Details for: GAD1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 108.8429
Cell Significance Index: -16.9300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 75.4209
Cell Significance Index: -19.1300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.9965
Cell Significance Index: -18.4900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 7.3399
Cell Significance Index: 176.0300 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 6.4024
Cell Significance Index: 79.4100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 5.0717
Cell Significance Index: 311.7300 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 3.8385
Cell Significance Index: 49.7800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.2626
Cell Significance Index: 71.4400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.1834
Cell Significance Index: 783.1400 - Cell Name: chandelier cell (CL4023083)
Fold Change: 2.1562
Cell Significance Index: 17.4100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 2.0773
Cell Significance Index: 127.3600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.4990
Cell Significance Index: 32.4800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.4854
Cell Significance Index: 56.2500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.3159
Cell Significance Index: 910.1100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.2455
Cell Significance Index: 55.0900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0054
Cell Significance Index: 52.2300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.8294
Cell Significance Index: 55.7700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.8016
Cell Significance Index: 15.8500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6708
Cell Significance Index: 127.6700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3426
Cell Significance Index: 33.9000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3299
Cell Significance Index: 17.3200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3104
Cell Significance Index: 280.3000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2920
Cell Significance Index: 57.9500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2341
Cell Significance Index: 360.3400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.1629
Cell Significance Index: 3.2700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1576
Cell Significance Index: 25.6300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1542
Cell Significance Index: 16.7700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1486
Cell Significance Index: 81.1800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1434
Cell Significance Index: 264.4100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1430
Cell Significance Index: 194.4500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0982
Cell Significance Index: 2.8300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0945
Cell Significance Index: 18.9700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0891
Cell Significance Index: 4.0400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0820
Cell Significance Index: 4.9200 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 0.0655
Cell Significance Index: 0.6600 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.0334
Cell Significance Index: 0.4000 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.0269
Cell Significance Index: 0.3400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0208
Cell Significance Index: 0.7300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.0132
Cell Significance Index: 0.2800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0049
Cell Significance Index: 9.2400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0037
Cell Significance Index: 0.6700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0059
Cell Significance Index: -0.0900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0089
Cell Significance Index: -6.4900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0240
Cell Significance Index: -1.6600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0255
Cell Significance Index: -16.1700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0262
Cell Significance Index: -19.4000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0268
Cell Significance Index: -0.6700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0279
Cell Significance Index: -21.1100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0326
Cell Significance Index: -20.3600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0331
Cell Significance Index: -18.6600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0364
Cell Significance Index: -16.5100 - Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
Fold Change: -0.0392
Cell Significance Index: -0.3700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0484
Cell Significance Index: -21.3800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0501
Cell Significance Index: -5.8400 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0513
Cell Significance Index: -1.0700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0522
Cell Significance Index: -15.0300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0542
Cell Significance Index: -1.1700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0565
Cell Significance Index: -1.5800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0632
Cell Significance Index: -6.4600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0874
Cell Significance Index: -12.7100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0894
Cell Significance Index: -10.9900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0941
Cell Significance Index: -19.8100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0972
Cell Significance Index: -16.5900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1187
Cell Significance Index: -16.3000 - Cell Name: interneuron (CL0000099)
Fold Change: -0.1314
Cell Significance Index: -1.5400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1328
Cell Significance Index: -17.0200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1353
Cell Significance Index: -14.0900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1382
Cell Significance Index: -15.8400 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.1444
Cell Significance Index: -2.8800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1516
Cell Significance Index: -19.5900 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.1534
Cell Significance Index: -1.4600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1636
Cell Significance Index: -5.2400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1711
Cell Significance Index: -3.5500 - Cell Name: neural cell (CL0002319)
Fold Change: -0.1843
Cell Significance Index: -2.1500 - Cell Name: neuron (CL0000540)
Fold Change: -0.1888
Cell Significance Index: -1.7900 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.2083
Cell Significance Index: -4.1000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2233
Cell Significance Index: -12.5300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2290
Cell Significance Index: -18.1400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2402
Cell Significance Index: -18.4300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2621
Cell Significance Index: -19.5400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2658
Cell Significance Index: -5.6600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3108
Cell Significance Index: -19.5900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3198
Cell Significance Index: -20.6300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3392
Cell Significance Index: -17.6700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3983
Cell Significance Index: -18.5700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4036
Cell Significance Index: -14.1400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4043
Cell Significance Index: -19.0000 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.4133
Cell Significance Index: -2.8000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4296
Cell Significance Index: -15.7700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4328
Cell Significance Index: -14.1700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4339
Cell Significance Index: -10.5100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.4420
Cell Significance Index: -6.6600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4685
Cell Significance Index: -14.9200 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4844
Cell Significance Index: -12.0800 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.5131
Cell Significance Index: -16.2300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5247
Cell Significance Index: -11.2200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5456
Cell Significance Index: -9.3500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5465
Cell Significance Index: -18.9900 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.5512
Cell Significance Index: -9.5300 - Cell Name: amacrine cell (CL0000561)
Fold Change: -0.5577
Cell Significance Index: -6.9900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1804459099
Symbol: DCE1_HUMAN
Name: Glutamate decarboxylase 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1549570
Title: Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.
