Details for: ZBTB32

Gene ID: 27033

Symbol: ZBTB32

Ensembl ID: ENSG00000011590

Description: zinc finger and BTB domain containing 32

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 31.0521
    Cell Significance Index: -4.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.2790
    Cell Significance Index: -4.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.9174
    Cell Significance Index: -4.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8291
    Cell Significance Index: -4.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4270
    Cell Significance Index: 41.9100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2701
    Cell Significance Index: 19.6500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.4788
    Cell Significance Index: 5.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2065
    Cell Significance Index: 40.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0923
    Cell Significance Index: 18.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0539
    Cell Significance Index: 37.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0341
    Cell Significance Index: 1.5100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0291
    Cell Significance Index: 0.9200
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.0248
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0199
    Cell Significance Index: 36.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0189
    Cell Significance Index: 35.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0166
    Cell Significance Index: 25.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0164
    Cell Significance Index: 1.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0151
    Cell Significance Index: 0.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0149
    Cell Significance Index: 5.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0133
    Cell Significance Index: 2.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0047
    Cell Significance Index: 0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0042
    Cell Significance Index: 5.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0029
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0065
    Cell Significance Index: -0.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0070
    Cell Significance Index: -2.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0081
    Cell Significance Index: -3.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0083
    Cell Significance Index: -4.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0084
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0085
    Cell Significance Index: -5.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0094
    Cell Significance Index: -1.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0098
    Cell Significance Index: -0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0142
    Cell Significance Index: -1.7500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0157
    Cell Significance Index: -0.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0168
    Cell Significance Index: -0.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0171
    Cell Significance Index: -2.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0179
    Cell Significance Index: -0.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0180
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0200
    Cell Significance Index: -3.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0218
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0239
    Cell Significance Index: -5.0400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0303
    Cell Significance Index: -0.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0331
    Cell Significance Index: -4.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0376
    Cell Significance Index: -3.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0400
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0428
    Cell Significance Index: -4.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0451
    Cell Significance Index: -2.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0454
    Cell Significance Index: -4.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0628
    Cell Significance Index: -3.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0692
    Cell Significance Index: -5.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0864
    Cell Significance Index: -1.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0865
    Cell Significance Index: -3.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0882
    Cell Significance Index: -4.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0883
    Cell Significance Index: -4.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0905
    Cell Significance Index: -3.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0911
    Cell Significance Index: -2.9000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0913
    Cell Significance Index: -3.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0919
    Cell Significance Index: -4.3200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0984
    Cell Significance Index: -1.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0996
    Cell Significance Index: -3.2600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1017
    Cell Significance Index: -0.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1022
    Cell Significance Index: -2.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1046
    Cell Significance Index: -2.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1080
    Cell Significance Index: -2.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1120
    Cell Significance Index: -3.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1156
    Cell Significance Index: -3.3000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1171
    Cell Significance Index: -1.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1221
    Cell Significance Index: -4.2900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1252
    Cell Significance Index: -1.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1317
    Cell Significance Index: -6.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1322
    Cell Significance Index: -2.5800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1329
    Cell Significance Index: -1.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1331
    Cell Significance Index: -1.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1387
    Cell Significance Index: -3.3600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1427
    Cell Significance Index: -2.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1459
    Cell Significance Index: -3.6400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1476
    Cell Significance Index: -3.1900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1481
    Cell Significance Index: -1.8000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1493
    Cell Significance Index: -3.7300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1496
    Cell Significance Index: -1.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1503
    Cell Significance Index: -4.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1506
    Cell Significance Index: -2.1400
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1544
    Cell Significance Index: -1.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1557
    Cell Significance Index: -3.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1568
    Cell Significance Index: -3.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1586
    Cell Significance Index: -5.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1589
    Cell Significance Index: -3.1900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1619
    Cell Significance Index: -2.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1619
    Cell Significance Index: -4.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1646
    Cell Significance Index: -4.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1650
    Cell Significance Index: -2.7800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1704
    Cell Significance Index: -4.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1704
    Cell Significance Index: -4.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1719
    Cell Significance Index: -8.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1728
    Cell Significance Index: -6.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1740
    Cell Significance Index: -5.1300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1763
    Cell Significance Index: -2.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1783
    Cell Significance Index: -5.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZBTB32 acts as a transcriptional regulator, influencing the expression of genes involved in immune responses, cell development, and tissue homeostasis. 2. **Zinc Finger Motifs:** The protein contains zinc finger motifs, which are essential for DNA binding and recognition of specific sequences. 3. **BTB Domain:** The BTB domain is a characteristic feature of BTB family transcription factors, which is involved in dimerization and DNA binding. 4. **Cellular Expression:** ZBTB32 is expressed in various cell types, including immune cells, neurons, and epithelial cells, indicating its broad functional scope. **Pathways and Functions:** 1. **Chromatin Remodeling:** ZBTB32 is involved in chromatin remodeling, which is essential for the regulation of gene expression. 2. **DNA Binding:** The protein binds to specific DNA sequences, influencing the expression of target genes. 3. **Transcriptional Repression:** ZBTB32 acts as a transcriptional repressor, regulating the expression of genes involved in immune responses and cell development. 4. **Immune System Regulation:** The protein is involved in the regulation of immune responses, including the production of cytokines and the activation of immune cells. 5. **Cell Development and Homeostasis:** ZBTB32 plays a role in cell development and tissue homeostasis, influencing the expression of genes involved in these processes. **Clinical Significance:** 1. **Immune System Disorders:** Abnormalities in ZBTB32 expression have been implicated in various immune system disorders, including autoimmune diseases and immunodeficiency disorders. 2. **Cancer:** The protein's role in cell development and homeostasis makes it a potential target for cancer therapy. 3. **Neurological Disorders:** ZBTB32's expression in neurons and its involvement in chromatin remodeling suggest its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Regenerative Medicine:** The protein's ability to regulate gene expression makes it a potential candidate for regenerative medicine applications, including tissue engineering and stem cell therapy. In conclusion, ZBTB32 is a multifunctional transcriptional regulator that plays a crucial role in various cellular processes, including immune responses, cell development, and tissue homeostasis. Its clinical significance extends to various diseases, including immune system disorders, cancer, and neurological disorders, making it an important target for therapeutic interventions.

