Gene EFNB3 - ENSG00000108947 | NCBI Gene ID: 1949

Details for: EFNB3

Gene ID: 1949

Symbol: EFNB3

Ensembl ID: ENSG00000108947

Description: ephrin B3

Associated with

Developmental biology
(R-HSA-1266738)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Ephrin signaling
(R-HSA-3928664)
Adult walking behavior
(GO:0007628)
Axon choice point recognition
(GO:0016198)
Axon guidance
(GO:0007411)
Cell-cell signaling
(GO:0007267)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Glutamatergic synapse
(GO:0098978)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Negative regulation of axonogenesis
(GO:0050771)
Nervous system development
(GO:0007399)
Plasma membrane
(GO:0005886)
Positive regulation of presynapse assembly
(GO:1905608)
Positive regulation of synaptic transmission
(GO:0050806)
Postsynaptic density membrane
(GO:0098839)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Symbiont entry into host cell
(GO:0046718)
T cell costimulation
(GO:0031295)
Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
(GO:0099557)
Transmembrane-ephrin receptor activity
(GO:0005005)
Virus receptor activity
(GO:0001618)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.56
Marker Score: 1348.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1989.5
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1166
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 866
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.25
Marker Score: 520.5
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4807.5
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.03
Marker Score: 695
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71818
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48042
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505.5
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.95
Marker Score: 394
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5349
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 371
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.86
Marker Score: 688
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.84
Marker Score: 948
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 609
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.77
Marker Score: 1803.5
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.76
Marker Score: 503
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.73
Marker Score: 404
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: neuron (CL0000540)
Fold Change: 0.68
Marker Score: 2757
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.66
Marker Score: 1788
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.63
Marker Score: 968
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.62
Marker Score: 210
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.62
Marker Score: 181
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.61
Marker Score: 5792
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.59
Marker Score: 375
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.56
Marker Score: 4832
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.53
Marker Score: 1822
Cell Name: neural cell (CL0002319)
Fold Change: 0.53
Marker Score: 255
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.49
Marker Score: 30255
Cell Name: motor neuron (CL0000100)
Fold Change: 0.49
Marker Score: 292
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.48
Marker Score: 16156.5
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.47
Marker Score: 4401
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.46
Marker Score: 6069
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.46
Marker Score: 151
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.45
Marker Score: 1877
Cell Name: plasma cell (CL0000786)
Fold Change: 0.45
Marker Score: 501
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.45
Marker Score: 143
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.45
Marker Score: 253
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.44
Marker Score: 3858
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.44
Marker Score: 1693
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.43
Marker Score: 203
Cell Name: acinar cell (CL0000622)
Fold Change: 0.4
Marker Score: 285
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.4
Marker Score: 843
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 385
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.39
Marker Score: 92
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.39
Marker Score: 384
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.38
Marker Score: 405
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.38
Marker Score: 152
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.37
Marker Score: 2420
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.37
Marker Score: 754
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.37
Marker Score: 521.5
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.37
Marker Score: 3696
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.37
Marker Score: 13928
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.36
Marker Score: 1679
Cell Name: kidney cell (CL1000497)
Fold Change: 0.36
Marker Score: 237
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.35
Marker Score: 5540
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.35
Marker Score: 182
Cell Name: mast cell (CL0000097)
Fold Change: 0.35
Marker Score: 203
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.35
Marker Score: 89
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.35
Marker Score: 339
Cell Name: Unknown (CL0002371)
Fold Change: 0.34
Marker Score: 362
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.34
Marker Score: 572
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.34
Marker Score: 6666
Cell Name: goblet cell (CL0000160)
Fold Change: 0.33
Marker Score: 2187
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.33
Marker Score: 2499
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.32
Marker Score: 2716.5
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.31
Marker Score: 1047
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.31
Marker Score: 590
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.31
Marker Score: 3457
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.31
Marker Score: 133
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.31
Marker Score: 255
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.3
Marker Score: 277.5
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.3
Marker Score: 148
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.29
Marker Score: 840
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.29
Marker Score: 3013
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.28
Marker Score: 1179
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.27
Marker Score: 1125.5
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.27
Marker Score: 100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.26
Marker Score: 9604.5
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.26
Marker Score: 312
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.24
Marker Score: 231
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.24
Marker Score: 129
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.24
Marker Score: 115
Cell Name: osteoblast (CL0000062)
Fold Change: 0.24
Marker Score: 127
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.23
Marker Score: 276

