Details for: ESR2

Gene ID: 2100

Symbol: ESR2

Ensembl ID: ENSG00000140009

Description: estrogen receptor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 3.12
    Marker Score: 1,575
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.57
    Marker Score: 6,428
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.05
    Marker Score: 2,267
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.85
    Marker Score: 774
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.75
    Marker Score: 6,231
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.72
    Marker Score: 1,525
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,162
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.56
    Marker Score: 3,673
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.56
    Marker Score: 843
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.54
    Marker Score: 6,460
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.48
    Marker Score: 599
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,965
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.39
    Marker Score: 380
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.38
    Marker Score: 403
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.34
    Marker Score: 29,998
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.34
    Marker Score: 1,518
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.34
    Marker Score: 929
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20,265
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.27
    Marker Score: 578
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.25
    Marker Score: 2,549
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.21
    Marker Score: 378
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.19
    Marker Score: 7,174
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.1
    Marker Score: 403
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.09
    Marker Score: 329
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.05
    Marker Score: 2,014
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.04
    Marker Score: 626
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.04
    Marker Score: 299
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.01
    Marker Score: 343
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,812
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1
    Marker Score: 2,191
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,037
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 665
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.98
    Marker Score: 1,318
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.97
    Marker Score: 313
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.97
    Marker Score: 1,171
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 393
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,187
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.9
    Marker Score: 233
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.88
    Marker Score: 1,364
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.86
    Marker Score: 411
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.86
    Marker Score: 32,696
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.85
    Marker Score: 3,470
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.84
    Marker Score: 1,386
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.82
    Marker Score: 882
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.81
    Marker Score: 454
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.8
    Marker Score: 6,842
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.78
    Marker Score: 1,014
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.78
    Marker Score: 465
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3,241
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.75
    Marker Score: 2,888
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.73
    Marker Score: 428
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.73
    Marker Score: 26,953
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.73
    Marker Score: 905
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.71
    Marker Score: 6,720
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.68
    Marker Score: 450
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.68
    Marker Score: 13,593
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.67
    Marker Score: 246
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.65
    Marker Score: 383
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.65
    Marker Score: 9,725
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.64
    Marker Score: 203
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.64
    Marker Score: 4,872
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.63
    Marker Score: 5,997
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.63
    Marker Score: 664
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.63
    Marker Score: 38,474
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.61
    Marker Score: 124
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.61
    Marker Score: 889
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.61
    Marker Score: 10,857
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 368
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.56
    Marker Score: 2,573
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.55
    Marker Score: 1,502
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.54
    Marker Score: 142
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.52
    Marker Score: 8,399
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.52
    Marker Score: 132
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.52
    Marker Score: 226
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.52
    Marker Score: 17,432
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.5
    Marker Score: 329
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.5
    Marker Score: 2,054
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.49
    Marker Score: 240
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.49
    Marker Score: 5,036
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.47
    Marker Score: 266
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 210
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.46
    Marker Score: 242
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.44
    Marker Score: 1,836

