Details for: EPHX2

Gene ID: 2053

Symbol: EPHX2

Ensembl ID: ENSG00000120915

Description: epoxide hydrolase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.5
    Marker Score: 2804
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.21
    Marker Score: 3043
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.96
    Marker Score: 3024.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.93
    Marker Score: 1127
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.89
    Marker Score: 9067
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.55
    Marker Score: 4870.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.54
    Marker Score: 4122
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.52
    Marker Score: 3612
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.47
    Marker Score: 811
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.45
    Marker Score: 7811
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.43
    Marker Score: 2031
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.43
    Marker Score: 6175
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4
    Marker Score: 14465
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.39
    Marker Score: 4940
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.39
    Marker Score: 8923
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.37
    Marker Score: 516
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.32
    Marker Score: 3116
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.28
    Marker Score: 2107
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.28
    Marker Score: 1353
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.23
    Marker Score: 717
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.21
    Marker Score: 809
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.21
    Marker Score: 284
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.19
    Marker Score: 296
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.18
    Marker Score: 3853
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.12
    Marker Score: 416
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.08
    Marker Score: 1076
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.08
    Marker Score: 2043
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.08
    Marker Score: 310
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 670
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.05
    Marker Score: 9058
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.04
    Marker Score: 253
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.03
    Marker Score: 7675
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.02
    Marker Score: 2145
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71747
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47970
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.98
    Marker Score: 902
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.97
    Marker Score: 391
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 14946
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1510
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5286
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.9
    Marker Score: 865
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.9
    Marker Score: 1251
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9
    Marker Score: 5849
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.89
    Marker Score: 945
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.89
    Marker Score: 258
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.89
    Marker Score: 978
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.88
    Marker Score: 6870
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.87
    Marker Score: 595
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.86
    Marker Score: 7490
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.85
    Marker Score: 966
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.85
    Marker Score: 11239
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.85
    Marker Score: 1765
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.84
    Marker Score: 3507.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.82
    Marker Score: 8291
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.82
    Marker Score: 2237
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.81
    Marker Score: 1785.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.8
    Marker Score: 1034
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.78
    Marker Score: 17478
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.77
    Marker Score: 1556
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.75
    Marker Score: 13366
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.74
    Marker Score: 430
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.73
    Marker Score: 229
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.72
    Marker Score: 302
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.72
    Marker Score: 1818
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.72
    Marker Score: 2561
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.72
    Marker Score: 746
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.72
    Marker Score: 26413
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.71
    Marker Score: 1176
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.71
    Marker Score: 37397
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.7
    Marker Score: 751
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.69
    Marker Score: 2881
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.69
    Marker Score: 14714
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 629
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.69
    Marker Score: 834
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2890
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.69
    Marker Score: 201
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.68
    Marker Score: 25638
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.67
    Marker Score: 563.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.67
    Marker Score: 132
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.67
    Marker Score: 224
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.66
    Marker Score: 1123
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.65
    Marker Score: 875
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.65
    Marker Score: 168
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.64
    Marker Score: 692
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.64
    Marker Score: 445
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.64
    Marker Score: 1451
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.63
    Marker Score: 200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.63
    Marker Score: 1197

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Other Information

## Summary EPHX2 is a protein that belongs to the epoxide hydrolase family of enzymes. It is expressed in a variety of cell types, including pulmonary interstitial fibroblast, double negative thymocyte, enterocyte of colon, secondary lens fiber, enterocyte, colon epithelial cell, kidney loop of Henle thick ascending limb epithelial cell, stem cell, respiratory epithelial cell, and periportal region hepatocyte. ## Key characteristics * EPHX2 is a protein of approximately 130 kDa. * It is a transmembrane protein that is expressed in the endoplasmic reticulum. * It is a key enzyme in the biosynthesis of specialized proresolving mediators (spms). * It is also involved in fatty acid metabolism and lipid phosphatase activity. ## Pathways and functions * EPHX2 is involved in the biosynthesis of spms, which are a family of cytokines that are produced by immune cells in response to injury or infection. * It is also involved in the regulation of inflammation. * It is involved in the metabolism of lipids and fatty acids. ## Clinical significance * Mutations in EPHX2 have been linked to several human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. * EPHX2 inhibitors are being investigated as a potential treatment for these diseases. ## Additional notes * EPHX2 is a highly conserved protein, with a similar protein found in mice. * It is expressed at low levels in healthy individuals, but its expression is increased in response to injury or infection. * EPHX2 is a promising target for the treatment of inflammatory diseases.

