Details for: CNNM3

Gene ID: 26505

Symbol: CNNM3

Ensembl ID: ENSG00000168763

Description: cyclin and CBS domain divalent metal cation transport mediator 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.3771
    Cell Significance Index: -13.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.5290
    Cell Significance Index: -13.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9980
    Cell Significance Index: -13.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0955
    Cell Significance Index: -13.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9465
    Cell Significance Index: -4.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4883
    Cell Significance Index: 102.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9215
    Cell Significance Index: 55.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9110
    Cell Significance Index: 90.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8663
    Cell Significance Index: 11.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7009
    Cell Significance Index: 76.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6686
    Cell Significance Index: 77.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5536
    Cell Significance Index: 34.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5026
    Cell Significance Index: 14.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5017
    Cell Significance Index: 10.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4901
    Cell Significance Index: 79.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4692
    Cell Significance Index: 93.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2797
    Cell Significance Index: 56.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2744
    Cell Significance Index: 52.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2134
    Cell Significance Index: 147.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2108
    Cell Significance Index: 38.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2055
    Cell Significance Index: 25.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2012
    Cell Significance Index: 5.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2003
    Cell Significance Index: 71.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1907
    Cell Significance Index: 10.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1796
    Cell Significance Index: 9.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1652
    Cell Significance Index: 7.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1320
    Cell Significance Index: 72.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1236
    Cell Significance Index: 35.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1169
    Cell Significance Index: 2.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1161
    Cell Significance Index: 14.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0762
    Cell Significance Index: 1.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0694
    Cell Significance Index: 1.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0665
    Cell Significance Index: 60.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0629
    Cell Significance Index: 2.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0621
    Cell Significance Index: 10.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0587
    Cell Significance Index: 25.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0575
    Cell Significance Index: 2.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0374
    Cell Significance Index: 2.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0161
    Cell Significance Index: 2.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0161
    Cell Significance Index: 1.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0144
    Cell Significance Index: 0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0063
    Cell Significance Index: 11.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0047
    Cell Significance Index: 8.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0047
    Cell Significance Index: 7.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0045
    Cell Significance Index: -2.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0051
    Cell Significance Index: -6.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0123
    Cell Significance Index: -6.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0137
    Cell Significance Index: -10.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0158
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0200
    Cell Significance Index: -2.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0290
    Cell Significance Index: -1.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0319
    Cell Significance Index: -4.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0360
    Cell Significance Index: -7.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0441
    Cell Significance Index: -5.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0572
    Cell Significance Index: -6.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0583
    Cell Significance Index: -2.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0637
    Cell Significance Index: -1.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0641
    Cell Significance Index: -4.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0704
    Cell Significance Index: -3.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0744
    Cell Significance Index: -7.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0824
    Cell Significance Index: -5.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0832
    Cell Significance Index: -10.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0890
    Cell Significance Index: -2.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0996
    Cell Significance Index: -2.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1038
    Cell Significance Index: -2.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1170
    Cell Significance Index: -4.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1190
    Cell Significance Index: -12.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1365
    Cell Significance Index: -10.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1474
    Cell Significance Index: -6.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1543
    Cell Significance Index: -2.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1566
    Cell Significance Index: -8.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1571
    Cell Significance Index: -12.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1726
    Cell Significance Index: -10.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1812
    Cell Significance Index: -2.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1926
    Cell Significance Index: -3.3000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2064
    Cell Significance Index: -2.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2170
    Cell Significance Index: -5.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2181
    Cell Significance Index: -2.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2400
    Cell Significance Index: -8.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2441
    Cell Significance Index: -5.8600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2568
    Cell Significance Index: -3.4700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2718
    Cell Significance Index: -3.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2722
    Cell Significance Index: -5.9600
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2928
    Cell Significance Index: -2.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2954
    Cell Significance Index: -2.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2956
    Cell Significance Index: -8.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2997
    Cell Significance Index: -6.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3008
    Cell Significance Index: -12.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3051
    Cell Significance Index: -9.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3053
    Cell Significance Index: -3.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3088
    Cell Significance Index: -9.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3111
    Cell Significance Index: -10.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3441
    Cell Significance Index: -12.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3462
    Cell Significance Index: -9.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3558
    Cell Significance Index: -5.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3571
    Cell Significance Index: -7.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Transporter:** CNNM3 is a transmembrane protein that transports divalent metal ions, including magnesium, across cell membranes. 2. **Cyclin and CBS Domain:** The gene possesses a unique cyclin and CBS (cystathionine beta-synthase) domain, which is involved in the regulation of magnesium transport. 3. **Tissue-Specific Expression:** CNNM3 is expressed in various tissues, including cardiac muscle myoblasts, germ cells, cerebral cortex GABAergic interneurons, and intestinal epithelial cells. 4. **Magnesium Ion Homeostasis:** The primary function of CNNM3 is to regulate magnesium ion homeostasis, ensuring proper cellular function and preventing magnesium deficiency or excess. **Pathways and Functions:** 1. **Magnesium Ion Homeostasis:** CNNM3 plays a crucial role in maintaining magnesium ion homeostasis by regulating its concentration within cells. 2. **Cellular Signaling:** The gene is involved in cellular signaling pathways, including the regulation of calcium and magnesium ion homeostasis. 3. **Neurotransmitter Release:** CNNM3 is involved in the regulation of neurotransmitter release, particularly GABA (gamma-aminobutyric acid), in the brain. 4. **Cardiac Function:** The gene is expressed in cardiac muscle myoblasts and plays a role in maintaining proper cardiac function. **Clinical Significance:** 1. **Neurological Disorders:** CNNM3 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease. 2. **Cardiac Disorders:** The gene has also been linked to cardiac disorders, such as arrhythmias and heart failure. 3. **Intestinal Function:** CNNM3 plays a role in maintaining proper intestinal function, and its dysregulation may contribute to gastrointestinal disorders. 4. **Therapeutic Potential:** Further research is needed to explore the therapeutic potential of CNNM3 in treating neurological and cardiac disorders. In conclusion, CNNM3 is a critical gene involved in maintaining magnesium ion homeostasis and regulating cellular function. Further research into its mechanisms and clinical applications is essential to fully understand its significance and potential therapeutic uses.

