AGO1 | ENSG00000092847 | NCBI 26523

Details for: AGO1

Gene ID: 26523

Symbol: AGO1

Ensembl ID: ENSG00000092847

Description: argonaute RISC component 1

Associated with

Adherens junctions interactions
(R-HSA-418990)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Competing endogenous rnas (cernas) regulate pten translation
(R-HSA-8948700)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-transcriptional silencing by small rnas
(R-HSA-426496)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Pten regulation
(R-HSA-6807070)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 mrna translation by micrornas
(R-HSA-9759811)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of mitf-m-dependent genes involved in apoptosis
(R-HSA-9824594)
Regulation of npas4 gene expression
(R-HSA-9768759)
Regulation of npas4 mrna translation
(R-HSA-9768778)
Regulation of pten mrna translation
(R-HSA-8943723)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by tgfbr3
(R-HSA-9839373)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Small interfering rna (sirna) biogenesis
(R-HSA-426486)
Tgfbr3 expression
(R-HSA-9839394)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by npas4
(R-HSA-9634815)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation by ventx
(R-HSA-8853884)
Core promoter sequence-specific dna binding
(GO:0001046)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytosol
(GO:0005829)
Double-stranded rna binding
(GO:0003725)
Mirna-mediated gene silencing by inhibition of translation
(GO:0035278)
Mirna-mediated gene silencing by mrna destabilization
(GO:0035279)
Mirna binding
(GO:0035198)
Mirna processing
(GO:0035196)
Negative regulation of angiogenesis
(GO:0016525)
Nuclear-transcribed mrna catabolic process
(GO:0000956)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Pre-mirna processing
(GO:0031054)
Protein binding
(GO:0005515)
Regulatory ncrna-mediated post-transcriptional gene silencing
(GO:0035194)
Risc-loading complex
(GO:0070578)
Risc complex
(GO:0016442)
Risc complex assembly
(GO:0070922)
Rna binding
(GO:0003723)
Rna endonuclease activity
(GO:0004521)
Rna polymerase ii complex binding
(GO:0000993)
Rna secondary structure unwinding
(GO:0010501)
Single-stranded rna binding
(GO:0003727)
Sirna-mediated gene silencing by mrna destabilization
(GO:0090625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 168.2469
Cell Significance Index: -26.1700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 96.5923
Cell Significance Index: -24.5000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 54.9160
Cell Significance Index: -22.3100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 50.1375
Cell Significance Index: -25.7900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.2903
Cell Significance Index: -26.2500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.7765
Cell Significance Index: -26.1900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.7032
Cell Significance Index: -23.6600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.7105
Cell Significance Index: -26.4800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.0443
Cell Significance Index: -11.0400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6991
Cell Significance Index: 168.0800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1355
Cell Significance Index: 68.1700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0973
Cell Significance Index: 220.1200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0709
Cell Significance Index: 116.4900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7349
Cell Significance Index: 145.8400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7108
Cell Significance Index: 20.4800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7103
Cell Significance Index: 254.7700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.6613
Cell Significance Index: 16.5300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6246
Cell Significance Index: 35.0500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6082
Cell Significance Index: 23.0300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.5936
Cell Significance Index: 15.9100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5631
Cell Significance Index: 37.8600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.5523
Cell Significance Index: 24.4300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5006
Cell Significance Index: 6.8300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4061
Cell Significance Index: 280.8500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3438
Cell Significance Index: 21.1300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3247
Cell Significance Index: 58.5300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3225
Cell Significance Index: 22.3100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2884
Cell Significance Index: 54.8900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2153
Cell Significance Index: 9.7600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2119
Cell Significance Index: 93.6700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2061
Cell Significance Index: 112.5600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1857
Cell Significance Index: 8.6600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1805
Cell Significance Index: 13.8600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1785
Cell Significance Index: 21.9500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1728
Cell Significance Index: 4.8300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1596
Cell Significance Index: 10.0600
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1568
Cell Significance Index: 3.7600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1529
Cell Significance Index: 21.0000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1446
Cell Significance Index: 130.5900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1381
Cell Significance Index: 22.4600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0980
Cell Significance Index: 1.6800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0894
Cell Significance Index: 1.9100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0727
Cell Significance Index: 1.0200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0647
Cell Significance Index: 1.7300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0502
Cell Significance Index: 3.2400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0299
Cell Significance Index: 56.3200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0233
Cell Significance Index: 35.8300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0204
Cell Significance Index: 37.6200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0195
Cell Significance Index: 12.3600
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.0176
Cell Significance Index: 0.1000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0002
