Details for: EPHA7

Gene ID: 2045

Symbol: EPHA7

Ensembl ID: ENSG00000135333

Description: EPH receptor A7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 80.9832
    Cell Significance Index: -32.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.6461
    Cell Significance Index: -34.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.5014
    Cell Significance Index: -32.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 10.1391
    Cell Significance Index: 222.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.0800
    Cell Significance Index: 341.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.4748
    Cell Significance Index: 153.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.4182
    Cell Significance Index: 129.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.0760
    Cell Significance Index: 87.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0272
    Cell Significance Index: 727.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9315
    Cell Significance Index: 387.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3353
    Cell Significance Index: 923.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1942
    Cell Significance Index: 67.0100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.0310
    Cell Significance Index: 13.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0009
    Cell Significance Index: 61.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8751
    Cell Significance Index: 18.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6136
    Cell Significance Index: 116.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5886
    Cell Significance Index: 45.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5316
    Cell Significance Index: 12.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4287
    Cell Significance Index: 387.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3035
    Cell Significance Index: 30.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2398
    Cell Significance Index: 4.1100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1484
    Cell Significance Index: 1.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.1140
    Cell Significance Index: 3.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1051
    Cell Significance Index: 3.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0606
    Cell Significance Index: 9.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0548
    Cell Significance Index: 1.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0309
    Cell Significance Index: 3.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0246
    Cell Significance Index: 0.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0216
    Cell Significance Index: 0.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0157
    Cell Significance Index: 0.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0152
    Cell Significance Index: 0.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0110
    Cell Significance Index: 2.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0039
    Cell Significance Index: -0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0157
    Cell Significance Index: -29.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0185
    Cell Significance Index: -34.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0228
    Cell Significance Index: -35.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0266
    Cell Significance Index: -36.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0370
    Cell Significance Index: -23.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0378
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0401
    Cell Significance Index: -29.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0413
    Cell Significance Index: -22.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0430
    Cell Significance Index: -19.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0511
    Cell Significance Index: -37.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0517
    Cell Significance Index: -39.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0549
    Cell Significance Index: -34.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0624
    Cell Significance Index: -1.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0642
    Cell Significance Index: -36.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0660
    Cell Significance Index: -1.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0778
    Cell Significance Index: -8.4700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0778
    Cell Significance Index: -0.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1003
    Cell Significance Index: -28.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1103
    Cell Significance Index: -19.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1225
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1681
    Cell Significance Index: -35.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1993
    Cell Significance Index: -34.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2019
    Cell Significance Index: -2.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2292
    Cell Significance Index: -31.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2320
    Cell Significance Index: -33.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2331
    Cell Significance Index: -4.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2351
    Cell Significance Index: -24.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2415
    Cell Significance Index: -29.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2562
    Cell Significance Index: -17.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2602
    Cell Significance Index: -33.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2845
    Cell Significance Index: -33.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2928
    Cell Significance Index: -33.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3278
    Cell Significance Index: -4.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3404
    Cell Significance Index: -35.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3603
    Cell Significance Index: -6.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3652
    Cell Significance Index: -9.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3789
    Cell Significance Index: -16.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3897
    Cell Significance Index: -20.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4062
    Cell Significance Index: -3.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4152
    Cell Significance Index: -8.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4329
    Cell Significance Index: -5.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4458
    Cell Significance Index: -23.1600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.4498
    Cell Significance Index: -3.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4678
    Cell Significance Index: -37.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4681
    Cell Significance Index: -34.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4925
    Cell Significance Index: -10.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4983
    Cell Significance Index: -17.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5020
    Cell Significance Index: -30.1400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5151
    Cell Significance Index: -6.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5172
    Cell Significance Index: -24.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5498
    Cell Significance Index: -35.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5579
    Cell Significance Index: -15.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6156
    Cell Significance Index: -32.0700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.6210
    Cell Significance Index: -3.6900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.6930
    Cell Significance Index: -8.4000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7230
    Cell Significance Index: -15.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7708
    Cell Significance Index: -16.7000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7906
    Cell Significance Index: -15.5600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8036
    Cell Significance Index: -10.1400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8212
    Cell Significance Index: -10.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8520
    Cell Significance Index: -21.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9426
    Cell Significance Index: -12.8600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.9565
    Cell Significance Index: -10.6900
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.9982
    Cell Significance Index: -12.3200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.0065
    Cell Significance Index: -20.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0155
    Cell Significance Index: -37.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0211
    Cell Significance Index: -26.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EPHA7 exhibits several distinct characteristics that distinguish it from other Eph receptors. These include: * **High expression in the nervous system**: EPHA7 is predominantly expressed in neurons, particularly in Purkinje cells, cerebellar granule cells, and GABAergic interneurons. * **Specificity for ephrin ligands**: EPHA7 binds to ephrin ligands, which are essential for its biological activity. * **Unique ligand specificity**: EPHA7 has a high affinity for ephrin-B1 and ephrin-B2 ligands, which are involved in repulsive axon guidance and branching morphogenesis. * **Involvement in axon guidance and dendritic development**: EPHA7 plays a critical role in the guidance of axons and the development of dendrites, which are essential for proper neuronal function. **Pathways and Functions** EPHA7 is involved in several key pathways and functions, including: * **Eph-ephrin signaling pathway**: EPHA7 binds to ephrin ligands, which triggers a signaling cascade that regulates cell-cell adhesion, migration, and differentiation. * **Axon guidance**: EPHA7 is involved in the repulsive guidance of axons, which is essential for proper neuronal connectivity and function. * **Dendritic development**: EPHA7 plays a critical role in the development of dendrites, which are essential for proper neuronal function. * **Synapse formation**: EPHA7 is involved in the formation of synapses, which are critical for neuronal communication and function. **Clinical Significance** EPHA7 has been implicated in several neurological disorders, including: * **Autism spectrum disorder**: EPHA7 has been shown to be associated with autism spectrum disorder, particularly in cases of severe intellectual disability. * **Schizophrenia**: EPHA7 has been implicated in schizophrenia, particularly in cases of cognitive impairment. * **Neurodegenerative diseases**: EPHA7 has been shown to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In summary, EPHA7 is a critical regulator of neuronal development and function, and its dysregulation has been implicated in several neurological disorders. Further research is needed to fully understand the mechanisms by which EPHA7 regulates neuronal function and to develop therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 735645282

