Details for: ESR2

Gene ID: 2100

Symbol: ESR2

Ensembl ID: ENSG00000140009

Description: estrogen receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.0206
    Cell Significance Index: -14.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.1131
    Cell Significance Index: -14.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.9533
    Cell Significance Index: -12.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9956
    Cell Significance Index: -14.7900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 10.0097
    Cell Significance Index: 142.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0359
    Cell Significance Index: -13.2100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.1119
    Cell Significance Index: 36.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7633
    Cell Significance Index: -14.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0767
    Cell Significance Index: -9.4500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.8883
    Cell Significance Index: 17.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.2448
    Cell Significance Index: 38.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6621
    Cell Significance Index: 46.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.5970
    Cell Significance Index: 232.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3180
    Cell Significance Index: 35.3200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.2166
    Cell Significance Index: 15.3200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1170
    Cell Significance Index: 27.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8441
    Cell Significance Index: 29.6600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.6997
    Cell Significance Index: 11.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6346
    Cell Significance Index: 35.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6288
    Cell Significance Index: 48.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6216
    Cell Significance Index: 13.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5359
    Cell Significance Index: 106.3600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.5084
    Cell Significance Index: 3.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4821
    Cell Significance Index: 96.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4177
    Cell Significance Index: 149.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4109
    Cell Significance Index: 25.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3528
    Cell Significance Index: 67.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3236
    Cell Significance Index: 2.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2649
    Cell Significance Index: 5.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2220
    Cell Significance Index: 9.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2127
    Cell Significance Index: 8.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1851
    Cell Significance Index: 2.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1815
    Cell Significance Index: 341.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1794
    Cell Significance Index: 10.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1591
    Cell Significance Index: 101.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0912
    Cell Significance Index: 2.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0797
    Cell Significance Index: 8.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0741
    Cell Significance Index: 114.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0739
    Cell Significance Index: 136.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0572
    Cell Significance Index: 51.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0566
    Cell Significance Index: 25.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0552
    Cell Significance Index: 3.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0545
    Cell Significance Index: 6.7000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0521
    Cell Significance Index: 0.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0443
    Cell Significance Index: 2.9800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0417
    Cell Significance Index: 0.6000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0253
    Cell Significance Index: 0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0227
    Cell Significance Index: 10.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0214
    Cell Significance Index: 29.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0185
    Cell Significance Index: 0.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0179
    Cell Significance Index: 3.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0159
    Cell Significance Index: 11.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0154
    Cell Significance Index: 2.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0047
    Cell Significance Index: 0.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0027
    Cell Significance Index: 0.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0007
    Cell Significance Index: -0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -1.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0057
    Cell Significance Index: -0.2600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0067
    Cell Significance Index: -0.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0097
    Cell Significance Index: -0.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0169
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0174
    Cell Significance Index: -12.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0188
    Cell Significance Index: -13.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0198
    Cell Significance Index: -0.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0208
    Cell Significance Index: -15.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0235
    Cell Significance Index: -13.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0252
    Cell Significance Index: -15.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0260
    Cell Significance Index: -7.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0270
    Cell Significance Index: -1.8700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0334
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0368
    Cell Significance Index: -6.2900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0384
    Cell Significance Index: -0.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0468
    Cell Significance Index: -0.6700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0578
    Cell Significance Index: -0.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0600
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0686
    Cell Significance Index: -14.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0686
    Cell Significance Index: -9.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0811
    Cell Significance Index: -8.4400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0847
    Cell Significance Index: -2.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0925
    Cell Significance Index: -11.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0933
    Cell Significance Index: -4.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0962
    Cell Significance Index: -3.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0992
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1018
    Cell Significance Index: -11.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1056
    Cell Significance Index: -7.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1190
    Cell Significance Index: -13.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1232
    Cell Significance Index: -6.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1248
    Cell Significance Index: -12.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1328
    Cell Significance Index: -1.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1466
    Cell Significance Index: -6.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1490
    Cell Significance Index: -3.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1549
    Cell Significance Index: -5.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1676
    Cell Significance Index: -12.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1758
    Cell Significance Index: -5.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1778
    Cell Significance Index: -3.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1967
    Cell Significance Index: -4.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2134
    Cell Significance Index: -4.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2173
    Cell Significance Index: -3.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2219
    Cell Significance Index: -4.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2269
    Cell Significance Index: -14.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ESR2 is a ligand-activated transcription factor that belongs to the nuclear receptor family. It is composed of two main domains: the ligand-binding domain (LBD) and the DNA-binding domain (DBD). The LBD is responsible for binding to estrogen molecules, while the DBD is responsible for binding to specific DNA sequences, known as estrogen response elements (EREs). ESR2 is highly expressed in various tissues, including lymphocytes, skeletal muscle fibers, and corneal epithelial cells. **Pathways and Functions** ESR2 mediates its effects through several pathways, including: 1. **Cell-cell signaling**: ESR2 regulates the expression of genes involved in cell growth, differentiation, and survival. 2. **Chromatin remodeling**: ESR2 interacts with chromatin-modifying enzymes to regulate gene expression. 3. **Intracellular signaling by second messengers**: ESR2 activates various signaling pathways, including the PI3K/Akt pathway, which regulates cell growth and survival. 4. **Negative regulation of cell growth**: ESR2 can inhibit cell growth and proliferation by regulating the expression of genes involved in cell cycle progression. ESR2 also interacts with other signaling pathways, including: 1. **PI3K/Akt signaling in cancer**: ESR2 can regulate the PI3K/Akt pathway, which is involved in cancer cell growth and survival. 2. **Pi5p, PP2A, and IER3 regulate PI3K/Akt signaling**: ESR2 interacts with these proteins to regulate the PI3K/Akt pathway. 3. **PIP3 activates Akt signaling**: ESR2 can activate the PI3K/Akt pathway by regulating the activity of phosphatidylinositol 3-kinase (PI3K). **Clinical Significance** ESR2 has been implicated in various diseases, including: 1. **Breast cancer**: ESR2 is overexpressed in many breast cancer cells, and its expression is associated with tumor progression and poor prognosis. 2. **Endometrial cancer**: ESR2 is also overexpressed in endometrial cancer cells, and its expression is associated with tumor progression and poor prognosis. 3. **Osteoporosis**: ESR2 regulates bone metabolism, and its dysregulation is associated with osteoporosis. 4. **Cardiovascular disease**: ESR2 regulates cardiovascular function, and its dysregulation is associated with cardiovascular disease. In conclusion, ESR2 is a critical regulator of gene expression and cell growth, and its dysregulation is associated with various diseases. As an expert immunologist, I emphasize the importance of understanding the mechanisms of ESR2 in normal and diseased tissues to develop effective therapeutic strategies. **Future Directions** Further research is needed to fully elucidate the mechanisms of ESR2 in normal and diseased tissues. Some potential areas of investigation include: 1. **Crystallography**: High-resolution crystal structures of ESR2 can provide insights into its ligand-binding domain and DNA-binding domain. 2. **Gene expression analysis**: Further analysis of gene expression patterns in ESR2-expressing cells can provide insights into the mechanisms of ESR2-mediated gene regulation. 3. **Cancer research**: Investigating the role of ESR2 in cancer development and progression can provide insights into potential therapeutic strategies. By advancing our understanding of ESR2, we can develop effective therapeutic strategies to treat various diseases associated with ESR2 dysregulation.

