605
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.59
    Marker Score: 344
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 353
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.58
    Marker Score: 3507
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.58
    Marker Score: 325
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.57
    Marker Score: 377
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 493
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.55
    Marker Score: 132
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.52
    Marker Score: 323
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.52
    Marker Score: 236
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.52
    Marker Score: 2388
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 8004
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.5
    Marker Score: 702
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.5
    Marker Score: 522
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5
    Marker Score: 191
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.47
    Marker Score: 2501
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 190
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.45
    Marker Score: 1859
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 435
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.4
    Marker Score: 484
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.39
    Marker Score: 1322
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.39
    Marker Score: 2105
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.39
    Marker Score: 13139
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.39
    Marker Score: 255
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.38
    Marker Score: 443
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.36
    Marker Score: 2344
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.36
    Marker Score: 722
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.35
    Marker Score: 946
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 91
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.33
    Marker Score: 749
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.32
    Marker Score: 361
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.32
    Marker Score: 286
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.32
    Marker Score: 218
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.32
    Marker Score: 100
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.31
    Marker Score: 2322
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3
    Marker Score: 70
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.3
    Marker Score: 284
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.3
    Marker Score: 217
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.29
    Marker Score: 288
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.29
    Marker Score: 276
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.29
    Marker Score: 139
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.29
    Marker Score: 681
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.28
    Marker Score: 74

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Other Information

**Key characteristics:** * DTX1 is a ubiquitin ligase that catalyzes the ubiquitination of target proteins. * It is a key regulator of Notch signaling, a signaling pathway that plays a crucial role in various developmental and physiological processes. * DTX1 negatively regulates Notch signaling by targeting and ubiquitinating key Notch signaling components, such as Notch1 and Delta-like 4 (Delta-like 4). * It also regulates cell surface receptor signaling, DNA-templated transcription, and Glial cell differentiation. **Pathways and functions:** * DTX1 is involved in Notch signaling by targeting and ubiquitinating Notch1 and Delta-like 4, key components of the Notch signaling pathway. * It inhibits Notch1 signaling by preventing its interaction with the Notch receptor. * It also regulates cell surface receptor signaling, which is essential for cell adhesion and migration. * DTX1 is involved in DNA-templated transcription and Glial cell differentiation. **Clinical significance:** * Mutations in the DTX1 gene have been linked to several human diseases, including colorectal cancer, liver cancer, and lung cancer. * Targeting DTX1 has emerged as a potential therapeutic strategy for these diseases. * By inhibiting DTX1, it is possible to overcome Notch signaling and reactivate the tumor suppressor function of Notch1. **Additional information:** * The DTX1 gene is located on chromosome 19q21.1. * It is a highly conserved gene with significant expression in vertebrates. * DTX1 is a relatively new protein, with the first known human gene encoding DTX1 being identified in 2004.

Genular Protein ID: 1210404130

Symbol: DTX1_HUMAN

Name: E3 ubiquitin-protein ligase DTX1

UniProtKB Accession Codes:

Q86Y01 O60630 Q9BS04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 21 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9590294

Title: Human deltex is a conserved regulator of Notch signalling.

PubMed ID: 9590294

DOI: 10.1038/ng0598-74

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11869684

Title: Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

PubMed ID: 11869684

DOI: 10.1016/s1074-7613(02)00271-6

PubMed ID: 11564735

Title: Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.

PubMed ID: 11564735

DOI: 10.1074/jbc.m105245200

PubMed ID: 12753744

Title: Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.

PubMed ID: 12753744

DOI: 10.1016/s1074-7613(03)00111-0

PubMed ID: 12670957

Title: The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.

PubMed ID: 12670957

DOI: 10.1074/jbc.m301157200

PubMed ID: 17028573

Title: Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains.

PubMed ID: 17028573

DOI: 10.1038/sj.embor.7400822

PubMed ID: 21124883

Title: The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation.

PubMed ID: 21124883

DOI: 10.1371/journal.pbio.1000545

Sequence Information:

  • Length: 620
  • Mass: 67368
  • Checksum: 3BF3ECE46E25CCD4
  • Sequence:
    • MSRPGHGGLM PVNGLGFPPQ NVARVVVWEW LNEHSRWRPY TATVCHHIEN VLKEDARGSV 
VLGQVDAQLV PYIIDLQSMH QFRQDTGTMR PVRRNFYDPS SAPGKGIVWE WENDGGAWTA 
YDMDICITIQ NAYEKQHPWL DLSSLGFCYL IYFNSMSQMN RQTRRRRRLR RRLDLAYPLT 
VGSIPKSQSW PVGASSGQPC SCQQCLLVNS TRAASNAILA SQRRKAPPAP PLPPPPPPGG 
PPGALAVRPS ATFTGAALWA APAAGPAEPA PPPGAPPRSP GAPGGARTPG QNNLNRPGPQ 
RTTSVSARAS IPPGVPALPV KNLNGTGPVH PALAGMTGIL LCAAGLPVCL TRAPKPILHP 
PPVSKSDVKP VPGVPGVCRK TKKKHLKKSK NPEDVVRRYM QKVKNPPDED CTICMERLVT 
ASGYEGVLRH KGVRPELVGR LGRCGHMYHL LCLVAMYSNG NKDGSLQCPT CKAIYGEKTG 
TQPPGKMEFH LIPHSLPGFP DTQTIRIVYD IPTGIQGPEH PNPGKKFTAR GFPRHCYLPN 
NEKGRKVLRL LITAWERRLI FTIGTSNTTG ESDTVVWNEI HHKTEFGSNL TGHGYPDASY 
LDNVLAELTA QGVSEAAAKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.