Details for: EYA2

Gene ID: 2139

Symbol: EYA2

Ensembl ID: ENSG00000064655

Description: EYA transcriptional coactivator and phosphatase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.7609
    Cell Significance Index: -24.6000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 17.3212
    Cell Significance Index: 153.7600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 12.9165
    Cell Significance Index: 79.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 10.9203
    Cell Significance Index: 233.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 6.3561
    Cell Significance Index: 923.9300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 5.3930
    Cell Significance Index: 75.7500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 4.0072
    Cell Significance Index: 44.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.2240
    Cell Significance Index: 90.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.8824
    Cell Significance Index: 19.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.9973
    Cell Significance Index: 48.3800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.9916
    Cell Significance Index: 27.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3770
    Cell Significance Index: 262.0600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.2051
    Cell Significance Index: 12.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9605
    Cell Significance Index: 22.1900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.9538
    Cell Significance Index: 12.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9341
    Cell Significance Index: 18.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8404
    Cell Significance Index: 1582.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7791
    Cell Significance Index: 77.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6171
    Cell Significance Index: 557.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5282
    Cell Significance Index: 29.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4325
    Cell Significance Index: 236.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3944
    Cell Significance Index: 64.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3763
    Cell Significance Index: 260.2600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3649
    Cell Significance Index: 6.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2837
    Cell Significance Index: 180.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2740
    Cell Significance Index: 29.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2678
    Cell Significance Index: 12.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2556
    Cell Significance Index: 4.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2483
    Cell Significance Index: 2.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1665
    Cell Significance Index: 3.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1397
    Cell Significance Index: 6.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1390
    Cell Significance Index: 6.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1174
    Cell Significance Index: 6.1000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1126
    Cell Significance Index: 0.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1082
    Cell Significance Index: 147.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0470
    Cell Significance Index: 1.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0097
    Cell Significance Index: 0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0063
    Cell Significance Index: 11.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0037
    Cell Significance Index: 5.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0011
    Cell Significance Index: 0.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0036
    Cell Significance Index: -1.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0044
    Cell Significance Index: -0.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0050
    Cell Significance Index: -0.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0072
    Cell Significance Index: -1.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0085
    Cell Significance Index: -1.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0090
    Cell Significance Index: -0.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0233
    Cell Significance Index: -1.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0325
    Cell Significance Index: -23.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0382
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0403
    Cell Significance Index: -29.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0405
    Cell Significance Index: -30.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0432
    Cell Significance Index: -1.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0449
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0483
    Cell Significance Index: -30.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0564
    Cell Significance Index: -31.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0592
    Cell Significance Index: -7.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0599
    Cell Significance Index: -26.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0743
    Cell Significance Index: -14.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0803
    Cell Significance Index: -23.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1114
    Cell Significance Index: -1.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1472
    Cell Significance Index: -15.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1496
    Cell Significance Index: -31.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1630
    Cell Significance Index: -27.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1690
    Cell Significance Index: -23.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1761
    Cell Significance Index: -20.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1795
    Cell Significance Index: -3.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1837
    Cell Significance Index: -3.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1904
    Cell Significance Index: -19.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1954
    Cell Significance Index: -9.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2024
    Cell Significance Index: -23.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2081
    Cell Significance Index: -6.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2326
    Cell Significance Index: -26.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3013
    Cell Significance Index: -23.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3058
    Cell Significance Index: -5.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3387
    Cell Significance Index: -26.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3653
    Cell Significance Index: -22.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3790
    Cell Significance Index: -28.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4076
    Cell Significance Index: -27.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4204
    Cell Significance Index: -6.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4216
    Cell Significance Index: -4.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4274
    Cell Significance Index: -22.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4651
    Cell Significance Index: -24.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4725
    Cell Significance Index: -29.7800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4809
    Cell Significance Index: -7.4400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.5463
    Cell Significance Index: -5.6400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.6025
    Cell Significance Index: -8.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6189
    Cell Significance Index: -22.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6197
    Cell Significance Index: -27.4100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6446
    Cell Significance Index: -8.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6673
    Cell Significance Index: -19.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6743
    Cell Significance Index: -17.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6981
    Cell Significance Index: -24.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7023
    Cell Significance Index: -18.7900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7133
    Cell Significance Index: -22.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7256
    Cell Significance Index: -25.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7370
    Cell Significance Index: -27.9100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.7489
    Cell Significance Index: -5.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7979
    Cell Significance Index: -20.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8012
    Cell Significance Index: -26.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Coactivator and Phosphatase**: EYA2 functions as a transcriptional coactivator, enhancing the expression of target genes, and also possesses phosphatase activity, regulating protein tyrosine phosphorylation. 2. **Signaling Pathway Interactions**: EYA2 interacts with multiple signaling pathways, including chromatin remodeling, DNA repair, apoptosis, and extrinsic apoptotic signaling pathways. 3. **Cell Type-Specific Expression**: EYA2 is expressed in various cell types, including basal epithelial cells of the prostate, photoreceptor cells, retinal bipolar neurons, and astrocytes of the cerebral cortex. 4. **Phosphorylation and Regulation**: EYA2's phosphatase activity regulates protein tyrosine phosphorylation, while its coactivator activity enhances gene expression. **Pathways and Functions** 1. **Chromatin Remodeling**: EYA2 is involved in chromatin remodeling, facilitating the regulation of gene expression and cellular differentiation. 2. **DNA Repair**: EYA2 plays a role in DNA repair, particularly in the recruitment and phosphorylation of repair and signaling proteins at DNA double-strand breaks. 3. **Apoptosis**: EYA2 is involved in apoptosis, regulating the extrinsic apoptotic signaling pathway in the absence of ligand. 4. **Histone Modification**: EYA2's phosphatase activity regulates histone H2A.x142 phosphorylation, which is essential for chromatin remodeling and gene expression. 5. **Cell Differentiation**: EYA2's coactivator activity promotes cell differentiation, regulating the expression of target genes involved in anatomical structure development. **Clinical Significance** 1. **Genetic Disorders**: EYA2 mutations have been associated with genetic disorders, such as autosomal recessive polycystic kidney disease (ARPKD) and congenital bilateral renal aplasia (CBRA). 2. **Cancer**: EYA2's involvement in DNA repair and chromatin remodeling pathways makes it a potential target for cancer therapy. 3. **Neurological Disorders**: EYA2's expression in retinal bipolar neurons and astrocytes of the cerebral cortex highlights its potential role in neurological disorders, such as retinitis pigmentosa and cerebral cortex disorders. 4. **Prostate Cancer**: EYA2's expression in basal epithelial cells of the prostate suggests its potential role in prostate cancer development and progression. In conclusion, EYA2 is a multifunctional gene that plays a critical role in various developmental and cellular processes. Its involvement in chromatin remodeling, DNA repair, apoptosis, and histone modification highlights its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the clinical significance of EYA2 and its potential applications in disease treatment and prevention.

