Details for: OXGR1

Gene ID: 27199

Symbol: OXGR1

Ensembl ID: ENSG00000165621

Description: oxoglutarate receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9797
    Cell Significance Index: 20.8700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.9167
    Cell Significance Index: 3.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6603
    Cell Significance Index: 65.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5750
    Cell Significance Index: 34.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.5405
    Cell Significance Index: 55.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3512
    Cell Significance Index: 317.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3388
    Cell Significance Index: 55.1100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3330
    Cell Significance Index: 2.8300
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.2648
    Cell Significance Index: 2.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2528
    Cell Significance Index: 13.1300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2446
    Cell Significance Index: 1.5200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2219
    Cell Significance Index: 2.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2210
    Cell Significance Index: 15.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1827
    Cell Significance Index: 4.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0828
    Cell Significance Index: 3.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0795
    Cell Significance Index: 15.1300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0466
    Cell Significance Index: 0.7400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0456
    Cell Significance Index: 0.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0366
    Cell Significance Index: 1.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0295
    Cell Significance Index: 0.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0294
    Cell Significance Index: 0.6100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0267
    Cell Significance Index: 0.1800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0248
    Cell Significance Index: 0.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0217
    Cell Significance Index: 0.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0215
    Cell Significance Index: 0.6900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.0191
    Cell Significance Index: 0.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0153
    Cell Significance Index: 0.2300
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: 0.0097
    Cell Significance Index: 0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0080
    Cell Significance Index: 1.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0060
    Cell Significance Index: 0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0056
    Cell Significance Index: 1.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0041
    Cell Significance Index: 0.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0040
    Cell Significance Index: 0.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0036
    Cell Significance Index: 0.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0030
    Cell Significance Index: 0.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0009
    Cell Significance Index: 0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0012
    Cell Significance Index: -0.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0015
    Cell Significance Index: -0.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0016
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0021
    Cell Significance Index: -1.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0026
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0029
    Cell Significance Index: -0.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0033
    Cell Significance Index: -1.2000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0033
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0036
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0063
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0072
    Cell Significance Index: -1.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0079
    Cell Significance Index: -0.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0089
    Cell Significance Index: -1.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0096
    Cell Significance Index: -1.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0105
    Cell Significance Index: -1.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0112
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0117
    Cell Significance Index: -1.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0133
    Cell Significance Index: -1.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0139
    Cell Significance Index: -0.7000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0145
    Cell Significance Index: -0.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0157
    Cell Significance Index: -0.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0183
    Cell Significance Index: -0.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0185
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0190
    Cell Significance Index: -1.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0205
    Cell Significance Index: -1.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0239
    Cell Significance Index: -1.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0245
    Cell Significance Index: -0.9000
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0249
    Cell Significance Index: -0.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0276
    Cell Significance Index: -1.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0276
    Cell Significance Index: -1.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0279
    Cell Significance Index: -0.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0297
    Cell Significance Index: -0.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0301
    Cell Significance Index: -0.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0317
    Cell Significance Index: -0.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0320
    Cell Significance Index: -1.1200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0327
    Cell Significance Index: -0.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0336
    Cell Significance Index: -0.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0348
    Cell Significance Index: -1.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0348
    Cell Significance Index: -1.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0361
    Cell Significance Index: -1.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0368
    Cell Significance Index: -0.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0379
    Cell Significance Index: -0.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0392
    Cell Significance Index: -1.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0396
    Cell Significance Index: -1.5000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0404
    Cell Significance Index: -0.3900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0425
    Cell Significance Index: -0.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0445
    Cell Significance Index: -1.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0452
    Cell Significance Index: -1.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0466
    Cell Significance Index: -0.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0472
    Cell Significance Index: -1.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0481
    Cell Significance Index: -1.0200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0498
    Cell Significance Index: -1.0400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0506
    Cell Significance Index: -0.7000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0514
    Cell Significance Index: -0.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0532
    Cell Significance Index: -1.4000
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0567
    Cell Significance Index: -0.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OXGR1 is a G protein-coupled receptor (GPCR) that belongs to the rhodopsin-like receptor family. It is characterized by its ability to bind to oxoglutarate, a key intermediate in the tricarboxylic acid (TCA) cycle, and to modulate signaling events through Gαi protein-coupled pathways. OXGR1 is widely expressed in various tissues and cell types, including immune cells, epithelial cells, and neural cells, suggesting its involvement in multiple physiological processes. **Pathways and Functions:** OXGR1 is involved in several signaling pathways, including: 1. **Gαi signaling events:** OXGR1 activates Gαi protein-coupled pathways, which regulate various cellular processes, such as cell proliferation, differentiation, and survival. 2. **G protein-coupled receptor activity:** OXGR1 acts as a GPCR, mediating the binding of oxoglutarate and modulating downstream signaling events. 3. **G protein-coupled receptor signaling pathway:** OXGR1 is part of a larger signaling pathway that regulates immune responses, cellular signaling, and tissue homeostasis. 4. **Membrane and plasma membrane signaling:** OXGR1 is localized to the plasma membrane, where it can interact with other signaling molecules and regulate membrane-bound processes. **Clinical Significance:** OXGR1 has been implicated in various immunological disorders, including: 1. **Autoimmune diseases:** OXGR1 has been shown to play a role in the regulation of immune responses and the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Inflammatory disorders:** OXGR1 has been implicated in the regulation of inflammatory responses and the development of inflammatory disorders, such as asthma and inflammatory bowel disease. 3. **Neurological disorders:** OXGR1 has been shown to regulate neural signaling and has been implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, OXGR1 is a novel gene that plays a crucial role in regulating immune responses, cellular signaling, and tissue homeostasis. Further research is needed to fully understand the mechanisms by which OXGR1 regulates these processes and to explore its potential as a therapeutic target for immunological disorders.