Genular Protein ID: 4196678910

Symbol: HYES_HUMAN

Name: Cytosolic epoxide hydrolase 2

UniProtKB Accession Codes:

P34913 B2Z3B1 B3KTU8 B3KUA0 G3V134 J3KPH7 Q16764 Q9HBJ1 Q9HBJ2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 89 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 30 EPD 1 ESTHER 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 Rhea 48 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8342951

Title: cDNA cloning and expression of a soluble epoxide hydrolase from human liver.

PubMed ID: 8342951

DOI: 10.1006/abbi.1993.1411

PubMed ID: 8619856

Title: Structural characterization of the human soluble epoxide hydrolase gene (EPHX2).

PubMed ID: 8619856

DOI: 10.1006/bbrc.1996.0596

PubMed ID: 10862610

Title: Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms.

PubMed ID: 10862610

DOI: 10.1074/jbc.m001153200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12869654

Title: Polymorphisms in human soluble epoxide hydrolase.

PubMed ID: 12869654

DOI: 10.1124/mol.64.2.482

PubMed ID: 12574508

Title: The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase.

PubMed ID: 12574508

DOI: 10.1073/pnas.0437829100

PubMed ID: 12574510

Title: The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity.

PubMed ID: 12574510

DOI: 10.1073/pnas.0437724100

PubMed ID: 15196990

Title: Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure.

PubMed ID: 15196990

DOI: 10.1016/j.abb.2004.05.003

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21164107

Title: Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation.

PubMed ID: 21164107

DOI: 10.1161/circresaha.110.235879

PubMed ID: 21217101

Title: Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase.

PubMed ID: 21217101

DOI: 10.1194/jlr.m009639

PubMed ID: 22387545

Title: Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids.

PubMed ID: 22387545

DOI: 10.1016/j.bbrc.2012.02.108

PubMed ID: 22217705

Title: Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase.

PubMed ID: 22217705

DOI: 10.1194/jlr.m022319

PubMed ID: 22798687

Title: EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides.

PubMed ID: 22798687

DOI: 10.1194/jlr.m024448

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15096040

Title: Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis.

PubMed ID: 15096040

DOI: 10.1021/bi036189j

PubMed ID: 16322563

Title: Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids.

PubMed ID: 16322563

DOI: 10.1110/ps.051720206

PubMed ID: 19746975

Title: Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase.

PubMed ID: 19746975

DOI: 10.1021/jm9005302

PubMed ID: 19969453

Title: Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.

PubMed ID: 19969453

DOI: 10.1016/j.bmcl.2009.11.091

PubMed ID: 20934334

Title: Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain.

PubMed ID: 20934334

DOI: 10.1016/j.bmcl.2010.09.095

Sequence Information:

  • Length: 555
  • Mass: 62616
  • Checksum: 1B5ACE7F80F9A26C
  • Sequence:
    • MTLRAAVFDL DGVLALPAVF GVLGRTEEAL ALPRGLLNDA FQKGGPEGAT TRLMKGEITL 
SQWIPLMEEN CRKCSETAKV CLPKNFSIKE IFDKAISARK INRPMLQAAL MLRKKGFTTA 
ILTNTWLDDR AERDGLAQLM CELKMHFDFL IESCQVGMVK PEPQIYKFLL DTLKASPSEV 
VFLDDIGANL KPARDLGMVT ILVQDTDTAL KELEKVTGIQ LLNTPAPLPT SCNPSDMSHG 
YVTVKPRVRL HFVELGSGPA VCLCHGFPES WYSWRYQIPA LAQAGYRVLA MDMKGYGESS 
APPEIEEYCM EVLCKEMVTF LDKLGLSQAV FIGHDWGGML VWYMALFYPE RVRAVASLNT 
PFIPANPNMS PLESIKANPV FDYQLYFQEP GVAEAELEQN LSRTFKSLFR ASDESVLSMH 
KVCEAGGLFV NSPEEPSLSR MVTEEEIQFY VQQFKKSGFR GPLNWYRNME RNWKWACKSL 
GRKILIPALM VTAEKDFVLV PQMSQHMEDW IPHLKRGHIE DCGHWTQMDK PTEVNQILIK 
WLDSDARNPP VVSKM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.