Details for: COPG2

Gene ID: 26958

Symbol: COPG2

Ensembl ID: ENSG00000158623

Description: COPI coat complex subunit gamma 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 172.8758
    Cell Significance Index: -26.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.7275
    Cell Significance Index: -25.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.5405
    Cell Significance Index: -22.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.0693
    Cell Significance Index: -22.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.3203
    Cell Significance Index: -27.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9076
    Cell Significance Index: -29.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0463
    Cell Significance Index: -27.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.9673
    Cell Significance Index: -13.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.0172
    Cell Significance Index: 44.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6969
    Cell Significance Index: 322.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6511
    Cell Significance Index: 92.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3295
    Cell Significance Index: 919.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2588
    Cell Significance Index: 252.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0881
    Cell Significance Index: 107.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0356
    Cell Significance Index: 14.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8280
    Cell Significance Index: 747.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8025
    Cell Significance Index: 50.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7556
    Cell Significance Index: 149.9500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6861
    Cell Significance Index: 8.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6407
    Cell Significance Index: 229.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5968
    Cell Significance Index: 26.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5878
    Cell Significance Index: 95.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5809
    Cell Significance Index: 63.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5686
    Cell Significance Index: 21.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4720
    Cell Significance Index: 24.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4186
    Cell Significance Index: 6.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4164
    Cell Significance Index: 60.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3836
    Cell Significance Index: 23.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3278
    Cell Significance Index: 9.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3225
    Cell Significance Index: 37.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2920
    Cell Significance Index: 22.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2383
    Cell Significance Index: 16.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2069
    Cell Significance Index: 13.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1990
    Cell Significance Index: 5.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1456
    Cell Significance Index: 26.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1389
    Cell Significance Index: 3.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1316
    Cell Significance Index: 2.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1231
    Cell Significance Index: 2.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1190
    Cell Significance Index: 65.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1122
    Cell Significance Index: 2.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1119
    Cell Significance Index: 49.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1004
    Cell Significance Index: 2.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0814
    Cell Significance Index: 0.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0768
    Cell Significance Index: 10.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0627
    Cell Significance Index: 39.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0384
    Cell Significance Index: 1.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0362
    Cell Significance Index: 4.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0357
    Cell Significance Index: 65.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0355
    Cell Significance Index: 66.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0344
    Cell Significance Index: 4.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0285
    Cell Significance Index: 43.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0223
    Cell Significance Index: 10.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0064
    Cell Significance Index: 8.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0198
    Cell Significance Index: -2.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0271
    Cell Significance Index: -19.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0279
    Cell Significance Index: -20.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0333
    Cell Significance Index: -25.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0435
    Cell Significance Index: -3.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0454
    Cell Significance Index: -2.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0459
    Cell Significance Index: -25.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0495
    Cell Significance Index: -30.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0744
    Cell Significance Index: -12.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0782
    Cell Significance Index: -10.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0819
    Cell Significance Index: -3.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0976
    Cell Significance Index: -28.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1232
    Cell Significance Index: -4.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1286
    Cell Significance Index: -3.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1325
    Cell Significance Index: -13.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1390
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1393
    Cell Significance Index: -29.3500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1490
    Cell Significance Index: -1.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1617
    Cell Significance Index: -3.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1698
    Cell Significance Index: -5.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1752
    Cell Significance Index: -20.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1939
    Cell Significance Index: -4.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2009
    Cell Significance Index: -6.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2171
    Cell Significance Index: -11.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2386
    Cell Significance Index: -24.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2641
    Cell Significance Index: -17.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2901
    Cell Significance Index: -13.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3047
    Cell Significance Index: -6.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3059
    Cell Significance Index: -5.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3109
    Cell Significance Index: -8.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3121
    Cell Significance Index: -24.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3270
    Cell Significance Index: -6.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3289
    Cell Significance Index: -17.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3500
    Cell Significance Index: -21.4600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3690
    Cell Significance Index: -4.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3790
    Cell Significance Index: -12.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3838
    Cell Significance Index: -7.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3848
    Cell Significance Index: -5.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3994
    Cell Significance Index: -5.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3995
    Cell Significance Index: -13.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4071
    Cell Significance Index: -10.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4398
    Cell Significance Index: -8.8300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4407
    Cell Significance Index: -5.5000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4600
    Cell Significance Index: -2.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4777
    Cell Significance Index: -10.0000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4840
    Cell Significance Index: -6.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **COPI Complex Subunit**: COPG2 is a subunit of the COPI-coated vesicle complex, which is essential for regulating membrane trafficking and protein secretion. 2. **Anterograde and Retrograde Transport**: COPG2 is involved in the transport of proteins and lipids between the ER and the Golgi apparatus, facilitating both anterograde (from ER to Golgi) and retrograde (from Golgi to ER) transport. 3. **Cell Type Specificity**: COPG2 is significantly expressed in various cell types, including cardiac muscle cells, epicardial adipocytes, mural cells, and GABAergic cortical interneurons, highlighting its importance in maintaining cellular homeostasis and regulating the secretory pathway. 4. **Protein Modification and Secretion**: COPG2 is involved in the modification and secretion of proteins, which is crucial for maintaining cellular function and regulating various physiological processes. **Pathways and Functions:** 1. **Asparagine N-Linked Glycosylation**: COPG2 is involved in the regulation of asparagine N-linked glycosylation, a post-translational modification process that is essential for protein function and secretion. 2. **CopI-Dependent Golgi-to-ER Retrograde Traffic**: COPG2 plays a critical role in the regulation of retrograde transport from the Golgi apparatus to the ER, ensuring the proper folding and secretion of proteins. 3. **CopI-Mediated Anterograde Transport**: COPG2 is involved in the regulation of anterograde transport from the ER to the Golgi apparatus, facilitating the delivery of proteins and lipids to the Golgi apparatus for modification and secretion. 4. **Endoplasmic Reticulum to Golgi Vesicle-Mediated Transport**: COPG2 regulates the formation and transport of COPI-coated vesicles, which are essential for the delivery of proteins and lipids between the ER and the Golgi apparatus. **Clinical Significance:** 1. **Dysregulation of Membrane Trafficking**: Abnormalities in COPG2 function or expression have been implicated in various diseases, including neurodegenerative disorders, cancer, and cardiovascular diseases. 2. **Protein Secretion Disorders**: Dysregulation of COPG2 function can lead to protein secretion disorders, such as amyloidosis and other protein-related diseases. 3. **Therapeutic Targeting**: Understanding the function and regulation of COPG2 has implications for the development of therapeutic strategies targeting membrane trafficking and protein secretion pathways. 4. **Cellular Homeostasis**: COPG2's role in regulating membrane trafficking and protein secretion highlights its importance in maintaining cellular homeostasis and regulating various physiological processes. In conclusion, COPG2 is a critical component of the COPI-coated vesicle complex, playing a vital role in regulating membrane trafficking and protein secretion within cells. Its dysregulation has been implicated in various diseases, and understanding its function and regulation has significant implications for the development of therapeutic strategies targeting membrane trafficking and protein secretion pathways.

