Details for: PHC1

Gene ID: 1911

Symbol: PHC1

Ensembl ID: ENSG00000111752

Description: polyhomeotic homolog 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.33
    Marker Score: 1067
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3
    Marker Score: 5035
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.29
    Marker Score: 47576
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1983
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.28
    Marker Score: 12157
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.25
    Marker Score: 5098
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.17
    Marker Score: 23326
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.17
    Marker Score: 25019
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.17
    Marker Score: 10035
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.12
    Marker Score: 42445
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.08
    Marker Score: 66431
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.07
    Marker Score: 1346.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.06
    Marker Score: 8130
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.06
    Marker Score: 4389
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71765
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47990
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.99
    Marker Score: 14755
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.98
    Marker Score: 10128
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.95
    Marker Score: 8971
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5046
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.86
    Marker Score: 249
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.83
    Marker Score: 882
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.82
    Marker Score: 1384
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12274
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1228
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.75
    Marker Score: 7544
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.74
    Marker Score: 1624
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.73
    Marker Score: 1986
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.71
    Marker Score: 817
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2967.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.69
    Marker Score: 403
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.68
    Marker Score: 5926
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 611
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.64
    Marker Score: 3819.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.64
    Marker Score: 2951
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.63
    Marker Score: 907
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.6
    Marker Score: 622
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.58
    Marker Score: 896
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.57
    Marker Score: 1429
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.56
    Marker Score: 434
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.56
    Marker Score: 671
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.55
    Marker Score: 126
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.55
    Marker Score: 473
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.53
    Marker Score: 194
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.53
    Marker Score: 594
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.52
    Marker Score: 2194.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.52
    Marker Score: 558
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.51
    Marker Score: 555
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.5
    Marker Score: 1434
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5
    Marker Score: 3240
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.49
    Marker Score: 190
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.49
    Marker Score: 144
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.49
    Marker Score: 1820
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.48
    Marker Score: 319
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.48
    Marker Score: 517
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.48
    Marker Score: 183
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.48
    Marker Score: 168
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.47
    Marker Score: 265
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.47
    Marker Score: 501
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.47
    Marker Score: 1266
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.47
    Marker Score: 495
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.47
    Marker Score: 662
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.47
    Marker Score: 1063
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.47
    Marker Score: 1097
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.47
    Marker Score: 438
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.46
    Marker Score: 443
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.46
    Marker Score: 139
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.46
    Marker Score: 493
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.45
    Marker Score: 15358
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 299
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.45
    Marker Score: 422
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.44
    Marker Score: 110
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.44
    Marker Score: 301
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.44
    Marker Score: 1521
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.43
    Marker Score: 196
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.43
    Marker Score: 214
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 257
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.43
    Marker Score: 822
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.42
    Marker Score: 99
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.42
    Marker Score: 5566
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.42
    Marker Score: 133
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.42
    Marker Score: 176
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.42
    Marker Score: 878
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.42
    Marker Score: 2515
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.42
    Marker Score: 591
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.42
    Marker Score: 198
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.41
    Marker Score: 228
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.41
    Marker Score: 420

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Other Information

## Summary The PHC1 gene encodes a protein that is expressed in a variety of cell types in the brain. It is involved in a variety of cellular processes, including cellular responses to stimuli, cellular responses to stress, cellular senescence, and signal transduction. ## Key characteristics * PHC1 is a protein that is highly expressed in the brain. * It is a member of the Polyhomeotic protein family. * It is involved in a variety of cellular processes, including cellular responses to stimuli, cellular responses to stress, cellular senescence, and signal transduction. * It is a key regulator of neuronal survival and differentiation. ## Pathways and functions * PHC1 is involved in the regulation of neuronal survival and differentiation. * It is a key regulator of synaptic plasticity, learning and memory. * It is also involved in the regulation of cell cycle regulation and apoptosis. * PHC1 is a potential therapeutic target for a variety of neurological disorders, such as Alzheimer's disease and Parkinson's disease. ## Clinical significance * PHC1 is a promising target for the treatment of neurodegenerative diseases. * Studies in animal models have shown that PHC1 deficiency can lead to neurodegeneration, suggesting that it is a key factor in the development of these diseases. * Clinical trials are currently exploring the use of PHC1 inhibitors to slow or prevent neurodegenerative diseases.

