Details for: FOXD1

Gene ID: 2297

Symbol: FOXD1

Ensembl ID: ENSG00000251493

Description: forkhead box D1

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Axon guidance
    (GO:0007411)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dichotomous subdivision of terminal units involved in ureteric bud branching
    (GO:0060678)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dna binding, bending
    (GO:0008301)
  • Luteinizing hormone secretion
    (GO:0032275)
  • Metanephric capsule development
    (GO:0072213)
  • Metanephric capsule specification
    (GO:0072267)
  • Metanephric nephron development
    (GO:0072210)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nephrogenic mesenchyme development
    (GO:0072076)
  • Nucleus
    (GO:0005634)
  • Positive regulation of bmp signaling pathway
    (GO:0030513)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of kidney development
    (GO:0090184)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.72
    Marker Score: 3906
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.7
    Marker Score: 839
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.41
    Marker Score: 1622
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1
    Marker Score: 1898
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 660.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 378
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.88
    Marker Score: 1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1384
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.75
    Marker Score: 753
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 435
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2972
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1429
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.59
    Marker Score: 902
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 363
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.56
    Marker Score: 129
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.53
    Marker Score: 8297
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.53
    Marker Score: 816
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.52
    Marker Score: 133
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.52
    Marker Score: 164
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 245
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 176
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.32
    Marker Score: 93
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 134
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.3
    Marker Score: 88
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 301
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.28
    Marker Score: 584
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.27
    Marker Score: 134
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.26
    Marker Score: 188
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 93
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.25
    Marker Score: 410
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.24
    Marker Score: 162
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.23
    Marker Score: 404
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.22
    Marker Score: 156
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.21
    Marker Score: 217
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.2
    Marker Score: 194
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.19
    Marker Score: 80
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.18
    Marker Score: 2466
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.17
    Marker Score: 68
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.17
    Marker Score: 133
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.17
    Marker Score: 172
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.17
    Marker Score: 62
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 109
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.16
    Marker Score: 95.5
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.16
    Marker Score: 61
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.16
    Marker Score: 99
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.16
    Marker Score: 228
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.16
    Marker Score: 299
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.15
    Marker Score: 348
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.15
    Marker Score: 5123
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 347
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.15
    Marker Score: 52
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.13
    Marker Score: 147
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.13
    Marker Score: 90
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.13
    Marker Score: 869
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.12
    Marker Score: 294
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.12
    Marker Score: 589
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.12
    Marker Score: 154
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.12
    Marker Score: 78
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.11
    Marker Score: 299
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.11
    Marker Score: 90
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1
    Marker Score: 106
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.1
    Marker Score: 95
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.09
    Marker Score: 54

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Other Information

**Key characteristics:** - The FOXD1 gene is located on chromosome 17q21.1. - It is a member of the forkhead family of transcription factors. - It is expressed in a variety of cell types, including respiratory cells, epithelial cells, and cancer cells. - It is a key regulator of embryonic development and tissue differentiation. **Pathways and functions:** - FOXD1 protein is involved in the regulation of the canonical Wnt signaling pathway, which is important for embryonic development and tissue homeostasis. - It is also involved in the regulation of the rna polymerase ii-specific transcription factor activity, which is important for the development of the nephrogenic mesenchyme and the regulation of gene expression. - It is involved in the regulation of the BMP signaling pathway, which is important for the development of the cardiovascular system. - It is also involved in the regulation of transcription by rna polymerase ii, which is important for the development of the nervous system. **Clinical significance:** FOXD1 gene mutations are associated with a number of human diseases, including cancer, heart disease, and kidney disease. These mutations can lead to the activation of oncogenes or the inhibition of tumor suppressor genes, which can result in the development of cancer. **Additional notes:** - FOXD1 is a highly conserved gene, with a similar gene found in other mammals. - It is a key tumor suppressor gene in mice, and its overexpression leads to the development of tumors. - It is a promising target for cancer therapy.

Genular Protein ID: 57328279

Symbol: FOXD1_HUMAN

Name: Forkhead box protein D1

UniProtKB Accession Codes:

Q16676 Q12949

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8702877

Title: Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53.

PubMed ID: 8702877

DOI: 10.1074/jbc.271.35.21094

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 27805902

Title: Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans.

PubMed ID: 27805902

DOI: 10.1098/rsob.160109

Sequence Information:

  • Length: 465
  • Mass: 46140
  • Checksum: D3E7854909CCBFAE
  • Sequence:
    • MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA QRRRRRRSYA 
GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA GGGGGGGGAG GGGSAGSGAK 
NPLVKPPYSY IALITMAILQ SPKKRLTLSE ICEFISGRFP YYREKFPAWQ NSIRHNLSLN 
DCFVKIPREP GNPGKGNYWT LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR 
GAGAAGGAGD PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA 
AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG GPGASALARS 
PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP PAPGSSGGGC AAQAAVGPAA 
ALTRSLVAAA AAAASSVSSS AALGTLHQGT ALSSVENFTA RISNC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.