Details for: PLEK2

Gene ID: 26499

Symbol: PLEK2

Ensembl ID: ENSG00000100558

Description: pleckstrin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.6155
    Cell Significance Index: -8.7800
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.7733
    Cell Significance Index: -4.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 12.9951
    Cell Significance Index: -8.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.6041
    Cell Significance Index: -7.2600
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 6.1634
    Cell Significance Index: 18.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.2800
    Cell Significance Index: -6.5100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 3.3771
    Cell Significance Index: 27.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.2500
    Cell Significance Index: 87.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8510
    Cell Significance Index: 148.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.5454
    Cell Significance Index: 38.1400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.3833
    Cell Significance Index: 20.4800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 2.1612
    Cell Significance Index: 30.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0465
    Cell Significance Index: 58.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5827
    Cell Significance Index: 71.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5338
    Cell Significance Index: 41.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1881
    Cell Significance Index: 25.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0484
    Cell Significance Index: 72.5100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.0390
    Cell Significance Index: 15.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0180
    Cell Significance Index: 21.6800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.7382
    Cell Significance Index: 8.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6013
    Cell Significance Index: 542.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4868
    Cell Significance Index: 15.5900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.3797
    Cell Significance Index: 3.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3471
    Cell Significance Index: 66.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3209
    Cell Significance Index: 11.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3151
    Cell Significance Index: 31.1800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.3046
    Cell Significance Index: 1.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2191
    Cell Significance Index: 26.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2111
    Cell Significance Index: 93.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1977
    Cell Significance Index: 5.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1583
    Cell Significance Index: 2.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1545
    Cell Significance Index: 27.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1368
    Cell Significance Index: 9.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1177
    Cell Significance Index: 5.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0659
    Cell Significance Index: 11.2600
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.0653
    Cell Significance Index: 0.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0527
    Cell Significance Index: 10.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0466
    Cell Significance Index: 5.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0317
    Cell Significance Index: 0.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0101
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0034
    Cell Significance Index: 0.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0012
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0017
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0030
    Cell Significance Index: -0.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0051
    Cell Significance Index: -0.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0057
    Cell Significance Index: -10.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0096
    Cell Significance Index: -0.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0099
    Cell Significance Index: -13.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0101
    Cell Significance Index: -1.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0127
    Cell Significance Index: -8.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0128
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0129
    Cell Significance Index: -2.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0193
    Cell Significance Index: -6.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0204
    Cell Significance Index: -9.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0276
    Cell Significance Index: -1.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0289
    Cell Significance Index: -1.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0303
    Cell Significance Index: -8.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0303
    Cell Significance Index: -2.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0336
    Cell Significance Index: -0.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0518
    Cell Significance Index: -7.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0538
    Cell Significance Index: -0.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0724
    Cell Significance Index: -4.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0780
    Cell Significance Index: -10.7100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0782
    Cell Significance Index: -0.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0785
    Cell Significance Index: -2.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0842
    Cell Significance Index: -8.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0891
    Cell Significance Index: -10.5100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0940
    Cell Significance Index: -0.9700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1027
    Cell Significance Index: -1.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1081
    Cell Significance Index: -8.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1186
    Cell Significance Index: -7.9800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1290
    Cell Significance Index: -0.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1296
    Cell Significance Index: -6.7500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1325
    Cell Significance Index: -3.3100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1341
    Cell Significance Index: -1.8600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1372
    Cell Significance Index: -1.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1490
    Cell Significance Index: -3.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1491
    Cell Significance Index: -11.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1492
    Cell Significance Index: -3.8400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1546
    Cell Significance Index: -2.6000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1669
    Cell Significance Index: -7.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1705
    Cell Significance Index: -1.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1728
    Cell Significance Index: -4.3100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1734
    Cell Significance Index: -1.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1801
    Cell Significance Index: -6.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1830
    Cell Significance Index: -1.9300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1833
    Cell Significance Index: -2.0800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1835
    Cell Significance Index: -1.9500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1837
    Cell Significance Index: -1.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1848
    Cell Significance Index: -5.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1894
    Cell Significance Index: -6.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1944
    Cell Significance Index: -10.9100
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.1974
    Cell Significance Index: -1.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2045
    Cell Significance Index: -3.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLEK2 is a member of the pleckstrin family of proteins, characterized by their ability to bind to phosphatidylinositol-3,4-bisphosphate (PIP2) and phosphatidylinositol-3,5-bisphosphate (PIP3). This phosphoinositide-binding capacity allows PLEK2 to regulate various cellular processes, including cytoskeleton organization, cell migration, and signaling. PLEK2 is a cytosolic protein, but its binding to PIP2 and PIP3 can modulate its localization and activity. **Pathways and Functions:** PLEK2 is implicated in several signaling pathways that regulate cell migration, adhesion, and survival. Notably, it interacts with the actin cytoskeleton, influencing cell shape, movement, and morphology. PLEK2 also plays a role in the regulation of plasma membrane-bound cell projections, such as lamellipodia, which are essential for cell migration and invasion. Furthermore, PLEK2 modulates the activity of various kinases and phosphatases, including PI3K and AKT, which are key regulators of cell survival and metabolism. **Signaling Pathways:** 1. **PI3K/AKT signaling pathway:** PLEK2 interacts with PI3K, regulating its activity and influencing cell survival, metabolism, and migration. 2. **Rho GTPase signaling pathway:** PLEK2 modulates the activity of Rho GTPases, which regulate cytoskeleton organization and cell migration. 3. **Cytoskeleton organization:** PLEK2 interacts with actin and microtubule-associated proteins, regulating cytoskeleton dynamics and cell shape. **Clinical Significance:** PLEK2 has been implicated in various diseases, including: 1. **Immunological disorders:** PLEK2 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it may contribute to immune cell dysfunction and tissue damage. 2. **Cancer:** PLEK2 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it may promote tumor growth and metastasis. 3. **Neurological disorders:** PLEK2 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may contribute to neuronal dysfunction and degeneration. In conclusion, PLEK2 is a multifunctional protein that plays a crucial role in various cellular processes, including cell migration, adhesion, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying PLEK2's functions.

Genular Protein ID: 2524441554

Symbol: PLEK2_HUMAN

Name: Pleckstrin-2

UniProtKB Accession Codes:

Q9NYT0 Q96JT0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 353
  • Mass: 39971
  • Checksum: CE355BF917F2385E
  • Sequence:
    • MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLVYYKLEG GRRVTPPKGR ILLDGCTITC 
PCLEYENRPL LIKLKTQTST EYFLEACSRE ERDAWAFEIT GAIHAGQPGK VQQLHSLRNS 
FKLPPHISLH RIVDKMHDSN TGIRSSPNME QGSTYKKTFL GSSLVDWLIS NSFTASRLEA 
VTLASMLMEE NFLRPVGVRS MGAIRSGDLA EQFLDDSTAL YTFAESYKKK ISPKEEISLS 
TVELSGTVVK QGYLAKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL 
VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK KLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.