Details for: F2R

Gene ID: 2149

Symbol: F2R

Ensembl ID: ENSG00000181104

Description: coagulation factor II thrombin receptor

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • Common pathway of fibrin clot formation
    (R-HSA-140875)
  • Formation of fibrin clot (clotting cascade)
    (R-HSA-140877)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Hemostasis
    (R-HSA-109582)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Platelet activation, signaling and aggregation
    (R-HSA-76002)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Thrombin signalling through proteinase activated receptors (pars)
    (R-HSA-456926)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Caveola
    (GO:0005901)
  • Cell-cell junction maintenance
    (GO:0045217)
  • Cell surface
    (GO:0009986)
  • Connective tissue replacement involved in inflammatory response wound healing
    (GO:0002248)
  • Dendritic cell homeostasis
    (GO:0036145)
  • Early endosome
    (GO:0005769)
  • Establishment of synaptic specificity at neuromuscular junction
    (GO:0007529)
  • Extracellular region
    (GO:0005576)
  • G-protein alpha-subunit binding
    (GO:0001965)
  • G-protein beta-subunit binding
    (GO:0031681)
  • Golgi apparatus
    (GO:0005794)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Homeostasis of number of cells within a tissue
    (GO:0048873)
  • Inflammatory response
    (GO:0006954)
  • Late endosome
    (GO:0005770)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of glomerular filtration
    (GO:0003105)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of renin secretion into blood stream
    (GO:1900134)
  • Neuromuscular junction
    (GO:0031594)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Platelet activation
    (GO:0030168)
  • Platelet dense granule organization
    (GO:0060155)
  • Platelet dense tubular network
    (GO:0031094)
  • Positive regulation of blood coagulation
    (GO:0030194)
  • Positive regulation of calcium ion transport
    (GO:0051928)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of receptor signaling pathway via jak-stat
    (GO:0046427)
  • Positive regulation of release of sequestered calcium ion into cytosol
    (GO:0051281)
  • Positive regulation of rho protein signal transduction
    (GO:0035025)
  • Positive regulation of smooth muscle contraction
    (GO:0045987)
  • Positive regulation of vasoconstriction
    (GO:0045907)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein binding
    (GO:0005515)
  • Protein kinase c-activating g protein-coupled receptor signaling pathway
    (GO:0007205)
  • Regulation of blood coagulation
    (GO:0030193)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Regulation of sensory perception of pain
    (GO:0051930)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to wounding
    (GO:0009611)
  • Signaling receptor binding
    (GO:0005102)
  • Thrombin-activated receptor activity
    (GO:0015057)
  • Thrombin-activated receptor signaling pathway
    (GO:0070493)
  • Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
    (GO:0099553)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.95
    Marker Score: 1666
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.8
    Marker Score: 6954
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.68
    Marker Score: 2305
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.65
    Marker Score: 400
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.51
    Marker Score: 2320
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.37
    Marker Score: 1178
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.35
    Marker Score: 296
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.3
    Marker Score: 1224
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.28
    Marker Score: 3599
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.23
    Marker Score: 16260
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.19
    Marker Score: 277
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.15
    Marker Score: 498
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.15
    Marker Score: 574
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.13
    Marker Score: 3296
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.07
    Marker Score: 36461
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251745
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.03
    Marker Score: 621
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.03
    Marker Score: 1514
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71765
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47990
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1
    Marker Score: 4298
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.99
    Marker Score: 1367
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.96
    Marker Score: 9464
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.93
    Marker Score: 10430
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5525
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.91
    Marker Score: 606
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.88
    Marker Score: 512
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4984
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.87
    Marker Score: 502
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5262
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.86
    Marker Score: 492
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.84
    Marker Score: 609
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.82
    Marker Score: 1643
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.82
    Marker Score: 2578
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.82
    Marker Score: 687
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.8
    Marker Score: 862
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.8
    Marker Score: 6885
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.8
    Marker Score: 248
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.8
    Marker Score: 2092
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.78
    Marker Score: 944
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.77
    Marker Score: 247
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.75
    Marker Score: 679
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.75
    Marker Score: 1768.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.75
    Marker Score: 413
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.74
    Marker Score: 1132
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.73
    Marker Score: 169
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 683
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.7
    Marker Score: 292
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2907
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 627.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.68
    Marker Score: 995
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.67
    Marker Score: 213
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.66
    Marker Score: 581
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.64
    Marker Score: 208.5
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.64
    Marker Score: 144
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.64
    Marker Score: 322
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.63
    Marker Score: 811
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.63
    Marker Score: 219
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.63
    Marker Score: 772
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.63
    Marker Score: 418
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.62
    Marker Score: 148
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.61
    Marker Score: 759
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.6
    Marker Score: 207
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.6
    Marker Score: 535
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1196
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.59
    Marker Score: 360
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.58
    Marker Score: 616
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.57
    Marker Score: 156
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.56
    Marker Score: 4186
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.56
    Marker Score: 366
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.56
    Marker Score: 372
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.56
    Marker Score: 1159
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.54
    Marker Score: 580
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.54
    Marker Score: 143
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.54
    Marker Score: 1228
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.54
    Marker Score: 650
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.54
    Marker Score: 540
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 255
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.53
    Marker Score: 386
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.52
    Marker Score: 8162.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.52
    Marker Score: 303
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.51
    Marker Score: 437
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.51
    Marker Score: 574
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.51
    Marker Score: 675
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 134
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.5
    Marker Score: 475

