Details for: FKBP1B

Gene ID: 2281

Symbol: FKBP1B

Ensembl ID: ENSG00000119782

Description: FKBP prolyl isomerase 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 91.8061
    Cell Significance Index: -14.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.3209
    Cell Significance Index: -15.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.1334
    Cell Significance Index: -14.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9026
    Cell Significance Index: -15.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7815
    Cell Significance Index: -10.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1667
    Cell Significance Index: 252.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9783
    Cell Significance Index: 42.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9405
    Cell Significance Index: 134.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2237
    Cell Significance Index: 1104.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1995
    Cell Significance Index: 62.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1412
    Cell Significance Index: 17.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0326
    Cell Significance Index: -2.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9426
    Cell Significance Index: 56.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9077
    Cell Significance Index: 98.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7630
    Cell Significance Index: 10.4100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6517
    Cell Significance Index: 10.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5897
    Cell Significance Index: 5.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5455
    Cell Significance Index: 15.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5445
    Cell Significance Index: 53.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4968
    Cell Significance Index: 14.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4071
    Cell Significance Index: 25.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3327
    Cell Significance Index: 15.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3118
    Cell Significance Index: 38.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2800
    Cell Significance Index: 56.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2716
    Cell Significance Index: 48.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2668
    Cell Significance Index: 14.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2341
    Cell Significance Index: 4.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1881
    Cell Significance Index: 37.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1801
    Cell Significance Index: 98.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1629
    Cell Significance Index: 4.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1171
    Cell Significance Index: 22.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1053
    Cell Significance Index: 4.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1039
    Cell Significance Index: 13.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0968
    Cell Significance Index: 3.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0938
    Cell Significance Index: 41.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0808
    Cell Significance Index: 1.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0674
    Cell Significance Index: 1.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0502
    Cell Significance Index: 0.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0357
    Cell Significance Index: 12.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0344
    Cell Significance Index: 23.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0304
    Cell Significance Index: 0.7300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0256
    Cell Significance Index: 0.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0201
    Cell Significance Index: 2.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0167
    Cell Significance Index: 0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0072
    Cell Significance Index: -13.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0122
    Cell Significance Index: -18.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0148
    Cell Significance Index: -20.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0176
    Cell Significance Index: -11.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0197
    Cell Significance Index: -11.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0252
    Cell Significance Index: -15.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0320
    Cell Significance Index: -14.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0343
    Cell Significance Index: -9.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0350
    Cell Significance Index: -5.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0352
    Cell Significance Index: -2.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0417
    Cell Significance Index: -1.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0451
    Cell Significance Index: -1.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0582
    Cell Significance Index: -8.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0614
    Cell Significance Index: -1.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0627
    Cell Significance Index: -1.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0673
    Cell Significance Index: -4.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0781
    Cell Significance Index: -16.4600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0782
    Cell Significance Index: -0.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0832
    Cell Significance Index: -10.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0834
    Cell Significance Index: -9.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0848
    Cell Significance Index: -2.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0853
    Cell Significance Index: -8.7100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0939
    Cell Significance Index: -1.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0968
    Cell Significance Index: -11.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0972
    Cell Significance Index: -6.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0983
    Cell Significance Index: -4.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1019
    Cell Significance Index: -6.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1102
    Cell Significance Index: -7.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1109
    Cell Significance Index: -4.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1186
    Cell Significance Index: -5.5800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1219
    Cell Significance Index: -1.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1342
    Cell Significance Index: -10.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1380
    Cell Significance Index: -1.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1430
    Cell Significance Index: -3.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1478
    Cell Significance Index: -15.3900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1648
    Cell Significance Index: -2.3100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1975
    Cell Significance Index: -1.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2048
    Cell Significance Index: -11.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2136
    Cell Significance Index: -16.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2202
    Cell Significance Index: -5.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2280
    Cell Significance Index: -13.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2314
    Cell Significance Index: -7.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2328
    Cell Significance Index: -5.8200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2544
    Cell Significance Index: -2.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2660
    Cell Significance Index: -9.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2724
    Cell Significance Index: -8.9200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2749
    Cell Significance Index: -3.9400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2823
    Cell Significance Index: -6.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2824
    Cell Significance Index: -7.2600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2918
    Cell Significance Index: -2.4800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2951
    Cell Significance Index: -1.9200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3028
    Cell Significance Index: -2.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FKBP1B exhibits a range of characteristics that highlight its importance in calcium signaling and cardiac conduction. These include: * **FK506 binding**: FKBP1B binds to FK506, a potent immunosuppressive agent, which suggests its role in modulating protein-protein interactions. * **Prolyl isomerase activity**: FKBP1B catalyzes the cis-trans isomerization of peptidyl-prolyl bonds, a process essential for protein folding and maturation. * **Calcium-mediated signaling**: FKBP1B is involved in calcium-mediated signaling pathways, including those that regulate cardiac muscle contraction and cardiac conduction. * **Positive and negative regulation**: FKBP1B exhibits both positive and negative regulatory activities, influencing the release of sequestered calcium ions into the cytosol and modulating cardiac muscle contraction. **Pathways and Functions** FKBP1B is integral to several critical pathways that regulate cardiac conduction and overall cardiovascular health. These include: * **Calcium-mediated signaling**: FKBP1B modulates calcium-mediated signaling pathways, influencing the release of sequestered calcium ions into the cytosol and regulating cardiac muscle contraction. * **Cardiac conduction**: FKBP1B plays a critical role in regulating cardiac conduction, influencing the release of sequestered calcium ions and modulating the ryanodine-sensitive calcium-release channel activity. * **Muscle contraction**: FKBP1B regulates muscle contraction by influencing the release of sequestered calcium ions and modulating the activity of the sarcoplasmic reticulum. * **Neuronal action potential propagation**: FKBP1B is involved in the regulation of neuronal action potential propagation, influencing the release of sequestered calcium ions and modulating the activity of the ryanodine-sensitive calcium-release channel. **Clinical Significance** FKBP1B's involvement in calcium-mediated signaling and cardiac conduction pathways highlights its clinical significance in various cardiovascular diseases. These include: * **Hypertrophic cardiomyopathy**: FKBP1B mutations have been linked to hypertrophic cardiomyopathy, a condition characterized by abnormal cardiac muscle contraction. * **Arrhythmias**: FKBP1B dysfunction has been implicated in arrhythmias, including atrial fibrillation and ventricular tachycardia. * **Cardiac conduction disorders**: FKBP1B plays a critical role in regulating cardiac conduction, and its dysfunction can lead to cardiac conduction disorders, such as bradycardia and tachycardia. In conclusion, FKBP1B is a vital component of the calcium signaling pathway that plays a critical role in regulating cardiac conduction and overall cardiovascular health. Its involvement in various disease states highlights the importance of further research into the molecular mechanisms of FKBP1B and its potential as a therapeutic target for cardiovascular diseases.

