FGF9 | ENSG00000102678 | NCBI 2254

Details for: FGF9

Gene ID: 2254

Symbol: FGF9

Ensembl ID: ENSG00000102678

Description: fibroblast growth factor 9

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3b ligand binding and activation
(R-HSA-190371)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Transcriptional regulation of testis differentiation
(R-HSA-9690406)
Activin receptor signaling pathway
(GO:0032924)
Angiogenesis
(GO:0001525)
Cell-cell signaling
(GO:0007267)
Chondrocyte differentiation
(GO:0002062)
Embryonic limb morphogenesis
(GO:0030326)
Eye development
(GO:0001654)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Inner ear morphogenesis
(GO:0042472)
Male gonad development
(GO:0008584)
Male sex determination
(GO:0030238)
Mesenchymal cell proliferation
(GO:0010463)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of wnt signaling pathway
(GO:0030178)
Neurogenesis
(GO:0022008)
Osteoblast differentiation
(GO:0001649)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Protein import into nucleus
(GO:0006606)
Regulation of cell migration
(GO:0030334)
Signal transduction
(GO:0007165)
Smoothened signaling pathway
(GO:0007224)
Substantia nigra development
(GO:0021762)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 104.3426
Cell Significance Index: -16.2300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 63.8298
Cell Significance Index: -16.1900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 36.2910
Cell Significance Index: -14.9500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.1635
Cell Significance Index: -16.2300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.1033
Cell Significance Index: 109.9500
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.0165
Cell Significance Index: 11.5500
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.9674
Cell Significance Index: 43.0800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.5246
Cell Significance Index: 18.9100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5218
Cell Significance Index: 79.9000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.4365
Cell Significance Index: 80.6100
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.2660
Cell Significance Index: 9.7400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.1047
Cell Significance Index: 12.0100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8650
Cell Significance Index: 173.5200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.8367
Cell Significance Index: 51.4300
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.6659
Cell Significance Index: 15.9700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6342
Cell Significance Index: 62.7400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.6115
Cell Significance Index: 10.4800
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.5222
Cell Significance Index: 5.4400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5078
Cell Significance Index: 182.1500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4925
Cell Significance Index: 29.5700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4694
Cell Significance Index: 36.0200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3955
Cell Significance Index: 43.0200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3797
Cell Significance Index: 14.3800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3786
Cell Significance Index: 341.8600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3776
Cell Significance Index: 16.7000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3594
Cell Significance Index: 16.2900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3415
Cell Significance Index: 64.9900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3354
Cell Significance Index: 22.5500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3321
Cell Significance Index: 54.0200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3304
Cell Significance Index: 9.5200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3106
Cell Significance Index: 169.6400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1769
Cell Significance Index: 12.2400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1317
Cell Significance Index: 26.1300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.1046
Cell Significance Index: 2.1700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0997
Cell Significance Index: 2.1600
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.0994
Cell Significance Index: 1.2400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0825
Cell Significance Index: 60.4700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0543
Cell Significance Index: 1.4000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0512
Cell Significance Index: 1.8000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0230
Cell Significance Index: 0.3400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.0052
Cell Significance Index: 0.1100
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0024
Cell Significance Index: 0.0300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0034
Cell Significance Index: -2.5500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0036
Cell Significance Index: -2.2300
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0047
Cell Significance Index: -0.0600
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0078
Cell Significance Index: -0.1100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0080
Cell Significance Index: -0.1700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0080
Cell Significance Index: -14.8200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0087
Cell Significance Index: -16.3600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0096
Cell Significance Index: -14.8200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0108
Cell Significance Index: -14.7500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0140
Cell Significance Index: -7.9000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0199
Cell Significance Index: -12.6400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0200
Cell Significance Index: -15.1700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0204
Cell Significance Index: -9.0000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0249
Cell Significance Index: -4.2500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0315
Cell Significance Index: -4.3300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0320
Cell Significance Index: -14.5400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0321
Cell Significance Index: -1.9700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0347
Cell Significance Index: -7.3000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0400
Cell Significance Index: -11.5200
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0412
Cell Significance Index: -0.5200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0459
Cell Significance Index: -1.3100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0559
Cell Significance Index: -0.8000
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0571
Cell Significance Index: -1.1300
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.0630
Cell Significance Index: -0.5200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0654
Cell Significance Index: -11.7900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0662
Cell Significance Index: -7.7100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0682
Cell Significance Index: -7.7900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0688
Cell Significance Index: -8.8200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0691
Cell Significance Index: -7.0600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1013
Cell Significance Index: -14.7200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1014
Cell Significance Index: -8.0300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1015
Cell Significance Index: -12.4800
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1023
Cell Significance Index: -2.2100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1083
Cell Significance Index: -12.4100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1201
Cell Significance Index: -15.5200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1220
Cell Significance Index: -8.6300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1240
Cell Significance Index: -3.4700
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1290
Cell Significance Index: -2.5900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1363
Cell Significance Index: -16.0700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1442
Cell Significance Index: -4.6200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1626
Cell Significance Index: -16.9400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1627
Cell Significance Index: -2.2200
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1652
Cell Significance Index: -7.1900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1677
Cell Significance Index: -5.3400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1732
Cell Significance Index: -2.6800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1785
Cell Significance Index: -11.2500
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1826
Cell Significance Index: -11.7800
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.1886
Cell Significance Index: -2.8700
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1893
Cell Significance Index: -3.9500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1912
Cell Significance Index: -6.2600
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.2013
Cell Significance Index: -2.6100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2103
Cell Significance Index: -15.6700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2113
Cell Significance Index: -9.8500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2164
Cell Significance Index: -5.4100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2251
Cell Significance Index: -6.6300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2345
Cell Significance Index: -12.2200
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2364
Cell Significance Index: -8.2800
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.2387
Cell Significance Index: -3.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Structure and Function:** FGF9 is a 22-kDa protein with a characteristic FGF domain, which is essential for its interaction with FGF receptors. 2. **Cellular Expression:** FGF9 is highly expressed in the liver, kidney, and pancreas, where it regulates cell growth, differentiation, and migration. 3. **Signal Transduction:** FGF9 signals through the FGF receptor (FGFR) family, which activates various downstream signaling pathways, including the PI3K/AKT, MAPK, and WNT pathways. 4. **Regulation of Cell Proliferation and Differentiation:** FGF9 promotes cell proliferation and differentiation in various cell types, including mesenchymal cells, chondrocytes, and osteoblasts. **Pathways and Functions:** 1. **Angiogenesis:** FGF9 promotes angiogenesis by activating the PI3K/AKT pathway, which regulates vascular endothelial growth factor (VEGF) expression and endothelial cell migration. 2. **Cell Differentiation:** FGF9 regulates chondrocyte and osteoblast differentiation by activating the WNT pathway, which controls gene expression and cell fate determination. 3. **Tissue Development:** FGF9 is involved in the development of various tissues, including the liver, kidney, and pancreas, where it regulates cell proliferation and differentiation. 4. **Cancer:** Aberrant FGF9 signaling has been implicated in several cancers, including liver, kidney, and pancreatic cancer, where it promotes tumor growth and metastasis. **Clinical Significance:** 1. **Cancer Therapy:** Targeting FGF9 signaling has been explored as a potential therapeutic strategy for cancer treatment, including anti-angiogenic therapy and cancer immunotherapy. 2. **Vascular Disease:** FGF9 signaling has been implicated in the development of vascular disease, including atherosclerosis and hypertension, where it regulates vascular cell proliferation and migration. 3. **Developmental Disorders:** FGF9 signaling has been implicated in the development of various developmental disorders, including cancer, cardiovascular disease, and metabolic disorders. 4. **Regenerative Medicine:** FGF9 has been explored as a potential therapeutic agent for tissue engineering and regenerative medicine, where it promotes cell proliferation and differentiation. In conclusion, FGF9 is a multifaceted growth factor that plays a crucial role in regulating development, cell signaling, and disease. Understanding the mechanisms of FGF9 signaling has significant implications for the development of novel therapeutic strategies for various diseases, including cancer, cardiovascular disease, and developmental disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Fibroblast growth factor 9

