Details for: FKBP1B

Gene ID: 2281

Symbol: FKBP1B

Ensembl ID: ENSG00000119782

Description: FKBP prolyl isomerase 1B

Associated with

  • Cardiac conduction
    (R-HSA-5576891)
  • Ion channel transport
    (R-HSA-983712)
  • Ion homeostasis
    (R-HSA-5578775)
  • Muscle contraction
    (R-HSA-397014)
  • Stimuli-sensing channels
    (R-HSA-2672351)
  • Transport of small molecules
    (R-HSA-382551)
  • 'de novo' protein folding
    (GO:0006458)
  • Calcium-mediated signaling using intracellular calcium source
    (GO:0035584)
  • Calcium channel complex
    (GO:0034704)
  • Calcium channel inhibitor activity
    (GO:0019855)
  • Cell communication by electrical coupling involved in cardiac conduction
    (GO:0086064)
  • Cyclic nucleotide binding
    (GO:0030551)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Fk506 binding
    (GO:0005528)
  • Insulin secretion involved in cellular response to glucose stimulus
    (GO:0035773)
  • Membrane
    (GO:0016020)
  • Negative regulation of heart rate
    (GO:0010459)
  • Negative regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0061179)
  • Negative regulation of phosphoprotein phosphatase activity
    (GO:0032515)
  • Negative regulation of release of sequestered calcium ion into cytosol
    (GO:0051280)
  • Negative regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060315)
  • Neuronal action potential propagation
    (GO:0019227)
  • Peptidyl-prolyl cis-trans isomerase activity
    (GO:0003755)
  • Positive regulation of axon regeneration
    (GO:0048680)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of sequestering of calcium ion
    (GO:0051284)
  • Protein binding
    (GO:0005515)
  • Protein maturation by protein folding
    (GO:0022417)
  • Protein peptidyl-prolyl isomerization
    (GO:0000413)
  • Protein refolding
    (GO:0042026)
  • Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
    (GO:0010881)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
    (GO:0010880)
  • Regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060314)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to hydrogen peroxide
    (GO:0042542)
  • Response to redox state
    (GO:0051775)
  • Response to vitamin e
    (GO:0033197)
  • Ryanodine-sensitive calcium-release channel activity
    (GO:0005219)
  • Sarcoplasmic reticulum membrane
    (GO:0033017)
  • Signaling receptor binding
    (GO:0005102)
  • Smooth muscle contraction
    (GO:0006939)
  • T cell proliferation
    (GO:0042098)
  • Transmembrane transporter binding
    (GO:0044325)
  • Z disc
    (GO:0030018)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 4.91
    Marker Score: 7048
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.94
    Marker Score: 1901.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.71
    Marker Score: 2992
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.67
    Marker Score: 1880
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.66
    Marker Score: 557
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.27
    Marker Score: 475
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5108
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.85
    Marker Score: 1059.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.82
    Marker Score: 489.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8
    Marker Score: 1180
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.77
    Marker Score: 191
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 659
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.71
    Marker Score: 1019
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.7
    Marker Score: 242
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 527.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.67
    Marker Score: 3231
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.66
    Marker Score: 319
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.66
    Marker Score: 1385
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10245.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.64
    Marker Score: 355
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.62
    Marker Score: 3967.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.61
    Marker Score: 316
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.6
    Marker Score: 1367
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1217
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.57
    Marker Score: 1157
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.57
    Marker Score: 247
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.55
    Marker Score: 220
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.5
    Marker Score: 145
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 299
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5
    Marker Score: 516
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.49
    Marker Score: 764
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.48
    Marker Score: 199
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.47
    Marker Score: 301
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.47
    Marker Score: 1277
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.46
    Marker Score: 108
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.44
    Marker Score: 475
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.44
    Marker Score: 4457
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.44
    Marker Score: 487.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.44
    Marker Score: 411
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.43
    Marker Score: 341
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.42
    Marker Score: 1029.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.42
    Marker Score: 440
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 198
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.41
    Marker Score: 3935.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.41
    Marker Score: 4264
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.41
    Marker Score: 217.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.41
    Marker Score: 488
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.4
    Marker Score: 253
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.4
    Marker Score: 834
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.4
    Marker Score: 405
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.39
    Marker Score: 126
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.39
    Marker Score: 786
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.39
    Marker Score: 2540
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.39
    Marker Score: 467
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.38
    Marker Score: 112
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.38
    Marker Score: 356
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.37
    Marker Score: 188
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.36
    Marker Score: 180
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.36
    Marker Score: 12561
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.36
    Marker Score: 81
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 237
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.36
    Marker Score: 3074
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.36
    Marker Score: 896
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.36
    Marker Score: 2643
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.35
    Marker Score: 3036
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.34
    Marker Score: 329
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.34
    Marker Score: 98
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.34
    Marker Score: 769
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.34
    Marker Score: 317
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.34
    Marker Score: 191
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.34
    Marker Score: 569.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.33
    Marker Score: 113
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.33
    Marker Score: 1220
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.33
    Marker Score: 79
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.33
    Marker Score: 1325
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.32
    Marker Score: 344
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.32
    Marker Score: 520
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.32
    Marker Score: 19655.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.32
    Marker Score: 287
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.32
    Marker Score: 526
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.32
    Marker Score: 283

