Details for: ESRRB

Gene ID: 2103

Symbol: ESRRB

Ensembl ID: ENSG00000119715

Description: estrogen related receptor beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 8.7325
    Cell Significance Index: 191.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 5.4932
    Cell Significance Index: 346.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2676
    Cell Significance Index: 15.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.2445
    Cell Significance Index: 30.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7961
    Cell Significance Index: 61.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5923
    Cell Significance Index: 10.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3295
    Cell Significance Index: 8.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2853
    Cell Significance Index: 4.8900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.1931
    Cell Significance Index: 1.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1451
    Cell Significance Index: 1.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1246
    Cell Significance Index: 24.7200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1085
    Cell Significance Index: 1.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1067
    Cell Significance Index: 15.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1048
    Cell Significance Index: 3.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0972
    Cell Significance Index: 44.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0966
    Cell Significance Index: 19.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0922
    Cell Significance Index: 4.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0610
    Cell Significance Index: 0.9000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0603
    Cell Significance Index: 0.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0429
    Cell Significance Index: 15.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0372
    Cell Significance Index: 2.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0266
    Cell Significance Index: 18.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0164
    Cell Significance Index: 30.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0158
    Cell Significance Index: 11.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0155
    Cell Significance Index: 8.4900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.0151
    Cell Significance Index: 0.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0133
    Cell Significance Index: 1.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0074
    Cell Significance Index: 4.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0063
    Cell Significance Index: 8.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0042
    Cell Significance Index: 6.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0032
    Cell Significance Index: 5.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0028
    Cell Significance Index: 0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0075
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0086
    Cell Significance Index: -5.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0105
    Cell Significance Index: -3.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0105
    Cell Significance Index: -0.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0110
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0156
    Cell Significance Index: -2.6700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0166
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0226
    Cell Significance Index: -4.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0259
    Cell Significance Index: -2.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0303
    Cell Significance Index: -3.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0310
    Cell Significance Index: -4.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0319
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0384
    Cell Significance Index: -4.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0401
    Cell Significance Index: -5.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0417
    Cell Significance Index: -4.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0482
    Cell Significance Index: -2.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0547
    Cell Significance Index: -1.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0627
    Cell Significance Index: -4.6700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0630
    Cell Significance Index: -0.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0773
    Cell Significance Index: -4.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0792
    Cell Significance Index: -1.5500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0829
    Cell Significance Index: -1.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0831
    Cell Significance Index: -2.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0832
    Cell Significance Index: -4.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0847
    Cell Significance Index: -2.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0876
    Cell Significance Index: -4.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0886
    Cell Significance Index: -4.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0907
    Cell Significance Index: -2.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0911
    Cell Significance Index: -3.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0915
    Cell Significance Index: -1.3500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0955
    Cell Significance Index: -1.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0956
    Cell Significance Index: -3.1300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1003
    Cell Significance Index: -1.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1018
    Cell Significance Index: -2.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1029
    Cell Significance Index: -5.3600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1043
    Cell Significance Index: -1.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1079
    Cell Significance Index: -3.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1102
    Cell Significance Index: -2.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1255
    Cell Significance Index: -2.5200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1268
    Cell Significance Index: -4.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1282
    Cell Significance Index: -2.7700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1287
    Cell Significance Index: -1.5600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1289
    Cell Significance Index: -1.8100
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1289
    Cell Significance Index: -1.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1294
    Cell Significance Index: -3.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1325
    Cell Significance Index: -2.6200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1371
    Cell Significance Index: -1.7300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1371
    Cell Significance Index: -1.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1371
    Cell Significance Index: -3.9500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1382
    Cell Significance Index: -1.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1475
    Cell Significance Index: -3.0600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1503
    Cell Significance Index: -1.9500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1504
    Cell Significance Index: -2.5300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1536
    Cell Significance Index: -2.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1555
    Cell Significance Index: -3.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1572
    Cell Significance Index: -4.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1580
    Cell Significance Index: -4.3000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1594
    Cell Significance Index: -2.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1655
    Cell Significance Index: -5.7500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1658
    Cell Significance Index: -3.4600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1662
    Cell Significance Index: -2.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1693
    Cell Significance Index: -4.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1700
    Cell Significance Index: -4.2500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1706
    Cell Significance Index: -2.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1715
    Cell Significance Index: -3.5900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1762
    Cell Significance Index: -2.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ESRRB is a member of the estrogen-related receptor (ERR) family, which consists of three subtypes: ERRα, ERRβ, and ERRγ. These receptors are ligand-activated transcription factors that regulate gene expression in response to estrogen and other ligands. ESRRB is characterized by its ability to bind to specific DNA sequences, known as estrogen response elements (EREs), and modulate the expression of target genes involved in various cellular processes. **Pathways and Functions:** ESRRB is involved in several signaling pathways, including: 1. **Estrogen Response Pathway:** ESRRB regulates gene expression in response to estrogen, influencing cell growth, differentiation, and survival. 2. **Cell Differentiation:** ESRRB modulates the expression of genes involved in cell differentiation, including stem cell maintenance and development. 3. **Immune System Function:** ESRRB is expressed in immune cells, such as hematopoietic stem cells and double-negative thymocytes, and regulates the expression of genes involved in immune response and tolerance. 4. **Neurological Functions:** ESRRB is expressed in Purkinje cells and regulates the expression of genes involved in neuronal development and function. **Clinical Significance:** ESRRB has been implicated in various diseases, including: 1. **Breast Cancer:** ESRRB is overexpressed in breast cancer cells and promotes tumor growth and progression. 2. **Immune-Mediated Disorders:** ESRRB is involved in the regulation of immune cell function and has been implicated in autoimmune diseases, such as rheumatoid arthritis. 3. **Neurological Disorders:** ESRRB is expressed in Purkinje cells and has been implicated in neurodegenerative diseases, such as Parkinson's disease. In conclusion, ESRRB is a critical transcription factor that regulates gene expression and cellular processes in various biological contexts. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the role of ESRRB in maintaining tissue homeostasis and preventing disease. **Proteins:** ERR2_HUMAN (ERR beta-2) is the protein encoded by the ESRRB gene. **Significantly Expressed Cells:** * Erythrocyte * Purkinje cell * Cardiac endothelial cell * Mural cell * Eye photoreceptor cell * Immature innate lymphoid cell * Regular ventricular cardiac myocyte * Cardiac muscle myoblast * Hematopoietic stem cell * Double negative thymocyte **References:** * [Insert relevant references] Note: The references provided are hypothetical and not real. You should use actual references to support your discussion.

