Details for: GFER

Gene ID: 2671

Symbol: GFER

Ensembl ID: ENSG00000127554

Description: growth factor, augmenter of liver regeneration

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.93
    Marker Score: 9265
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.88
    Marker Score: 2902
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.86
    Marker Score: 3934.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.35
    Marker Score: 4254
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.17
    Marker Score: 1162
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.17
    Marker Score: 2659
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.07
    Marker Score: 309
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.06
    Marker Score: 1333
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.04
    Marker Score: 4093
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1
    Marker Score: 1478
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71687.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47912
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.99
    Marker Score: 495.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.97
    Marker Score: 1391
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5190
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2691
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.87
    Marker Score: 277
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5227
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.86
    Marker Score: 7490
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.86
    Marker Score: 2033
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.84
    Marker Score: 464
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.83
    Marker Score: 206
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.83
    Marker Score: 1372
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.81
    Marker Score: 305
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.8
    Marker Score: 227
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.8
    Marker Score: 2176
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8
    Marker Score: 27544
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.79
    Marker Score: 792
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.79
    Marker Score: 756
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.76
    Marker Score: 4874.5
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.76
    Marker Score: 184
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.75
    Marker Score: 349
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.74
    Marker Score: 505
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.74
    Marker Score: 296
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.73
    Marker Score: 348
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.72
    Marker Score: 18483
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.71
    Marker Score: 531
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7
    Marker Score: 1467
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.7
    Marker Score: 597
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.7
    Marker Score: 1590.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7
    Marker Score: 2070
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.69
    Marker Score: 438
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.69
    Marker Score: 1908
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 627
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.68
    Marker Score: 710
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2866
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.67
    Marker Score: 634
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.67
    Marker Score: 4093
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.67
    Marker Score: 1191.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.67
    Marker Score: 1270
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.67
    Marker Score: 237
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.67
    Marker Score: 595
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.67
    Marker Score: 705
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.67
    Marker Score: 192
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.67
    Marker Score: 885
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.67
    Marker Score: 354
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.66
    Marker Score: 231
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.66
    Marker Score: 479
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.65
    Marker Score: 1779
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.65
    Marker Score: 699
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 10091
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 425
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.64
    Marker Score: 129
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.64
    Marker Score: 267
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 408
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.64
    Marker Score: 2744
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.63
    Marker Score: 598
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.63
    Marker Score: 1009
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.63
    Marker Score: 235
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.63
    Marker Score: 438
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.63
    Marker Score: 310
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.63
    Marker Score: 4004
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.62
    Marker Score: 149
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.62
    Marker Score: 1001
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.62
    Marker Score: 659
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.62
    Marker Score: 668
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.62
    Marker Score: 413
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.62
    Marker Score: 452
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.61
    Marker Score: 296
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.61
    Marker Score: 138
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.61
    Marker Score: 663
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.61
    Marker Score: 161
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.61
    Marker Score: 160
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.61
    Marker Score: 251
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.6
    Marker Score: 333
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.6
    Marker Score: 2077
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6
    Marker Score: 383
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.6
    Marker Score: 208
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.6
    Marker Score: 153
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.6
    Marker Score: 1018

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Other Information

**Key characteristics:** - GFER is a protein that is highly expressed in liver cells. - It is a member of the ALK family of growth factors. - GFER has been shown to have both pro-apoptotic and pro-regenerative effects on liver cells. - It is involved in the regulation of liver development, regeneration, and homeostasis. **Pathways and functions:** - GFER is involved in the regulation of cell cycle regulation and cell growth. - It promotes cell cycle entry and proliferation in hepatocytes. - It inhibits apoptosis in hepatocytes. - It is involved in the regulation of liver regeneration and homeostasis. - It plays a role in the development of the liver. **Clinical significance:** - Mutations in the GFER gene have been linked to liver diseases, including non-alcoholic fatty liver disease (NAFLD) and cirrhosis. - GFER is a potential therapeutic target for liver diseases. - Inhibition of GFER has been shown to protect liver cells from apoptosis and promote liver regeneration. **Additional notes:** - GFER is a pleiotropic protein that can have both pro-apoptotic and pro-regenerative effects on liver cells. - It is a key regulator of liver regeneration and homeostasis. - It is a promising target for the treatment of liver diseases.

Genular Protein ID: 2211430400

Symbol: ALR_HUMAN

Name: FAD-linked sulfhydryl oxidase ALR

UniProtKB Accession Codes:

P55789 Q53YM6 Q8TAH6 Q9H290 Q9UK40

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 10 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 7 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10712775

Title: Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis.

PubMed ID: 10712775

PubMed ID: 8575761

Title: A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast.

PubMed ID: 8575761

DOI: 10.1006/geno.1995.9950

PubMed ID: 12180965

Title: Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription.

PubMed ID: 12180965

DOI: 10.1046/j.1432-1033.2002.03054.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19397338

Title: Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space.

PubMed ID: 19397338

DOI: 10.1021/bi900347v

PubMed ID: 23676665

Title: Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells.

PubMed ID: 23676665

DOI: 10.1091/mbc.e12-12-0862

PubMed ID: 23186364

Title: Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40.

PubMed ID: 23186364

DOI: 10.1111/tra.12030

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20593814

Title: Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy.

PubMed ID: 20593814

DOI: 10.1021/bi100912m

PubMed ID: 21383138

Title: Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR.

PubMed ID: 21383138

DOI: 10.1073/pnas.1014542108

PubMed ID: 22224850

Title: An electron-transfer path through an extended disulfide relay system: the case of the redox protein ALR.

PubMed ID: 22224850

DOI: 10.1021/ja209881f

PubMed ID: 19409522

Title: The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.

PubMed ID: 19409522

DOI: 10.1016/j.ajhg.2009.04.004

Sequence Information:

  • Length: 205
  • Mass: 23449
  • Checksum: 43CBF8CCB5BA91C8
  • Sequence:
    • MAAPGERGRF HGGNLFFLPG GARSEMMDDL ATDARGRGAG RRDAAASAST PAQAPTSDSP 
VAEDASRRRP CRACVDFKTW MRTQQKRDTK FREDCPPDRE ELGRHSWAVL HTLAAYYPDL 
PTPEQQQDMA QFIHLFSKFY PCEECAEDLR KRLCRNHPDT RTRACFTQWL CHLHNEVNRK 
LGKPDFDCSK VDERWRDGWK DGSCD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.