Gene CELSR2 - ENSG00000143126 | NCBI Gene ID: 1952

Details for: CELSR2

Gene ID: 1952

Symbol: CELSR2

Ensembl ID: ENSG00000143126

Description: cadherin EGF LAG seven-pass G-type receptor 2

Associated with

Calcium ion binding
(GO:0005509)
Cell-cell adhesion
(GO:0098609)
Cerebrospinal fluid secretion
(GO:0033326)
Cilium assembly
(GO:0060271)
Cilium movement
(GO:0003341)
Cytoplasm
(GO:0005737)
Dendrite morphogenesis
(GO:0048813)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Membrane
(GO:0016020)
Motor neuron migration
(GO:0097475)
Neural plate anterior/posterior regionalization
(GO:0021999)
Plasma membrane
(GO:0005886)
Regulation of cell-cell adhesion
(GO:0022407)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of protein localization
(GO:0032880)
Ventricular system development
(GO:0021591)
Wnt signaling pathway
(GO:0016055)
Wnt signaling pathway, planar cell polarity pathway
(GO:0060071)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.41
Marker Score: 13362
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.33
Marker Score: 11424
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.18
Marker Score: 859.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.18
Marker Score: 1820
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.17
Marker Score: 6267
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.16
Marker Score: 8906
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.15
Marker Score: 43623
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.13
Marker Score: 69645
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.12
Marker Score: 2817
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.05
Marker Score: 9850
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251793
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71811
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48036
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: neuron (CL0000540)
Fold Change: 0.98
Marker Score: 3973
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 502
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.93
Marker Score: 482
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 368
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5203
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.9
Marker Score: 13432
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 321
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5282
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.87
Marker Score: 3355
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.85
Marker Score: 1995
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.84
Marker Score: 13130
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.82
Marker Score: 867
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.82
Marker Score: 16279
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.81
Marker Score: 6043
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.79
Marker Score: 28977
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.78
Marker Score: 3622
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.77
Marker Score: 1852
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1256
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.77
Marker Score: 3222
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.77
Marker Score: 1559
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.77
Marker Score: 506
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.76
Marker Score: 838
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 391
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.74
Marker Score: 3881
Cell Name: brush cell (CL0002204)
Fold Change: 0.72
Marker Score: 658
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.7
Marker Score: 2921
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.7
Marker Score: 537
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.69
Marker Score: 1311
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: granule cell (CL0000120)
Fold Change: 0.67
Marker Score: 5058
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.65
Marker Score: 22009
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.65
Marker Score: 6727
Cell Name: basal cell (CL0000646)
Fold Change: 0.64
Marker Score: 832
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.63
Marker Score: 355
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.63
Marker Score: 896
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.62
Marker Score: 2419
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.62
Marker Score: 294
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.61
Marker Score: 3589.5
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.58
Marker Score: 587
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.56
Marker Score: 485
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.55
Marker Score: 1272
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.55
Marker Score: 771
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.54
Marker Score: 347
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.54
Marker Score: 239
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.52
Marker Score: 1395
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.52
Marker Score: 1476
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.48
Marker Score: 2013
Cell Name: germ cell (CL0000586)
Fold Change: 0.48
Marker Score: 834
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.48
Marker Score: 262
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.47
Marker Score: 357
Cell Name: secretory cell (CL0000151)
Fold Change: 0.47
Marker Score: 860
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.47
Marker Score: 786
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.46
Marker Score: 154
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.45
Marker Score: 486
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.44
Marker Score: 427.5
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.44
Marker Score: 495
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.44
Marker Score: 142
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.44
Marker Score: 1815
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.43
Marker Score: 180
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.42
Marker Score: 163
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.42
Marker Score: 354
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.42
Marker Score: 130
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.41
Marker Score: 443
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.41
Marker Score: 193
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.41
Marker Score: 83
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.41
Marker Score: 1459
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.41
Marker Score: 106
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.41
Marker Score: 245
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.4
Marker Score: 162
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.39
Marker Score: 13554
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.38
Marker Score: 3293
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.38
Marker Score: 358
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.38
Marker Score: 8023
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.37
Marker Score: 118
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.37
Marker Score: 2908.5
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.37
Marker Score: 154
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.37
Marker Score: 106
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.37
Marker Score: 213
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.37
Marker Score: 357.5
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.36
Marker Score: 412
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.36
Marker Score: 3624
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.36
Marker Score: 3587

Hover over a box to see details here...

**Key characteristics:** - Cadherin EGF LAG seven-pass G-type receptor - Ensembl ID: ENSG00000143126 - Highly expressed in the brain and spinal cord - Regulates cell-cell adhesion and migration **Pathways and functions:** - Calcium ion binding - Cell-cell adhesion - Cerebrospinal fluid secretion - Cilium assembly - Neuronal migration - Tissue morphogenesis **Clinical significance:** - Mutations in CELSR2 have been linked to several neurological disorders, including autism, schizophrenia, and epilepsy. - CELSR2 is a potential therapeutic target for these disorders, as it is involved in the regulation of neuronal migration and adhesion. **Additional notes:** - CELSR2 is a highly conserved protein, with a similar gene found in other mammals. - It is expressed in the developing and adult brain, where it plays a role in neuronal migration and adhesion. - Mutations in CELSR2 have been shown to disrupt neural tube formation and lead to neural tube defects.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cadherin family member 10

Genular Protein ID: 825451018

Symbol: CELR2_HUMAN

Name: Cadherin family member 10

UniProtKB Accession Codes:

Q9HCU4 Q5T2Y7 Q92566

Database IDs:

Citations:

PubMed ID: 10907856

Title: The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1.

