Details for: MTBP

Gene ID: 27085

Symbol: MTBP

Ensembl ID: ENSG00000172167

Description: MDM2 binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 62.6827
    Cell Significance Index: -9.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.3322
    Cell Significance Index: -10.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.0150
    Cell Significance Index: -9.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.8246
    Cell Significance Index: -9.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4918
    Cell Significance Index: -10.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8897
    Cell Significance Index: -10.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3531
    Cell Significance Index: -5.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2531
    Cell Significance Index: 70.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0088
    Cell Significance Index: 200.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8514
    Cell Significance Index: 18.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7230
    Cell Significance Index: 71.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6037
    Cell Significance Index: 114.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6030
    Cell Significance Index: 120.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4222
    Cell Significance Index: 11.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3633
    Cell Significance Index: 7.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3567
    Cell Significance Index: 38.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3537
    Cell Significance Index: 57.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3305
    Cell Significance Index: 6.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2981
    Cell Significance Index: 17.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2479
    Cell Significance Index: 223.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1770
    Cell Significance Index: 63.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1238
    Cell Significance Index: 7.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1211
    Cell Significance Index: 3.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1131
    Cell Significance Index: 7.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1088
    Cell Significance Index: 2.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1039
    Cell Significance Index: 1.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0958
    Cell Significance Index: 2.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0830
    Cell Significance Index: 3.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0823
    Cell Significance Index: 11.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0737
    Cell Significance Index: 2.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0682
    Cell Significance Index: 3.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0664
    Cell Significance Index: 4.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0601
    Cell Significance Index: 41.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0509
    Cell Significance Index: 9.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0314
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0214
    Cell Significance Index: 40.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0202
    Cell Significance Index: 8.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0191
    Cell Significance Index: 2.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0190
    Cell Significance Index: 25.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0149
    Cell Significance Index: 27.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0138
    Cell Significance Index: 0.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0126
    Cell Significance Index: 6.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0120
    Cell Significance Index: 0.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0097
    Cell Significance Index: 14.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0094
    Cell Significance Index: 1.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0071
    Cell Significance Index: 4.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0065
    Cell Significance Index: 2.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0130
    Cell Significance Index: -9.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0147
    Cell Significance Index: -11.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0174
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0191
    Cell Significance Index: -11.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0198
    Cell Significance Index: -11.1600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0207
    Cell Significance Index: -0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0222
    Cell Significance Index: -0.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0292
    Cell Significance Index: -8.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0301
    Cell Significance Index: -3.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0369
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0383
    Cell Significance Index: -6.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0410
    Cell Significance Index: -2.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0414
    Cell Significance Index: -5.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0429
    Cell Significance Index: -2.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0500
    Cell Significance Index: -2.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0502
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0558
    Cell Significance Index: -11.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0564
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0650
    Cell Significance Index: -7.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0681
    Cell Significance Index: -1.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0715
    Cell Significance Index: -7.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0733
    Cell Significance Index: -7.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0779
    Cell Significance Index: -10.0600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0982
    Cell Significance Index: -1.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0998
    Cell Significance Index: -7.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1011
    Cell Significance Index: -1.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1035
    Cell Significance Index: -5.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1081
    Cell Significance Index: -5.0800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1179
    Cell Significance Index: -1.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1200
    Cell Significance Index: -7.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1215
    Cell Significance Index: -3.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1289
    Cell Significance Index: -10.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1332
    Cell Significance Index: -9.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1350
    Cell Significance Index: -4.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1353
    Cell Significance Index: -2.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1423
    Cell Significance Index: -7.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1462
    Cell Significance Index: -4.7900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1546
    Cell Significance Index: -2.2200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1593
    Cell Significance Index: -2.0100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1705
    Cell Significance Index: -2.4000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1837
    Cell Significance Index: -1.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1856
    Cell Significance Index: -3.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1907
    Cell Significance Index: -4.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1918
    Cell Significance Index: -2.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1938
    Cell Significance Index: -5.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2029
    Cell Significance Index: -7.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2115
    Cell Significance Index: -7.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2136
    Cell Significance Index: -4.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2210
    Cell Significance Index: -5.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2245
    Cell Significance Index: -4.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The MTBP gene exhibits several key characteristics that underscore its importance in regulating cell cycle progression: 1. **Cell type specificity**: MTBP is significantly expressed in specific cell types, including retinal bipolar neurons, mural cells, and intestinal epithelial cells, suggesting a specialized role in these cell types. 2. **Interactions with MDM2**: MTBP interacts with the oncogene MDM2, modulating its activity and preventing excessive cell proliferation. 3. **Negative regulation of cell proliferation**: MTBP is involved in the negative regulation of cell population proliferation, preventing uncontrolled cell growth. 4. **Regulation of mitotic nuclear division**: MTBP plays a role in regulating mitotic nuclear division, ensuring proper cell division and preventing errors. **Pathways and Functions** The MTBP gene is involved in several key pathways, including: 1. **Cell cycle regulation**: MTBP regulates cell cycle progression, particularly in the negative regulation of cell population proliferation and mitotic nuclear division. 2. **Chromatin regulation**: MTBP interacts with chromatin, influencing gene expression and cell cycle progression. 3. **Kinetochore regulation**: MTBP regulates protein localization to the kinetochore, ensuring proper chromosome segregation during mitosis. 4. **Protein ubiquitination regulation**: MTBP modulates protein ubiquitination, influencing protein degradation and cell cycle progression. 5. **Traversing start control point of mitotic cell cycle**: MTBP regulates the start control point of the mitotic cell cycle, ensuring proper cell division. **Clinical Significance** The MTBP gene's dysregulation has been implicated in various cancers, including: 1. **Oncogenesis**: MTBP's interaction with MDM2 can lead to oncogenesis by preventing the degradation of MDM2, thereby promoting cell proliferation. 2. **Cancer progression**: MTBP's dysregulation can contribute to cancer progression by promoting uncontrolled cell growth and tumor formation. 3. **Cancer therapy**: Targeting MTBP or MDM2 may provide a new therapeutic strategy for cancer treatment. In conclusion, the MTBP gene plays a critical role in regulating cell cycle progression and preventing excessive cell proliferation. Its dysregulation has been implicated in various cancers, highlighting its clinical significance in cancer biology. Further research is needed to fully elucidate the mechanisms underlying MTBP's functions and its potential as a therapeutic target.

