Details for: F2R

Gene ID: 2149

Symbol: F2R

Ensembl ID: ENSG00000181104

Description: coagulation factor II thrombin receptor

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • Common pathway of fibrin clot formation
    (R-HSA-140875)
  • Formation of fibrin clot (clotting cascade)
    (R-HSA-140877)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Hemostasis
    (R-HSA-109582)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Platelet activation, signaling and aggregation
    (R-HSA-76002)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Thrombin signalling through proteinase activated receptors (pars)
    (R-HSA-456926)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Caveola
    (GO:0005901)
  • Cell-cell junction maintenance
    (GO:0045217)
  • Cell surface
    (GO:0009986)
  • Connective tissue replacement involved in inflammatory response wound healing
    (GO:0002248)
  • Dendritic cell homeostasis
    (GO:0036145)
  • Early endosome
    (GO:0005769)
  • Establishment of synaptic specificity at neuromuscular junction
    (GO:0007529)
  • Extracellular region
    (GO:0005576)
  • G-protein alpha-subunit binding
    (GO:0001965)
  • G-protein beta-subunit binding
    (GO:0031681)
  • Golgi apparatus
    (GO:0005794)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Homeostasis of number of cells within a tissue
    (GO:0048873)
  • Inflammatory response
    (GO:0006954)
  • Late endosome
    (GO:0005770)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of glomerular filtration
    (GO:0003105)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of renin secretion into blood stream
    (GO:1900134)
  • Neuromuscular junction
    (GO:0031594)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Platelet activation
    (GO:0030168)
  • Platelet dense granule organization
    (GO:0060155)
  • Platelet dense tubular network
    (GO:0031094)
  • Positive regulation of blood coagulation
    (GO:0030194)
  • Positive regulation of calcium ion transport
    (GO:0051928)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of receptor signaling pathway via jak-stat
    (GO:0046427)
  • Positive regulation of release of sequestered calcium ion into cytosol
    (GO:0051281)
  • Positive regulation of rho protein signal transduction
    (GO:0035025)
  • Positive regulation of smooth muscle contraction
    (GO:0045987)
  • Positive regulation of vasoconstriction
    (GO:0045907)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein binding
    (GO:0005515)
  • Regulation of blood coagulation
    (GO:0030193)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Regulation of sensory perception of pain
    (GO:0051930)
  • Regulation of synaptic plasticity
    (GO:0048167)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to wounding
    (GO:0009611)
  • Signaling receptor binding
    (GO:0005102)
  • Thrombin-activated receptor activity
    (GO:0015057)
  • Thrombin-activated receptor signaling pathway
    (GO:0070493)
  • Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
    (GO:0099553)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.9271
    Cell Significance Index: -21.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.7793
    Cell Significance Index: -18.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 57.3859
    Cell Significance Index: -23.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.6391
    Cell Significance Index: -19.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.0474
    Cell Significance Index: -21.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.2166
    Cell Significance Index: -22.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.6967
    Cell Significance Index: -19.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.8514
    Cell Significance Index: -22.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6450
    Cell Significance Index: -20.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6335
    Cell Significance Index: -22.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7339
    Cell Significance Index: -14.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.2592
    Cell Significance Index: 81.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.9344
    Cell Significance Index: 558.4400
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.3567
    Cell Significance Index: 8.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9077
    Cell Significance Index: 26.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8525
    Cell Significance Index: 9.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5680
    Cell Significance Index: 512.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4985
    Cell Significance Index: 10.6200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3975
    Cell Significance Index: 6.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3855
    Cell Significance Index: 62.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3746
    Cell Significance Index: 40.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3612
    Cell Significance Index: 7.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3201
    Cell Significance Index: 19.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2150
    Cell Significance Index: 21.2700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1804
    Cell Significance Index: 2.5900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1725
    Cell Significance Index: 1.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1630
    Cell Significance Index: 11.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1571
    Cell Significance Index: 69.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1352
    Cell Significance Index: 84.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1069
    Cell Significance Index: 14.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1039
    Cell Significance Index: 20.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0747
    Cell Significance Index: 9.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0473
    Cell Significance Index: 5.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0462
    Cell Significance Index: 16.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0405
    Cell Significance Index: 62.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0311
    Cell Significance Index: 0.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0223
    Cell Significance Index: 12.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0180
    Cell Significance Index: 0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0119
    Cell Significance Index: 21.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0091
    Cell Significance Index: 0.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0020
    Cell Significance Index: -0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0096
    Cell Significance Index: -18.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0137
    Cell Significance Index: -18.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0146
    Cell Significance Index: -10.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0199
    Cell Significance Index: -11.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0221
    Cell Significance Index: -1.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0287
    Cell Significance Index: -21.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0294
    Cell Significance Index: -21.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0327
    Cell Significance Index: -20.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0453
    Cell Significance Index: -2.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0467
    Cell Significance Index: -13.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0495
    Cell Significance Index: -22.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0531
    Cell Significance Index: -11.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0542
    Cell Significance Index: -9.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0547
    Cell Significance Index: -3.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0572
    Cell Significance Index: -1.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0781
    Cell Significance Index: -4.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0846
    Cell Significance Index: -9.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0921
    Cell Significance Index: -16.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1001
    Cell Significance Index: -20.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1044
    Cell Significance Index: -2.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1056
    Cell Significance Index: -3.6700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1256
    Cell Significance Index: -0.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1392
    Cell Significance Index: -8.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1416
    Cell Significance Index: -17.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1476
    Cell Significance Index: -16.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1481
    Cell Significance Index: -21.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1515
    Cell Significance Index: -19.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1654
    Cell Significance Index: -8.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1662
    Cell Significance Index: -4.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1674
    Cell Significance Index: -17.1000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1781
    Cell Significance Index: -1.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1866
    Cell Significance Index: -22.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2083
    Cell Significance Index: -15.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2123
    Cell Significance Index: -22.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2236
    Cell Significance Index: -6.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2338
    Cell Significance Index: -6.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2608
    Cell Significance Index: -19.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2671
    Cell Significance Index: -12.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2919
    Cell Significance Index: -18.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2987
    Cell Significance Index: -19.2700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3168
    Cell Significance Index: -1.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3361
    Cell Significance Index: -22.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3717
    Cell Significance Index: -8.1400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3946
    Cell Significance Index: -5.6600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3981
    Cell Significance Index: -2.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4097
    Cell Significance Index: -10.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4227
    Cell Significance Index: -13.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4365
    Cell Significance Index: -11.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4415
    Cell Significance Index: -23.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4433
    Cell Significance Index: -23.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4492
    Cell Significance Index: -4.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4493
    Cell Significance Index: -6.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4615
    Cell Significance Index: -20.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4808
    Cell Significance Index: -15.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4964
    Cell Significance Index: -12.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5023
    Cell Significance Index: -10.4200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5037
    Cell Significance Index: -8.3000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5126
    Cell Significance Index: -7.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression in various cell types:** The F2R gene is significantly expressed in endocardial cells, neural progenitor cells, bronchus fibroblasts, endothelial cells, enterocytes, pancreatic stellate cells, and pulmonary artery endothelial cells, among others. 2. **Receptor structure:** The F2R is a seven-transmembrane GPCR that binds to thrombin, a serine protease involved in blood coagulation. 3. **Signaling pathways:** The F2R activates multiple signaling pathways, including G-protein alpha-subunit binding, phospholipase C-activating G-protein coupled receptor signaling pathway, and MAPK cascade. **Pathways and Functions:** 1. **Coagulation:** The F2R plays a crucial role in blood coagulation by regulating thrombin-activated receptor activity and thrombin signalling through proteinase-activated receptors (PARs). 2. **Inflammation:** The F2R is involved in inflammatory responses, including the regulation of interleukin-1 beta production, interleukin-8 production, and the response to lipopolysaccharide. 3. **Cellular homeostasis:** The F2R regulates cellular homeostasis by controlling cell migration, proliferation, and differentiation, as well as the homeostasis of cell number within a tissue. 4. **Neurological functions:** The F2R is involved in the regulation of synaptic transmission and the modulation of synaptic transmission through trans-synaptic signaling by endocannabinoids. **Clinical Significance:** 1. **Blood coagulation disorders:** Dysregulation of the F2R gene has been implicated in various blood coagulation disorders, including thrombosis and hemostasis. 2. **Inflammatory diseases:** The F2R plays a role in the pathogenesis of inflammatory diseases, such as cardiovascular disease, atherosclerosis, and cancer. 3. **Cancer:** The F2R is involved in the regulation of cell proliferation and apoptosis in various cancers, including colorectal cancer and pancreatic cancer. 4. **Neurological disorders:** The F2R is implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, the F2R gene is a critical regulator of coagulation, inflammation, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of F2R signaling and its role in maintaining tissue homeostasis. Further research is necessary to elucidate the functional significance of the F2R gene and its potential as a therapeutic target for various diseases.