PubMed ID: 1549570
PubMed ID: 8088791
Title: The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD.
PubMed ID: 8088791
PubMed ID: 1683462
Title: Cloning of large isoform of human brain glutamic acid decarboxylase.
PubMed ID: 1683462
PubMed ID: 1339255
Title: Nucleotide sequence and chromosomal assignment of a cDNA encoding the large isoform of human glutamate decarboxylase.
PubMed ID: 1339255
PubMed ID: 8507202
Title: Molecular cloning of full-length glutamic acid decarboxylase 67 from human pancreas and islets.
PubMed ID: 8507202
PubMed ID: 8507203
Title: Cloning and expression of large isoform of glutamic acid decarboxylase from human pancreatic islet.
PubMed ID: 8507203
PubMed ID: 10671565
Title: Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues.
PubMed ID: 10671565
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2039509
Title: Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets.
PubMed ID: 2039509
PubMed ID: 1697032
Title: Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cells.
PubMed ID: 1697032
PubMed ID: 32282878
Title: Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.
PubMed ID: 32282878
PubMed ID: 17384644
Title: GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
PubMed ID: 17384644
DOI: 10.1038/nsmb1228
PubMed ID: 23126365
Title: Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates.
PubMed ID: 23126365
DOI: 10.1042/bsr20120111
PubMed ID: 15571623
Title: Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
PubMed ID: 15571623
PubMed ID: 33634263
Title: Evidence that autosomal recessive spastic cerebral palsy-1 (CPSQ1) is caused by a missense variant in HPDL.
PubMed ID: 33634263
Sequence Information:
- Length: 594
- Mass: 66897
- Checksum: 6D761C471C81FDAE
- Sequence:
MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK SRLVSAFKER QSSKNLLSCE NSDRDARFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS SKDGDGIFSP GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEQS HYSIKKAGAA LGFGTDNVIL IKCNERGKII PADFEAKILE AKQKGYVPFY VNATAGTTVY GAFDPIQEIA DICEKYNLWL HVDAAWGGGL LMSRKHRHKL NGIERANSVT WNPHKMMGVL LQCSAILVKE KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI NKCLELAEYL YAKIKNREEF EMVFNGEPEH TNVCFWYIPQ SLRGVPDSPQ RREKLHKVAP KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL
Genular Protein ID: 3603765977
Symbol: Q8IVA8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 594
- Mass: 66917
- Checksum: 580F11F932F8B1F3
- Sequence:
MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK SRLVSAFKER QSSKNLLSCE NSDRDARFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS SKDGDGIFSP GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEQS RYSIKKAGAA LGFGTDNVIL IKCNERGEII PADFEAKILE AKQKGYVPFY VNATAGTTVY GAFDPIQEIA DICEKYNLWL HVDAAWGGGL LMSRKHRHKL NGIERANSVT WNPHKMMGVL LQCSAILVKE KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI NKCLELAEYL YAKIKNREEF EMVFNGEPEH TNVCFWYIPQ SLRGVPDSPQ RREKLHKVAP KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.