Genular Protein ID: 3950568372

Symbol: OXGR1_HUMAN

Name: 2-oxoglutarate receptor 1

UniProtKB Accession Codes:

Q96P68 Q5T5A7 Q86TL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 10 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11574155

Title: Discovery and mapping of ten novel G protein-coupled receptor genes.

PubMed ID: 11574155

DOI: 10.1016/s0378-1119(01)00651-5

PubMed ID: 12098360

Title: GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors.

PubMed ID: 12098360

DOI: 10.1186/1471-2164-3-17

PubMed ID: 12044878

Title: Identification of G protein-coupled receptor genes from the human genome sequence.

PubMed ID: 12044878

DOI: 10.1016/s0014-5793(02)02775-8

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 36571463

Title: OXGR1 is a candidate disease gene for human calcium oxalate nephrolithiasis.

PubMed ID: 36571463

DOI: 10.1016/j.gim.2022.11.019

Sequence Information:

  • Length: 337
  • Mass: 38251
  • Checksum: 6814EA0044756CE6
  • Sequence:
    • MNEPLDYLAN ASDFPDYAAA FGNCTDENIP LKMHYLPVIY GIIFLVGFPG NAVVISTYIF 
KMRPWKSSTI IMLNLACTDL LYLTSLPFLI HYYASGENWI FGDFMCKFIR FSFHFNLYSS 
ILFLTCFSIF RYCVIIHPMS CFSIHKTRCA VVACAVVWII SLVAVIPMTF LITSTNRTNR 
SACLDLTSSD ELNTIKWYNL ILTATTFCLP LVIVTLCYTT IIHTLTHGLQ TDSCLKQKAR 
RLTILLLLAF YVCFLPFHIL RVIRIESRLL SISCSIENQI HEAYIVSRPL AALNTFGNLL 
LYVVVSDNFQ QAVCSTVRCK VSGNLEQAKK ISYSNNP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.