Details for: FHL2

Gene ID: 2274

Symbol: FHL2

Ensembl ID: ENSG00000115641

Description: four and a half LIM domains 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.42
    Marker Score: 121203
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.79
    Marker Score: 9259
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.32
    Marker Score: 2376.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.97
    Marker Score: 2634
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.51
    Marker Score: 12321
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.5
    Marker Score: 1968
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.47
    Marker Score: 835
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.45
    Marker Score: 32572
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.14
    Marker Score: 703
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.13
    Marker Score: 758
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.13
    Marker Score: 8215
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.12
    Marker Score: 3120
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.12
    Marker Score: 37569
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.06
    Marker Score: 8086
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.05
    Marker Score: 4836.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.03
    Marker Score: 12940
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.02
    Marker Score: 4589
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.98
    Marker Score: 751
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.87
    Marker Score: 6649
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.85
    Marker Score: 7977
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.84
    Marker Score: 3259.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.77
    Marker Score: 1911
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.73
    Marker Score: 5423.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7
    Marker Score: 11049
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.67
    Marker Score: 1924
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.67
    Marker Score: 1754
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.65
    Marker Score: 3173
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.61
    Marker Score: 1544
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.6
    Marker Score: 2080
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.58
    Marker Score: 11763
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.58
    Marker Score: 2583
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.54
    Marker Score: 7379
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.48
    Marker Score: 90729
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.47
    Marker Score: 3999
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168340
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.46
    Marker Score: 1814
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.44
    Marker Score: 497
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.42
    Marker Score: 983
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.41
    Marker Score: 1942
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.37
    Marker Score: 676
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21256
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.34
    Marker Score: 12770.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.34
    Marker Score: 45507
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.33
    Marker Score: 1641
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.29
    Marker Score: 539
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.29
    Marker Score: 1379
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.28
    Marker Score: 308
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.26
    Marker Score: 4665
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.22
    Marker Score: 512
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.19
    Marker Score: 13378
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.18
    Marker Score: 1128
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.18
    Marker Score: 688
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.16
    Marker Score: 1314
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.15
    Marker Score: 285
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.15
    Marker Score: 331
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.15
    Marker Score: 292
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.14
    Marker Score: 9781
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.13
    Marker Score: 2114
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.12
    Marker Score: 1445
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.11
    Marker Score: 1182
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.11
    Marker Score: 2020
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.09
    Marker Score: 219
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.08
    Marker Score: 270
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.08
    Marker Score: 305
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.08
    Marker Score: 270
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.07
    Marker Score: 273
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.06
    Marker Score: 1022
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.05
    Marker Score: 714
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.04
    Marker Score: 13686.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.03
    Marker Score: 770
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1939.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.02
    Marker Score: 640.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.02
    Marker Score: 504
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.01
    Marker Score: 2890
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71774
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47998
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.98
    Marker Score: 220
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.98
    Marker Score: 557
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.96
    Marker Score: 399
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.95
    Marker Score: 674
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5545
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5261
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2171
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.91
    Marker Score: 838
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.91
    Marker Score: 454
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.91
    Marker Score: 448
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.9
    Marker Score: 1388
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.89
    Marker Score: 459
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.89
    Marker Score: 1038
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.89
    Marker Score: 256
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.89
    Marker Score: 8920
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.88
    Marker Score: 410
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.87
    Marker Score: 247
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1771

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Other Information

**Key characteristics:** - FHL2 is a transmembrane protein with four LIM domains. - It is expressed in a variety of cell types, including cardiac muscle cells, prostate epithelial cells, and mammary gland epithelial cells. - It is known to play a role in the regulation of cardiac muscle cell development, as well as in the regulation of lipid metabolism and apoptosis. **Pathways and functions:** - FHL2 is involved in the development of the heart. It is expressed in the heart tube and is essential for the formation of the cardiac muscle cell layer. - It also plays a role in the regulation of lipid metabolism. FHL2 is a key regulator of the expression of genes involved in lipid metabolism, including those involved in the synthesis of fatty acids and cholesterol. - FHL2 is also involved in the regulation of apoptosis. It is a negative regulator of apoptosis, which means that it prevents cells from dying. **Clinical significance:** Mutations in the FHL2 gene have been linked to a number of human diseases, including hypertrophic cardiomyopathy, pulmonary hypertension, and congenital heart defects. These diseases are characterized by heart muscle disease, which is often caused by mutations in genes that are involved in cardiac muscle cell development and function. FHL2 is a promising target for the treatment of these diseases, as it is a key regulator of cardiac muscle cell development and function.

