Details for: EFNA3

Gene ID: 1944

Symbol: EFNA3

Ensembl ID: ENSG00000143590

Description: ephrin A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3070
    Cell Significance Index: -6.1800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.6234
    Cell Significance Index: 3.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1034
    Cell Significance Index: 209.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0380
    Cell Significance Index: 47.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8577
    Cell Significance Index: 379.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8399
    Cell Significance Index: 59.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6321
    Cell Significance Index: 37.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5170
    Cell Significance Index: 60.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4969
    Cell Significance Index: 26.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4855
    Cell Significance Index: 52.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4828
    Cell Significance Index: 7.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4752
    Cell Significance Index: 429.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4133
    Cell Significance Index: 8.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3425
    Cell Significance Index: 55.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2771
    Cell Significance Index: 3.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2486
    Cell Significance Index: 17.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2168
    Cell Significance Index: 43.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2109
    Cell Significance Index: 7.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2072
    Cell Significance Index: 5.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1905
    Cell Significance Index: 9.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1716
    Cell Significance Index: 4.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1538
    Cell Significance Index: 15.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1523
    Cell Significance Index: 3.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1403
    Cell Significance Index: 4.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1366
    Cell Significance Index: 6.4200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1116
    Cell Significance Index: 0.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1063
    Cell Significance Index: 13.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0940
    Cell Significance Index: 3.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0872
    Cell Significance Index: 31.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0794
    Cell Significance Index: 1.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0784
    Cell Significance Index: 5.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0479
    Cell Significance Index: 1.3400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0449
    Cell Significance Index: 0.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0378
    Cell Significance Index: 20.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0322
    Cell Significance Index: 1.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0308
    Cell Significance Index: 0.5200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.0307
    Cell Significance Index: 0.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0200
    Cell Significance Index: 3.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0199
    Cell Significance Index: 1.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0167
    Cell Significance Index: 1.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0142
    Cell Significance Index: 0.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0129
    Cell Significance Index: 0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0080
    Cell Significance Index: 1.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0065
    Cell Significance Index: 0.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0016
    Cell Significance Index: 0.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0050
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0051
    Cell Significance Index: -6.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0087
    Cell Significance Index: -6.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0104
    Cell Significance Index: -5.8500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0154
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0166
    Cell Significance Index: -2.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0182
    Cell Significance Index: -0.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0203
    Cell Significance Index: -2.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0227
    Cell Significance Index: -6.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0256
    Cell Significance Index: -2.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0290
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0300
    Cell Significance Index: -3.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0316
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0328
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0348
    Cell Significance Index: -7.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0349
    Cell Significance Index: -5.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0357
    Cell Significance Index: -1.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0362
    Cell Significance Index: -0.3800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0406
    Cell Significance Index: -0.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0502
    Cell Significance Index: -1.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0536
    Cell Significance Index: -1.4100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0553
    Cell Significance Index: -0.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0584
    Cell Significance Index: -1.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0624
    Cell Significance Index: -6.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0625
    Cell Significance Index: -7.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0682
    Cell Significance Index: -1.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0714
    Cell Significance Index: -0.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0755
    Cell Significance Index: -1.8100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0789
    Cell Significance Index: -0.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0805
    Cell Significance Index: -1.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0816
    Cell Significance Index: -1.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0833
    Cell Significance Index: -2.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0843
    Cell Significance Index: -1.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0882
    Cell Significance Index: -4.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0893
    Cell Significance Index: -6.8600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0967
    Cell Significance Index: -1.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0971
    Cell Significance Index: -1.9200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0991
    Cell Significance Index: -0.8200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1056
    Cell Significance Index: -1.4800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1089
    Cell Significance Index: -0.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1109
    Cell Significance Index: -3.6300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1180
    Cell Significance Index: -0.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1190
    Cell Significance Index: -3.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1262
    Cell Significance Index: -4.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1297
    Cell Significance Index: -3.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1313
    Cell Significance Index: -4.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1316
    Cell Significance Index: -3.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EFNA3 is a transmembrane protein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. Its extracellular domain interacts with Eph receptors, leading to the activation of various signaling pathways. EFNA3 is highly expressed in various tissues, including the nervous system, kidney, heart, and placenta, and is specifically expressed in cells involved in axon guidance, neuron differentiation, and angiogenesis. **Pathways and Functions:** EFNA3 is involved in several key signaling pathways, including: 1. **Axon guidance:** EFNA3 interacts with Eph receptors to regulate the growth cone collapse of neurons, influencing axon guidance and neural development. 2. **Cell-cell signaling:** EFNA3 mediates repulsive interactions between cells, which is essential for tissue patterning and morphogenesis. 3. **Eph-ephrin mediated repulsion of cells:** EFNA3 binds to Eph receptors, triggering a signaling cascade that promotes cell repulsion and tissue organization. 4. **Ephrin receptor signaling pathway:** EFNA3 activates the Eph receptor signaling pathway, which regulates cell migration, proliferation, and differentiation. 5. **Regulation of angiogenesis:** EFNA3 inhibits angiogenesis by suppressing the expression of pro-angiogenic factors. **Clinical Significance:** EFNA3 is implicated in various diseases and disorders, including: 1. **Neurological disorders:** EFNA3 mutations have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** EFNA3 is involved in the regulation of tumor cell migration and invasion, making it a potential target for cancer therapy. 3. **Cardiovascular disease:** EFNA3 is expressed in cardiac endothelial cells and plays a role in the regulation of angiogenesis and vascular remodeling. 4. **Placental development:** EFNA3 is essential for placental development and function, highlighting its importance in pregnancy-related disorders. In conclusion, EFNA3 is a vital protein involved in various cellular processes, including axon guidance, cell-cell signaling, and angiogenesis. Its dysregulation has been implicated in several diseases and disorders, making it a promising target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms by which EFNA3 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 1665584921

Symbol: EFNA3_HUMAN

Name: Ephrin-A3

UniProtKB Accession Codes:

P52797 B7ZAD3 D3DV85 Q0VGC9 Q5SR70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7838529

Title: Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

PubMed ID: 7838529

PubMed ID: 7973638

Title: Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.

PubMed ID: 7973638

DOI: 10.1126/science.7973638

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 238
  • Mass: 26350
  • Checksum: 8EFD6AE8FE33FDDA
  • Sequence:
    • MAAAPLLLLL LLVPVPLLPL LAQGPGGALG NRHAVYWNSS NQHLRREGYT VQVNVNDYLD 
IYCPHYNSSG VGPGAGPGPG GGAEQYVLYM VSRNGYRTCN ASQGFKRWEC NRPHAPHSPI 
KFSEKFQRYS AFSLGYEFHA GHEYYYISTP THNLHWKCLR MKVFVCCAST SHSGEKPVPT 
LPQFTMGPNV KINVLEDFEG ENPQVPKLEK SISGTSPKRE HLPLAVGIAF FLMTFLAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.