Details for: FOXB1

Gene ID: 27023

Symbol: FOXB1

Ensembl ID: ENSG00000171956

Description: forkhead box B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.1402
    Cell Significance Index: 15.8200
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.1383
    Cell Significance Index: 6.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7251
    Cell Significance Index: 17.5700
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.6963
    Cell Significance Index: 1.7200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5619
    Cell Significance Index: 8.1900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.5601
    Cell Significance Index: 6.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4350
    Cell Significance Index: 6.2300
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.2517
    Cell Significance Index: 1.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1930
    Cell Significance Index: 4.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1768
    Cell Significance Index: 4.5400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.1049
    Cell Significance Index: 0.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1004
    Cell Significance Index: 1.7200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0790
    Cell Significance Index: 1.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0601
    Cell Significance Index: 1.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0059
    Cell Significance Index: 0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0047
    Cell Significance Index: 0.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0039
    Cell Significance Index: 2.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0036
    Cell Significance Index: 0.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0034
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0012
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0006
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -1.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0009
    Cell Significance Index: -0.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0025
    Cell Significance Index: -0.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0027
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0029
    Cell Significance Index: -1.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0044
    Cell Significance Index: -0.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0054
    Cell Significance Index: -0.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0056
    Cell Significance Index: -0.1500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0069
    Cell Significance Index: -0.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0071
    Cell Significance Index: -0.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0076
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0084
    Cell Significance Index: -1.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0102
    Cell Significance Index: -1.2600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0115
    Cell Significance Index: -0.1500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0116
    Cell Significance Index: -0.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0116
    Cell Significance Index: -0.8200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0118
    Cell Significance Index: -0.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0121
    Cell Significance Index: -1.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0125
    Cell Significance Index: -1.4800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0127
    Cell Significance Index: -0.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0140
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0146
    Cell Significance Index: -1.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0149
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0192
    Cell Significance Index: -1.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0209
    Cell Significance Index: -1.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0238
    Cell Significance Index: -1.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0251
    Cell Significance Index: -0.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0253
    Cell Significance Index: -1.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0258
    Cell Significance Index: -0.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0271
    Cell Significance Index: -1.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0285
    Cell Significance Index: -1.3400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0295
    Cell Significance Index: -0.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0300
    Cell Significance Index: -1.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0300
    Cell Significance Index: -1.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0307
    Cell Significance Index: -0.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0308
    Cell Significance Index: -1.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0327
    Cell Significance Index: -0.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0331
    Cell Significance Index: -1.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0347
    Cell Significance Index: -1.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0361
    Cell Significance Index: -1.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0367
    Cell Significance Index: -1.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0370
    Cell Significance Index: -0.9900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0381
    Cell Significance Index: -0.5400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0387
    Cell Significance Index: -1.2300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0413
    Cell Significance Index: -0.5300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0424
    Cell Significance Index: -1.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0438
    Cell Significance Index: -0.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0440
    Cell Significance Index: -0.6100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0466
    Cell Significance Index: -0.6000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0469
    Cell Significance Index: -0.4500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0475
    Cell Significance Index: -0.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0475
    Cell Significance Index: -1.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0481
    Cell Significance Index: -1.3100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0495
    Cell Significance Index: -0.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0496
    Cell Significance Index: -1.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0497
    Cell Significance Index: -1.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0499
    Cell Significance Index: -1.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0500
    Cell Significance Index: -1.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0505
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0511
    Cell Significance Index: -1.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0516
    Cell Significance Index: -1.0400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0523
    Cell Significance Index: -0.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0532
    Cell Significance Index: -1.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0549
    Cell Significance Index: -1.4000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0552
    Cell Significance Index: -0.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0556
    Cell Significance Index: -0.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0558
    Cell Significance Index: -1.6000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0565
    Cell Significance Index: -0.6400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0570
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The FOXB1 gene exhibits several key characteristics that highlight its importance in cellular processes. These include: 1. **Transcriptional regulation**: FOXB1 acts as a transcription factor, binding to specific DNA sequences to regulate gene expression. 2. **Developmental expression**: FOXB1 is highly expressed during embryonic development and tissue differentiation, suggesting its role in regulating cellular processes during these stages. 3. **Cell type specificity**: FOXB1 is expressed in various cell types, including blood vessel endothelial cells, granulocyte monocyte progenitor cells, and intestinal crypt stem cells, indicating its role in specific cellular functions. 4. **Regulation of transcription**: FOXB1 regulates transcription by interacting with RNA polymerase II, a key enzyme involved in gene expression. **Pathways and Functions** FOXB1 is involved in several signaling pathways and cellular processes, including: 1. **Anatomical structure morphogenesis**: FOXB1 regulates the development of various anatomical structures, such as the brain, mammary gland, and urogenital system. 2. **Cell differentiation**: FOXB1 promotes the differentiation of various cell types, including blood vessel endothelial cells and intestinal crypt stem cells. 3. **Cell migration**: FOXB1 regulates the migration of cells during development, including the migration of forebrain radial glial cells and hypothalamic cells. 4. **Epithelial cell differentiation**: FOXB1 regulates the differentiation of epithelial cells in the mammary gland and urogenital system. 5. **Negative regulation of neuron apoptosis**: FOXB1 inhibits apoptosis in neurons, which is essential for neuronal survival and development. **Clinical Significance** The FOXB1 gene has been implicated in various human diseases and disorders, including: 1. **Cancer**: FOXB1 is overexpressed in several types of cancer, including breast cancer and colon cancer, suggesting its potential role as an oncogene. 2. **Neurological disorders**: FOXB1 is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders, such as autism and schizophrenia. 3. **Developmental disorders**: FOXB1 is essential for embryonic development, and its dysregulation has been implicated in developmental disorders, such as neural tube defects and congenital heart defects. In conclusion, the FOXB1 gene plays a crucial role in regulating various cellular processes, including development, differentiation, and migration. Its dysregulation has been implicated in various human diseases and disorders, highlighting the importance of further research into the function and regulation of this gene.

Genular Protein ID: 3781571277

Symbol: FOXB1_HUMAN

Name: Forkhead box protein B1

UniProtKB Accession Codes:

Q99853 O60652 O75917 Q14CL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 325
  • Mass: 34978
  • Checksum: FAEE1B16B1997CB0
  • Sequence:
    • MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY RENTQRWQNS 
LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG SFLRRRKRFK VLKSDHLAPS 
KPADAAQYLQ QQAKLRLSAL AASGTHLPQM PAAAYNLGGV AQPSGFKHPF AIENIIAREY 
KMPGGLAFSA MQPVPAAYPL PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA 
YGVPLKPLCH AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT 
SQSSPATPSE TLTSPASALH SVAVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.