Genular Protein ID: 2727912284

Symbol: EYA2_HUMAN

Name: Eyes absent homolog 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9195991

Title: Eyes absent: a gene family found in several metazoan phyla.

PubMed ID: 9195991

DOI: 10.1007/s003359900480

PubMed ID: 9020840

Title: A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.

PubMed ID: 9020840

DOI: 10.1038/ng0297-157

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9049631

Title: Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.

PubMed ID: 9049631

DOI: 10.1101/gr.7.2.128

PubMed ID: 9887327

Title: EYA4, a novel vertebrate gene related to Drosophila eyes absent.

PubMed ID: 9887327

DOI: 10.1093/hmg/8.1.11

PubMed ID: 10906137

Title: The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins.

PubMed ID: 10906137

DOI: 10.1074/jbc.m004577200

PubMed ID: 12500905

Title: Six and Eya expression during human somitogenesis and MyoD gene family activation.

PubMed ID: 12500905

DOI: 10.1023/a:1020990825644

PubMed ID: 19497856

Title: Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations.

PubMed ID: 19497856

DOI: 10.1074/jbc.m109.016832

PubMed ID: 21706047

Title: Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-beta signaling, epithelial-mesenchymal transition, and cancer stem cell properties.

PubMed ID: 21706047

DOI: 10.1038/onc.2011.259

PubMed ID: 19351884

Title: Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent.

PubMed ID: 19351884

DOI: 10.1074/jbc.c900032200

PubMed ID: 19858093

Title: Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor.

PubMed ID: 19858093

DOI: 10.1096/fj.09-143891

PubMed ID: 23435380

Title: Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.

PubMed ID: 23435380

DOI: 10.1038/nsmb.2505

Sequence Information:

  • Length: 538
  • Mass: 59232
  • Checksum: 3DBFC31D8BE1E85D
  • Sequence:
  • MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR 
    QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG 
    SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS 
    SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR 
    PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDTTT 
    SVRIGLMMEE MIFNLADTHL FFNDLEDCDQ IHVDDVSSDD NGQDLSTYNF SADGFHSSAP 
    GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL 
    TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK 
    ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL

Genular Protein ID: 2508292662

Symbol: E7ETN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 508
  • Mass: 55745
  • Checksum: C2DAC8AE5D83042D
  • Sequence:
  • MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR 
    QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG 
    SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS 
    SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR 
    PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDCDQ 
    IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM 
    YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ 
    LIPALAKVLL YGLGSVFPIE NIYSATKTGK ESCFERIMQR FGRKAVYVVI GDGVEEEQGA 
    KKHNMPFWRI SCHADLEALR HALELEYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.