Cell Significance Index: -0.2300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0013
Cell Significance Index: -0.0900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0063
Cell Significance Index: -0.8100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0175
Cell Significance Index: -12.8300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0215
Cell Significance Index: -9.7600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0244
Cell Significance Index: -3.5500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0272
Cell Significance Index: -20.6200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0306
Cell Significance Index: -0.6400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0324
Cell Significance Index: -5.5400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0325
Cell Significance Index: -24.0400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0426
Cell Significance Index: -24.0500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0465
Cell Significance Index: -29.0300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0468
Cell Significance Index: -2.4300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0532
Cell Significance Index: -1.4200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0606
Cell Significance Index: -1.7300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0717
Cell Significance Index: -8.4500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0792
Cell Significance Index: -22.7900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0871
Cell Significance Index: -10.1500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1233
Cell Significance Index: -12.6000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1260
Cell Significance Index: -16.2800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1422
Cell Significance Index: -29.9500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1443
Cell Significance Index: -5.0700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1451
Cell Significance Index: -3.9500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1735
Cell Significance Index: -8.1600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1744
Cell Significance Index: -19.9800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1802
Cell Significance Index: -5.7700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2167
Cell Significance Index: -16.1500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2229
Cell Significance Index: -5.7300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2300
Cell Significance Index: -23.9500
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2342
Cell Significance Index: -2.9100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2393
Cell Significance Index: -5.2400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2646
Cell Significance Index: -13.8900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2869
Cell Significance Index: -22.7200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3182
Cell Significance Index: -19.5100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3190
Cell Significance Index: -16.6200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3587
Cell Significance Index: -6.6300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3628
Cell Significance Index: -7.8600
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.3800
Cell Significance Index: -3.2300
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3968
Cell Significance Index: -5.9800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4159
Cell Significance Index: -13.6200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4190
Cell Significance Index: -14.5600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4231
Cell Significance Index: -13.4800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4594
Cell Significance Index: -12.0800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4773
Cell Significance Index: -10.1300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4797
Cell Significance Index: -9.6300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4870
Cell Significance Index: -5.8100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5148
Cell Significance Index: -10.1800
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5438
Cell Significance Index: -19.0500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5558
Cell Significance Index: -16.3700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5736
Cell Significance Index: -9.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **RISC component:** AGO1 is a critical component of the RISC complex, which is responsible for the recognition and degradation of specific RNA sequences. 2. **RNA binding:** AGO1 possesses a highly specific RNA-binding domain, allowing it to recognize and bind to miRNAs and siRNAs. 3. **Post-transcriptional regulation:** AGO1 mediates the post-transcriptional regulation of gene expression by degrading or repressing target mRNAs. 4. **Cellular localization:** AGO1 is primarily localized in the cytoplasm, where it plays a crucial role in the regulation of gene expression. **Pathways and Functions:** AGO1 is involved in various cellular pathways, including: 1. **MicroRNA-mediated gene silencing:** AGO1 mediates the degradation of target mRNAs by binding to miRNAs. 2. **Small interfering RNA-mediated gene silencing:** AGO1 mediates the degradation of target mRNAs by binding to siRNAs. 3. **Cell-cell communication:** AGO1 regulates cell-cell communication by modulating the expression of adhesion molecules and receptors. 4. **Cellular responses to stimuli:** AGO1 regulates cellular responses to various stimuli, including growth factor signaling and oxidative stress. 5. **Disease regulation:** AGO1 is involved in the regulation of various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. **Clinical Significance:** AGO1 plays a crucial role in the regulation of gene expression, and dysregulation of AGO1 has been implicated in various diseases. Some of the clinical significance of AGO1 includes: 1. **Cancer:** AGO1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative disorders:** AGO1 is involved in the regulation of gene expression in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Metabolic disorders:** AGO1 regulates gene expression in metabolic disorders, such as type 2 diabetes and obesity. 4. **Neurodevelopmental disorders:** AGO1 is involved in the regulation of gene expression in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, AGO1 is a critical component of the RISC complex that plays a pivotal role in the regulation of gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of AGO1 in maintaining cellular homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 3066719857

Symbol: AGO1_HUMAN

Name: Protein argonaute-1

UniProtKB Accession Codes:

Q9UL18 Q5TA57 Q6P4S0

Database IDs:

Citations:

PubMed ID: 10534406

Title: Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.