Genular Protein ID: 2156690700

Symbol: PAR1_HUMAN

Name: Coagulation factor II receptor

UniProtKB Accession Codes:

P25116 Q53XV0 Q96RF7 Q9BUN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 61 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1672265

Title: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

PubMed ID: 1672265

DOI: 10.1016/0092-8674(91)90261-v

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7744748

Title: Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G.

PubMed ID: 7744748

DOI: 10.1074/jbc.270.19.11168

PubMed ID: 8955127

Title: Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization.

PubMed ID: 8955127

DOI: 10.1074/jbc.271.51.32874

PubMed ID: 10079109

Title: Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.

PubMed ID: 10079109

DOI: 10.1172/jci6042

PubMed ID: 18988770

Title: Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis.

PubMed ID: 18988770

DOI: 10.1124/jpet.108.145664

PubMed ID: 22659187

Title: The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.

PubMed ID: 22659187

DOI: 10.1016/j.febslet.2012.05.042

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 8136362

Title: Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.

PubMed ID: 8136362

DOI: 10.1021/bi00177a018

Sequence Information:

  • Length: 425
  • Mass: 47441
  • Checksum: 41B742A99EEC96AB
  • Sequence:
    • MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE 
KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN 
IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA 
AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK 
EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS 
AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS 
SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY 
KKLLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.