Details for: FOXD1

Gene ID: 2297

Symbol: FOXD1

Ensembl ID: ENSG00000251493

Description: forkhead box D1

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Axon guidance
    (GO:0007411)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dichotomous subdivision of terminal units involved in ureteric bud branching
    (GO:0060678)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dna binding, bending
    (GO:0008301)
  • Luteinizing hormone secretion
    (GO:0032275)
  • Metanephric capsule development
    (GO:0072213)
  • Metanephric capsule specification
    (GO:0072267)
  • Metanephric nephron development
    (GO:0072210)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nephrogenic mesenchyme development
    (GO:0072076)
  • Nucleus
    (GO:0005634)
  • Positive regulation of bmp signaling pathway
    (GO:0030513)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of kidney development
    (GO:0090184)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1148
    Cell Significance Index: 67.7300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.6601
    Cell Significance Index: 14.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3402
    Cell Significance Index: 255.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0164
    Cell Significance Index: 100.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9187
    Cell Significance Index: 19.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8070
    Cell Significance Index: 6.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7752
    Cell Significance Index: 699.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7016
    Cell Significance Index: 11.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5626
    Cell Significance Index: 91.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5401
    Cell Significance Index: 58.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3711
    Cell Significance Index: 22.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3697
    Cell Significance Index: 5.7200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2961
    Cell Significance Index: 6.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2604
    Cell Significance Index: 18.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1869
    Cell Significance Index: 11.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1721
    Cell Significance Index: 3.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1137
    Cell Significance Index: 3.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0770
    Cell Significance Index: 3.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0460
    Cell Significance Index: 1.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0370
    Cell Significance Index: 4.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0350
    Cell Significance Index: 1.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0211
    Cell Significance Index: 2.4600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0198
    Cell Significance Index: 0.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0018
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0026
    Cell Significance Index: -0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0029
    Cell Significance Index: -0.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0054
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0054
    Cell Significance Index: -0.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0061
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0091
    Cell Significance Index: -4.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0096
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0096
    Cell Significance Index: -5.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0131
    Cell Significance Index: -5.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0161
    Cell Significance Index: -0.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0199
    Cell Significance Index: -2.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0222
    Cell Significance Index: -6.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0224
    Cell Significance Index: -0.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0253
    Cell Significance Index: -4.5600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0269
    Cell Significance Index: -0.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0281
    Cell Significance Index: -5.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0332
    Cell Significance Index: -6.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0345
    Cell Significance Index: -0.9600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0374
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0396
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0420
    Cell Significance Index: -4.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0420
    Cell Significance Index: -1.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0441
    Cell Significance Index: -6.0500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0498
    Cell Significance Index: -0.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0524
    Cell Significance Index: -6.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0531
    Cell Significance Index: -5.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0541
    Cell Significance Index: -1.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0575
    Cell Significance Index: -7.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0581
    Cell Significance Index: -6.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0652
    Cell Significance Index: -0.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0698
    Cell Significance Index: -5.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0706
    Cell Significance Index: -1.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0734
    Cell Significance Index: -3.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0781
    Cell Significance Index: -2.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0889
    Cell Significance Index: -4.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0895
    Cell Significance Index: -2.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0922
    Cell Significance Index: -6.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0988
    Cell Significance Index: -5.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1010
    Cell Significance Index: -6.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1041
    Cell Significance Index: -5.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1041
    Cell Significance Index: -7.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1059