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Other Information

**Key characteristics:** * It is a prolyl isomerase, which is an enzyme that catalyzes the isomerization of proline residues in proteins. * It is a key regulator of protein folding and trafficking. * It is involved in the regulation of cardiac conduction, calcium channel activity, and muscle contraction. * It is also involved in the regulation of cell signaling and development. **Pathways and functions:** * **De novo protein folding:** FKBP1B is involved in the de novo protein folding of a variety of proteins, including those involved in cardiac conduction, calcium channel inhibition, and muscle contraction. * **Calcium channel inhibitor activity:** FKBP1B is a calcium channel inhibitor, which means that it binds to calcium channels and blocks their activity. This can lead to a decrease in calcium signaling and prevent the activation of downstream signaling pathways. * **Cardiac conduction:** FKBP1B is expressed in the heart and is involved in the regulation of cardiac conduction. It helps to maintain calcium homeostasis in the heart and prevents the activation of the cardiac conduction pathway. * **Cyclic nucleotide binding:** FKBP1B is also involved in the regulation of cyclic nucleotide binding. It binds to cyclic nucleotides, which are second messengers that regulate a variety of cellular processes. This binding can modulate the activity of downstream signaling pathways. * **Fk506 binding:** FKBP1B is also involved in the regulation of the Fk506 signaling pathway. The Fk506 pathway is a major regulator of cell growth and differentiation. FKBP1B binds to Fk506 and inhibits its activity. This can lead to the inhibition of cell growth and differentiation. **Clinical significance:** Mutations in FKBP1B have been linked to a variety of human diseases, including hypertrophic cardiomyopathy, arrhythmias, and heart failure. FKBP1B is a potential therapeutic target for these diseases.

Genular Protein ID: 747832995

Symbol: FKB1B_HUMAN

Name: 12.6 kDa FK506-binding protein

UniProtKB Accession Codes:

P68106 Q13664 Q16645 Q53TM2 Q9BQ40

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 9 EMDB 78 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 90 PDBsum 89 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7513996

Title: Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts.

PubMed ID: 7513996

DOI: 10.1006/bbrc.1994.1527

PubMed ID: 7592869

Title: A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor.

PubMed ID: 7592869

DOI: 10.1074/jbc.270.44.26511

PubMed ID: 16122887

Title: Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6.

PubMed ID: 16122887

DOI: 10.1016/j.gene.2005.07.004

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10830164

Title: PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

PubMed ID: 10830164

DOI: 10.1016/s0092-8674(00)80847-8

PubMed ID: 10713512

Title: Structure of FKBP12.6 in complex with rapamycin.

PubMed ID: 10713512

DOI: 10.1107/s0907444999016571

Sequence Information:

  • Length: 108
  • Mass: 11783
  • Checksum: BAC2A25945F63AC4
  • Sequence:
    • MGVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF 
EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE

Genular Protein ID: 2603062046

Symbol: F8W6G9_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W6G9

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 EC 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 6 Rhea 3 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 79
  • Mass: 8692
  • Checksum: 8E7293C364F40D3D
  • Sequence:
    • MLQNGKKFDS SRDRNKPFKF RIGKQEVIKG FEEGAAQMSL GQRAKLTCTP DVAYGATGHP 
GVIPPNATLI FDVELLNLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.