Genular Protein ID: 1393377049

Symbol: ESR2_HUMAN

Name: Estrogen receptor beta

UniProtKB Accession Codes:

Q92731 A8K8K5 G3V5M5 O60608 O60685 O60702 O60703 O75583 O75584 Q0MWT5 Q0MWT6 Q86Z31 Q9UEV6 Q9UHD3 Q9UQK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 62 DrugCentral 1 ELM 1 EMBL 22 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 37 PIR 3 PIRSF 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 RNAct 1 Reactome 6 RefSeq 13 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9473491

Title: The complete primary structure of human estrogen receptor beta (hERbeta) and its heterodimerization with ER alpha in vivo and in vitro.

PubMed ID: 9473491

DOI: 10.1006/bbrc.1997.7893

PubMed ID: 9636657

Title: Cloning and characterization of human estrogen receptor beta isoforms.

PubMed ID: 9636657

DOI: 10.1006/bbrc.1998.8738

PubMed ID: 9685228

Title: Estrogen receptor-beta mRNA variants in human and murine tissues.

PubMed ID: 9685228

DOI: 10.1016/s0303-7207(98)00050-1

PubMed ID: 9671811

Title: Molecular cloning and characterization of human estrogen receptor beta cx: a potential inhibitor of estrogen action in human.