PubMed ID: 10534406

DOI: 10.1006/geno.1999.5951

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15260970

Title: Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

PubMed ID: 15260970

DOI: 10.1016/j.molcel.2004.07.007

PubMed ID: 16289642

Title: Identification of novel argonaute-associated proteins.

PubMed ID: 16289642

DOI: 10.1016/j.cub.2005.10.048

PubMed ID: 16936728

Title: Involvement of AGO1 and AGO2 in mammalian transcriptional silencing.

PubMed ID: 16936728

DOI: 10.1038/nsmb1140

PubMed ID: 16756390

Title: Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.

PubMed ID: 16756390

DOI: 10.1371/journal.pbio.0040210

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 18771919

Title: Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.

PubMed ID: 18771919

DOI: 10.1016/j.cub.2008.07.072

PubMed ID: 19167051

Title: Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.

PubMed ID: 19167051

DOI: 10.1016/j.cell.2008.12.023

PubMed ID: 20616046

Title: LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

PubMed ID: 20616046

DOI: 10.1073/pnas.0914987107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22915799

Title: HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.

PubMed ID: 22915799

DOI: 10.1128/jvi.00595-12

PubMed ID: 15152257

Title: Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.

PubMed ID: 15152257

DOI: 10.1038/nature02519

PubMed ID: 23809764

Title: Eukaryote-specific insertion elements control human ARGONAUTE slicer activity.

PubMed ID: 23809764

DOI: 10.1016/j.celrep.2013.06.010

PubMed ID: 23746446

Title: The making of a slicer: activation of human Argonaute-1.

PubMed ID: 23746446

DOI: 10.1016/j.celrep.2013.05.033

PubMed ID: 23020937

Title: Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study.

PubMed ID: 23020937

DOI: 10.1016/s0140-6736(12)61480-9

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

PubMed ID: 27620904

Title: High diagnostic yield of syndromic intellectual disability by targeted next-generation sequencing.

PubMed ID: 27620904

DOI: 10.1136/jmedgenet-2016-103964

PubMed ID: 30213762

Title: Further evidence of a causal association between AGO1, a critical regulator of microRNA formation, and intellectual disability/autism spectrum disorder.

PubMed ID: 30213762

DOI: 10.1016/j.ejmg.2018.09.004

PubMed ID: 34930816

Title: De novo coding variants in the AGO1 gene cause a neurodevelopmental disorder with intellectual disability.

PubMed ID: 34930816

DOI: 10.1136/jmedgenet-2021-107751

Sequence Information:

Length: 857
Mass: 97214
Checksum: 1DBB524AE7CBAF66
Sequence:

MEAGPSGAAA GAYLPPLQQV FQAPRRPGIG TVGKPIKLLA NYFEVDIPKI DVYHYEVDIK 
PDKCPRRVNR EVVEYMVQHF KPQIFGDRKP VYDGKKNIYT VTALPIGNER VDFEVTIPGE 
GKDRIFKVSI KWLAIVSWRM LHEALVSGQI PVPLESVQAL DVAMRHLASM RYTPVGRSFF 
SPPEGYYHPL GGGREVWFGF HQSVRPAMWK MMLNIDVSAT AFYKAQPVIE FMCEVLDIRN 
IDEQPKPLTD SQRVRFTKEI KGLKVEVTHC GQMKRKYRVC NVTRRPASHQ TFPLQLESGQ 
TVECTVAQYF KQKYNLQLKY PHLPCLQVGQ EQKHTYLPLE VCNIVAGQRC IKKLTDNQTS 
TMIKATARSA PDRQEEISRL MKNASYNLDP YIQEFGIKVK DDMTEVTGRV LPAPILQYGG 
RNRAIATPNQ GVWDMRGKQF YNGIEIKVWA IACFAPQKQC REEVLKNFTD QLRKISKDAG 
MPIQGQPCFC KYAQGADSVE PMFRHLKNTY SGLQLIIVIL PGKTPVYAEV KRVGDTLLGM 
ATQCVQVKNV VKTSPQTLSN LCLKINVKLG GINNILVPHQ RSAVFQQPVI FLGADVTHPP 
AGDGKKPSIT AVVGSMDAHP SRYCATVRVQ RPRQEIIEDL SYMVRELLIQ FYKSTRFKPT 
RIIFYRDGVP EGQLPQILHY ELLAIRDACI KLEKDYQPGI TYIVVQKRHH TRLFCADKNE 
RIGKSGNIPA GTTVDTNITH PFEFDFYLCS HAGIQGTSRP SHYYVLWDDN RFTADELQIL 
TYQLCHTYVR CTRSVSIPAP AYYARLVAFR ARYHLVDKEH DSGEGSHISG QSNGRDPQAL 
AKAVQVHQDT LRTMYFA

Genular Protein ID: 3280262914

Symbol: B2RAD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RAD8

Database IDs:

Sequence Information:

Length: 857
Mass: 97244
Checksum: 5F3903B410EB2399
Sequence:

MEAGPSGAAA SAYLPPLQQV FQAPRRPGIG TVGKPIKLLA NYFEVDIPKI DVYHYEVDIK 
PDKCPRRVNR EVVEYMVQHF KPQIFGDRKP VYDGKKNIYT VTALPIGNER VDFEVTIPGE 
GKDRIFKVSI KWLAIVSWRM LHEALVSGQI PVPLESVQAL DVAMRHLASM RYTPVGRSFF 
SPPEGYYHPL GGGREVWFGF HQSVRPAMWK MMLNIDVSAT AFYKAQPVIE FMCEVLDIRN 
IDEQPKPLTD SQRVRFTKEI KGLKVEVTHC GQMKRKYRVC NVTRRPASHQ TFPLQLESGQ 
TVECTVAQYF KQKYNLQLKY PHLPCLQVGQ EQKHTYLPLE VCNIVAGQRC IKKLTDNQTS 
TMIKATARSA PDRQEEISRL MKNASYNLDP YIQEFGIKVK DDMTEVTGRV LPAPILQYGG 
RNRAIATPNQ GVWDMRGKQF YNGIEIKVWA IACFAPQKQC REEVLKNFTD QLRKISKDAG 
MPIQGQPCFC KYAQGADSVE PMFRHLKNTY SGLQLIIVIL PGKTPVYAEV KRVGDTLLGM 
ATQCVQVKNV VKTSPQTLSN LCLKINVKLG GINNILVPHQ RSAVFQQPVI FLGADVTHPP 
AGDGKKPSIT AVVGSMDAHP SRYCATVRVQ RPRQEIIEDL SYMVRELLIQ FYKSTRFKPT 
RIIFYRDGVP EGQLPQILHY ELLAIRDACI KLEKDYQPGI TYIVVQKRHH TRLFCADKNE 
RIGKSGNIPA GTTVDTNITH PFEFDFYLCS HAGIQGTSRP SHYYVLWDDN RFTADELQIL 
TYQLCHTYVR CTRSVSIPAP AYYARLVAFR ARYHLVDKEH DSGEGSHISG QSNGRDPQAL 
AKAVQVHQDT LRTMYFA

Genular Protein ID: 105027257

Symbol: B3KME0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KME0

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

Length: 782
Mass: 88720
Checksum: E2EFBDF9CE573B0E
Sequence:

MVQHFKPQIF GDRKPVYDGK KNIYTVTALP IGNERVDFEV TIPGEGKDRI FKVSIKWLAI 
VSWRMLHEAL VSGQIPVPLE SVQALDVAMR HLASMRYTPV GRSFFSPPEG YYHPLGGGRE 
VWFGFHQSVR PAMWKMMLNI DVSATAFYKA QPVIEFMCEV LDIRNIDEQP KPLTDSQRVR 
FTKEIKGLKV EVTHCGQMKR KYRVCNVTRR PASHQTFPLQ LESGQTVECT VAQYFKQKYN 
LQLKYPHLPC LQVGQEQKHT YLPLEVCNIV AGQRCIKKLT DNQTSTMIKA TARSAPDRQE 
EISRLMKNAS YNLDPYIQEF GIKVKDDMTE VTGRVLPAPI LQYGGRNRAI ATPNQGVWDM 
RGKQFYNGIE IKVWAIACFA PQKQCREEVL KNFTDQLRKI SKDAGMPIQG QPCFCKYAQG 
ADSVEPMFRH LKNTYSGLQL IIVILPGKTP VYAEVKRVGD TLLGMATQCV QVKNVVKTSP 
QTLSNLCLKI NVKLGGINSI LVPHQRSAVF QQPVIFLGAD VTHPPAGDGK KPSITAVVGS 
MDAHPSRYCA TVRVQRPRQE IIEDLSYMVR ELLIQFYKST RFKPTRIIFC RDGVPEGQLP 
QILHYELLAI RDACIKLEKD YQPGITYIVV QKRHHTRLFC ADKNGRIGKS GNIPAGTTVD 
TNITHPFEFD FYLCSHAGIQ GTSRPSHYYV LWDDNRFTAD ELQILTYQLC HTYVRCTRSV 
SIPAPAYYAR LVAFRARYHL VDKEHDSGEG SHISGQSNGR DPQALAKAVQ VHQDTLRTMY 
FA

Genular Protein ID: 3227723486

Symbol: A0A6I8PTZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A6I8PTZ8

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

Length: 891
Mass: 101179
Checksum: 32E150BA42FAC9E5
Sequence:

MEAGPSGAAA GAYLPPLQQV FQAPRRPGIG TVGKPIKLLA NYFEVDIPKI DVYHYEVDIK 
PDKCPRRVNR EVVEYMVQHF KPQIFGDRKP VYDGKKNIYT VTALPIGNER VDFEVTIPGE 
GKDRIFKVSI KWLAIVSWRM LHEALVSGQI PVPLESVQAL DVAMRHLASM RYTPVGRSFF 
SPPEGYYHPL GGGREVWFGF HQSVRPAMWK MMLNIDVSAT AFYKAQPVIE FMCEVLDIRN 
IDEQPKPLTD SQRVRFTKEI KGLKVEVTHC GQMKRKYRVC NVTRRPASHQ TFPLQLESGQ 
TVECTVAQYF KQKYNLQLKY PHLPCLQVGQ EQKHTYLPLE VCNIVAGQRC IKKLTDNQTS 
TMIKATARSA PDRQEEISRL MKNASYNLDP YIQEFGIKVK DDMTEVTGRV LPAPILQYGG 
RNRAIATPNQ GVWDMRGKQF YNGIEIKVWA IACFAPQKQC REEVLKNFTD QLRKISKDAG 
MPIQGQPCFC KYAQGADSVE PMFRHLKNTY SGLQLIIVIL PGKTPVYAEV KRVGDTLLGM 
ATQCVQVKNV VKTSPQTLSN LCLKINVKLG GINNILVPHQ RSAVFQQPVI FLGADVTHPP 
AGDGKKPSIT AVVGSMDAHP SRYCATVRVQ RPRQEIIEDL SYMVRELLIQ FYKSTRFKPT 
RIIFYRDGVP EGQLPQILHY ELLAIRDACI KLEKDYQPGI TYIVVQKRHH TRLFCADKNE 
RIGKSGNIPA GTTVDTNITH PFEFDFYLCS HAGIQGTSRP SHYYVLWDDN RFTADELQIL 
TYQLCHTYVR CTRSVSIPAP AYYARLVAFR ARYHLVDKEH DSGEGSHISG QSNGRDPQAL 
AKAVQVHQDT LRTMYFAXRQ NAVTSLDRRK LSKPQELCHP NPEEARRREV G

Genular Protein ID: 3945695125

Symbol: Q5TA58_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TA58

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 782
Mass: 88879
Checksum: 9B2F2112E4B56215
Sequence:

