Gene FGF9 - ENSG00000102678 | NCBI Gene ID: 2254

Details for: FGF9

Gene ID: 2254

Symbol: FGF9

Ensembl ID: ENSG00000102678

Description: fibroblast growth factor 9

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3b ligand binding and activation
(R-HSA-190371)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Transcriptional regulation of testis differentiation
(R-HSA-9690406)
Activin receptor signaling pathway
(GO:0032924)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Cell-cell signaling
(GO:0007267)
Cell differentiation
(GO:0030154)
Chondrocyte differentiation
(GO:0002062)
Embryonic limb morphogenesis
(GO:0030326)
Eye development
(GO:0001654)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Lung development
(GO:0030324)
Male gonad development
(GO:0008584)
Male sex determination
(GO:0030238)
Mesenchymal cell proliferation
(GO:0010463)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of wnt signaling pathway
(GO:0030178)
Osteoblast differentiation
(GO:0001649)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Protein import into nucleus
(GO:0006606)
Regulation of cell migration
(GO:0030334)
Signal transduction
(GO:0007165)
Smoothened signaling pathway
(GO:0007224)
Substantia nigra development
(GO:0021762)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.11
Marker Score: 37474
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.93
Marker Score: 2778
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.76
Marker Score: 929
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.56
Marker Score: 653
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.5
Marker Score: 4024
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169139
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.4
Marker Score: 51579
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.39
Marker Score: 2306
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.36
Marker Score: 2102
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.35
Marker Score: 45438.5
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.31
Marker Score: 5413
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.28
Marker Score: 351
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.27
Marker Score: 2397
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.21
Marker Score: 2452
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.19
Marker Score: 18608
Cell Name: neuron (CL0000540)
Fold Change: 1.13
Marker Score: 4594
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.12
Marker Score: 16800
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.11
Marker Score: 645
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.1
Marker Score: 5082
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.1
Marker Score: 1326
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.09
Marker Score: 5841
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.05
Marker Score: 665.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 793
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.04
Marker Score: 63711
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.02
Marker Score: 963
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71819
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48044
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 506
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 460
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.96
Marker Score: 8216
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.95
Marker Score: 1924
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.93
Marker Score: 8875
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.93
Marker Score: 299
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5225
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.91
Marker Score: 3517
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.91
Marker Score: 4753
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.9
Marker Score: 286
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.9
Marker Score: 9264
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5285
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.86
Marker Score: 1986
Cell Name: granule cell (CL0000120)
Fold Change: 0.86
Marker Score: 6448
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.83
Marker Score: 7774
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.8
Marker Score: 30413
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.8
Marker Score: 1298
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.8
Marker Score: 478
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.79
Marker Score: 6075
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.79
Marker Score: 837
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.79
Marker Score: 185
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.77
Marker Score: 309
Cell Name: interneuron (CL0000099)
Fold Change: 0.77
Marker Score: 351
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.76
Marker Score: 3206
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.74
Marker Score: 14696
Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 670
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.73
Marker Score: 390.5
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.73
Marker Score: 1008
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 463
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.64
Marker Score: 426
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.64
Marker Score: 1507
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.63
Marker Score: 1587
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.62
Marker Score: 2576
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.61
Marker Score: 2527
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.58
Marker Score: 2078
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.58
Marker Score: 184
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.57
Marker Score: 581
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.55
Marker Score: 231
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.52
Marker Score: 11663
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5
Marker Score: 17363
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.48
Marker Score: 118
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.47
Marker Score: 196
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.47
Marker Score: 154
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.46
Marker Score: 177
Cell Name: stromal cell (CL0000499)
Fold Change: 0.46
Marker Score: 534
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.45
Marker Score: 444
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.44
Marker Score: 1244
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.43
Marker Score: 413
Cell Name: kidney cell (CL1000497)
Fold Change: 0.43
Marker Score: 286
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.42
Marker Score: 1025
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.42
Marker Score: 587.5
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.41
Marker Score: 237
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.4
Marker Score: 312
Cell Name: germ cell (CL0000586)
Fold Change: 0.4
Marker Score: 699
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.39
Marker Score: 186
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.39
Marker Score: 125
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.38
Marker Score: 94
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.38
Marker Score: 474
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.38
Marker Score: 211
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.37
Marker Score: 181
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.37
Marker Score: 148
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.36
Marker Score: 235
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.35
Marker Score: 94
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.35
Marker Score: 111

Hover over a box to see details here...

**Key characteristics:** * FGF9 is a secreted protein that is produced by various cell types. * It is a transmembrane protein with a molecular weight of approximately 150 kDa. * FGF9 is a potent activator of the PI3K/Akt signaling pathway. * It also plays a role in the MAPK/MAPK1/MAPK3 signaling pathway and the FGF receptor 1 (FGFR1) signaling pathway. **Pathways and functions:** * FGF9 is known to promote cell proliferation and migration through the PI3K/Akt pathway. * It also plays a role in cell differentiation and survival through the MAPK/MAPK1/MAPK3 pathway and the FGF receptor 1 (FGFR1) signaling pathway. * FGF9 is also involved in the regulation of male fertility and development. **Clinical significance:** * Mutations in the FGF9 gene have been linked to various cancers, including breast cancer, lung cancer, and colon cancer. * Targeting FGF9 has been explored as a therapeutic strategy for cancer, but it has not been successful due to the complex and multifaceted nature of the protein. * Further research is needed to understand the role of FGF9 in cancer and to develop effective therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 9

Genular Protein ID: 3392190112

Symbol: FGF9_HUMAN

Name: Fibroblast growth factor 9

UniProtKB Accession Codes:

P31371 A8K427 Q3SY32

Database IDs:

Citations:

PubMed ID: 8321227

Title: Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.

PubMed ID: 8321227

DOI: 10.1128/mcb.13.7.4251-4259.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8428960

Title: Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties.

PubMed ID: 8428960

DOI: 10.1016/s0021-9258(18)53852-7

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 11223514

Title: Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces.

PubMed ID: 11223514

DOI: 10.1107/s0907444900020813

PubMed ID: 11060292

Title: Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.

PubMed ID: 11060292

DOI: 10.1074/jbc.m006502200

PubMed ID: 19589401

Title: Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene.

PubMed ID: 19589401

DOI: 10.1016/j.ajhg.2009.06.007

Sequence Information:

Length: 208
Mass: 23441
Checksum: F32A0E7106EF59C9
Sequence:

MAPLGEVGNY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA VTDLDHLKGI 
LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI AVGLVSIRGV DSGLYLGMNE 
KGELYGSEKL TQECVFREQF EENWYNTYSS NLYKHVDTGR RYYVALNKDG TPREGTRTKR 
HQKFTHFLPR PVDPDKVPEL YKDILSQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FGF9

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. PubMed ID: 8321227

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties. PubMed ID: 8428960

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. PubMed ID: 11223514

Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. PubMed ID: 11060292

Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. PubMed ID: 19589401