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## Summary EFNB3 is a cell surface protein that plays a crucial role in regulating cell-cell interactions and immune responses. It is expressed in various cell types, including hematopoietic stem cells, enterocytes, and immune cells. ## Key characteristics * EFNB3 is a single-pass transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the Eph family of cell adhesion molecules, which are involved in cell-cell adhesion, migration, and signaling. * EFNB3 is expressed on the surface of immune cells, including T cells, B cells, and dendritic cells. * It is a key regulator of T cell costimulation, promoting the activation and differentiation of naive T cells. * It is also involved in the regulation of epithelial cell migration and barrier function. ## Pathways and functions * EFNB3 signaling is involved in cell adhesion, migration, and signaling in various tissues, including the immune system. * It plays a crucial role in the regulation of T cell costimulation, a key step in the activation of naive T cells. * It is also involved in the regulation of epithelial cell migration and barrier function. * Dysregulation of EFNB3 signaling has been linked to various diseases, including cancer and autoimmune disorders. ## Clinical significance * Mutations in the EFNB3 gene have been linked to several human diseases, including cancer, autoimmune disorders, and inflammation. * Targeting EFNB3 signaling has emerged as a potential therapeutic strategy for these diseases. * In preclinical studies, blocking EFNB3 signaling has been shown to inhibit cancer growth and metastasis, suggesting that it could be a potential therapeutic agent for cancer treatment. ## Additional notes * EFNB3 is also known as CD112 or CD112a. * It is a highly conserved protein across species. * It is a promising target for cancer immunotherapy due to its role in cell signaling and immune regulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ephrin-B3

Genular Protein ID: 1652090284

Symbol: EFNB3_HUMAN

Name: Ephrin-B3

UniProtKB Accession Codes:

Q15768 B2RBW2 D3DTQ6 O00680 Q8TBH7 Q92875

Database IDs:

Citations:

PubMed ID: 9126477

Title: cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors.

PubMed ID: 9126477

DOI: 10.1006/geno.1997.4615

PubMed ID: 8808709

Title: Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.

PubMed ID: 8808709

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10197531

Title: EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.

PubMed ID: 10197531

DOI: 10.1016/s0896-6273(00)80706-0

PubMed ID: 16477309

Title: Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus.

PubMed ID: 16477309

DOI: 10.1371/journal.ppat.0020007

PubMed ID: 17376907

Title: Identification of Hendra virus G glycoprotein residues that are critical for receptor binding.

PubMed ID: 17376907

DOI: 10.1128/jvi.02022-06

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 340
Mass: 35835
Checksum: EDFF2A23C2FDE79F
Sequence:

MGPPHSGPGG VRVGALLLLG VLGLVSGLSL EPVYWNSANK RFQAEGGYVL YPQIGDRLDL 
LCPRARPPGP HSSPNYEFYK LYLVGGAQGR RCEAPPAPNL LLTCDRPDLD LRFTIKFQEY 
SPNLWGHEFR SHHDYYIIAT SDGTREGLES LQGGVCLTRG MKVLLRVGQS PRGGAVPRKP 
VSEMPMERDR GAAHSLEPGK ENLPGDPTSN ATSRGAEGPL PPPSMPAVAG AAGGLALLLL 
GVAGAGGAMC WRRRRAKPSE SRHPGPGSFG RGGSLGLGGG GGMGPREAEP GELGIALRGG 
GAADPPFCPH YEKVSGDYGH PVYIVQDGPP QSPPNIYYKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EFNB3

Associated with

Cells (max top 100)

Other Information

cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors. PubMed ID: 9126477

Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. PubMed ID: 8808709

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. PubMed ID: 10197531

Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus. PubMed ID: 16477309

Identification of Hendra virus G glycoprotein residues that are critical for receptor binding. PubMed ID: 17376907

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569