Details for: EFNB3

Gene ID: 1949

Symbol: EFNB3

Ensembl ID: ENSG00000108947

Description: ephrin B3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.7728
    Cell Significance Index: -11.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.6563
    Cell Significance Index: 60.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.7935
    Cell Significance Index: 60.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1314
    Cell Significance Index: 68.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3671
    Cell Significance Index: -2.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8759
    Cell Significance Index: 19.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6618
    Cell Significance Index: 65.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5778
    Cell Significance Index: 521.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4144
    Cell Significance Index: 8.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3777
    Cell Significance Index: 41.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3650
    Cell Significance Index: 24.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3459
    Cell Significance Index: 56.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3313
    Cell Significance Index: 66.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2955
    Cell Significance Index: 17.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2699
    Cell Significance Index: 5.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2430
    Cell Significance Index: 46.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2348
    Cell Significance Index: 14.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2114
    Cell Significance Index: 10.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1970
    Cell Significance Index: 7.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1854
    Cell Significance Index: 8.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1854
    Cell Significance Index: 81.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1682
    Cell Significance Index: 60.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1673
    Cell Significance Index: 11.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1077
    Cell Significance Index: 1.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1044
    Cell Significance Index: 72.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0554
    Cell Significance Index: 30.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0476
    Cell Significance Index: 6.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0419
    Cell Significance Index: 2.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0350
    Cell Significance Index: 0.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0267
    Cell Significance Index: 1.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0232
    Cell Significance Index: 3.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0141
    Cell Significance Index: 0.4900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0092
    Cell Significance Index: 0.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0035
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0002
    Cell Significance Index: 0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0016
    Cell Significance Index: -1.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0059
    Cell Significance Index: -10.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0062
    Cell Significance Index: -0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0146
    Cell Significance Index: -2.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0149
    Cell Significance Index: -0.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0160
    Cell Significance Index: -12.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0168
    Cell Significance Index: -12.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0170
    Cell Significance Index: -3.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0187
    Cell Significance Index: -0.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0227
    Cell Significance Index: -0.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0236
    Cell Significance Index: -1.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0272
    Cell Significance Index: -12.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0286
    Cell Significance Index: -3.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0294
    Cell Significance Index: -8.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0369
    Cell Significance Index: -4.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0374
    Cell Significance Index: -7.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0381
    Cell Significance Index: -6.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0476
    Cell Significance Index: -3.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0493
    Cell Significance Index: -6.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0572
    Cell Significance Index: -7.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0620
    Cell Significance Index: -3.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0693
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0742
    Cell Significance Index: -8.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0792
    Cell Significance Index: -11.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0853
    Cell Significance Index: -1.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0984
    Cell Significance Index: -1.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1067
    Cell Significance Index: -12.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1094
    Cell Significance Index: -11.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1149
    Cell Significance Index: -3.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1194
    Cell Significance Index: -12.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1216
    Cell Significance Index: -3.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1228
    Cell Significance Index: -5.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1356
    Cell Significance Index: -4.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1381
    Cell Significance Index: -10.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1474
    Cell Significance Index: -4.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1494
    Cell Significance Index: -2.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1515
    Cell Significance Index: -4.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1527
    Cell Significance Index: -11.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1597
    Cell Significance Index: -7.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1608
    Cell Significance Index: -4.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1718
    Cell Significance Index: -3.4500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1889
    Cell Significance Index: -3.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1914
    Cell Significance Index: -3.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1936
    Cell Significance Index: -5.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1988
    Cell Significance Index: -4.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2032
    Cell Significance Index: -7.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2047
    Cell Significance Index: -1.9400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2056
    Cell Significance Index: -1.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2110
    Cell Significance Index: -10.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2245
    Cell Significance Index: -2.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2389
    Cell Significance Index: -5.9600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2597
    Cell Significance Index: -3.0300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2635
    Cell Significance Index: -2.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2884
    Cell Significance Index: -6.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2937
    Cell Significance Index: -3.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3023
    Cell Significance Index: -6.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3054
    Cell Significance Index: -11.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3079
    Cell Significance Index: -4.6400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3227
    Cell Significance Index: -5.1200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3355
    Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EFNB3 is a transmembrane protein that belongs to the ephrin family, which consists of six subfamilies (A to F). EFNB3 is specifically expressed in various cell types, including hematopoietic stem cells, enterocytes, and GABAergic interneurons in the cerebral cortex. It is also found in the plasma membrane and is involved in cell-cell signaling, where it interacts with ephrin receptors (Eph receptors) to regulate various cellular processes. **Pathways and Functions** EFNB3 is involved in several key pathways, including: 1. **Axon Guidance**: EFNB3 plays a crucial role in axon guidance during neural development, where it interacts with EphB receptors to regulate the formation of axonal connections. 2. **Cell-Cell Signaling**: EFNB3 is involved in cell-cell signaling, where it interacts with Eph receptors to regulate the adhesion, migration, and differentiation of cells. 3. **Synaptic Transmission**: EFNB3 is involved in the regulation of synaptic transmission, where it interacts with EphB receptors to regulate the formation of synaptic connections. 4. **Developmental Biology**: EFNB3 is involved in the development of various tissues, including the nervous system, where it regulates the formation of neural connections. **Clinical Significance** EFNB3 has been implicated in several neurological and psychiatric disorders, including: 1. **Autism Spectrum Disorder**: EFNB3 has been associated with autism spectrum disorder, where it is thought to play a role in the regulation of synaptic transmission and neural connectivity. 2. **Schizophrenia**: EFNB3 has been implicated in schizophrenia, where it is thought to play a role in the regulation of synaptic transmission and neural connectivity. 3. **Neurodevelopmental Disorders**: EFNB3 has been implicated in various neurodevelopmental disorders, including ADHD, OCD, and Tourette's syndrome. In addition, EFNB3 has been implicated in several other diseases, including: 1. **Cancer**: EFNB3 has been implicated in the regulation of cell adhesion and migration, where it is thought to play a role in cancer progression. 2. **Inflammatory Diseases**: EFNB3 has been implicated in the regulation of inflammatory responses, where it is thought to play a role in the development of inflammatory diseases. **Conclusion** In conclusion, EFNB3 is a crucial protein involved in various cellular processes, including cell-cell signaling, axon guidance, and synaptic transmission. Its dysregulation has been implicated in several neurological and psychiatric disorders, as well as other diseases. Further research is needed to fully understand the mechanisms by which EFNB3 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1652090284

