Details for: ESR2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 95.0206
Cell Significance Index: -14.7800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 58.1131
Cell Significance Index: -14.7400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 30.9533
Cell Significance Index: -12.5800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.9956
Cell Significance Index: -14.7900 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 10.0097
Cell Significance Index: 142.4900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.0359
Cell Significance Index: -13.2100 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 4.1119
Cell Significance Index: 36.5000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.7633
Cell Significance Index: -14.8500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.0767
Cell Significance Index: -9.4500 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.8883
Cell Significance Index: 17.8200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 2.2448
Cell Significance Index: 38.4700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6621
Cell Significance Index: 46.4500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.5970
Cell Significance Index: 232.1500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.3180
Cell Significance Index: 35.3200 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.2166
Cell Significance Index: 15.3200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.1170
Cell Significance Index: 27.2600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8441
Cell Significance Index: 29.6600 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.6997
Cell Significance Index: 11.2900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6346
Cell Significance Index: 35.6100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6288
Cell Significance Index: 48.2500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.6216
Cell Significance Index: 13.6100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5359
Cell Significance Index: 106.3600 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.5084
Cell Significance Index: 3.4500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4821
Cell Significance Index: 96.7100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4177
Cell Significance Index: 149.8300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.4109
Cell Significance Index: 25.2000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3528
Cell Significance Index: 67.1500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.3236
Cell Significance Index: 2.9800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2649
Cell Significance Index: 5.1700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2220
Cell Significance Index: 9.8200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2127
Cell Significance Index: 8.0600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1851
Cell Significance Index: 2.7900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1815
Cell Significance Index: 341.7700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1794
Cell Significance Index: 10.7700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1591
Cell Significance Index: 101.0600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0912
Cell Significance Index: 2.2800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0797
Cell Significance Index: 8.6700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0741
Cell Significance Index: 114.0400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0739
Cell Significance Index: 136.2600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0572
Cell Significance Index: 51.6200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0566
Cell Significance Index: 25.0200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0552
Cell Significance Index: 3.4800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0545
Cell Significance Index: 6.7000 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.0521
Cell Significance Index: 0.6500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0443
Cell Significance Index: 2.9800 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0417
Cell Significance Index: 0.6000 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.0253
Cell Significance Index: 0.1100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0227
Cell Significance Index: 10.3100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0214
Cell Significance Index: 29.0500 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0185
Cell Significance Index: 0.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0179
Cell Significance Index: 3.2300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0159
Cell Significance Index: 11.0000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0154
Cell Significance Index: 2.5000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0047
Cell Significance Index: 0.1300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0027
Cell Significance Index: 0.0700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0007
Cell Significance Index: -0.0600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0018
Cell Significance Index: -1.0100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0057
Cell Significance Index: -0.2600 - Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0067
Cell Significance Index: -0.0400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0097
Cell Significance Index: -0.2800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0169
Cell Significance Index: -1.9900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0174
Cell Significance Index: -12.9200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0188
Cell Significance Index: -13.7900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0198
Cell Significance Index: -0.5200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0208
Cell Significance Index: -15.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0235
Cell Significance Index: -13.2600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0252
Cell Significance Index: -15.7600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0260
Cell Significance Index: -7.4900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0270
Cell Significance Index: -1.8700 - Cell Name: glioblast (CL0000030)
Fold Change: -0.0334
Cell Significance Index: -0.2100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0368
Cell Significance Index: -6.2900 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.0384
Cell Significance Index: -0.4000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0468
Cell Significance Index: -0.6700 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0578
Cell Significance Index: -0.7300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0600
Cell Significance Index: -1.3000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0686
Cell Significance Index: -14.4600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0686
Cell Significance Index: -9.4300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0811
Cell Significance Index: -8.4400 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0847
Cell Significance Index: -2.6800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0925
Cell Significance Index: -11.9500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0933
Cell Significance Index: -4.3500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0962
Cell Significance Index: -3.0800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0992
Cell Significance Index: -2.8300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1018
Cell Significance Index: -11.6600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1056
Cell Significance Index: -7.4700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1190
Cell Significance Index: -13.8700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1232
Cell Significance Index: -6.4000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1248
Cell Significance Index: -12.7500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1328
Cell Significance Index: -1.9600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1466
Cell Significance Index: -6.8900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1490
Cell Significance Index: -3.0900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1549
Cell Significance Index: -5.0700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1676
Cell Significance Index: -12.4900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1758
Cell Significance Index: -5.6000 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1778
Cell Significance Index: -3.5700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1967
Cell Significance Index: -4.1900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2134
Cell Significance Index: -4.2200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2173
Cell Significance Index: -3.6600 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2219
Cell Significance Index: -4.7100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2269
Cell Significance Index: -14.6400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1393377049
Symbol: ESR2_HUMAN
Name: Estrogen receptor beta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9473491
Title: The complete primary structure of human estrogen receptor beta (hERbeta) and its heterodimerization with ER alpha in vivo and in vitro.