PubMed ID: 10907856

DOI: 10.1093/dnares/7.3.233

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 29983323

Title: De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus.

PubMed ID: 29983323

DOI: 10.1016/j.neuron.2018.06.019

Sequence Information:

Length: 2923
Mass: 317453
Checksum: 382757D315158ED8
Sequence:

MRSPATGVPL PTPPPPLLLL LLLLLPPPLL GDQVGPCRSL GSRGRGSSGA CAPMGWLCPS 
SASNLWLYTS RCRDAGTELT GHLVPHHDGL RVWCPESEAH IPLPPAPEGC PWSCRLLGIG 
GHLSPQGKLT LPEEHPCLKA PRLRCQSCKL AQAPGLRAGE RSPEESLGGR RKRNVNTAPQ 
FQPPSYQATV PENQPAGTPV ASLRAIDPDE GEAGRLEYTM DALFDSRSNQ FFSLDPVTGA 
VTTAEELDRE TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE 
NLEVGYEVLT VRATDGDAPP NANILYRLLE GSGGSPSEVF EIDPRSGVIR TRGPVDREEV 
ESYQLTVEAS DQGRDPGPRS TTAAVFLSVE DDNDNAPQFS EKRYVVQVRE DVTPGAPVLR 
VTASDRDKGS NAVVHYSIMS GNARGQFYLD AQTGALDVVS PLDYETTKEY TLRVRAQDGG 
RPPLSNVSGL VTVQVLDIND NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL 
EYRLAGVGHD FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTV 
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG NTRNRFSITS 
QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV NVTDANTHRP VFQSSHYTVN 
VNEDRPAGTT VVLISATDED TGENARITYF MEDSIPQFRI DADTGAVTTQ AELDYEDQVS 
YTLAITARDN GIPQKSDTTY LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT 
DRDSGLNGRV FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP 
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE GTNAQIMYQI 
VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS APLVSRATVH VRLLDRNDNP 
PVLGNFEILF NNYVTNRSSS FPGGAIGRVP AHDPDISDSL TYSFERGNEL SLVLLNASTG 
ELKLSRALDN NRPLEAIMSV LVSDGVHSVT AQCALRVTII TDEMLTHSIT LRLEDMSPER 
FLSPLLGLFI QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL 
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD SSAPFIASSS 
VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH GRCRSREGGY TCLCRDGYTG 
EHCEVSARSG RCTPGVCKNG GTCVNLLVGG FKCDCPSGDF EKPYCQVTTR SFPAHSFITF 
RGLRQRFHFT LALSFATKER DGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS 
PFVPGGVSDG QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVTVDGCDTG VALRFGSVLG 
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR QFVGCMRNLQ VDSRHIDMAD 
FIANNGTVPG CPAKKNVCDS NTCHNGGTCV NQWDAFSCEC PLGFGGKSCA QEMANPQHFL 
GSSLVAWHGL SLPISQPWYL SLMFRTRQAD GVLLQAITRG RSTITLQLRE GHVMLSVEGT 
GLQASSLRLE PGRANDGDWH HAQLALGASG GPGHAILSFD YGQQRAEGNL GPRLHGLHLS 
NITVGGIPGP AGGVARGFRG CLQGVRVSDT PEGVNSLDPS HGESINVEQG CSLPDPCDSN 
PCPANSYCSN DWDSYSCSCD PGYYGDNCTN VCDLNPCEHQ SVCTRKPSAP HGYTCECPPN 
YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN KTSGECHCKE NHYRPPGSPT 
CLLCDCYPTG SLSRVCDPED GQCPCKPGVI GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI 
EAGIWWPRTR FGLPAAAPCP KGSFGTAVRH CDEHRGWLPP NLFNCTSITF SELKGFAERL 
QRNESGLDSG RSQQLALLLR NATQHTAGYF GSDVKVAYQL ATRLLAHEST QRGFGLSATQ 
DVHFTENLLR VGSALLDTAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ NMRHTYLSPF 
TIVTPNIVIS VVRLDKGNFA GAKLPRYEAL RGEQPPDLET TVILPESVFR ETPPVVRPAG 
PGEAQEPEEL ARRQRRHPEL SQGEAVASVI IYRTLAGLLP HNYDPDKRSL RVPKRPIINT 
PVVSISVHDD EELLPRALDK PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE 
VVFRNESHVS CQCNHMTSFA VLMDVSRREN GEILPLKTLT YVALGVTLAA LLLTFFFLTL 
LRILRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY LCTFSWALLE 
ALHLYRALTE VRDVNTGPMR FYYMLGWGVP AFITGLAVGL DPEGYGNPDF CWLSIYDTLI 
WSFAGPVAFA VSMSVFLYIL AARASCAAQR QGFEKKGPVS GLQPSFAVLL LLSATWLLAL 
LSVNSDTLLF HYLFATCNCI QGPFIFLSYV VLSKEVRKAL KLACSRKPSP DPALTTKSTL 
TSSYNCPSPY ADGRLYQPYG DSAGSLHSTS RSGKSQPSYI PFLLREESAL NPGQGPPGLG 
DPGSLFLEGQ DQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEEE EEAAFPGEQG 
WDSLLGPGAE RLPLHSTPKD GGPGPGKAPW PGDFGTTAKE SSGNGAPEER LRENGDALSR 
EGSLGPLPGS SAQPHKGILK KKCLPTISEK SSLLRLPLEQ CTGSSRGSSA SEGSRGGPPP 
RPPPRQSLQE QLNGVMPIAM SIKAGTVDED SSGSEFLFFN FLH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CELSR2

Associated with

Cells (max top 100)

Other Information

The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1. PubMed ID: 10907856

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. PubMed ID: 9039502