Symbol: EPHA7_HUMAN

Name: Ephrin type-A receptor 7

UniProtKB Accession Codes:

Q15375 A0AUX7 B2R8W1 B7ZLJ9 B7ZLK0 Q59G40 Q5VTU0 Q8N368 Q9H124

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 5 CPTAC 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 12 Ensembl 3 EvolutionaryTrace 1 GO 30 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 20 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 9 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7898931

Title: cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.

PubMed ID: 7898931

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 17726105

Title: ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias.

PubMed ID: 17726105

DOI: 10.1073/pnas.0703211104

PubMed ID: 20126984

Title: Secreted form of EphA7 in lung cancer.

PubMed ID: 20126984

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 998
  • Mass: 112097
  • Checksum: 479B9CA0D2BB06EB
  • Sequence:
    • MVFQTRYPSW IILCYIWLLR FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPNGWEEISG 
LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 
ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 
GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAIFPDTVT GSEFSSLVEV RGTCVSSAEE 
EAENAPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RGFYKSSSQD LQCSRCPTHS 
FSDKEGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR 
NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV TVMDLLAHAN YTFEVEAVNG 
VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY 
YEKDQRERTY STVKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEATG 
KMFEATAVSS EQNPVIIIAV VAVAGTIILV FMVFGFIIGR RHCGYSKADQ EGDEELYFHF 
KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG AGEFGEVCSG RLKLPGKRDV 
AVAIKTLKVG YTEKQRRDFL CEASIMGQFD HPNVVHLEGV VTRGKPVMIV IEFMENGALD 
AFLRKHDGQF TVIQLVGMLR GIAAGMRYLA DMGYVHRDLA ARNILVNSNL VCKVSDFGLS 
RVIEDDPEAV YTTTGGKIPV RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM 
SNQDVIKAIE EGYRLPAPMD CPAGLHQLML DCWQKERAER PKFEQIVGIL DKMIRNPNSL 
KTPLGTCSRP ISPLLDQNTP DFTTFCSVGE WLQAIKMERY KDNFTAAGYN SLESVARMTI 
EDVMSLGITL VGHQKKIMSS IQTMRAQMLH LHGTGIQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.