Details for: ESRRB

Gene ID: 2103

Symbol: ESRRB

Ensembl ID: ENSG00000119715

Description: estrogen related receptor beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.51
    Marker Score: 1945
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.36
    Marker Score: 79856
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.25
    Marker Score: 4260.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167898
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.41
    Marker Score: 421
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.38
    Marker Score: 2816
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.21
    Marker Score: 27128
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18848
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.08
    Marker Score: 571
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.08
    Marker Score: 1491
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.07
    Marker Score: 480
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.01
    Marker Score: 3597
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71799
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.98
    Marker Score: 2151
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 534
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 275
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.85
    Marker Score: 297
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 355
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1165
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.71
    Marker Score: 1911
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.68
    Marker Score: 285
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.63
    Marker Score: 1487
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.62
    Marker Score: 4116
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6
    Marker Score: 1716
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.58
    Marker Score: 329
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.57
    Marker Score: 601
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 449
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.56
    Marker Score: 789
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 179
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 144
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 206
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.46
    Marker Score: 717
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.46
    Marker Score: 437
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.42
    Marker Score: 462
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.41
    Marker Score: 109
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.41
    Marker Score: 214
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.41
    Marker Score: 228
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.4
    Marker Score: 367
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.39
    Marker Score: 425
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.36
    Marker Score: 134
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.36
    Marker Score: 164
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.36
    Marker Score: 650
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.35
    Marker Score: 301
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.34
    Marker Score: 200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.34
    Marker Score: 157
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.34
    Marker Score: 860
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 297
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.32
    Marker Score: 1295
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.31
    Marker Score: 2950
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.31
    Marker Score: 151
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.31
    Marker Score: 3157
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.3
    Marker Score: 179
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.28
    Marker Score: 342
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.28
    Marker Score: 137
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.27
    Marker Score: 157
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.27
    Marker Score: 180.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.26
    Marker Score: 1107
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.26
    Marker Score: 1583
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.26
    Marker Score: 498.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.26
    Marker Score: 150
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.26
    Marker Score: 175
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.24
    Marker Score: 270
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.24
    Marker Score: 93
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.24
    Marker Score: 282
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.23
    Marker Score: 46
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.23
    Marker Score: 56
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.23
    Marker Score: 2138
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.22
    Marker Score: 170
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.22
    Marker Score: 776
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.22
    Marker Score: 211
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.22
    Marker Score: 52
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.22
    Marker Score: 59
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.22
    Marker Score: 280
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 442
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.21
    Marker Score: 871
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.2
    Marker Score: 203
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.2
    Marker Score: 56
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.2
    Marker Score: 188
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.19
    Marker Score: 185

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Other Information

**Key characteristics:** * The ESRRB gene is located on chromosome 14q32.1. * It is a member of the estrogen receptor superfamily of transcription factors. * It is a key regulator of the development and function of the cardiovascular system. * It is also involved in the development and function of the immune system. **Pathways and functions:** * The ESRRB gene is a key regulator of the expression of a variety of genes involved in cardiovascular development and function. These genes include those that encode proteins involved in blood cell production, cardiac contractility, and vascular development. * ESRRB is also a key regulator of the expression of genes involved in the immune system. These genes include those that encode proteins involved in the activation of immune cells, the regulation of inflammation, and the development of immune tolerance. * In addition to its role in cardiovascular development and the immune system, ESRRB is also involved in the regulation of cell growth, differentiation, and apoptosis. **Clinical significance:** * Mutations in the ESRRB gene have been linked to a number of human diseases, including cardiovascular disease, stroke, cancer, and autoimmune disorders. * The development of drugs that target ESRRB is an active area of research, as there is a potential to use these drugs to treat a variety of diseases. **Additional notes:** * ESRRB is a highly conserved protein, with similar genes found in organisms ranging from yeast to humans. * The ESRRB protein is a transmembrane protein that is expressed in a variety of cell types. * ESRRB is a nuclear protein that interacts with a variety of other proteins to regulate gene expression.

Genular Protein ID: 1920649517

Symbol: ERR2_HUMAN

Name: ERR beta-2

UniProtKB Accession Codes:

O95718 A2VDJ2 B6ZGU4 Q5F0P7 Q5F0P8 Q9HCB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 DrugCentral 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIRSF 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10072763

Title: Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR.

PubMed ID: 10072763

DOI: 10.1016/s0378-1119(98)00619-2

PubMed ID: 16332939

Title: Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta.

PubMed ID: 16332939

DOI: 10.1210/jc.2004-1957

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17920186

Title: ERRbeta: a potent inhibitor of Nrf2 transcriptional activity.

PubMed ID: 17920186

DOI: 10.1016/j.mce.2007.08.011

PubMed ID: 19755138

Title: Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants.

PubMed ID: 19755138

DOI: 10.1016/j.mce.2009.09.007

PubMed ID: 23836911

Title: Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.

PubMed ID: 23836911

DOI: 10.1074/jbc.m113.489674

PubMed ID: 18775884

Title: Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle.

PubMed ID: 18775884

DOI: 10.1093/humrep/den298

PubMed ID: 20484414

Title: An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.

PubMed ID: 20484414

DOI: 10.1210/me.2009-0441

PubMed ID: 12654265

Title: Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition.

PubMed ID: 12654265

DOI: 10.1016/s0022-2836(03)00183-9

PubMed ID: 18179891

Title: Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal-recessive nonsyndromic hearing impairment DFNB35.

PubMed ID: 18179891

DOI: 10.1016/j.ajhg.2007.09.008

Sequence Information:

  • Length: 433
  • Mass: 48054
  • Checksum: ED1D3F87E2798DD1
  • Sequence:
    • MSSDDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGLALG THANGLDSPP 
MFAGAGLGGT PCRKSYEDCA SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC 
EACKAFFKRT IQGNIEYSCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG 
GRQKYKRRLD SESSPYLSLQ ISPPAKKPLT KIVSYLLVAE PDKLYAMPPP GMPEGDIKAL 
TTLCDLADRE LVVIIGWAKH IPGFSSLSLG DQMSLLQSAW MEILILGIVY RSLPYDDKLV 
YAEDYIMDEE HSRLAGLLEL YRAILQLVRR YKKLKVEKEE FVTLKALALA NSDSMYIEDL 
EAVQKLQDLL HEALQDYELS QRHEEPWRTG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP 
MHKLFLEMLE AKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.