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ESR2 is a ligand-activated transcription factor that belongs to the nuclear receptor family. It is composed of two main domains: the ligand-binding domain (LBD) and the DNA-binding domain (DBD). The LBD is responsible for binding to estrogen molecules, while the DBD is responsible for binding to specific DNA sequences, known as estrogen response elements (EREs). ESR2 is highly expressed in various tissues, including lymphocytes, skeletal muscle fibers, and corneal epithelial cells. **Pathways and Functions** ESR2 mediates its effects through several pathways, including: 1. **Cell-cell signaling**: ESR2 regulates the expression of genes involved in cell growth, differentiation, and survival. 2. **Chromatin remodeling**: ESR2 interacts with chromatin-modifying enzymes to regulate gene expression. 3. **Intracellular signaling by second messengers**: ESR2 activates various signaling pathways, including the PI3K/Akt pathway, which regulates cell growth and survival. 4. **Negative regulation of cell growth**: ESR2 can inhibit cell growth and proliferation by regulating the expression of genes involved in cell cycle progression. ESR2 also interacts with other signaling pathways, including: 1. **PI3K/Akt signaling in cancer**: ESR2 can regulate the PI3K/Akt pathway, which is involved in cancer cell growth and survival. 2. **Pi5p, PP2A, and IER3 regulate PI3K/Akt signaling**: ESR2 interacts with these proteins to regulate the PI3K/Akt pathway. 3. **PIP3 activates Akt signaling**: ESR2 can activate the PI3K/Akt pathway by regulating the activity of phosphatidylinositol 3-kinase (PI3K). **Clinical Significance** ESR2 has been implicated in various diseases, including: 1. **Breast cancer**: ESR2 is overexpressed in many breast cancer cells, and its expression is associated with tumor progression and poor prognosis. 2. **Endometrial cancer**: ESR2 is also overexpressed in endometrial cancer cells, and its expression is associated with tumor progression and poor prognosis. 3. **Osteoporosis**: ESR2 regulates bone metabolism, and its dysregulation is associated with osteoporosis. 4. **Cardiovascular disease**: ESR2 regulates cardiovascular function, and its dysregulation is associated with cardiovascular disease. In conclusion, ESR2 is a critical regulator of gene expression and cell growth, and its dysregulation is associated with various diseases. As an expert immunologist, I emphasize the importance of understanding the mechanisms of ESR2 in normal and diseased tissues to develop effective therapeutic strategies. **Future Directions** Further research is needed to fully elucidate the mechanisms of ESR2 in normal and diseased tissues. Some potential areas of investigation include: 1. **Crystallography**: High-resolution crystal structures of ESR2 can provide insights into its ligand-binding domain and DNA-binding domain. 2. **Gene expression analysis**: Further analysis of gene expression patterns in ESR2-expressing cells can provide insights into the mechanisms of ESR2-mediated gene regulation. 3. **Cancer research**: Investigating the role of ESR2 in cancer development and progression can provide insights into potential therapeutic strategies. By advancing our understanding of ESR2, we can develop effective therapeutic strategies to treat various diseases associated with ESR2 dysregulation.

Genular Protein ID: 1393377049

Symbol: ESR2_HUMAN

Name: Estrogen receptor beta

UniProtKB Accession Codes:

Q92731 A8K8K5 G3V5M5 O60608 O60685 O60702 O60703 O75583 O75584 Q0MWT5 Q0MWT6 Q86Z31 Q9UEV6 Q9UHD3 Q9UQK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 61 DrugCentral 1 ELM 1 EMBL 22 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 46 PDBsum 37 PIR 3 PIRSF 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 RNAct 1 Reactome 6 RefSeq 13 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9473491

Title: The complete primary structure of human estrogen receptor beta (hERbeta) and its heterodimerization with ER alpha in vivo and in vitro.

PubMed ID: 9473491

DOI: 10.1006/bbrc.1997.7893

PubMed ID: 9636657

Title: Cloning and characterization of human estrogen receptor beta isoforms.

PubMed ID: 9636657

DOI: 10.1006/bbrc.1998.8738

PubMed ID: 9685228

Title: Estrogen receptor-beta mRNA variants in human and murine tissues.

PubMed ID: 9685228

DOI: 10.1016/s0303-7207(98)00050-1

PubMed ID: 9671811

Title: Molecular cloning and characterization of human estrogen receptor beta cx: a potential inhibitor of estrogen action in human.

PubMed ID: 9671811

DOI: 10.1093/nar/26.15.3505

PubMed ID: 16938840

Title: Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling.

PubMed ID: 16938840

DOI: 10.1073/pnas.0605676103

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10964723

Title: Cloning and characterization of human estrogen receptor beta promoter.

PubMed ID: 10964723

DOI: 10.1006/bbrc.2000.3363

PubMed ID: 8769313

Title: ER beta: identification and characterization of a novel human estrogen receptor.

