Details for: SMC1B

Gene ID: 27127

Symbol: SMC1B

Ensembl ID: ENSG00000077935

Description: structural maintenance of chromosomes 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 28.9305
    Cell Significance Index: -4.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.3275
    Cell Significance Index: -4.4000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 6.1193
    Cell Significance Index: 46.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.8039
    Cell Significance Index: -4.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2997
    Cell Significance Index: 58.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.7950
    Cell Significance Index: -1.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4546
    Cell Significance Index: 7.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2469
    Cell Significance Index: 49.0000
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.2041
    Cell Significance Index: 1.2600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1635
    Cell Significance Index: 2.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1485
    Cell Significance Index: 4.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1042
    Cell Significance Index: 0.9600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0845
    Cell Significance Index: 0.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0767
    Cell Significance Index: 0.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0681
    Cell Significance Index: 1.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0664
    Cell Significance Index: 13.3200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0638
    Cell Significance Index: 0.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0563
    Cell Significance Index: 3.1600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0464
    Cell Significance Index: 0.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0425
    Cell Significance Index: 6.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0385
    Cell Significance Index: 59.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0365
    Cell Significance Index: 1.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0316
    Cell Significance Index: 1.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0272
    Cell Significance Index: 3.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0249
    Cell Significance Index: 2.4700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0223
    Cell Significance Index: 0.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0223
    Cell Significance Index: 15.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0195
    Cell Significance Index: 2.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0176
    Cell Significance Index: 2.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0172
    Cell Significance Index: 32.3700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0162
    Cell Significance Index: 0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0149
    Cell Significance Index: 20.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0125
    Cell Significance Index: 23.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0107
    Cell Significance Index: 3.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0107
    Cell Significance Index: 0.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0093
    Cell Significance Index: 1.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0082
    Cell Significance Index: 1.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0044
    Cell Significance Index: 2.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0022
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0052
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0085
    Cell Significance Index: -5.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0087
    Cell Significance Index: -0.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0098
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0109
    Cell Significance Index: -0.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0132
    Cell Significance Index: -3.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0165
    Cell Significance Index: -0.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0180
    Cell Significance Index: -0.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0212
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0248
    Cell Significance Index: -5.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0286
    Cell Significance Index: -3.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0295
    Cell Significance Index: -3.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0296
    Cell Significance Index: -1.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0297
    Cell Significance Index: -2.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0315
    Cell Significance Index: -0.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0321
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0361
    Cell Significance Index: -4.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0363
    Cell Significance Index: -4.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0364
    Cell Significance Index: -1.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0366
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0369
    Cell Significance Index: -3.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0390
    Cell Significance Index: -1.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0390
    Cell Significance Index: -0.8300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0420
    Cell Significance Index: -0.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0439
    Cell Significance Index: -4.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0466
    Cell Significance Index: -2.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0573
    Cell Significance Index: -0.7500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0575
    Cell Significance Index: -0.8600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0578
    Cell Significance Index: -1.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0582
    Cell Significance Index: -1.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0633
    Cell Significance Index: -3.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0662
    Cell Significance Index: -4.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0674
    Cell Significance Index: -5.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0820
    Cell Significance Index: -5.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0845
    Cell Significance Index: -5.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0845
    Cell Significance Index: -3.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0855
    Cell Significance Index: -4.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0870
    Cell Significance Index: -4.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0898
    Cell Significance Index: -2.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0901
    Cell Significance Index: -2.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0917
    Cell Significance Index: -2.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0931
    Cell Significance Index: -4.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0941
    Cell Significance Index: -3.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1024
    Cell Significance Index: -2.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1040
    Cell Significance Index: -2.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1069
    Cell Significance Index: -2.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1072
    Cell Significance Index: -3.0600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1072
    Cell Significance Index: -1.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1076
    Cell Significance Index: -2.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1125
    Cell Significance Index: -1.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1159
    Cell Significance Index: -2.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1180
    Cell Significance Index: -2.4700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1182
    Cell Significance Index: -1.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1246
    Cell Significance Index: -1.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1292
    Cell Significance Index: -3.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Maintenance of Chromosomes (SMC) Complex:** SMC1B is a part of the cohesin complex, which is a multi-protein complex responsible for holding sister chromatids together during cell division. 2. **Highly Conserved Gene:** SMC1B is highly conserved across species, suggesting its essential role in maintaining genome stability. 3. **Cell-Specific Expression:** SMC1B is expressed in various cell types, including retinal cells, germ cells, and epithelial cells, highlighting its importance in different tissues. 4. **Nucleoplasmic Localization:** SMC1B is primarily localized to the nucleoplasm, where it interacts with other cohesin components to maintain sister chromatid cohesion. **Pathways and Functions:** 1. **Cell Cycle Regulation:** SMC1B plays a critical role in regulating the cell cycle, ensuring accurate chromosome segregation and preventing genetic abnormalities. 2. **Meiosis and Mitosis:** SMC1B is involved in both meiotic and mitotic cell divisions, where it maintains sister chromatid cohesion and ensures accurate chromosome segregation. 3. **DNA Binding and Hydrolysis:** SMC1B interacts with DNA-binding proteins, such as topoisomerase II, to regulate chromatin structure and facilitate DNA replication. 4. **Chromosome Condensation:** SMC1B contributes to the condensation of chromosomes during mitosis, ensuring accurate chromosome segregation. **Clinical Significance:** 1. **Cancer Diagnosis and Treatment:** Abnormalities in SMC1B expression have been linked to various types of cancer, including breast, ovarian, and colon cancer. Understanding SMC1B's role in cancer development can lead to the development of novel diagnostic and therapeutic strategies. 2. **Genetic Disorders:** Mutations in SMC1B have been associated with genetic disorders, such as aneuploidy and chromosomal instability. Elucidating the mechanisms underlying SMC1B dysfunction can provide insights into the development of novel therapeutic approaches. 3. **Retinal Diseases:** SMC1B's expression in retinal cells makes it a potential target for the development of novel therapies for retinal diseases, such as age-related macular degeneration. 4. **Epigenetic Regulation:** SMC1B's role in regulating chromatin structure and DNA replication makes it an important player in epigenetic regulation, which is crucial for maintaining genome stability and preventing disease. In conclusion, SMC1B is a crucial gene that plays a vital role in maintaining genome stability. Its dysregulation has been linked to various diseases, including cancer and genetic disorders. Further research into SMC1B's mechanisms of action and its role in different tissues will provide valuable insights into the development of novel diagnostic and therapeutic strategies.