    Cell Significance Index: -1.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1077
    Cell Significance Index: -6.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1208
    Cell Significance Index: -1.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1286
    Cell Significance Index: -6.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1477
    Cell Significance Index: -6.5400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1497
    Cell Significance Index: -1.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1553
    Cell Significance Index: -3.2500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1572
    Cell Significance Index: -2.5900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1586
    Cell Significance Index: -3.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1723
    Cell Significance Index: -4.5300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1749
    Cell Significance Index: -2.5400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1781
    Cell Significance Index: -1.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1793
    Cell Significance Index: -6.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1844
    Cell Significance Index: -6.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1966
    Cell Significance Index: -6.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1990
    Cell Significance Index: -6.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1993
    Cell Significance Index: -6.5300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2005
    Cell Significance Index: -2.4300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2008
    Cell Significance Index: -1.5500
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.2012
    Cell Significance Index: -2.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2045
    Cell Significance Index: -5.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2093
    Cell Significance Index: -5.2200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2173
    Cell Significance Index: -2.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2183
    Cell Significance Index: -6.2300
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2237
    Cell Significance Index: -2.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2250
    Cell Significance Index: -6.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2300
    Cell Significance Index: -3.8500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2487
    Cell Significance Index: -5.0600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2488
    Cell Significance Index: -1.0800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2520
    Cell Significance Index: -3.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2558
    Cell Significance Index: -6.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FXD1 is a member of the forkhead box (FOX) family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. FOXD1 is a transcriptional activator, meaning it promotes the expression of target genes. It has a high degree of specificity in its binding to DNA sequences, and its activity is regulated by phosphorylation, ubiquitination, and other post-translational modifications. FXD1 is primarily expressed in cells of the kidney, nervous system, and reproductive system, including renal epithelial cells, neurons, and gonadal cells. Its expression is also detected in other cell types, such as immune cells and epithelial cells. FOXD1 is a relatively small protein, consisting of 242 amino acids, and is highly conserved across species. **Pathways and Functions** FXD1 is involved in several key signaling pathways, including: 1. **Canonical Wnt signaling pathway**: FOXD1 regulates the activity of β-catenin, a key component of the Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 2. ** BMP signaling pathway**: FOXD1 positively regulates the activity of BMP (Bone Morphogenetic Protein) signaling pathway, which is involved in cell differentiation and patterning. 3. **Gene expression regulation**: FOXD1 regulates the expression of target genes involved in cell differentiation, growth, and development. 4. **DNA damage response**: FOXD1 is involved in the regulation of gene expression in response to DNA damage, which is critical for maintaining genome stability. **Clinical Significance** Dysregulation of FOXD1 has been implicated in various diseases, including: 1. **Kidney disorders**: Mutations in FOXD1 have been linked to kidney disorders, such as congenital anomalies of the kidney and urinary tract (CAKUT). 2. **Cancer**: FOXD1 is overexpressed in various types of cancer, including renal cell carcinoma and melanoma. 3. **Neurological disorders**: FOXD1 has been implicated in the regulation of gene expression in neurons and glial cells, and its dysregulation has been linked to neurological disorders, such as autism and schizophrenia. 4. **Reproductive disorders**: FOXD1 is involved in the regulation of gonadal development and function, and its dysregulation has been linked to reproductive disorders, such as infertility and erectile dysfunction. In conclusion, FOXD1 is a critical transcription factor involved in various developmental and physiological processes. Its dysregulation has been linked to various diseases, highlighting the importance of understanding its function and regulation. Further studies are needed to fully elucidate the role of FOXD1 in human disease and to develop therapeutic strategies for its dysregulation.

Genular Protein ID: 57328279

Symbol: FOXD1_HUMAN

Name: Forkhead box protein D1

UniProtKB Accession Codes:

Q16676 Q12949

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8702877

Title: Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53.

PubMed ID: 8702877

DOI: 10.1074/jbc.271.35.21094

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 27805902

Title: Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans.

PubMed ID: 27805902

DOI: 10.1098/rsob.160109

Sequence Information:

  • Length: 465
  • Mass: 46140
  • Checksum: D3E7854909CCBFAE
  • Sequence:
    • MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA QRRRRRRSYA 
GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA GGGGGGGGAG GGGSAGSGAK 
NPLVKPPYSY IALITMAILQ SPKKRLTLSE ICEFISGRFP YYREKFPAWQ NSIRHNLSLN 
DCFVKIPREP GNPGKGNYWT LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR 
GAGAAGGAGD PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA 
AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG GPGASALARS 
PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP PAPGSSGGGC AAQAAVGPAA 
ALTRSLVAAA AAAASSVSSS AALGTLHQGT ALSSVENFTA RISNC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.