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Other Information

## Summary The F2R gene encodes the protein F2R, a coagulation factor that plays a crucial role in blood clotting. It belongs to the class a/1 of rhodopsin-like receptors and is involved in the formation of fibrin clots through the clotting cascade. ## Key characteristics * F2R is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in various cell types, including endothelial cells, immune cells, and epithelial cells. * F2R is a key regulator of blood coagulation, as it controls the balance between the coagulation and anticoagulant systems. * It is a key component of the platelet aggregation cascade, which is responsible for the formation of blood clots. ## Pathways and functions * F2R binds to thrombin, a protein that is produced by platelets and activated by thrombin-activated factor VII (TFVII). * Binding of F2R to thrombin initiates a cascade of events that lead to the formation of fibrin, a mesh-like protein that helps to form blood clots. * F2R also binds to other proteins, such as fibrinogen and von Willebrand factor, which are essential for the formation of fibrin. * These interactions reinforce the formation of the fibrin clot and help to stop bleeding. ## Clinical significance Mutations in the F2R gene have been linked to several blood disorders, including hemophilia A and von Willebrand disease. In these disorders, F2R is not able to bind thrombin, which leads to a decrease in the formation of fibrin clots and an increased risk of bleeding. F2R is a promising target for the treatment of blood clotting disorders. By blocking F2R, it is possible to prevent the formation of blood clots and reduce the risk of bleeding complications.

Genular Protein ID: 2156690700

Symbol: PAR1_HUMAN

Name: Proteinase-activated receptor 1

UniProtKB Accession Codes:

P25116 Q53XV0 Q96RF7 Q9BUN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 59 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 10 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1672265

Title: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

PubMed ID: 1672265

DOI: 10.1016/0092-8674(91)90261-v

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7744748

Title: Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G.

PubMed ID: 7744748

DOI: 10.1074/jbc.270.19.11168

PubMed ID: 8955127

Title: Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization.

PubMed ID: 8955127

DOI: 10.1074/jbc.271.51.32874

PubMed ID: 10079109

Title: Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.

PubMed ID: 10079109

DOI: 10.1172/jci6042

PubMed ID: 18988770

Title: Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis.

PubMed ID: 18988770

DOI: 10.1124/jpet.108.145664

PubMed ID: 22659187

Title: The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.

PubMed ID: 22659187

DOI: 10.1016/j.febslet.2012.05.042

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 8136362

Title: Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.

PubMed ID: 8136362

DOI: 10.1021/bi00177a018

Sequence Information:

  • Length: 425
  • Mass: 47441
  • Checksum: 41B742A99EEC96AB
  • Sequence:
    • MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE 
KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN 
IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA 
AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK 
EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS 
AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS 
SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY 
KKLLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.