Genular Protein ID: 3392190112

Symbol: FGF9_HUMAN

Name: Fibroblast growth factor 9

UniProtKB Accession Codes:

P31371 A8K427 Q3SY32

Database IDs:

Citations:

PubMed ID: 8321227

Title: Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.

PubMed ID: 8321227

DOI: 10.1128/mcb.13.7.4251-4259.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8428960

Title: Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties.

PubMed ID: 8428960

DOI: 10.1016/s0021-9258(18)53852-7

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 11223514

Title: Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces.

PubMed ID: 11223514

DOI: 10.1107/s0907444900020813

PubMed ID: 11060292

Title: Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.

PubMed ID: 11060292

DOI: 10.1074/jbc.m006502200

PubMed ID: 19589401

Title: Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene.

PubMed ID: 19589401

DOI: 10.1016/j.ajhg.2009.06.007

Sequence Information:

Length: 208
Mass: 23441
Checksum: F32A0E7106EF59C9
Sequence:

MAPLGEVGNY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA VTDLDHLKGI 
LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI AVGLVSIRGV DSGLYLGMNE 
KGELYGSEKL TQECVFREQF EENWYNTYSS NLYKHVDTGR RYYVALNKDG TPREGTRTKR 
HQKFTHFLPR PVDPDKVPEL YKDILSQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF9

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. PubMed ID: 8321227

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties. PubMed ID: 8428960

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. PubMed ID: 11223514

Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. PubMed ID: 11060292

Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. PubMed ID: 19589401