PubMed ID: 9671811

DOI: 10.1093/nar/26.15.3505

PubMed ID: 16938840

Title: Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling.

PubMed ID: 16938840

DOI: 10.1073/pnas.0605676103

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10964723

Title: Cloning and characterization of human estrogen receptor beta promoter.

PubMed ID: 10964723

DOI: 10.1006/bbrc.2000.3363

PubMed ID: 8769313

Title: ER beta: identification and characterization of a novel human estrogen receptor.

PubMed ID: 8769313

DOI: 10.1016/0014-5793(96)00782-x

PubMed ID: 9267036

Title: Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

PubMed ID: 9267036

DOI: 10.1016/s0092-8674(00)80516-4

PubMed ID: 9325313

Title: Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha.

PubMed ID: 9325313

DOI: 10.1074/jbc.272.41.25832

PubMed ID: 10681503

Title: Cloning and characterization of RAP250, a nuclear receptor coactivator.

PubMed ID: 10681503

DOI: 10.1074/jbc.275.8.5308

PubMed ID: 11113208

Title: CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant.

PubMed ID: 11113208

DOI: 10.1128/mcb.21.1.343-353.2001

PubMed ID: 11579095

Title: The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway.

PubMed ID: 11579095

DOI: 10.1074/jbc.m106927200

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 12415108

Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.

PubMed ID: 12415108

DOI: 10.1073/pnas.192569699

PubMed ID: 19666546

Title:

PubMed ID: 19666546

DOI: 10.1073/pnas.0908685106

PubMed ID: 15047147

Title: ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.

PubMed ID: 15047147

DOI: 10.1016/j.bbrc.2004.02.179

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15199063

Title: An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.

PubMed ID: 15199063

DOI: 10.1074/jbc.m402753200

PubMed ID: 15862947

Title: Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway.

PubMed ID: 15862947

DOI: 10.1016/j.jsbmb.2005.02.001

PubMed ID: 19126643

Title: CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells.

PubMed ID: 19126643

DOI: 10.1093/carcin/bgn288

PubMed ID: 20074560

Title: Repression of estrogen receptor beta function by putative tumor suppressor DBC1.

PubMed ID: 20074560

DOI: 10.1016/j.bbrc.2010.01.025

PubMed ID: 29261182

Title: Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development.

PubMed ID: 29261182

DOI: 10.1038/gim.2017.163

PubMed ID: 30113650

Title: Early-onset complete ovarian failure and lack of puberty in a woman with mutated estrogen receptor beta (ESR2).

PubMed ID: 30113650

DOI: 10.1210/jc.2018-00769

Sequence Information:

  • Length: 530
  • Mass: 59216
  • Checksum: 8CAE34215992418A
  • Sequence:
    • MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 
NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 
RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH 
CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 
DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHASN KGMEHLLNMK 
CKNVVPVYDL LLEMLNAHVL RGCKSSITGS ECSPAEDSKS KEGSQNPQSQ

Genular Protein ID: 3219624409

Symbol: Q0PTK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0PTK2

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 2 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 2 PRINTS 2 PROSITE 5 PeptideAtlas 1 Pfam 3 RefSeq 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 16230778

Title: Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization.

PubMed ID: 16230778

DOI: 10.1385/ENDO:27:3:227

Sequence Information:

  • Length: 474
  • Mass: 53151
  • Checksum: FD659791D0095919
  • Sequence:
    • MDIKNSPSSL NSPSSYDCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 
NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 
RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSAGEQLH 
CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 
DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARS CVYK

Genular Protein ID: 768492342

Symbol: A0A348FV93_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A348FV93

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 10 Gene3D 2 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 2 PRINTS 2 PROSITE 5 Pfam 3 RefSeq 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 474
  • Mass: 53209
  • Checksum: 4558F2986355FAF0
  • Sequence:
    • MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 
NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 
RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH 
CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 
DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARS CVYK

Genular Protein ID: 3147762313

Symbol: F1D8N3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1D8N3

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 10 Gene3D 2 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 2 PRINTS 2 PROSITE 3 Pfam 3 RefSeq 4 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 495
  • Mass: 55483
  • Checksum: F068DBC63DC838A6
  • Sequence:
    • MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 
NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 
RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH 
CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 
LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 
VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 
DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHARA EKASQTLTSF 
GMKMETLLPE ATMEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.