Details for: EN2

Gene ID: 2020

Symbol: EN2

Ensembl ID: ENSG00000164778

Description: engrailed homeobox 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.7274
    Cell Significance Index: 8.0800
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.6432
    Cell Significance Index: 6.9800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.5892
    Cell Significance Index: 6.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5759
    Cell Significance Index: 13.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3717
    Cell Significance Index: 6.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2843
    Cell Significance Index: 4.5100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2359
    Cell Significance Index: 3.4300
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.2222
    Cell Significance Index: 2.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2160
    Cell Significance Index: 4.7300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0966
    Cell Significance Index: 1.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0794
    Cell Significance Index: 3.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0429
    Cell Significance Index: 1.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0141
    Cell Significance Index: 7.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -4.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0025
    Cell Significance Index: -0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0047
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0056
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0064
    Cell Significance Index: -3.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0080
    Cell Significance Index: -0.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0121
    Cell Significance Index: -1.5500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0132
    Cell Significance Index: -0.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0138
    Cell Significance Index: -1.4100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0148
    Cell Significance Index: -0.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0153
    Cell Significance Index: -2.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0161
    Cell Significance Index: -3.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0182
    Cell Significance Index: -0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0202
    Cell Significance Index: -4.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0211
    Cell Significance Index: -2.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0224
    Cell Significance Index: -3.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0235
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0237
    Cell Significance Index: -2.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0246
    Cell Significance Index: -3.0300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0274
    Cell Significance Index: -0.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0322
    Cell Significance Index: -0.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0366
    Cell Significance Index: -4.7300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0379
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0385
    Cell Significance Index: -1.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0425
    Cell Significance Index: -1.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0459
    Cell Significance Index: -0.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0510
    Cell Significance Index: -2.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0599
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0600
    Cell Significance Index: -0.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0635
    Cell Significance Index: -3.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0635
    Cell Significance Index: -4.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0641
    Cell Significance Index: -4.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0695
    Cell Significance Index: -0.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0828
    Cell Significance Index: -0.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0829
    Cell Significance Index: -4.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0861
    Cell Significance Index: -3.1600
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0896
    Cell Significance Index: -0.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0904
    Cell Significance Index: -1.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1001
    Cell Significance Index: -3.4800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1003
    Cell Significance Index: -2.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1035
    Cell Significance Index: -4.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1039
    Cell Significance Index: -2.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1055
    Cell Significance Index: -3.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1079
    Cell Significance Index: -1.8600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1124
    Cell Significance Index: -1.4200
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1141
    Cell Significance Index: -1.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1165
    Cell Significance Index: -3.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1195
    Cell Significance Index: -3.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1196
    Cell Significance Index: -4.5300
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1209
    Cell Significance Index: -0.9600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1212
    Cell Significance Index: -1.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1217
    Cell Significance Index: -3.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1232
    Cell Significance Index: -4.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1265
    Cell Significance Index: -4.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1276
    Cell Significance Index: -3.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1385
    Cell Significance Index: -3.7100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1408
    Cell Significance Index: -1.1200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1456
    Cell Significance Index: -1.5200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1457
    Cell Significance Index: -1.4100
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1464
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.1469
    Cell Significance Index: -1.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1493
    Cell Significance Index: -3.9300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1493
    Cell Significance Index: -1.6300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1583
    Cell Significance Index: -1.6000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1584
    Cell Significance Index: -1.9900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1632
    Cell Significance Index: -1.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1644
    Cell Significance Index: -4.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1647
    Cell Significance Index: -5.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1664
    Cell Significance Index: -3.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1697
    Cell Significance Index: -4.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1715
    Cell Significance Index: -3.6400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1741
    Cell Significance Index: -1.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1746
    Cell Significance Index: -4.2600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1750
    Cell Significance Index: -2.3800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1760
    Cell Significance Index: -1.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1760
    Cell Significance Index: -4.4000
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1766
    Cell Significance Index: -1.9800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1799
    Cell Significance Index: -2.4700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1804
    Cell Significance Index: -1.7100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1813
    Cell Significance Index: -1.9900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1823
    Cell Significance Index: -2.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EN2 is a homeobox gene, which belongs to a family of transcription factors that regulate gene expression during development. The EN2 gene encodes a protein called HME2, which is a member of the engrailed family of transcription factors. These proteins are characterized by their ability to bind to specific DNA sequences and regulate the expression of target genes involved in various developmental processes. EN2 is specifically involved in the regulation of neuronal differentiation, particularly in the development of the hindbrain and midbrain regions of the brain. **Pathways and Functions** EN2 is involved in several signaling pathways that regulate neuronal development and differentiation. These include: 1. **Dopaminergic neuron differentiation**: EN2 plays a crucial role in the development of dopaminergic neurons, which are a type of neuron that synthesizes dopamine. 2. **Neuronal development**: EN2 regulates the expression of genes involved in neuronal development, including those involved in axon guidance and neuronal migration. 3. **Hindbrain development**: EN2 is specifically involved in the development of the hindbrain region of the brain, which gives rise to structures involved in auditory and vestibular function. 4. **Neuron differentiation**: EN2 regulates the expression of genes involved in neuronal differentiation, including those involved in the development of neuronal morphology and function. EN2 functions as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. It is also involved in the regulation of transcription by RNA polymerase II, which is a key enzyme involved in the transcription of genes. **Clinical Significance** Dysregulation of EN2 has been implicated in various neurodevelopmental disorders, including: 1. **Hirschsprung disease**: EN2 mutations have been associated with Hirschsprung disease, a congenital disorder characterized by the absence of ganglion cells in the distal colon. 2. **Neurodevelopmental disorders**: EN2 has been implicated in various neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 3. **Neurodegenerative disorders**: EN2 has been implicated in neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease. In conclusion, EN2 is a transcription factor gene that plays a crucial role in neuronal development and differentiation. Its dysregulation has been implicated in various neurodevelopmental disorders, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 4060627496

Symbol: HME2_HUMAN

Name: Homeobox protein engrailed-2

UniProtKB Accession Codes:

P19622 A4D252 Q549U3 Q9UD58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1363401

Title: Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions.

PubMed ID: 1363401

DOI: 10.1002/dvg.1020130505

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2565873

Title: Isolation and chromosomal localization of the human En-2 gene.

PubMed ID: 2565873

DOI: 10.1016/0888-7543(89)90324-8

PubMed ID: 7518789

Title: Identification of homeobox genes expressed in human haemopoietic progenitor cells.

PubMed ID: 7518789

DOI: 10.1016/0378-1119(94)90380-8

PubMed ID: 16252243

Title: Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus.

PubMed ID: 16252243

DOI: 10.1086/497705

Sequence Information:

  • Length: 333
  • Mass: 34211
  • Checksum: ACF5399E383D6257
  • Sequence:
    • MEENDPKPGE AAAAVEGQRQ PESSPGGGSG GGGGSSPGEA DTGRRRALML PAVLQAPGNH 
QHPHRITNFF IDNILRPEFG RRKDAGTCCA GAGGGRGGGA GGEGGASGAE GGGGAGGSEQ 
LLGSGSREPR QNPPCAPGAG GPLPAAGSDS PGDGEGGSKT LSLHGGAKKG GDPGGPLDGS 
LKARGLGGGD LSVSSDSDSS QAGANLGAQP MLWPAWVYCT RYSDRPSSGP RSRKPKKKNP 
NKEDKRPRTA FTAEQLQRLK AEFQTNRYLT EQRRQSLAQE LSLNESQIKI WFQNKRAKIK 
KATGNKNTLA VHLMAQGLYN HSTTAKEGKS DSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.