Details for: ZNF777

Gene ID: 27153

Symbol: ZNF777

Ensembl ID: ENSG00000196453

Description: zinc finger protein 777

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.8616
    Cell Significance Index: -10.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.2784
    Cell Significance Index: -10.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.2396
    Cell Significance Index: -9.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.5209
    Cell Significance Index: -9.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.5648
    Cell Significance Index: -10.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.9632
    Cell Significance Index: -6.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5734
    Cell Significance Index: 299.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9876
    Cell Significance Index: 97.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7309
    Cell Significance Index: 659.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6572
    Cell Significance Index: 71.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5133
    Cell Significance Index: 83.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4390
    Cell Significance Index: 5.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4163
    Cell Significance Index: 26.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3837
    Cell Significance Index: 76.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3374
    Cell Significance Index: 23.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2880
    Cell Significance Index: 33.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2315
    Cell Significance Index: 45.9500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2093
    Cell Significance Index: 3.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1997
    Cell Significance Index: 9.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1989
    Cell Significance Index: 5.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1943
    Cell Significance Index: 4.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1871
    Cell Significance Index: 67.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1870
    Cell Significance Index: 129.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1574
    Cell Significance Index: 4.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1544
    Cell Significance Index: 8.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1503
    Cell Significance Index: 2.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1463
    Cell Significance Index: 7.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1377
    Cell Significance Index: 3.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1337
    Cell Significance Index: 24.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1312
    Cell Significance Index: 3.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0970
    Cell Significance Index: 42.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0937
    Cell Significance Index: 51.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0760
    Cell Significance Index: 3.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0636
    Cell Significance Index: 8.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0622
    Cell Significance Index: 3.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0573
    Cell Significance Index: 2.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0461
    Cell Significance Index: 1.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0443
    Cell Significance Index: 2.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0401
    Cell Significance Index: 4.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0386
    Cell Significance Index: 5.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0366
    Cell Significance Index: 2.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0165
    Cell Significance Index: 0.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0141
    Cell Significance Index: 0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0136
    Cell Significance Index: 2.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0134
    Cell Significance Index: 0.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0022
    Cell Significance Index: 4.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0014
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0041
    Cell Significance Index: -2.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0053
    Cell Significance Index: -7.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0063
    Cell Significance Index: -9.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -2.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0119
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0143
    Cell Significance Index: -0.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0150
    Cell Significance Index: -1.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0172
    Cell Significance Index: -9.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0193
    Cell Significance Index: -12.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0231
    Cell Significance Index: -2.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0255
    Cell Significance Index: -1.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0298
    Cell Significance Index: -8.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0430
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0572
    Cell Significance Index: -12.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0582
    Cell Significance Index: -7.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0658
    Cell Significance Index: -6.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0700
    Cell Significance Index: -1.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0753
    Cell Significance Index: -3.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0764
    Cell Significance Index: -2.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0771
    Cell Significance Index: -4.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0793
    Cell Significance Index: -1.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0806
    Cell Significance Index: -9.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0972
    Cell Significance Index: -10.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1047
    Cell Significance Index: -2.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1098
    Cell Significance Index: -8.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1102
    Cell Significance Index: -8.7300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1128
    Cell Significance Index: -1.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1163
    Cell Significance Index: -2.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1284
    Cell Significance Index: -2.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1497
    Cell Significance Index: -7.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1531
    Cell Significance Index: -7.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1711
    Cell Significance Index: -4.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1745
    Cell Significance Index: -5.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1824
    Cell Significance Index: -5.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1973
    Cell Significance Index: -3.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2018
    Cell Significance Index: -4.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2022
    Cell Significance Index: -6.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2057
    Cell Significance Index: -4.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2073
    Cell Significance Index: -4.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2083
    Cell Significance Index: -4.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2092
    Cell Significance Index: -7.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2104
    Cell Significance Index: -4.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2161
    Cell Significance Index: -7.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2260
    Cell Significance Index: -4.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2299
    Cell Significance Index: -2.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2324
    Cell Significance Index: -6.1100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2592
    Cell Significance Index: -4.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2642
    Cell Significance Index: -6.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF777 exhibits the following key characteristics: 1. **DNA-binding activity**: ZNF777 possesses a zinc finger motif that allows it to bind to specific DNA sequences, thereby regulating gene expression. 2. **Transcriptional repressor**: ZNF777 functions as a transcriptional repressor, negatively regulating the expression of target genes involved in cell proliferation and differentiation. 3. **Cell-type specificity**: ZNF777 is expressed in various cell types, including neural cells, epithelial cells, and stem cells, suggesting its involvement in tissue development and homeostasis. 4. **Metal ion binding**: ZNF777's zinc finger motif is capable of binding metal ions, which is essential for its DNA-binding activity. **Pathways and Functions:** ZNF777 is involved in several biological pathways, including: 1. **Negative regulation of cell population proliferation**: ZNF777 acts as a transcriptional repressor, inhibiting the expression of genes involved in cell proliferation, thereby regulating cell growth and development. 2. **Negative regulation of DNA-templated transcription**: ZNF777 modulates the transcription of genes involved in DNA replication and repair, ensuring accurate genome maintenance. 3. **Metal ion binding**: ZNF777's zinc finger motif allows it to bind metal ions, which is essential for its DNA-binding activity and transcriptional regulation. 4. **Protein heterooligomerization**: ZNF777 can interact with other proteins, forming heterooligomers that modulate its transcriptional activity. **Clinical Significance:** The dysregulation of ZNF777 has been implicated in various diseases and disorders, including: 1. **Cancer**: ZNF777's role in regulating cell proliferation and differentiation makes it a potential target for cancer therapy. 2. **Neurological disorders**: ZNF777's expression in neural cells suggests its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Intestinal disorders**: ZNF777's expression in intestinal cells highlights its potential role in intestinal disorders, such as inflammatory bowel disease. In conclusion, ZNF777 is a transcription factor that plays a critical role in regulating gene expression, particularly in the context of cell proliferation and differentiation. Its dysregulation has been implicated in various diseases and disorders, making it a potential target for therapeutic intervention. Further research is necessary to fully elucidate the functional significance of ZNF777 and its role in human disease.

