Details for: EN2

Gene ID: 2020

Symbol: EN2

Ensembl ID: ENSG00000164778

Description: engrailed homeobox 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.47
    Marker Score: 1638.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 877
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.12
    Marker Score: 2118
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 803
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.97
    Marker Score: 3265
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.94
    Marker Score: 1002
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.88
    Marker Score: 885
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.86
    Marker Score: 3985
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1602
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.73
    Marker Score: 426
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11473
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1170
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.73
    Marker Score: 1255
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 471
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.7
    Marker Score: 2921
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.68
    Marker Score: 3571
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 521
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.58
    Marker Score: 5978
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.58
    Marker Score: 550
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.5
    Marker Score: 553
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.49
    Marker Score: 1018.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 287
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 151
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.47
    Marker Score: 1148
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 449.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.45
    Marker Score: 253
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.43
    Marker Score: 331
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.41
    Marker Score: 186
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 186
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.38
    Marker Score: 329
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.35
    Marker Score: 354
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.34
    Marker Score: 232
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.33
    Marker Score: 176
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 126
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.23
    Marker Score: 1765
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.22
    Marker Score: 106
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.17
    Marker Score: 39
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.17
    Marker Score: 903
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.16
    Marker Score: 5405
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.14
    Marker Score: 56
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.13
    Marker Score: 140
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.13
    Marker Score: 201
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 278
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 105
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.11
    Marker Score: 200
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1
    Marker Score: 176
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 28.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.08
    Marker Score: 107
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.08
    Marker Score: 498
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.07
    Marker Score: 107
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.07
    Marker Score: 103
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.07
    Marker Score: 162
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 86
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.06
    Marker Score: 2140
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 66
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.06
    Marker Score: 558
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.05
    Marker Score: 710
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 211
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.05
    Marker Score: 105
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 105
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 20

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Other Information

**Key characteristics:** * EN2 is a transcription factor belonging to the homeobox family of proteins. * It is expressed in a wide range of cell types, including neurons, astrocytes, oligodendrocytes, and endothelial cells. * EN2 is a key regulator of neurogenesis, survival, and differentiation in the developing CNS. * It is involved in the regulation of neuronal survival through the control of apoptosis. * EN2 also plays a role in synaptic plasticity and learning and memory. **Pathways and functions:** * EN2 is a key regulator of the development and survival of neurons. * It is essential for the specification of neural cell fate and the subsequent differentiation of neurons from other cell types. * EN2 is also involved in the regulation of synaptic plasticity and learning and memory processes. * Dysregulation of EN2 has been linked to several neurodevelopmental disorders, including autism, schizophrenia, and epilepsy. **Clinical significance:** * EN2 is a promising target for the treatment of neurodevelopmental disorders. * Small molecule inhibitors of EN2 have shown promise in preclinical models of neurodevelopmental disorders, suggesting that they could be used to treat these disorders. * Further research is needed to investigate the role of EN2 in human health and to develop more effective therapeutic strategies.

Genular Protein ID: 4060627496

Symbol: HME2_HUMAN

Name: Homeobox protein engrailed-2

UniProtKB Accession Codes:

P19622 A4D252 Q549U3 Q9UD58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1363401

Title: Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions.

PubMed ID: 1363401

DOI: 10.1002/dvg.1020130505

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2565873

Title: Isolation and chromosomal localization of the human En-2 gene.

PubMed ID: 2565873

DOI: 10.1016/0888-7543(89)90324-8

PubMed ID: 7518789

Title: Identification of homeobox genes expressed in human haemopoietic progenitor cells.

PubMed ID: 7518789

DOI: 10.1016/0378-1119(94)90380-8

PubMed ID: 16252243

Title: Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus.

PubMed ID: 16252243

DOI: 10.1086/497705

Sequence Information:

  • Length: 333
  • Mass: 34211
  • Checksum: ACF5399E383D6257
  • Sequence:
    • MEENDPKPGE AAAAVEGQRQ PESSPGGGSG GGGGSSPGEA DTGRRRALML PAVLQAPGNH 
QHPHRITNFF IDNILRPEFG RRKDAGTCCA GAGGGRGGGA GGEGGASGAE GGGGAGGSEQ 
LLGSGSREPR QNPPCAPGAG GPLPAAGSDS PGDGEGGSKT LSLHGGAKKG GDPGGPLDGS 
LKARGLGGGD LSVSSDSDSS QAGANLGAQP MLWPAWVYCT RYSDRPSSGP RSRKPKKKNP 
NKEDKRPRTA FTAEQLQRLK AEFQTNRYLT EQRRQSLAQE LSLNESQIKI WFQNKRAKIK 
KATGNKNTLA VHLMAQGLYN HSTTAKEGKS DSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.