PubMed ID: 9473491
PubMed ID: 9636657
Title: Cloning and characterization of human estrogen receptor beta isoforms.
PubMed ID: 9636657
PubMed ID: 9685228
Title: Estrogen receptor-beta mRNA variants in human and murine tissues.
PubMed ID: 9685228
PubMed ID: 9671811
Title: Molecular cloning and characterization of human estrogen receptor beta cx: a potential inhibitor of estrogen action in human.
PubMed ID: 9671811
PubMed ID: 16938840
Title: Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling.
PubMed ID: 16938840
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10964723
Title: Cloning and characterization of human estrogen receptor beta promoter.
PubMed ID: 10964723
PubMed ID: 8769313
Title: ER beta: identification and characterization of a novel human estrogen receptor.
PubMed ID: 8769313
PubMed ID: 9267036
Title: Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
PubMed ID: 9267036
PubMed ID: 9325313
Title: Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha.
PubMed ID: 9325313
PubMed ID: 10681503
Title: Cloning and characterization of RAP250, a nuclear receptor coactivator.
PubMed ID: 10681503
PubMed ID: 11113208
Title: CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant.
PubMed ID: 11113208
PubMed ID: 11579095
Title: The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway.
PubMed ID: 11579095
PubMed ID: 12039952
Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.
PubMed ID: 12039952
PubMed ID: 12415108
Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.
PubMed ID: 12415108
PubMed ID: 19666546
PubMed ID: 15047147
Title: ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.
PubMed ID: 15047147
PubMed ID: 14759258
PubMed ID: 15199063
Title: An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.
PubMed ID: 15199063
PubMed ID: 15862947
Title: Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway.
PubMed ID: 15862947
PubMed ID: 19126643
Title: CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells.
PubMed ID: 19126643
PubMed ID: 20074560
Title: Repression of estrogen receptor beta function by putative tumor suppressor DBC1.
PubMed ID: 20074560
PubMed ID: 29261182
Title: Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development.
PubMed ID: 29261182
DOI: 10.1038/gim.2017.163
PubMed ID: 30113650
Title: Early-onset complete ovarian failure and lack of puberty in a woman with mutated estrogen receptor beta (ESR2).
PubMed ID: 30113650
Sequence Information:
- Length: 530
- Mass: 59216
- Checksum: 8CAE34215992418A
- Sequence:
MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHASN KGMEHLLNMK CKNVVPVYDL LLEMLNAHVL RGCKSSITGS ECSPAEDSKS KEGSQNPQSQ
Genular Protein ID: 3219624409
Symbol: Q0PTK2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16230778
Title: Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization.
PubMed ID: 16230778
Sequence Information:
- Length: 474
- Mass: 53151
- Checksum: FD659791D0095919
- Sequence:
MDIKNSPSSL NSPSSYDCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSAGEQLH CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARS CVYK
Genular Protein ID: 768492342
Symbol: A0A348FV93_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 474
- Mass: 53209
- Checksum: 4558F2986355FAF0
- Sequence:
MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARS CVYK
Genular Protein ID: 3147762313
Symbol: F1D8N3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 495
- Mass: 55483
- Checksum: F068DBC63DC838A6
- Sequence:
MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARA EKASQTLTSF GMKMETLLPE ATMEQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.