Genular Protein ID: 1442626531

Symbol: MTBP_HUMAN

Name: Mdm2-binding protein

UniProtKB Accession Codes:

Q96DY7 B4DUR5 Q9HA89

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632057

Title: Regulation of p53 and MDM2 activity by MTBP.

PubMed ID: 15632057

DOI: 10.1128/mcb.25.2.545-553.2005

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 904
  • Mass: 102193
  • Checksum: 753DF4A98AB62E4F
  • Sequence:
    • MDRYLLLVIW GEGKFPSAAS REAEHGPEVS SGEGTENQPD FTAANVYHLL KRSISASINP 
EDSTFPACSV GGIPGSKKWF FAVQAIYGFY QFCSSDWQEI HFDTEKDKIE DVLQTNIEEC 
LGAVECFEEE DSNSRESLSL ADLYEEAAEN LHQLSDKLPA PGRAMVDIIL LLSDKDPPKL 
KDYLPTVGAL KHLREWYSAK ITIAGNHCEI NCQKIAEYLS ANVVSLEDLR NVIDSKELWR 
GKIQIWERKF GFEISFPEFC LKGVTLKNFS TSNLNTDFLA KKIIPSKDKN ILPKVFHYYG 
PALEFVQMIK LSDLPSCYMS DIEFELGLTN STKQNSVLLL EQISSLCSKV GALFVLPCTI 
SNILIPPPNQ LSSRKWKEYI AKKPKTISVP DVEVKGECSS YYLLLQGNGN RRCKATLIHS 
ANQINGSFAL NLIHGKMKTK TEEAKLSFPF DLLSLPHFSG EQIVQREKQL ANVQVLALEE 
CLKRRKLAKQ PETVSVAELK SLLVLTRKHF LDYFDAVIPK MILRKMDKIK TFNILNDFSP 
VEPNSSSLME TNPLEWPERH VLQNLETFEK TKQKMRTGSL PHSSEQLLGH KEGPRDSITL 
LDAKELLKYF TSDGLPIGDL QPLPIQKGEK TFVLTPELSP GKLQVLPFEK ASVCHYHGIE 
YCLDDRKALE RDGGFSELQS RLIRYETQTT CTRESFPVPT VLSPLPSPVV SSDPGSVPDG 
EVLQNELRTE VSRLKRRSKD LNCLYPRKRL VKSESSESLL SQTTGNSNHY HHHVTSRKPQ 
TERSLPVTCP LVPIPSCETP KLATKTSSGQ KSMHESKTSR QIKESRSQKH TRILKEVVTE 
TLKKHSITET HECFTACSQR LFEISKFYLK DLKTSRGLFE EMKKTANNNA VQVIDWVLEK 
TSKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.