Details for: EYA2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 25.7609
Cell Significance Index: -24.6000 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 17.3212
Cell Significance Index: 153.7600 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 12.9165
Cell Significance Index: 79.6900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 10.9203
Cell Significance Index: 233.4300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 6.3561
Cell Significance Index: 923.9300 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 5.3930
Cell Significance Index: 75.7500 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 4.0072
Cell Significance Index: 44.7900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.2240
Cell Significance Index: 90.1000 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.8824
Cell Significance Index: 19.5300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.9973
Cell Significance Index: 48.3800 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 1.9916
Cell Significance Index: 27.8500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3770
Cell Significance Index: 262.0600 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 1.2051
Cell Significance Index: 12.0600 - Cell Name: peg cell (CL4033014)
Fold Change: 0.9605
Cell Significance Index: 22.1900 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.9538
Cell Significance Index: 12.0100 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.9341
Cell Significance Index: 18.2300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.8404
Cell Significance Index: 1582.2800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7791
Cell Significance Index: 77.0800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6171
Cell Significance Index: 557.1900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5282
Cell Significance Index: 29.6400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4325
Cell Significance Index: 236.2000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3944
Cell Significance Index: 64.1500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3763
Cell Significance Index: 260.2600 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.3649
Cell Significance Index: 6.3100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2837
Cell Significance Index: 180.2000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2740
Cell Significance Index: 29.8100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2678
Cell Significance Index: 12.1400 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.2556
Cell Significance Index: 4.0600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.2483
Cell Significance Index: 2.0300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1665
Cell Significance Index: 3.5500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1397
Cell Significance Index: 6.5700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1390
Cell Significance Index: 6.4800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1174
Cell Significance Index: 6.1000 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.1126
Cell Significance Index: 0.4900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1082
Cell Significance Index: 147.1300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0470
Cell Significance Index: 1.2800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0097
Cell Significance Index: 0.3400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0063
Cell Significance Index: 11.5500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0037
Cell Significance Index: 5.6700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0011
Cell Significance Index: 0.4800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0036
Cell Significance Index: -1.2900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0044
Cell Significance Index: -0.5700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0050
Cell Significance Index: -0.9100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0072
Cell Significance Index: -1.4500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0085
Cell Significance Index: -1.0500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0087
Cell Significance Index: -0.2500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0090
Cell Significance Index: -0.2000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0233
Cell Significance Index: -1.6100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0325
Cell Significance Index: -23.8300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0382
Cell Significance Index: -2.3400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0403
Cell Significance Index: -29.8700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0405
Cell Significance Index: -30.6700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0432
Cell Significance Index: -1.0800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0449
Cell Significance Index: -1.2000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0483
Cell Significance Index: -30.1900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0564
Cell Significance Index: -31.7900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0592
Cell Significance Index: -7.5900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0599
Cell Significance Index: -26.4700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0743
Cell Significance Index: -14.7500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0803
Cell Significance Index: -23.1100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1114
Cell Significance Index: -1.5200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1472
Cell Significance Index: -15.3300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1496
Cell Significance Index: -31.5000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1630
Cell Significance Index: -27.8300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1690
Cell Significance Index: -23.2100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1761
Cell Significance Index: -20.7700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1795
Cell Significance Index: -3.9300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1837
Cell Significance Index: -3.8100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1904
Cell Significance Index: -19.4500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1954
Cell Significance Index: -9.8800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2024
Cell Significance Index: -23.5900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2081
Cell Significance Index: -6.6700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2326
Cell Significance Index: -26.6500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3013
Cell Significance Index: -23.8600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3058
Cell Significance Index: -5.2400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3387
Cell Significance Index: -26.0000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3653
Cell Significance Index: -22.4600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3790
Cell Significance Index: -28.2500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4076
Cell Significance Index: -27.4100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4204
Cell Significance Index: -6.0200 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.4216
Cell Significance Index: -4.8300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4274
Cell Significance Index: -22.4400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4651
Cell Significance Index: -24.2300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4725
Cell Significance Index: -29.7800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.4809
Cell Significance Index: -7.4400 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: -0.5463
Cell Significance Index: -5.6400 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.6025
Cell Significance Index: -8.3600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6189
Cell Significance Index: -22.7200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6197
Cell Significance Index: -27.4100 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.6446
Cell Significance Index: -8.8400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6673
Cell Significance Index: -19.6600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6743
Cell Significance Index: -17.7300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6981
Cell Significance Index: -24.2600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.7023
Cell Significance Index: -18.7900 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.7133
Cell Significance Index: -22.5600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7256
Cell Significance Index: -25.4200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.7370
Cell Significance Index: -27.9100 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.7489
Cell Significance Index: -5.7300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7979
Cell Significance Index: -20.5100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8012
Cell Significance Index: -26.2300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2727912284
Symbol: EYA2_HUMAN
Name: Eyes absent homolog 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9195991
Title: Eyes absent: a gene family found in several metazoan phyla.
PubMed ID: 9195991
PubMed ID: 9020840
Title: A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.
PubMed ID: 9020840
DOI: 10.1038/ng0297-157
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9049631
Title: Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.
PubMed ID: 9049631
DOI: 10.1101/gr.7.2.128
PubMed ID: 9887327
Title: EYA4, a novel vertebrate gene related to Drosophila eyes absent.
PubMed ID: 9887327
DOI: 10.1093/hmg/8.1.11
PubMed ID: 10906137
Title: The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins.
PubMed ID: 10906137
PubMed ID: 12500905
Title: Six and Eya expression during human somitogenesis and MyoD gene family activation.
PubMed ID: 12500905
PubMed ID: 19497856
Title: Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations.
PubMed ID: 19497856
PubMed ID: 21706047
Title: Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-beta signaling, epithelial-mesenchymal transition, and cancer stem cell properties.
PubMed ID: 21706047
DOI: 10.1038/onc.2011.259
PubMed ID: 19351884
Title: Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent.
PubMed ID: 19351884
PubMed ID: 19858093
Title: Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor.
PubMed ID: 19858093
DOI: 10.1096/fj.09-143891
PubMed ID: 23435380
Title: Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
PubMed ID: 23435380
DOI: 10.1038/nsmb.2505
Sequence Information:
- Length: 538
- Mass: 59232
- Checksum: 3DBFC31D8BE1E85D
- Sequence:
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDTTT SVRIGLMMEE MIFNLADTHL FFNDLEDCDQ IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL
Genular Protein ID: 2508292662
Symbol: E7ETN2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 508
- Mass: 55745
- Checksum: C2DAC8AE5D83042D
- Sequence:
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDCDQ IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.