Genular Protein ID: 2957810274

Symbol: FHL2_HUMAN

Name: Four and a half LIM domains protein 2

UniProtKB Accession Codes:

Q14192 Q13229 Q13644 Q2I5I4 Q5TM15 Q9P294

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9150430

Title: Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma.

PubMed ID: 9150430

DOI: 10.1089/dna.1997.16.433

PubMed ID: 9573400

Title: Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart.

PubMed ID: 9573400

DOI: 10.1016/s0378-1119(97)00644-6

PubMed ID: 11001931

Title: Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein.

PubMed ID: 11001931

DOI: 10.1093/oxfordjournals.hmg.a018919

PubMed ID: 15453830

Title: FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1.

PubMed ID: 15453830

DOI: 10.1042/bj20040775

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8753811

Title: Slim defines a novel family of LIM-proteins expressed in skeletal muscle.

PubMed ID: 8753811

DOI: 10.1006/bbrc.1996.1222

PubMed ID: 11813260

Title: Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220.

PubMed ID: 11813260

DOI: 10.1002/jcb.10041.abs

PubMed ID: 12432079

Title: Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.

PubMed ID: 12432079

DOI: 10.1242/jcs.00181

PubMed ID: 15692560

Title: Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.

PubMed ID: 15692560

DOI: 10.1038/sj.emboj.7600570

PubMed ID: 16652157

Title: The LIM-only protein FHL2 is a negative regulator of E4F1.

PubMed ID: 16652157

DOI: 10.1038/sj.onc.1209567

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18853468

Title: The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner.

PubMed ID: 18853468

DOI: 10.1002/jmr.916

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22851699

Title: FHL2 binds calcineurin and represses pathological cardiac growth.

PubMed ID: 22851699

DOI: 10.1128/mcb.05948-11

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28717008

Title: The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling.

PubMed ID: 28717008

DOI: 10.1074/jbc.m117.786764

Sequence Information:

  • Length: 279
  • Mass: 32193
  • Checksum: E94E3A7F6601F9F3
  • Sequence:
    • MTERFDCHHC NESLFGKKYI LREESPYCVV CFETLFANTC EECGKPIGCD CKDLSYKDRH 
WHEACFHCSQ CRNSLVDKPF AAKEDQLLCT DCYSNEYSSK CQECKKTIMP GTRKMEYKGS 
SWHETCFICH RCQQPIGTKS FIPKDNQNFC VPCYEKQHAM QCVQCKKPIT TGGVTYREQP 
WHKECFVCTA CRKQLSGQRF TARDDFAYCL NCFCDLYAKK CAGCTNPISG LGGTKYISFE 
ERQWHNDCFN CKKCSLSLVG RGFLTERDDI LCPDCGKDI

Genular Protein ID: 1840158310

Symbol: Q2XQU9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2XQU9

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 8 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 389
  • Mass: 44177
  • Checksum: DC2CA23C90353ED1
  • Sequence:
    • MTRRGFSRAG AAQRSTRPAA EPQPPAARAL QPRPGVPGPL RCREYLQPPA PRREAEGLSH 
QGSEVGAESG ARPKERGAEP ELGRLWLKTV SSWRLGWHFD FGVAEKPGVK MTERFDCHHC 
NESLFGKKYI LREESPYCVV CFETLFANTC EECGKPIGCD CKDLSYKDRH WHEACFHCSQ 
CRNSLVDKPF AAKEDQLLCT DCYSNEYSSK CQECKKTIMP GTRKMEYKGS SWHETCFICH 
RCQQPIGTKS FIPKDNQNFC VPCYEKQHAM QCVQCKKPIT TGGVTYREQP WHKECFVCTA 
CRKQLSGQRF TARDDFAYCL NCFCDLYAKK CAGCTNPISG LGGTKYISFE ERQWHNDCFN 
CKKCSLSLVG RGFLTERDDI LCPDCGKDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.