Details for: GAD1

Gene ID: 2571

Symbol: GAD1

Ensembl ID: ENSG00000128683

Description: glutamate decarboxylase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.8429
    Cell Significance Index: -16.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 75.4209
    Cell Significance Index: -19.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.9965
    Cell Significance Index: -18.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 7.3399
    Cell Significance Index: 176.0300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 6.4024
    Cell Significance Index: 79.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 5.0717
    Cell Significance Index: 311.7300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 3.8385
    Cell Significance Index: 49.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.2626
    Cell Significance Index: 71.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1834
    Cell Significance Index: 783.1400
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 2.1562
    Cell Significance Index: 17.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.0773
    Cell Significance Index: 127.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4990
    Cell Significance Index: 32.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4854
    Cell Significance Index: 56.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3159
    Cell Significance Index: 910.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2455
    Cell Significance Index: 55.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0054
    Cell Significance Index: 52.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8294
    Cell Significance Index: 55.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.8016
    Cell Significance Index: 15.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6708
    Cell Significance Index: 127.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3426
    Cell Significance Index: 33.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3299
    Cell Significance Index: 17.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3104
    Cell Significance Index: 280.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2920
    Cell Significance Index: 57.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2341
    Cell Significance Index: 360.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.1629
    Cell Significance Index: 3.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1576
    Cell Significance Index: 25.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1542
    Cell Significance Index: 16.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1486
    Cell Significance Index: 81.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1434
    Cell Significance Index: 264.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1430
    Cell Significance Index: 194.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0982
    Cell Significance Index: 2.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0945
    Cell Significance Index: 18.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0891
    Cell Significance Index: 4.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0820
    Cell Significance Index: 4.9200
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.0655
    Cell Significance Index: 0.6600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0334
    Cell Significance Index: 0.4000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0269
    Cell Significance Index: 0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0208
    Cell Significance Index: 0.7300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0132
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0049
    Cell Significance Index: 9.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0037
    Cell Significance Index: 0.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0059
    Cell Significance Index: -0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0089
    Cell Significance Index: -6.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0240
    Cell Significance Index: -1.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0255
    Cell Significance Index: -16.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0262
    Cell Significance Index: -19.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0268
    Cell Significance Index: -0.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0279
    Cell Significance Index: -21.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0326
    Cell Significance Index: -20.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0331
    Cell Significance Index: -18.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0364
    Cell Significance Index: -16.5100
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: -0.0392
    Cell Significance Index: -0.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0484
    Cell Significance Index: -21.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0501
    Cell Significance Index: -5.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0513
    Cell Significance Index: -1.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0522
    Cell Significance Index: -15.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0542
    Cell Significance Index: -1.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0565
    Cell Significance Index: -1.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0632
    Cell Significance Index: -6.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0874
    Cell Significance Index: -12.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0894
    Cell Significance Index: -10.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0941
    Cell Significance Index: -19.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0972
    Cell Significance Index: -16.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1187
    Cell Significance Index: -16.3000
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1314
    Cell Significance Index: -1.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1328
    Cell Significance Index: -17.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1353
    Cell Significance Index: -14.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1382
    Cell Significance Index: -15.8400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1444
    Cell Significance Index: -2.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1516
    Cell Significance Index: -19.5900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1534
    Cell Significance Index: -1.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1636
    Cell Significance Index: -5.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1711
    Cell Significance Index: -3.5500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1843
    Cell Significance Index: -2.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1888
    Cell Significance Index: -1.7900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2083
    Cell Significance Index: -4.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2233
    Cell Significance Index: -12.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2290
    Cell Significance Index: -18.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2402
    Cell Significance Index: -18.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2621
    Cell Significance Index: -19.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2658
    Cell Significance Index: -5.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3108
    Cell Significance Index: -19.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3198
    Cell Significance Index: -20.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3392
    Cell Significance Index: -17.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3983
    Cell Significance Index: -18.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4036
    Cell Significance Index: -14.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4043
    Cell Significance Index: -19.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4133
    Cell Significance Index: -2.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4296
    Cell Significance Index: -15.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4328
    Cell Significance Index: -14.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4339
    Cell Significance Index: -10.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4420
    Cell Significance Index: -6.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4685
    Cell Significance Index: -14.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4844
    Cell Significance Index: -12.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5131
    Cell Significance Index: -16.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5247
    Cell Significance Index: -11.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5456
    Cell Significance Index: -9.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5465
    Cell Significance Index: -18.9900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5512
    Cell Significance Index: -9.5300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.5577
    Cell Significance Index: -6.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzymatic activity**: GAD1 catalyzes the decarboxylation of glutamate to GABA, a reaction that is essential for the synthesis of the inhibitory neurotransmitter. 2. **Tissue specificity**: GAD1 is highly expressed in inhibitory interneurons, Purkinje cells, and certain types of GABAergic neurons, suggesting a specific role in regulating neural circuits. 3. **Transcriptional regulation**: GAD1 expression is tightly regulated by the MeCP2 protein, which highlights the importance of epigenetic mechanisms in controlling GAD1 activity. 4. **Evolutionary conservation**: GAD1 is highly conserved across species, indicating its fundamental role in neural function and evolution. **Pathways and Functions** 1. **GABA synthesis**: GAD1 is the key enzyme in the synthesis of GABA from glutamate, a reaction that is essential for regulating neuronal excitability and synaptic plasticity. 2. **Inhibitory synapse**: GAD1 plays a critical role in maintaining the inhibitory balance of the CNS by regulating the release and uptake of GABA. 3. **Neurotransmitter release cycle**: GAD1 is involved in the regulation of neurotransmitter release, including the release of GABA from presynaptic terminals. 4. **Synaptic plasticity**: GAD1's activity is essential for regulating synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). **Clinical Significance** 1. **Neurological disorders**: Abnormalities in GAD1 expression and function have been implicated in various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. 2. **Neurodevelopmental disorders**: GAD1's role in regulating neural circuits and synaptic plasticity makes it a potential target for the treatment of neurodevelopmental disorders, such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder. 3. **Neurodegenerative diseases**: GAD1's involvement in regulating GABA levels and synaptic function makes it a potential target for the treatment of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Therapeutic applications**: GAD1's role in regulating neurotransmitter release and synaptic plasticity makes it a potential target for the development of novel therapeutic agents, including GABA-based therapies and neurostimulatory treatments. In conclusion, GAD1 is a critical enzyme involved in the synthesis of the inhibitory neurotransmitter GABA, which plays a vital role in regulating neuronal excitability, synaptic plasticity, and overall brain function. Its highly conserved expression and functional significance across species highlight its fundamental importance in neural function and evolution.

