Details for: EYA2

Gene ID: 2139

Symbol: EYA2

Ensembl ID: ENSG00000064655

Description: EYA transcriptional coactivator and phosphatase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 5.18
    Marker Score: 4,595
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.88
    Marker Score: 2,696
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.66
    Marker Score: 2,758
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.14
    Marker Score: 26,564
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.87
    Marker Score: 61,202
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.73
    Marker Score: 1,349
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.71
    Marker Score: 11,335
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.37
    Marker Score: 2,683
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.25
    Marker Score: 1,255
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.04
    Marker Score: 6,839
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.02
    Marker Score: 688
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.02
    Marker Score: 904
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.94
    Marker Score: 560
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.89
    Marker Score: 1,552
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.88
    Marker Score: 1,240
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.87
    Marker Score: 4,301
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.79
    Marker Score: 1,176
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.67
    Marker Score: 3,399
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.66
    Marker Score: 606
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.64
    Marker Score: 1,419
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.51
    Marker Score: 11,254
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.5
    Marker Score: 437
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.49
    Marker Score: 3,503
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,060
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.45
    Marker Score: 460
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.42
    Marker Score: 2,695
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.41
    Marker Score: 5,015
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.34
    Marker Score: 340
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.32
    Marker Score: 770
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.31
    Marker Score: 2,512
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.3
    Marker Score: 341
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.27
    Marker Score: 257
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.26
    Marker Score: 735
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.24
    Marker Score: 1,453
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.22
    Marker Score: 813
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.15
    Marker Score: 369
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.14
    Marker Score: 415
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,788
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.09
    Marker Score: 441
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.09
    Marker Score: 4,029
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.04
    Marker Score: 500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 431
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.04
    Marker Score: 1,704
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,772
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1
    Marker Score: 563
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,792
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,016
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.98
    Marker Score: 1,792
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15,342
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.96
    Marker Score: 450
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.96
    Marker Score: 248
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5,510
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,732
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9
    Marker Score: 952
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,146
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 534
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.87
    Marker Score: 451
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.86
    Marker Score: 587
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.85
    Marker Score: 244
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.81
    Marker Score: 1,015
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8
    Marker Score: 185
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.8
    Marker Score: 295
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.79
    Marker Score: 190
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.78
    Marker Score: 372
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.78
    Marker Score: 480
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.78
    Marker Score: 378
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.78
    Marker Score: 3,051
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.77
    Marker Score: 354
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,253
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.76
    Marker Score: 636
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2,610
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.75
    Marker Score: 238
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 497
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.73
    Marker Score: 25,172
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.73
    Marker Score: 6,257
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.7
    Marker Score: 222
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.7
    Marker Score: 862
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.7
    Marker Score: 172
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.69
    Marker Score: 1,887
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.69
    Marker Score: 894
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.68
    Marker Score: 1,301
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 325
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.67
    Marker Score: 1,641
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.66
    Marker Score: 162
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.65
    Marker Score: 322
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.65
    Marker Score: 227

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Coactivator and Phosphatase**: EYA2 functions as a transcriptional coactivator, enhancing the expression of target genes, and also possesses phosphatase activity, regulating protein tyrosine phosphorylation. 2. **Signaling Pathway Interactions**: EYA2 interacts with multiple signaling pathways, including chromatin remodeling, DNA repair, apoptosis, and extrinsic apoptotic signaling pathways. 3. **Cell Type-Specific Expression**: EYA2 is expressed in various cell types, including basal epithelial cells of the prostate, photoreceptor cells, retinal bipolar neurons, and astrocytes of the cerebral cortex. 4. **Phosphorylation and Regulation**: EYA2's phosphatase activity regulates protein tyrosine phosphorylation, while its coactivator activity enhances gene expression. **Pathways and Functions** 1. **Chromatin Remodeling**: EYA2 is involved in chromatin remodeling, facilitating the regulation of gene expression and cellular differentiation. 2. **DNA Repair**: EYA2 plays a role in DNA repair, particularly in the recruitment and phosphorylation of repair and signaling proteins at DNA double-strand breaks. 3. **Apoptosis**: EYA2 is involved in apoptosis, regulating the extrinsic apoptotic signaling pathway in the absence of ligand. 4. **Histone Modification**: EYA2's phosphatase activity regulates histone H2A.x142 phosphorylation, which is essential for chromatin remodeling and gene expression. 5. **Cell Differentiation**: EYA2's coactivator activity promotes cell differentiation, regulating the expression of target genes involved in anatomical structure development. **Clinical Significance** 1. **Genetic Disorders**: EYA2 mutations have been associated with genetic disorders, such as autosomal recessive polycystic kidney disease (ARPKD) and congenital bilateral renal aplasia (CBRA). 2. **Cancer**: EYA2's involvement in DNA repair and chromatin remodeling pathways makes it a potential target for cancer therapy. 3. **Neurological Disorders**: EYA2's expression in retinal bipolar neurons and astrocytes of the cerebral cortex highlights its potential role in neurological disorders, such as retinitis pigmentosa and cerebral cortex disorders. 4. **Prostate Cancer**: EYA2's expression in basal epithelial cells of the prostate suggests its potential role in prostate cancer development and progression. In conclusion, EYA2 is a multifunctional gene that plays a critical role in various developmental and cellular processes. Its involvement in chromatin remodeling, DNA repair, apoptosis, and histone modification highlights its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the clinical significance of EYA2 and its potential applications in disease treatment and prevention.