Genular Protein ID: 747832995

Symbol: FKB1B_HUMAN

Name: 12.6 kDa FK506-binding protein

UniProtKB Accession Codes:

P68106 Q13664 Q16645 Q53TM2 Q9BQ40

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 9 EMDB 92 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7513996

Title: Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts.

PubMed ID: 7513996

DOI: 10.1006/bbrc.1994.1527

PubMed ID: 7592869

Title: A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor.

PubMed ID: 7592869

DOI: 10.1074/jbc.270.44.26511

PubMed ID: 16122887

Title: Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6.

PubMed ID: 16122887

DOI: 10.1016/j.gene.2005.07.004

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10830164

Title: PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

PubMed ID: 10830164

DOI: 10.1016/s0092-8674(00)80847-8

PubMed ID: 10713512

Title: Structure of FKBP12.6 in complex with rapamycin.

PubMed ID: 10713512

DOI: 10.1107/s0907444999016571

Sequence Information:

  • Length: 108
  • Mass: 11783
  • Checksum: BAC2A25945F63AC4
  • Sequence:
    • MGVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF 
EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE

Genular Protein ID: 2603062046

Symbol: F8W6G9_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W6G9

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 6 Rhea 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 79
  • Mass: 8692
  • Checksum: 8E7293C364F40D3D
  • Sequence:
    • MLQNGKKFDS SRDRNKPFKF RIGKQEVIKG FEEGAAQMSL GQRAKLTCTP DVAYGATGHP 
GVIPPNATLI FDVELLNLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.