Genular Protein ID: 1804459099

Symbol: DCE1_HUMAN

Name: Glutamate decarboxylase 1

UniProtKB Accession Codes:

Q99259 Q49AK1 Q53TQ7 Q9BU91 Q9UHH4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 16 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 6 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1549570

Title: Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.

PubMed ID: 1549570

DOI: 10.1073/pnas.89.6.2115

PubMed ID: 8088791

Title: The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD.

PubMed ID: 8088791

DOI: 10.1006/geno.1994.1246

PubMed ID: 1683462

Title: Cloning of large isoform of human brain glutamic acid decarboxylase.

PubMed ID: 1683462

DOI: 10.1016/0140-6736(91)92780-6

PubMed ID: 1339255

Title: Nucleotide sequence and chromosomal assignment of a cDNA encoding the large isoform of human glutamate decarboxylase.

PubMed ID: 1339255

DOI: 10.1111/j.1469-1809.1992.tb01150.x

PubMed ID: 8507202

Title: Molecular cloning of full-length glutamic acid decarboxylase 67 from human pancreas and islets.

PubMed ID: 8507202

DOI: 10.1006/bbrc.1993.1564

PubMed ID: 8507203

Title: Cloning and expression of large isoform of glutamic acid decarboxylase from human pancreatic islet.

PubMed ID: 8507203

DOI: 10.1006/bbrc.1993.1565

PubMed ID: 10671565

Title: Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues.

PubMed ID: 10671565

DOI: 10.1074/jbc.275.7.5188

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2039509

Title: Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets.

PubMed ID: 2039509

DOI: 10.1016/0006-291x(91)90418-7

PubMed ID: 1697032

Title: Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cells.

PubMed ID: 1697032

DOI: 10.1128/mcb.10.9.4701-4711.1990

PubMed ID: 32282878

Title: Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.

PubMed ID: 32282878

DOI: 10.1093/brain/awaa085

PubMed ID: 17384644

Title: GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.

PubMed ID: 17384644

DOI: 10.1038/nsmb1228

PubMed ID: 23126365

Title: Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates.

PubMed ID: 23126365

DOI: 10.1042/bsr20120111

PubMed ID: 15571623

Title: Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.

PubMed ID: 15571623

DOI: 10.1186/1471-2377-4-20

PubMed ID: 33634263

Title: Evidence that autosomal recessive spastic cerebral palsy-1 (CPSQ1) is caused by a missense variant in HPDL.

PubMed ID: 33634263

DOI: 10.1093/braincomms/fcab002

Sequence Information:

  • Length: 594
  • Mass: 66897
  • Checksum: 6D761C471C81FDAE
  • Sequence:
    • MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK 
SRLVSAFKER QSSKNLLSCE NSDRDARFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV 
VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV 
RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS 
SKDGDGIFSP GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEQS HYSIKKAGAA 
LGFGTDNVIL IKCNERGKII PADFEAKILE AKQKGYVPFY VNATAGTTVY GAFDPIQEIA 
DICEKYNLWL HVDAAWGGGL LMSRKHRHKL NGIERANSVT WNPHKMMGVL LQCSAILVKE 
KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI 
NKCLELAEYL YAKIKNREEF EMVFNGEPEH TNVCFWYIPQ SLRGVPDSPQ RREKLHKVAP 
KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL

Genular Protein ID: 3603765977

Symbol: Q8IVA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IVA8

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 2 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 2 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 594
  • Mass: 66917
  • Checksum: 580F11F932F8B1F3
  • Sequence:
    • MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK 
SRLVSAFKER QSSKNLLSCE NSDRDARFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV 
VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV 
RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS 
SKDGDGIFSP GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEQS RYSIKKAGAA 
LGFGTDNVIL IKCNERGEII PADFEAKILE AKQKGYVPFY VNATAGTTVY GAFDPIQEIA 
DICEKYNLWL HVDAAWGGGL LMSRKHRHKL NGIERANSVT WNPHKMMGVL LQCSAILVKE 
KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI 
NKCLELAEYL YAKIKNREEF EMVFNGEPEH TNVCFWYIPQ SLRGVPDSPQ RREKLHKVAP 
KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.