Symbol: EFNB3_HUMAN

Name: Ephrin-B3

UniProtKB Accession Codes:

Q15768 B2RBW2 D3DTQ6 O00680 Q8TBH7 Q92875

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9126477

Title: cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors.

PubMed ID: 9126477

DOI: 10.1006/geno.1997.4615

PubMed ID: 8808709

Title: Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.

PubMed ID: 8808709

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10197531

Title: EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.

PubMed ID: 10197531

DOI: 10.1016/s0896-6273(00)80706-0

PubMed ID: 16477309

Title: Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus.

PubMed ID: 16477309

DOI: 10.1371/journal.ppat.0020007

PubMed ID: 17376907

Title: Identification of Hendra virus G glycoprotein residues that are critical for receptor binding.

PubMed ID: 17376907

DOI: 10.1128/jvi.02022-06

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 340
  • Mass: 35835
  • Checksum: EDFF2A23C2FDE79F
  • Sequence:
    • MGPPHSGPGG VRVGALLLLG VLGLVSGLSL EPVYWNSANK RFQAEGGYVL YPQIGDRLDL 
LCPRARPPGP HSSPNYEFYK LYLVGGAQGR RCEAPPAPNL LLTCDRPDLD LRFTIKFQEY 
SPNLWGHEFR SHHDYYIIAT SDGTREGLES LQGGVCLTRG MKVLLRVGQS PRGGAVPRKP 
VSEMPMERDR GAAHSLEPGK ENLPGDPTSN ATSRGAEGPL PPPSMPAVAG AAGGLALLLL 
GVAGAGGAMC WRRRRAKPSE SRHPGPGSFG RGGSLGLGGG GGMGPREAEP GELGIALRGG 
GAADPPFCPH YEKVSGDYGH PVYIVQDGPP QSPPNIYYKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.