Details for: SPATA19

Gene ID: 219938

Symbol: SPATA19

Ensembl ID: ENSG00000166118

Description: spermatogenesis associated 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.2032
    Cell Significance Index: 2.7100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0369
    Cell Significance Index: 0.4700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0253
    Cell Significance Index: 0.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0237
    Cell Significance Index: 1.2300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0203
    Cell Significance Index: 0.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0180
    Cell Significance Index: 0.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0169
    Cell Significance Index: 0.3700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0162
    Cell Significance Index: 0.1600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0115
    Cell Significance Index: 0.1500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0094
    Cell Significance Index: 0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0031
    Cell Significance Index: 0.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0024
    Cell Significance Index: 0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0022
    Cell Significance Index: 0.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0015
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0007
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0017
    Cell Significance Index: -0.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0043
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0043
    Cell Significance Index: -0.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0045
    Cell Significance Index: -0.4700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0052
    Cell Significance Index: -0.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0067
    Cell Significance Index: -0.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0070
    Cell Significance Index: -0.5400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0077
    Cell Significance Index: -0.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0107
    Cell Significance Index: -0.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0115
    Cell Significance Index: -0.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0116
    Cell Significance Index: -0.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0127
    Cell Significance Index: -0.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0127
    Cell Significance Index: -0.4800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0146
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0154
    Cell Significance Index: -0.4400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0162
    Cell Significance Index: -0.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0165
    Cell Significance Index: -0.4500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0168
    Cell Significance Index: -0.4200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0173
    Cell Significance Index: -0.1200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0176
    Cell Significance Index: -0.4400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0180
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0180
    Cell Significance Index: -0.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0187
    Cell Significance Index: -0.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0188
    Cell Significance Index: -0.4600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0206
    Cell Significance Index: -0.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0208
    Cell Significance Index: -0.4500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0211
    Cell Significance Index: -0.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0212
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0216
    Cell Significance Index: -0.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0219
    Cell Significance Index: -0.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0223
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0223
    Cell Significance Index: -0.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0228
    Cell Significance Index: -0.4500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0234
    Cell Significance Index: -0.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0235
    Cell Significance Index: -0.6000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0238
    Cell Significance Index: -0.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0251
    Cell Significance Index: -0.3700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0281
    Cell Significance Index: -0.6800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0283
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0285
    Cell Significance Index: -0.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0296
    Cell Significance Index: -0.7600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0300
    Cell Significance Index: -0.4000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0304
    Cell Significance Index: -0.3700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0314
    Cell Significance Index: -0.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0320
    Cell Significance Index: -0.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0320
    Cell Significance Index: -0.8000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0324
    Cell Significance Index: -0.4100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0331
    Cell Significance Index: -0.4000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0341
    Cell Significance Index: -0.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0342
    Cell Significance Index: -1.4000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0343
    Cell Significance Index: -0.4300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0344
    Cell Significance Index: -0.4000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0350
    Cell Significance Index: -0.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0353
    Cell Significance Index: -0.5900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0360
    Cell Significance Index: -0.3800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0370
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0375
    Cell Significance Index: -0.5700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0375
    Cell Significance Index: -0.3600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0377
    Cell Significance Index: -0.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0380
    Cell Significance Index: -0.3600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0382
    Cell Significance Index: -0.4900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0388
    Cell Significance Index: -0.4900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0391
    Cell Significance Index: -0.4200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0393
    Cell Significance Index: -0.4700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0406
    Cell Significance Index: -0.5300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0406
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0414
    Cell Significance Index: -0.4000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0415
    Cell Significance Index: -0.4600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0418
    Cell Significance Index: -0.4400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0423
    Cell Significance Index: -0.5700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0423
    Cell Significance Index: -0.6800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0426
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0432
    Cell Significance Index: -0.6200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0436
    Cell Significance Index: -0.5600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0441
    Cell Significance Index: -0.5200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0441
    Cell Significance Index: -0.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPATA19 is a mitochondrial protein that is specifically expressed in spermatogenic cells, where it is involved in the organization and function of mitochondria in the sperm midpiece and flagellum. The protein is highly conserved across species, suggesting its essential role in spermatogenesis. SPATA19 is also expressed in other cell types, including progenitor cells, microglial cells, and intestinal epithelial cells, highlighting its broader cellular context. **Pathways and Functions:** SPATA19 is involved in several cellular pathways that are critical for spermatogenesis, including: 1. **Spermatogenesis**: SPATA19 is essential for the development of sperm cells, particularly in the organization and function of mitochondria in the sperm midpiece and flagellum. 2. **Mitochondrial outer membrane**: SPATA19 is involved in the regulation of mitochondrial outer membrane proteins, which is essential for maintaining mitochondrial function and integrity. 3. **Cell differentiation**: SPATA19 is involved in the regulation of cell differentiation, particularly in the development of spermatogenic cells. 4. **Sperm flagellum**: SPATA19 is essential for the organization and function of the sperm flagellum, which is critical for sperm motility and fertilization. **Clinical Significance:** Dysregulation of SPATA19 has been implicated in various male infertility disorders, including spermatogenic failure and infertility. Mutations in the SPATA19 gene have been associated with male infertility, highlighting the importance of this gene in spermatogenesis. Furthermore, SPATA19 has been implicated in other clinical contexts, including: 1. **Neurodegenerative diseases**: SPATA19 has been implicated in the regulation of mitochondrial function in neurons, which is critical for maintaining neuronal health and function. 2. **Intestinal disorders**: SPATA19 has been implicated in the regulation of intestinal epithelial cell function, which is critical for maintaining intestinal homeostasis. In conclusion, SPATA19 is a critical gene that plays a central role in spermatogenesis and other cellular processes. Its dysregulation has been implicated in various male infertility disorders and other clinical contexts. Further research is needed to fully elucidate the role of SPATA19 in these contexts and to explore potential therapeutic strategies for the treatment of male infertility disorders and other related conditions.

Genular Protein ID: 3785118700

Symbol: SPT19_HUMAN

Name: Spermatogenesis-associated protein 19, mitochondrial

UniProtKB Accession Codes:

Q7Z5L4 Q8N7A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12688595

Title: Isolation and expression analysis of the human testis-specific gene, SPERGEN-1, a spermatogenic cell-specific gene-1.

PubMed ID: 12688595

DOI: 10.1023/a:1021748310102

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 167
  • Mass: 19186
  • Checksum: 4FBEFCD966887FEB
  • Sequence:
    • MIITTWIVYI LARKGVGLPF LPITSSDIDV VESEAVSVLH HWLKKTEEEA SRGIKEKLSI 
NHPSQGVREK MSTDSPPTHG QDIHVTRDVV KHHLSKSDLL ANQSQEVLEE RTRIQFIRWS 
HTRIFQVPSE MTEDIMRDRI EQVRRSISRL TDVSAQDFSM RPSSSDC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.