Details for: EYA2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 5.18
Marker Score: 4,595 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 3.88
Marker Score: 2,696 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 3.66
Marker Score: 2,758 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.14
Marker Score: 26,564 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.87
Marker Score: 61,202 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.73
Marker Score: 1,349 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.71
Marker Score: 11,335 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.37
Marker Score: 2,683 - Cell Name: fat cell (CL0000136)
Fold Change: 2.25
Marker Score: 1,255 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 2.04
Marker Score: 6,839 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 2.02
Marker Score: 688 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 2.02
Marker Score: 904 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.94
Marker Score: 560 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.89
Marker Score: 1,552 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.88
Marker Score: 1,240 - Cell Name: macroglial cell (CL0000126)
Fold Change: 1.87
Marker Score: 4,301 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.79
Marker Score: 1,176 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.67
Marker Score: 3,399 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.66
Marker Score: 606 - Cell Name: astrocyte (CL0000127)
Fold Change: 1.64
Marker Score: 1,419 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.51
Marker Score: 11,254 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.5
Marker Score: 437 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.49
Marker Score: 3,503 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,060 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.45
Marker Score: 460 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.42
Marker Score: 2,695 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.41
Marker Score: 5,015 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 861 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.34
Marker Score: 340 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.32
Marker Score: 770 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.31
Marker Score: 2,512 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.3
Marker Score: 341 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.27
Marker Score: 257 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.26
Marker Score: 735 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 846 - Cell Name: club cell (CL0000158)
Fold Change: 1.24
Marker Score: 1,453 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.22
Marker Score: 813 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.15
Marker Score: 369 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.14
Marker Score: 415 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4,788 - Cell Name: melanocyte (CL0000148)
Fold Change: 1.09
Marker Score: 441 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.09
Marker Score: 4,029 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.04
Marker Score: 500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.04
Marker Score: 431 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.04
Marker Score: 1,704 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,772 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 788 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1
Marker Score: 563 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,792 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,016 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.98
Marker Score: 1,792 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,405 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.98
Marker Score: 15,342 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.96
Marker Score: 450 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.96
Marker Score: 248 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,410 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 371 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.92
Marker Score: 5,510 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,732 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9
Marker Score: 952 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5,146 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.89
Marker Score: 534 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.87
Marker Score: 451 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,276 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.86
Marker Score: 587 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.85
Marker Score: 244 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.81
Marker Score: 1,015 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.8
Marker Score: 185 - Cell Name: podocyte (CL0000653)
Fold Change: 0.8
Marker Score: 295 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.79
Marker Score: 190 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.78
Marker Score: 372 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.78
Marker Score: 480 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.78
Marker Score: 378 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.78
Marker Score: 3,051 - Cell Name: interneuron (CL0000099)
Fold Change: 0.77
Marker Score: 354 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,253 - Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 695 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.76
Marker Score: 636 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.76
Marker Score: 2,610 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.75
Marker Score: 238 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.75
Marker Score: 497 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.73
Marker Score: 25,172 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.73
Marker Score: 6,257 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 459 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.7
Marker Score: 222 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.7
Marker Score: 862 - Cell Name: oocyte (CL0000023)
Fold Change: 0.7
Marker Score: 172 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.69
Marker Score: 1,887 - Cell Name: basal cell (CL0000646)
Fold Change: 0.69
Marker Score: 894 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.68
Marker Score: 1,301 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.68
Marker Score: 325 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.67
Marker Score: 1,641 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.66
Marker Score: 162 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.65
Marker Score: 322 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.65
Marker Score: 227
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2727912284
Symbol: EYA2_HUMAN
Name: Eyes absent homolog 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9195991
Title: Eyes absent: a gene family found in several metazoan phyla.
PubMed ID: 9195991
PubMed ID: 9020840
Title: A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.
PubMed ID: 9020840
DOI: 10.1038/ng0297-157
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9049631
Title: Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.
PubMed ID: 9049631
DOI: 10.1101/gr.7.2.128
PubMed ID: 9887327
Title: EYA4, a novel vertebrate gene related to Drosophila eyes absent.
PubMed ID: 9887327
DOI: 10.1093/hmg/8.1.11
PubMed ID: 10906137
Title: The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins.
PubMed ID: 10906137
PubMed ID: 12500905
Title: Six and Eya expression during human somitogenesis and MyoD gene family activation.
PubMed ID: 12500905
PubMed ID: 19497856
Title: Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations.
PubMed ID: 19497856
PubMed ID: 21706047
Title: Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-beta signaling, epithelial-mesenchymal transition, and cancer stem cell properties.
PubMed ID: 21706047
DOI: 10.1038/onc.2011.259
PubMed ID: 19351884
Title: Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent.
PubMed ID: 19351884
PubMed ID: 19858093
Title: Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor.
PubMed ID: 19858093
DOI: 10.1096/fj.09-143891
PubMed ID: 23435380
Title: Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
PubMed ID: 23435380
DOI: 10.1038/nsmb.2505
Sequence Information:
- Length: 538
- Mass: 59232
- Checksum: 3DBFC31D8BE1E85D
- Sequence:
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDTTT SVRIGLMMEE MIFNLADTHL FFNDLEDCDQ IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL
Genular Protein ID: 2508292662
Symbol: E7ETN2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
Sequence Information:
- Length: 508
- Mass: 55745
- Checksum: C2DAC8AE5D83042D
- Sequence:
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDCDQ IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.