Genular Protein ID: 470836131

Symbol: ZBT32_HUMAN

Name: Zinc finger and BTB domain-containing protein 32

UniProtKB Accession Codes:

Q9Y2Y4 Q8WVP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10544010

Title: Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP.

PubMed ID: 10544010

DOI: 10.1006/bbrc.1999.1594

PubMed ID: 10572087

Title: A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF.

PubMed ID: 10572087

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20493880

Title: Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.

PubMed ID: 20493880

DOI: 10.1016/j.jmb.2010.05.028

Sequence Information:

  • Length: 487
  • Mass: 52963
  • Checksum: B528F3C2AFFC4838
  • Sequence:
    • MSLPPIRLPS PYGSDRLVQL AARLRPALCD TLITVGSQEF PAHSLVLAGV SQQLGRRGQW 
ALGEGISPST FAQLLNFVYG ESVELQPGEL RPLQEAARAL GVQSLEEACW RARGDRAKKP 
DPGLKKHQEE PEKPSRNPER ELGDPGEKQK PEQVSRTGGR EQEMLHKHSP PRGRPEMAGA 
TQEAQQEQTR SKEKRLQAPV GQRGADGKHG VLTWLRENPG GSEESLRKLP GPLPPAGSLQ 
TSVTPRPSWA EAPWLVGGQP ALWSILLMPP RYGIPFYHST PTTGAWQEVW REQRIPLSLN 
APKGLWSQNQ LASSSPTPGS LPQGPAQLSP GEMEESDQGH TGALATCAGH EDKAGCPPRP 
HPPPAPPARS RPYACSVCGK RFSLKHQMET HYRVHTGEKP FSCSLCPQRS RDFSAMTKHL 
RTHGAAPYRC SLCGAGCPSL ASMQAHMRGH SPSQLPPGWT IRSTFLYSSS RPSRPSTSPC 
CPSSSTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.