Genular Protein ID: 729191914

Symbol: SMC1B_HUMAN

Name: Structural maintenance of chromosomes protein 1B

UniProtKB Accession Codes:

Q8NDV3 A0AV46 B0QY23 B0QY24 Q5TIC3 Q6ZUF9 Q9Y3G5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14660695

Title: The evolution of SMC proteins: phylogenetic analysis and structural implications.

PubMed ID: 14660695

DOI: 10.1093/molbev/msh023

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 1235
  • Mass: 143789
  • Checksum: 5E72F3B720570843
  • Sequence:
    • MAHLELLLVE NFKSWRGRQV IGPFRRFTCI IGPNGSGKSN VMDALSFVMG EKIANLRVKN 
IQELIHGAHI GKPISSSASV KIIYVEESGE EKTFARIIRG GCSEFRFNDN LVSRSVYIAE 
LEKIGIIVKA QNCLVFQGTV ESISVKKPKE RTQFFEEIST SGELIGEYEE KKRKLQKAEE 
DAQFNFNKKK NIAAERRQAK LEKEEAERYQ SLLEELKMNK IQLQLFQLYH NEKKIHLLNT 
KLEHVNRDLS VKRESLSHHE NIVKARKKEH GMLTRQLQQT EKELKSVETL LNQKRPQYIK 
AKENTSHHLK KLDVAKKSIK DSEKQCSKQE DDIKALETEL ADLDAAWRSF EKQIEEEILH 
KKRDIELEAS QLDRYKELKE QVRKKVATMT QQLEKLQWEQ KTDEERLAFE KRRHGEVQGN 
LKQIKEQIED HKKRIEKLEE YTKTCMDCLK EKKQQEETLV DEIEKTKSRM SEVNEELNLI 
RSELQNAGID THEGKRQQKR AEVLEHLKRL YPDSVFGRLF DLCHPIHKKY QLAVTKVFGR 
FITAIVVASE KVAKDCIRFL KEERAEPETF LALDYLDIKP INERLRELKG CKMVIDVIKT 
QFPQLKKVIQ FVCGNGLVCE TMEEARHIAL SGPERQKTVA LDGTLFLKSG VISGGSSDLK 
YKARCWDEKE LKNLRDRRSQ KIQELKGLMK TLRKETDLKQ IQTLIQGTQT RLKYSQNELE 
MIKKKHLVAF YQEQSQLQSE LLNIESQCIM LSEGIKERQR RIKEFQEKID KVEDDIFQHF 
CEEIGVENIR EFENKHVKRQ QEIDQKRLEF EKQKTRLNVQ LEYSRSHLKK KLNKINTLKE 
TIQKGSEDID HLKKAEENCL QTVNELMAKQ QQLKDIRVTQ NSSAEKVQTQ IEEERKKFLA 
VDREVGKLQK EVVSIQTSLE QKRLEKHNLL LDCKVQDIEI ILLSGSLDDI IEVEMGTEAE 
STQATIDIYE KEEAFEIDYS SLKEDLKALQ SDQEIEAHLR LLLQQVASQE DILLKTAAPN 
LRALENLKTV RDKFQESTDA FEASRKEARL CRQEFEQVKK RRYDLFTQCF EHVSISIDQI 
YKKLCRNNSA QAFLSPENPE EPYLEGISYN CVAPGKRFMP MDNLSGGEKC VAALALLFAV 
HSFRPAPFFV LDEVDAALDN TNIGKVSSYI KEQTQDQFQM IVISLKEEFY SRADALIGIY 
PEYDDCMFSR VLTLDLSQYP DTEGQESSKR HGESR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.