Genular Protein ID: 2727912284

Symbol: EYA2_HUMAN

Name: Eyes absent homolog 2

UniProtKB Accession Codes:

O00167 Q5JSW8 Q86U84 Q96CV6 Q96H97 Q99503 Q99812 Q9BWF6 Q9H4S3 Q9H4S9 Q9NPZ4 Q9UIX7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 7 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 Rhea 3 SABIO-RK 1 SAM 1 SFLD 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9195991

Title: Eyes absent: a gene family found in several metazoan phyla.

PubMed ID: 9195991

DOI: 10.1007/s003359900480

PubMed ID: 9020840

Title: A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.

PubMed ID: 9020840

DOI: 10.1038/ng0297-157

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9049631

Title: Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.

PubMed ID: 9049631

DOI: 10.1101/gr.7.2.128

PubMed ID: 9887327

Title: EYA4, a novel vertebrate gene related to Drosophila eyes absent.

PubMed ID: 9887327

DOI: 10.1093/hmg/8.1.11

PubMed ID: 10906137

Title: The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins.

PubMed ID: 10906137

DOI: 10.1074/jbc.m004577200

PubMed ID: 12500905

Title: Six and Eya expression during human somitogenesis and MyoD gene family activation.

PubMed ID: 12500905

DOI: 10.1023/a:1020990825644

PubMed ID: 19497856

Title: Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations.

PubMed ID: 19497856

DOI: 10.1074/jbc.m109.016832

PubMed ID: 21706047

Title: Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-beta signaling, epithelial-mesenchymal transition, and cancer stem cell properties.

PubMed ID: 21706047

DOI: 10.1038/onc.2011.259

PubMed ID: 19351884

Title: Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent.

PubMed ID: 19351884

DOI: 10.1074/jbc.c900032200

PubMed ID: 19858093

Title: Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor.

PubMed ID: 19858093

DOI: 10.1096/fj.09-143891

PubMed ID: 23435380

Title: Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.

PubMed ID: 23435380

DOI: 10.1038/nsmb.2505

Sequence Information:

  • Length: 538
  • Mass: 59232
  • Checksum: 3DBFC31D8BE1E85D
  • Sequence:
    • MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR 
QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG 
SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS 
SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR 
PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDTTT 
SVRIGLMMEE MIFNLADTHL FFNDLEDCDQ IHVDDVSSDD NGQDLSTYNF SADGFHSSAP 
GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL 
TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK 
ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL

Genular Protein ID: 2508292662

Symbol: E7ETN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ETN2

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 EC 1 EMBL 6 Ensembl 3 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PIRSR 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SFLD 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

Sequence Information:

  • Length: 508
  • Mass: 55745
  • Checksum: C2DAC8AE5D83042D
  • Sequence:
    • MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR 
QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG 
SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS 
SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR 
PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDCDQ 
IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM 
YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ 
LIPALAKVLL YGLGSVFPIE NIYSATKTGK ESCFERIMQR FGRKAVYVVI GDGVEEEQGA 
KKHNMPFWRI SCHADLEALR HALELEYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.