Genular Protein ID: 72649447

Symbol: CNNM3_HUMAN

Name: Metal transporter CNNM3

UniProtKB Accession Codes:

Q8NE01 B3KX67 Q8TBV4 Q96IW4 Q9NRK4 Q9NXW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 3 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12657465

Title: Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP).

PubMed ID: 12657465

DOI: 10.1016/s0378-1119(02)01210-6

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 707
  • Mass: 76119
  • Checksum: 22BE4A950A8DA7F5
  • Sequence:
    • MAAAVAAAGR LGWLFAALCL GNAAGEAAPG PRVLGFCLEE DGAAGAGWVR GGAARDTPDA 
TFLLRLFGPG FANSSWSWVA PEGAGCREEA ASPAGEWRAL LRLRLRAEAV RPHSALLAVR 
VEPGGGAAEE AAPPWALGLG AAGLLALAAL ARGLQLSALA LAPAEVQVLR ESGSEAERAA 
ARRLEPARRW AGCALGALLL LASLAQAALA VLLYRAAGQR AVPAVLGSAG LVFLVGEVVP 
AAVSGRWTLA LAPRALGLSR LAVLLTLPVA LPVGQLLELA ARPGRLRERV LELARGGGDP 
YSDLSKGVLR CRTVEDVLTP LEDCFMLDAS TVLDFGVLAS IMQSGHTRIP VYEEERSNIV 
DMLYLKDLAF VDPEDCTPLS TITRFYNHPL HFVFNDTKLD AVLEEFKRGK SHLAIVQKVN 
NEGEGDPFYE VLGLVTLEDV IEEIIRSEIL DESEDYRDTV VKRKPASLMA PLKRKEEFSL 
FKVSDDEYKV TISPQLLLAT QRFLSREVDV FSPLRISEKV LLHLLKHPSV NQEVRFDESN 
RLATHHYLYQ RSQPVDYFIL ILQGRVEVEI GKEGLKFENG AFTYYGVSAL TVPSSVHQSP 
VSSLQPIRHD LQPDPGDGTH SSAYCPDYTV RALSDLQLIK VTRLQYLNAL LATRAQNLPQ 
SPENTDLQVI PGSQTRLLGE KTTTAAGSSH SRPGVPVEGS PGRNPGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.