Genular Protein ID: 3937435817

Symbol: ZN777_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9ULD5 Q8N2R2 Q8N659

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25560148

Title: Overexpression of zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A.

PubMed ID: 25560148

DOI: 10.1002/jcb.25046

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31856708

Title: DUF3669, a 'domain of unknown function' within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression.

PubMed ID: 31856708

DOI: 10.1186/s12860-019-0243-y

Sequence Information:

  • Length: 831
  • Mass: 93762
  • Checksum: 6AE3346E1A4EDF80
  • Sequence:
    • MENQRSSPLS FPSVPQEETL RQAPAGLPRE TLFQSRVLPP KEIPSLSPTI PRQGSLPQTS 
SAPKQETSGR MPHVLQKGPS LLCSAASEQE TSLQGPLASQ EGTQYPPPAA AEQEVSLLSH 
SPHHQEAPVH SPEAPEKDPL TLSPTVPETD MDPLLQSPVS QKDTPFQISS AVQKEQPLPT 
AEITRLAVWA AVQAVERKLE AQAMRLLTLE GRTGTNEKKI ADCEKTAVEF ANHLESKWVV 
LGTLLQEYGL LQRRLENMEN LLKNRNFWIL RLPPGSNGEV PKVPVTFDDV AVHFSEQEWG 
NLSEWQKELY KNVMRGNYES LVSMDYAISK PDLMSQMERG ERPTMQEQED SEEGETPTDP 
SAAHDGIVIK IEVQTNDEGS ESLETPEPLM GQVEEHGFQD SELGDPCGEQ PDLDMQEPEN 
TLEESTEGSS EFSELKQMLV QQRNCTEGIV IKTEEQDEEE EEEEEDELPQ HLQSLGQLSG 
RYEASMYQTP LPGEMSPEGE ESPPPLQLGN PAVKRLAPSV HGERHLSENR GASSQQQRNR 
RGERPFTCME CGKSFRLKIN LIIHQRNHIK EGPYECAECE ISFRHKQQLT LHQRIHRVRG 
GCVSPERGPT FNPKHALKPR PKSPSSGSGG GGPKPYKCPE CDSSFSHKSS LTKHQITHTG 
ERPYTCPECK KSFRLHISLV IHQRVHAGKH EVSFICSLCG KSFSRPSHLL RHQRTHTGER 
PFKCPECEKS FSEKSKLTNH CRVHSRERPH ACPECGKSFI RKHHLLEHRR IHTGERPYHC 
AECGKRFTQK HHLLEHQRAH TGERPYPCTH CAKCFRYKQS LKYHLRTHTG E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.