PubMed ID: 8769313

DOI: 10.1016/0014-5793(96)00782-x

PubMed ID: 9267036

Title: Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

PubMed ID: 9267036

DOI: 10.1016/s0092-8674(00)80516-4

PubMed ID: 9325313

Title: Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha.

PubMed ID: 9325313

DOI: 10.1074/jbc.272.41.25832

PubMed ID: 10681503

Title: Cloning and characterization of RAP250, a nuclear receptor coactivator.

PubMed ID: 10681503

DOI: 10.1074/jbc.275.8.5308

PubMed ID: 11113208

Title: CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant.

PubMed ID: 11113208

DOI: 10.1128/mcb.21.1.343-353.2001

PubMed ID: 11579095

Title: The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway.

PubMed ID: 11579095

DOI: 10.1074/jbc.m106927200

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 12415108

Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.

PubMed ID: 12415108

DOI: 10.1073/pnas.192569699

PubMed ID: 19666546

Title:

PubMed ID: 19666546

DOI: 10.1073/pnas.0908685106

PubMed ID: 15047147

Title: ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.

PubMed ID: 15047147

DOI: 10.1016/j.bbrc.2004.02.179

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15199063

Title: An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.

PubMed ID: 15199063

DOI: 10.1074/jbc.m402753200

PubMed ID: 15862947

Title: Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway.

PubMed ID: 15862947

DOI: 10.1016/j.jsbmb.2005.02.001

PubMed ID: 19126643

Title: CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells.

PubMed ID: 19126643

DOI: 10.1093/carcin/bgn288

PubMed ID: 20074560

Title: Repression of estrogen receptor beta function by putative tumor suppressor DBC1.

PubMed ID: 20074560

DOI: 10.1016/j.bbrc.2010.01.025

PubMed ID: 29261182

Title: Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development.

PubMed ID: 29261182

DOI: 10.1038/gim.2017.163

PubMed ID: 30113650

Title: Early-onset complete ovarian failure and lack of puberty in a woman with mutated estrogen receptor beta (ESR2).

PubMed ID: 30113650

DOI: 10.1210/jc.2018-00769

Sequence Information:

  • Length: 530
  • Mass: 59216
  • Checksum: 8CAE34215992418A
  • Sequence:
    • MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 
NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 
RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH 
CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 
DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHASN KGMEHLLNMK 
CKNVVPVYDL LLEMLNAHVL RGCKSSITGS ECSPAEDSKS KEGSQNPQSQ

Genular Protein ID: 768492342

Symbol: A0A348FV93_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A348FV93

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 9 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 2 PRINTS 2 PROSITE 5 Pfam 3 RefSeq 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 474
  • Mass: 53209
  • Checksum: 4558F2986355FAF0
  • Sequence:
    • MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 
NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 
RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH 
CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 
DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARS CVYK

Genular Protein ID: 3219624409

Symbol: Q0PTK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0PTK2

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 8 Gene3D 2 GenomeRNAi 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 2 PRINTS 2 PROSITE 5 PeptideAtlas 1 Pfam 3 RefSeq 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 16230778

Title: Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization.

PubMed ID: 16230778

DOI: 10.1385/ENDO:27:3:227

Sequence Information:

  • Length: 474
  • Mass: 53151
  • Checksum: FD659791D0095919
  • Sequence:
    • MDIKNSPSSL NSPSSYDCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 
NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 
RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSAGEQLH 
CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 
DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARS CVYK

Genular Protein ID: 3147762313

Symbol: F1D8N3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1D8N3

Database IDs:

ARBA 12 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 9 Gene3D 2 GenomeRNAi 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 2 PRINTS 2 PROSITE 3 Pfam 3 RefSeq 4 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 495
  • Mass: 55483
  • Checksum: F068DBC63DC838A6
  • Sequence:
    • MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 
NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 
RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH 
CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 
DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARA EKASQTLTSF 
GMKMETLLPE ATMEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.