Genular Protein ID: 134274901

Symbol: COPG2_HUMAN

Name: Coatomer subunit gamma-2

UniProtKB Accession Codes:

Q9UBF2 A6NH74 Q2NLA0 Q54AC3 Q8WVW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10556286

Title: Gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome.

PubMed ID: 10556286

DOI: 10.1093/hmg/8.13.2387

PubMed ID: 11056392

Title: Identification and characterization of novel isoforms of COP I subunits.

PubMed ID: 11056392

DOI: 10.1093/oxfordjournals.jbchem.a022817

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25129144

Title: JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia.

PubMed ID: 25129144

DOI: 10.1038/ng.3069

Sequence Information:

  • Length: 871
  • Mass: 97622
  • Checksum: D361A0E74069CBEB
  • Sequence:
    • MIKKFDKKDE ESGSGSNPFQ HLEKSAVLQE ARIFNETPIN PRRCLHILTK ILYLLNQGEH 
FGTTEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMATISE DVIIVTSSLT KDMTGKEDVY 
RGPAIRALCR ITDGTMLQAI ERYMKQAIVD KVSSVSSSAL VSSLHMMKIS YDVVKRWINE 
AQEAASSDNI MVQYHALGVL YHLRKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL 
KETEDGHESP LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK 
PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK TGSESSVDRL 
MKQISSFVSE ISDEFKVVVV QAISALCQKY PRKHSVMMTF LSNMLRDDGG FEYKRAIVDC 
IISIVEENPE SKEAGLAHLC EFIEDCEHTV LATKILHLLG KEGPRTPVPS KYIRFIFNRV 
VLENEAVRAA AVSALAKFGA QNESLLPSIL VLLQRCMMDT DDEVRDRATF YLNVLQQRQM 
ALNATYIFNG LTVSVPGMEK ALHQYTLEPS EKPFDMKSIP LAMAPVFEQK AEITLVATKP 
EKLAPSRQDI FQEQLAAIPE FLNIGPLFKS SEPVQLTEAE TEYFVRCIKH MFTNHIVFQF 
DCTNTLNDQL LEKVTVQMEP SDSYEVLSCI PAPSLPYNQP GICYTLVRLP DDDPTAVAGS 
FSCTMKFTVR DCDPNTGVPD EDGYDDEYVL EDLEVTVSDH IQKVLKPNFA AAWEEVGDTF 
EKEETFALSS TKTLEEAVNN IITFLGMQPC ERSDKVPENK NSHSLYLAGI FRGGYDLLVR 
SRLALADGVT MQVTVRSKER TPVDVILASV G

Genular Protein ID: 3384414703

Symbol: Q9NSM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NSM7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 133
  • Mass: 14862
  • Checksum: 86F045E58106E0B1
  • Sequence:
    • TLVATKPEKL APSRQDIFQE QLAAIPEFLN IGPLFKSSEP VQLTEAETEY FVRCIKHMFT 
NHIVFQFDCT NTLNDQLLEK VTVQMEPSDS YEVLSCIPAP SLPYNQPGIC YTLVRLPDDD 
PTAGTNPQKG GDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.