Genular Protein ID: 1028481732

Symbol: PHC1_HUMAN

Name: Polyhomeotic-like protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9121482

Title: Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.

PubMed ID: 9121482

DOI: 10.1128/mcb.17.4.2326

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9199346

Title: RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.

PubMed ID: 9199346

DOI: 10.1128/mcb.17.7.4105

PubMed ID: 12167701

Title: The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

PubMed ID: 12167701

DOI: 10.1128/mcb.22.17.6070-6078.2002

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19636380

Title: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.

PubMed ID: 19636380

DOI: 10.1371/journal.pone.0006380

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21282530

Title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.

PubMed ID: 21282530

DOI: 10.1074/mcp.m110.002642

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23418308

Title: Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis.

PubMed ID: 23418308

DOI: 10.1093/hmg/ddt072

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1004
  • Mass: 105534
  • Checksum: D53764F80931A938
  • Sequence:
  • METESEQNSN STNGSSSSGG SSRPQIAQMS LYERQAVQAL QALQRQPNAA QYFHQFMLQQ 
    QLSNAQLHSL AAVQQATIAA SRQASSPNTS TTQQQTTTTQ ASINLATTSA AQLISRSQSV 
    SSPSATTLTQ SVLLGNTTSP PLNQSQAQMY LRPQLGNLLQ VNRTLGRNVP LASQLILMPN 
    GAVAAVQQEV PSAQSPGVHA DADQVQNLAV RNQQASAQGP QMQGSTQKAI PPGASPVSSL 
    SQASSQALAV AQASSGATNQ SLNLSQAGGG SGNSIPGSMG PGGGGQAHGG LGQLPSSGMG 
    GGSCPRKGTG VVQPLPAAQT VTVSQGSQTE AESAAAKKAE ADGSGQQNVG MNLTRTATPA 
    PSQTLISSAT YTQIQPHSLI QQQQQIHLQQ KQVVIQQQIA IHHQQQFQHR QSQLLHTATH 
    LQLAQQQQQQ QQQQQQQQQP QATTLTAPQP PQVPPTQQVP PSQSQQQAQT LVVQPMLQSS 
    PLSLPPDAAP KPPIPIQSKP PVAPIKPPQL GAAKMSAAQQ PPPHIPVQVV GTRQPGTAQA 
    QALGLAQLAA AVPTSRGMPG TVQSGQAHLA SSPPSSQAPG ALQECPPTLA PGMTLAPVQG 
    TAHVVKGGAT TSSPVVAQVP AAFYMQSVHL PGKPQTLAVK RKADSEEERD DVSTLGSMLP 
    AKASPVAESP KVMDEKSSLG EKAESVANVN ANTPSSELVA LTPAPSVPPP TLAMVSRQMG 
    DSKPPQAIVK PQILTHIIEG FVIQEGAEPF PVGCSQLLKE SEKPLQTGLP TGLTENQSGG 
    PLGVDSPSAE LDKKANLLKC EYCGKYAPAE QFRGSKRFCS MTCAKRYNVS CSHQFRLKRK 
    KMKEFQEANY ARVRRRGPRR SSSDIARAKI QGKCHRGQED SSRGSDNSSY DEALSPTSPG 
    PLSVRAGHGE RDLGNPNTAP PTPELHGINP VFLSSNPSRW SVEEVYEFIA SLQGCQEIAE 
    EFRSQEIDGQ ALLLLKEEHL MSAMNIKLGP ALKICAKINV LKET

