Gene EFNA3 - ENSG00000143590 | NCBI Gene ID: 1944

Details for: EFNA3

Gene ID: 1944

Symbol: EFNA3

Ensembl ID: ENSG00000143590

Description: ephrin A3

Associated with

Developmental biology
(R-HSA-1266738)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Epha-mediated growth cone collapse
(R-HSA-3928663)
Nervous system development
(R-HSA-9675108)
Axon guidance
(GO:0007411)
Cell-cell signaling
(GO:0007267)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Negative regulation of angiogenesis
(GO:0016525)
Plasma membrane
(GO:0005886)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902961)
Protein binding
(GO:0005515)
Regulation of neuron differentiation
(GO:0045664)
Side of membrane
(GO:0098552)
Transmembrane-ephrin receptor activity
(GO:0005005)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: respiratory basal cell (CL0002633)
Fold Change: 2.47
Marker Score: 3543.5
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.46
Marker Score: 3072.5
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 2.03
Marker Score: 4194
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.54
Marker Score: 2925
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.51
Marker Score: 1344
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.39
Marker Score: 1162
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.32
Marker Score: 2691
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.12
Marker Score: 17508
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.09
Marker Score: 344.5
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.06
Marker Score: 1284
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71824
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48049
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.99
Marker Score: 522
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 504
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.95
Marker Score: 898.5
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5262
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.92
Marker Score: 1492
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 368
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2738
Cell Name: thymocyte (CL0000893)
Fold Change: 0.91
Marker Score: 953
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.9
Marker Score: 543
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5285
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.86
Marker Score: 1756
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.85
Marker Score: 7366
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.85
Marker Score: 6673
Cell Name: germ cell (CL0000586)
Fold Change: 0.82
Marker Score: 1438
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 580
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 391
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3053.5
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.73
Marker Score: 234
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.67
Marker Score: 755
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.67
Marker Score: 318
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.64
Marker Score: 421
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.61
Marker Score: 1448
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.59
Marker Score: 197
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.54
Marker Score: 1281
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.53
Marker Score: 166
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.52
Marker Score: 332
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.48
Marker Score: 693
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.48
Marker Score: 213
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.48
Marker Score: 112
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.47
Marker Score: 654
Cell Name: motor neuron (CL0000100)
Fold Change: 0.46
Marker Score: 274
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.45
Marker Score: 1661
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.45
Marker Score: 238
Cell Name: malignant cell (CL0001064)
Fold Change: 0.44
Marker Score: 5855
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.43
Marker Score: 181
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.42
Marker Score: 241
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.42
Marker Score: 878
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.41
Marker Score: 106
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.4
Marker Score: 679
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.4
Marker Score: 614
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.39
Marker Score: 114
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.38
Marker Score: 670
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.38
Marker Score: 3235
Cell Name: goblet cell (CL0000160)
Fold Change: 0.37
Marker Score: 2487
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.37
Marker Score: 391.5
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.36
Marker Score: 13485
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.35
Marker Score: 340
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.34
Marker Score: 317
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.34
Marker Score: 81
Cell Name: neuron (CL0000540)
Fold Change: 0.33
Marker Score: 1358
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.32
Marker Score: 403
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.31
Marker Score: 18829
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.3
Marker Score: 164
Cell Name: kidney cell (CL1000497)
Fold Change: 0.3
Marker Score: 198
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.29
Marker Score: 139
Cell Name: male germ cell (CL0000015)
Fold Change: 0.29
Marker Score: 84
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.28
Marker Score: 217
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.28
Marker Score: 2632
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.28
Marker Score: 1291
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.28
Marker Score: 278
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.28
Marker Score: 88
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.27
Marker Score: 3593
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.26
Marker Score: 2624
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.26
Marker Score: 5161
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.25
Marker Score: 2398
Cell Name: stem cell (CL0000034)
Fold Change: 0.25
Marker Score: 587
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.23
Marker Score: 900
Cell Name: Unknown (CL0002371)
Fold Change: 0.23
Marker Score: 247
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.23
Marker Score: 318
Cell Name: neural cell (CL0002319)
Fold Change: 0.23
Marker Score: 109
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.22
Marker Score: 8234
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.21
Marker Score: 1605
Cell Name: podocyte (CL0000653)
Fold Change: 0.21
Marker Score: 77
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.2
Marker Score: 3056
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.2
Marker Score: 79
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.19
Marker Score: 66
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.19
Marker Score: 74
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.19
Marker Score: 205
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.19
Marker Score: 730
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.19
Marker Score: 590

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**Key characteristics:** * EFNA3 is a transmembrane protein that is expressed in both endothelial cells and epithelial cells. * It is a member of the Eph family of cell adhesion molecules. * It is a key regulator of cell-cell signaling, as it is involved in the repulsion of endothelial cells from each other. * It is also involved in the regulation of angiogenesis, as it can promote the migration of endothelial cells and the formation of new blood vessels. **Pathways and functions:** * EFNA3 is involved in the axonal guidance of neurons, as it is expressed in neurons and is known to interact with Eph receptors on other neurons. * It is also involved in cell-cell signaling, as it is a key regulator of the repulsion of endothelial cells from each other. * It is involved in the regulation of angiogenesis, as it can promote the migration of endothelial cells and the formation of new blood vessels. * It is also involved in the development of the nervous system, as it is expressed in neurons and is known to interact with Eph receptors on other neurons. **Clinical significance:** Mutations in the EFNA3 gene have been linked to a number of human diseases, including vascular diseases, cancer, and developmental disorders. These diseases are characterized by abnormal cell-cell interactions and angiogenesis. Therefore, EFNA3 is a promising target for the development of new therapies for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ephrin-A3

Genular Protein ID: 1665584921

Symbol: EFNA3_HUMAN

Name: Ephrin-A3

UniProtKB Accession Codes:

P52797 B7ZAD3 D3DV85 Q0VGC9 Q5SR70

Database IDs:

Citations:

PubMed ID: 7838529

Title: Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

PubMed ID: 7838529

PubMed ID: 7973638

Title: Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.

PubMed ID: 7973638

DOI: 10.1126/science.7973638

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 238
Mass: 26350
Checksum: 8EFD6AE8FE33FDDA
Sequence:

MAAAPLLLLL LLVPVPLLPL LAQGPGGALG NRHAVYWNSS NQHLRREGYT VQVNVNDYLD 
IYCPHYNSSG VGPGAGPGPG GGAEQYVLYM VSRNGYRTCN ASQGFKRWEC NRPHAPHSPI 
KFSEKFQRYS AFSLGYEFHA GHEYYYISTP THNLHWKCLR MKVFVCCAST SHSGEKPVPT 
LPQFTMGPNV KINVLEDFEG ENPQVPKLEK SISGTSPKRE HLPLAVGIAF FLMTFLAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EFNA3

Associated with

Cells (max top 100)

Other Information

Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. PubMed ID: 7838529

Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. PubMed ID: 7973638

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039