MVQHFKPQIF GDRKPVYDGK KNIYTVTALP IGNERVDFEV TIPGEGKDRI FKVSIKWLAI 
VSWRMLHEAL VSGQIPVPLE SVQALDVAMR HLASMRYTPV GRSFFSPPEG YYHPLGGGRE 
VWFGFHQSVR PAMWKMMLNI DVSATAFYKA QPVIEFMCEV LDIRNIDEQP KPLTDSQRVR 
FTKEIKGLKV EVTHCGQMKR KYRVCNVTRR PASHQTFPLQ LESGQTVECT VAQYFKQKYN 
LQLKYPHLPC LQVGQEQKHT YLPLEVCNIV AGQRCIKKLT DNQTSTMIKA TARSAPDRQE 
EISRLMKNAS YNLDPYIQEF GIKVKDDMTE VTGRVLPAPI LQYGGRNRAI ATPNQGVWDM 
RGKQFYNGIE IKVWAIACFA PQKQCREEVL KNFTDQLRKI SKDAGMPIQG QPCFCKYAQG 
ADSVEPMFRH LKNTYSGLQL IIVILPGKTP VYAEVKRVGD TLLGMATQCV QVKNVVKTSP 
QTLSNLCLKI NVKLGGINNI LVPHQRSAVF QQPVIFLGAD VTHPPAGDGK KPSITAVVGS 
MDAHPSRYCA TVRVQRPRQE IIEDLSYMVR ELLIQFYKST RFKPTRIIFY RDGVPEGQLP 
QILHYELLAI RDACIKLEKD YQPGITYIVV QKRHHTRLFC ADKNERIGKS GNIPAGTTVD 
TNITHPFEFD FYLCSHAGIQ GTSRPSHYYV LWDDNRFTAD ELQILTYQLC HTYVRCTRSV 
SIPAPAYYAR LVAFRARYHL VDKEHDSGEG SHISGQSNGR DPQALAKAVQ VHQDTLRTMY 
FA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AGO1

Associated with

Cells (max top 100)

Other Information

Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. PubMed ID: 10534406

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. PubMed ID: 15260970

Identification of novel argonaute-associated proteins. PubMed ID: 16289642

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. PubMed ID: 16936728

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PubMed ID: 16756390

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. PubMed ID: 17932509

Importance of translation and nonnucleolytic ago proteins for on-target RNA interference. PubMed ID: 18771919

Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. PubMed ID: 19167051

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. PubMed ID: 20616046

Initial characterization of the human central proteome. PubMed ID: 21269460

HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. PubMed ID: 22915799

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. PubMed ID: 15152257

Eukaryote-specific insertion elements control human ARGONAUTE slicer activity. PubMed ID: 23809764

The making of a slicer: activation of human Argonaute-1. PubMed ID: 23746446

Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study. PubMed ID: 23020937

De novo mutations in moderate or severe intellectual disability. PubMed ID: 25356899

High diagnostic yield of syndromic intellectual disability by targeted next-generation sequencing. PubMed ID: 27620904

Further evidence of a causal association between AGO1, a critical regulator of microRNA formation, and intellectual disability/autism spectrum disorder. PubMed ID: 30213762

De novo coding variants in the AGO1 gene cause a neurodevelopmental disorder with intellectual disability. PubMed ID: 34930816

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Initial characterization of the human central proteome. PubMed ID: 21269460

Database document:

PubMed ID: 10534406

PubMed ID: 16710414

PubMed ID: 15489334

PubMed ID: 15260970

PubMed ID: 16289642

PubMed ID: 16936728

PubMed ID: 16756390

PubMed ID: 17932509

PubMed ID: 18771919

PubMed ID: 19167051

PubMed ID: 20616046

PubMed ID: 21269460

PubMed ID: 22915799

PubMed ID: 15152257

PubMed ID: 23809764

PubMed ID: 23746446

PubMed ID: 23020937

PubMed ID: 25356899

PubMed ID: 27620904

PubMed ID: 30213762

PubMed ID: 34930816

PubMed ID: 14702039

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16710414

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16710414

PubMed ID: 21269460