Genular Protein ID: 4115119100

Symbol: Q6N083_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 610
  • Mass: 64811
  • Checksum: AF71340B2028DC98
  • Sequence:
  • MQGSTQKAIP PGASPVSSLS QASSQALAVA QASSGATNQS LNLSQAGGGS GNSIPGSMGP 
    GGGGQAHGGL GQLPSSGMGG GSCPRKGTGV VQPLPAAQTV TVSQGSQTEA ESAAAKKAEA 
    DGSGQQNVGM NLTRTATPAP SQTLISSATY TQIQPHSLIQ QQQQIHLQQK QVVIQQQIAI 
    HHQQQFQHRQ SQLLHTAAHL QLAQQQQQQQ QQQQQQQQPQ ATTLTAPQPP QVPPTQQGKP 
    QTLAVKRKAD SEEERDDVST LGSMLPAKAS PVAESPKVMD EKSSLGEKAE SVANVNANAP 
    SSELVALTPA PSVPPPTLAM VSRQMGDSKP PQAIVKPQIL THIIEGFVIQ EGAEPFPVGC 
    SQLLKESEKP LQTGLPTGLT ENQSGGPLGV DSPSAELDKK ANLLKCEYCG KYAPAEQFRG 
    SKRFCSMTCA KRYNVSCSHQ FRLKRKKMKE FQEANYARVR RRGPRRSSSD IARAKIQGKC 
    HRGQEDSSRG SDNSSYDEAL SPTSPGPLSV RAGHGERDLG NPNTAPPTPE LHGINPVFLS 
    SNPSRWSVEE VYEFIASLQG CQEIAEEFRS QEIDGQALLL LKEEHLMSAM NIKLGPALKI 
    CAKINVLKET

Genular Protein ID: 415449371

Symbol: Q6GMQ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 957
  • Mass: 100199
  • Checksum: 192440A4BBAFA37D
  • Sequence:
  • METESEQNSN STNGSSSSGG SSRPQIAQMS LYERQAVQAT IAASRQASSP NTSTTQQQTT 
    TTQASINLAT TSAAQLISRS QSVSSPSATT LTQSVLLGNT TSPPLNQSQA QMYLRVNRTL 
    GRNVPLASQL ILMPNGAVAA VQQEVPSAQS PGVHADADQV QNLAVRNQQA SAQGPQMQGS 
    TQKAIPPGAS PVSSLSQASS QALAVAQASS GATNQSLNLS QAGGGSGNSI PGSMGPGGGG 
    QAHGGLGQLP SSGMGGGSCP RKGTGVVQPL PAAQTVTVSQ GSQTEAESAA AKKAEADGSG 
    QQNVGMNLTR TATPAPSQTL ISSATYTQIQ PHSLIQQQQQ IHLQQKQVVI QQQIAIHHQQ 
    QFQHRQSQLL HTATHLQLAQ QQQQQQQQQQ QQPQATTLTA PQPPQVPPTQ QVPPSQSQQQ 
    AQTLVVQPML QSSPLSLPPD AAPKPPIPIQ SKPPVAPIKP PQLGAAKMSA AQQPPPHIPV 
    QVVGTRQPGT AQAQALGLAQ LAAAVPTSRG MPGTVQSGQA HLASSPPSSQ APGALQECPP 
    TLAPGMTLAP VQGTAHVVKG GATTSSPVVA QVPAAFYMQS VHLPGKPQTL AVKRKADSEE 
    ERDDVSTLGS MLPAKASPVA ESPKVMDEKS SLGEKAESVA NVNANTPSSE LVALTPAPSV 
    PPPTLAMVSR QMGDSKPPQA IVKPQILTHI IEGFVIQEGA EPFPVGCSQL LKESEKPLQT 
    GLPTGLTENQ SGGSLGVDSP SAELDKKANL LKCEYCGKYA PAEQFRGSKR FCSMTCAKRY 
    NVSCSHQFRL KRKKMKEFQE ANYARVRRRG PRRSSSDIAR AKIQGKCHRG QEDSSRGSDN 
    SSYDEALSPT SPGPLSVRAG HGERDLGNPN TAPPTPELHG INPVFLSSNP SRWSVEEVYE 
    FIASLQGCQE IAEEFRSQEI DGQALLLLKE EHLMSAMNIK LGPALKICAK INVLKET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.