Genular Protein ID: 1920649517

Symbol: ERR2_HUMAN

Name: ERR beta-2

UniProtKB Accession Codes:

O95718 A2VDJ2 B6ZGU4 Q5F0P7 Q5F0P8 Q9HCB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 DrugCentral 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10072763

Title: Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR.

PubMed ID: 10072763

DOI: 10.1016/s0378-1119(98)00619-2

PubMed ID: 16332939

Title: Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta.

PubMed ID: 16332939

DOI: 10.1210/jc.2004-1957

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17920186

Title: ERRbeta: a potent inhibitor of Nrf2 transcriptional activity.

PubMed ID: 17920186

DOI: 10.1016/j.mce.2007.08.011

PubMed ID: 19755138

Title: Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants.

PubMed ID: 19755138

DOI: 10.1016/j.mce.2009.09.007

PubMed ID: 23836911

Title: Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.

PubMed ID: 23836911

DOI: 10.1074/jbc.m113.489674

PubMed ID: 18775884

Title: Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle.

PubMed ID: 18775884

DOI: 10.1093/humrep/den298

PubMed ID: 20484414

Title: An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.

PubMed ID: 20484414

DOI: 10.1210/me.2009-0441

PubMed ID: 12654265

Title: Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition.

PubMed ID: 12654265

DOI: 10.1016/s0022-2836(03)00183-9

PubMed ID: 18179891

Title: Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal-recessive nonsyndromic hearing impairment DFNB35.

PubMed ID: 18179891

DOI: 10.1016/j.ajhg.2007.09.008

Sequence Information:

  • Length: 433
  • Mass: 48054
  • Checksum: ED1D3F87E2798DD1
  • Sequence:
    • MSSDDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGLALG THANGLDSPP 
MFAGAGLGGT PCRKSYEDCA SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC 
EACKAFFKRT IQGNIEYSCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG 
GRQKYKRRLD SESSPYLSLQ ISPPAKKPLT KIVSYLLVAE PDKLYAMPPP GMPEGDIKAL 
TTLCDLADRE LVVIIGWAKH IPGFSSLSLG DQMSLLQSAW MEILILGIVY RSLPYDDKLV 
YAEDYIMDEE HSRLAGLLEL YRAILQLVRR YKKLKVEKEE FVTLKALALA NSDSMYIEDL 
EAVQKLQDLL HEALQDYELS QRHEEPWRTG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP 
MHKLFLEMLE AKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.